Chapter 49 : Introduction

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This is the introductory chapter to the section . The chapter describes a variety of methods and their applications for detecting infections caused by bacteria, mycoplasmas, chlamydiae, rickettsiae, and bartonellae. In addition to antibody detection methods, procedures for assessing cellular immune responses to selected pathogens (e.g., ) are discussed in the chapter. Both in vivo assays (e.g., skin testing) and in vitro assays (e.g., gamma interferon secretion) for detecting cell-mediated immune reactivity are presented. Molecular methods for pathogen detection are increasingly performed under the auspices of the clinical immunology laboratory.

Citation: Prince H. 2006. Introduction, p 427-. In Detrick B, Hamilton R, Folds J (ed), Manual of Molecular and Clinical Laboratory Immunology, 7th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815905.ch49
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1. Centers for Disease Control and Prevention. 2001. Update: investigation of bioterrorism-related anthrax and interim guidelines for clinical evaluation of persons with possible anthrax. Morb. Mortal. Wkly. Rep. 50: 941948.
2. Sever, J. L. 1997. Major technological advances affecting clinical and diagnostic immunology. Clin. Diagn. Lab. Immunol. 4: 13.
3. von Konig, C. H.,, S. Halperin,, M. Riffelmann, and , N. Guiso. 2002. Pertussis in adults and infants. Lancet Infect. Dis. 2: 744750.

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