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Chapter 15 : Species

Authors: Keith A. Lampel1, Anthony T. Maurelli2
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Affiliations: 1: Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740; 2: Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F. Hébert School of Medicine, 4301 Jones Bridge Road, Bethesda, MD 20814-4799
Content Type: Reference
Publication Year: 2007

Category: Applied and Industrial Microbiology; Food Microbiology

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Abstract:

This chapter talks about the members of the species and the disease they cause. Modes of transmission and examples of recent foodborne outbreaks are also presented in the chapter. It also discusses the current understanding of the genetics of pathogenesis, the genes involved in causing disease, and how they are regulated. Common foods that have been implicated in outbreaks caused by shigellae include potato salad, chicken salad, tossed salad, and shellfish. The locations where these types of -contaminated foods were served ranged from the home to restaurants, camps, picnics, schools, airlines, sorority houses, and military mess halls. The adverse effect of foodborne pathogenesis on public health is reflected by its notable morbidity and mortality. Reactive arthritis is a postinfection sequela to shigellosis that is strongly associated with individuals of the HLA-B27 histocompatibility group. The syndrome is comprised of three symptoms, urethritis, conjunctivitis, and arthritis, with the last being the most dominant symptom. The single most effective means of preventing secondary transmission is handwashing. Observation of mutants established intracellular spread as the fourth hallmark of virulence.

Citation: Lampel K, Maurelli A. 2007. Species, p 323-341. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch15
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Shigella Species
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Citation: Lampel K, Maurelli A. 2007. Species, p 323-341. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch15
/content/10.1128/9781555815912.ch15.ch15fig01
Figure 15.1
Map of virulence plasmid from 2a. A SalI restriction map of the 220-kb plasmid is shown in the center. Sections of SalI fragments B and P (top map) and fragments P, H, and D (bottom map) are expanded to illustrate the virulence loci carried in these regions. The expanded regions are contiguous and cover 32 kb. The open reading frame for is separated from that of by 314 bp. The entire sequences of the virulence plasmids from 2a and 5 have been determined ( ).
10.1128/9781555815912/f0332-01_thmb.gif
10.1128/9781555815912/f0332-01.gif
Image of Figure 15.1
Figure 15.1

Map of virulence plasmid from 2a. A SalI restriction map of the 220-kb plasmid is shown in the center. Sections of SalI fragments B and P (top map) and fragments P, H, and D (bottom map) are expanded to illustrate the virulence loci carried in these regions. The expanded regions are contiguous and cover 32 kb. The open reading frame for is separated from that of by 314 bp. The entire sequences of the virulence plasmids from 2a and 5 have been determined ( ).

Citation: Lampel K, Maurelli A. 2007. Species, p 323-341. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch15
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References

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1. Adler, B.,, C. Sasakawa,, T. Tobe,, S. Makino,, K. Komatsu, and, M. Yoshikawa. 1989. A dual transcriptional activation system for the 230 kb plasmid genes coding for virulence-associated antigens of Shigella flexneri. Mol. Microbiol. 3: 627– 635.
2. Agle, M. E.,, S. E. Martin, and, H. P. Blaschek. 2005. Survival of Shigella boydii 18 in bean salad. J. Food Prot. 68: 838– 840.
3. Allaoui, A.,, P. J. Sansonetti, and, C. Parsot. 1992. MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is homologous to YscJ, a secretion factor of the Yersinia Yop proteins. J. Bacteriol. 174: 7661– 7669.
4. Allaoui, A.,, P. J. Sansonetti, and, C. Parsot. 1993. MxiD, an outer membrane protein necessary for the secretion of the Shigella flexneri Ipa invasins. Mol. Microbiol. 7: 59– 68.
5. Andrews, G. P.,, A. E. Hromockyj,, C. Coker, and, A. T. Maurelli. 1991. Two novel virulence loci, mxiA and mxiB, in Shigella flexneri 2a facilitate excretion of invasion plasmid antigen. Infect. Immun. 59: 1997– 2005.
6. Andrews, G. P., and, A. T. Maurelli. 1992. mxiA of Shigella flexneri 2a, which facilitates export of invasion plasmid antigens, encodes a homologue of the low-calcium response protein LcrD, of Yersinia pestis. Infect. Immun. 60: 3287– 3295.
7. Andrews, W. H. 1989. Methods for recovering injured classical enteric pathogenic bacteria ( Salmonella, Shigella and enteropathogenic Escherichia coli) from foods, p. 55– 113. In B. Ray (ed.), Injured Index and Pathogenic Bacteria: Occurrence and Detection in Foods, Water and Feeds. CRC Press, Boca Raton, Fla.
8. Barzu, S.,, A. Fontaine,, P. Sansonetti, and, A. Phalipon. 1996. Induction of a local anti-IpaC antibody response in mice by use of a Shigella flexneri 2a vaccine candidate: implications for use of IpaC as a protein carrier. Infect. Immun. 64: 1190– 1196.
9. Bean, N. H., and, P. M. Griffin. 1990. Foodborne disease outbreaks in the United States, 1973–1987: pathogens, vehicles, and trends. J. Food Prot. 53: 804– 817.
10. Beloin, C., and, C. J. Dorman. 2003. An extended role for the nucleoid structuring protein H-NS in the virulence gene regulatory cascade of Shigella flexneri. Mol. Microbiol. 47: 825– 838.
11. Bennett, J. V.,, S. D. Holmberg,, M. F. Rogers, and, S. L. Solomon. 1987. Infectious and parasitic diseases, p. 102– 114. In R. W. Amlet and, H. B. Dull (ed.), Closing the Gap: the Burden of Unnecessary Illness. Oxford Press, New York, N.Y.
12. Bennish, M. L. 1991. Potentially lethal complications of shigellosis. Rev. Infect. Dis. 13( Suppl. 4): S319– S324.
13. Bennish, M. L.,, J. R. Harris,, B. J. Wojtynaik, and, M. Struelens. 1990. Death in shigellosis: incidence and risk factors in hospitalized patients. J. Infect. Dis. 161: 500– 506.
14. Bennish, M. L., and, M. A. Salam. 1992. Rethinking options for the treatment of shigellosis. J. Antimicrob. Chemother. 30: 243– 247.
15. Bernardini, M. L.,, J. Mounier,, H. d’Hauteville,, M. CoquisRondon, and, P. J. Sansonetti. 1989. Identification of icsA, a plasmid locus in Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin. Proc. Natl. Acad. Sci. USA 86: 3867– 3871.
16. Blocker, A.,, N. Jouihri,, E. Larquet,, P. Gounon,, F. Ebel,, C. Parsot,, P. Sansonetti, and, A. Allaoui. 2001. Structure and composition of the Shigella flexneri “needle complex,” a part of its type III secreton. Mol. Microbiol. 39: 652– 663.
17. Bourdet-Sicard, R.,, M. Rudiger,, B. M. Jockusch,, P. Gounon,, P. J. Sansonetti, and, G. T. Nhieu. 1999. Binding of the Shigella protein IpaA to vinculin induces F-actin depolymerization. EMBO J. 18: 5853– 5862.
18. Brahmbhatt, H. N.,, A. A. Lindberg, and, K. N. Timmis. 1992. Shigella lipopolysaccharide: structure, genetics, and vaccine development. Curr. Top. Microbiol. Immunol. 180: 45– 64.
19. Buchrieser, C.,, P. Glaser,, C. Rusniok,, H. Nedjari,, H. d’Hauteville,, F. Kunst,, P. Sansonetti, and, C. Parsot. 2000. The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri. Mol. Microbiol. 38: 760– 771.
20. Bunning, V. K.,, R. B. Raybourne, and, D. L. Archer. 1988. Foodborne enterobacterial pathogens and rheumatoid disease. J. Appl. Bacteriol. Symp. 65(Suppl.): 87S– 107S.
21. Buysse, J. M.,, M. M. Venkatesan,, J. Mills, and, E. V. Oaks. 1990. Molecular characterization of a transacting, positive effector ( ipaR) of invasion plasmid antigen synthesis in Shigella flexneri serotype 5. Microb. Pathog. 8: 197– 211.
22. Centers for Disease Control and Prevention. 1994. Personal communication.
23. Centers for Disease Control and Prevention. 1994. Outbreak of Shigella flexneri 2a infections on a cruise ship. Morb. Mortal. Wkly. Rep. 43: 657.
24. Centers for Disease Control and Prevention. 1996. The Foodborne Diseases Active Surveillance Network. Morb. Mortal. Wkly. Rep. 46: 258– 261.
25. Centers for Disease Control and Prevention. 1999. Outbreaks of Shigella sonnei infection associated with eating fresh parsley—United States and Canada, July–August, 1998. Morb. Mortal. Wkly. Rep. 48: 285– 289.
26. Centers for Disease Control and Prevention. 2000. Outbreaks of Shigella sonnei infections associated with eating a nationally distributed dip—California, Oregon, and Washington, January 2000. Morb. Mortal. Wkly. Rep. 49: 60– 61.
27. Centers for Disease Control and Prevention. 2005. Preliminary FoodNet data on the incidence of infections with pathogens transmitted commonly through food—10 sites, United States. Morb. Mortal. Wkly. Rep. 54: 352– 356.
28. Charles, M.,, M. Perez,, J. H. Kobil, and, M. B. Goldberg. 2001. Polar targeting of Shigella virulence factor IcsA in Enterobacteriaceae and Vibrio. Proc. Natl. Acad. Sci. USA 98: 9871– 9876.
29. Coster, T. S.,, C. W. Hoge,, L. L. VanDeVerg,, A. B. Hartman,, E. V. Oaks,, M. M. Venkatesan,, D. Cohen,, G. Robin,, A. Fontaine-Thompson,, P. J. Sansonetti, and, T. L. Hale. 1999. Vaccination against shigellosis with attenuated Shigella flexneri 2a strain SC602. Infect. Immun. 67: 3437– 3443.
30. Davis, H.,, J. P. Taylor,, J. N. Perdue,, G. N. Stelma, Jr.,, J. M. Humphreys, Jr.,, R. Rowntree III, and, K. D. Greene. 1988. A shigellosis outbreak traced to commercially distributed lettuce. Am. J. Epidemiol. 128: 1312– 1321.
31. Dorman, C. J., and, M. E. Porter. 1998. The Shigella virulence gene regulatory cascade: a paradigm of bacterial gene control mechanisms. Mol. Microbiol. 29: 677– 684.
32. DuPont, H. L. 2005. Shigella species (bacillary dysentery), p. 2655– 2661. In G. L. Mandell,, J. E. Bennett, and, R. Dolin (ed.), Principles and Practice of Infectious Diseases. Churchill Livingstone, New York, N.Y.
33. DuPont, H. L.,, M. M. Levine,, R. B. Hornick, and, S. B. Formal. 1989. Inoculum size in shigellosis and implications for expected mode of transmission. J. Infect. Dis. 159: 1126– 1128.
34. Edwards, P. R., and, W. H. Ewing. 1972. Identification of Enterobacteriaceae. Burgess Publishing Co., Minneapolis, Minn.
35. Egile, C.,, H. d’Hauteville,, C. Parsot, and, P. J. Sansonetti. 1997. SopA, the outer membrane protease responsible for polar localization of IcsA in Shigella flexneri. Mol. Microbiol. 23: 1063– 1073.
36. Ekdahl, K., and, Y. Andersson. 2005. The epidemiology of travel-associated shigellosis—regional risks, seasonality and serogroups. J. Infect. 51: 222– 229.
37. Falconi, M.,, B. Colonna,, G. Prosseda,, G. Micheli, and, C. O. Gualerzi. 1998. Thermoregulation of Shigella and Escherichia coli EIEC pathogenicity. A temperature-dependent structural transition of DNA modulates accessibility of virF promoter to transcriptional repressor H-NS. EMBOJ. 17: 7033– 7043.
38. Falkow, S.,, H. Schneider,, L. Baron, and, S. B. Formal. 1963. Virulence of Escherichia-Shigella genetic hybrids for the guinea pig. J. Bacteriol. 86: 1251– 1258.
39. Fasano, A.,, F. R. Noriega,, D. R. Maneval, Jr.,, S. Chanasongcram,, R. Russell,, S. Guandalini, and, M. M. Levine. 1995. Shigella enterotoxin 1: an enterotoxin of Shigella flexneri 2a active in rabbit small intestine in vivo and in vitro. J. Clin. Investig. 95: 2853– 2861.
40. Flint, J. A.,, Y. T. Van Duynhoven,, F. J. Angulo,, S. M. DeLong,, P. Braun,, M. Kirk,, E. Scallan,, M. Fitzgerald,, G. K. Adak,, P. Sockett,, A. Ellis,, G. Hall,, N. Gargouri,, H. Walke, and, P. Braam. 2005. Estimating the burden of acute gastroenteritis, foodborne disease, and pathogens commonly transmitted by food: an international review. Clin. Infect. Dis. 41: 698– 704.
41. Fontaine, A.,, J. Arondel, and, P. J. Sansonetti. 1988. Role of the Shiga toxin in the pathogenesis of bacillary dysentery studied by using a Tox–mutant of Shigella dysenteriae 1. Infect. Immun. 56: 3099– 3109.
42. Formal, S. B.,, E. H. LaBrec,, T. H. Kent, and, S. Falkow. 1965. Abortive intestinal infection with an Escherichia coliShigella flexneri hybrid strain. J. Bacteriol. 89: 1374– 1382.
43. Frost, J. A.,, M. B. McEvoy,, C. A. Bentley,, Y. Andersson, and, B. Rowe. 1995. An outbreak of Shigella sonnei infection associated with consumption of iceberg lettuce. Emerg. Infect. Dis. 1: 26– 29.
44. Galán, J. E., and, P. J. Sansonetti. 1996. Molecular and cellular bases of Salmonella and Shigella interactions with host cells, p. 2757– 2773. In F. C. Neidhardt,, R. Curtiss III,, C. A. Gross,, J. I. Ingraham,, E. C. Lin,, K. B. Low, Jr.,, B. Magasanik,, W. Reznikoff,, M. Riley,, M. Schaechter, and, H. E. Umbarger (ed.), Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology, 2nd ed. American Society for Microbiology, Washington, D.C.
45. Gallegos, M. T.,, C. Michan, and, J. L. Ramos. 1993. The XylS/AraC family of regulators. Nucleic Acids Res. 21: 807– 810.
46. Gessner, B. D., and, M. Beller. 1994. Moose soup shigellosis in Alaska. West. J. Med. 160: 430– 433.
47. Goldberg, M. B.,, O. Barzu,, C. Parsot, and, P. J. Sansonetti. 1993. Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement. J. Bacteriol. 175: 2189– 2196.
48. Goma Epidemiology Group. 1995. Public health impact of Rwandan refugee crisis: what happened in Goma, Zaire, in July, 1994? Lancet 345: 339– 344.
49. Groisman, E. A., and, H. Ochman. 1993. Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri. EMBO J. 12: 3779– 3787.
50. Guerrero, L.,, J. J. Calva,, A. L. Morrow,, F. R. Velazquez,, F. Tuz-Dzib,, Y. Lopez-Vidal,, H. Ortega,, H. Arroyo,, T. G. Cleary,, L. K. Pickering, and, G. M. Ruiz-Palacios. 1994. Asymptomatic Shigella infections in a cohort of Mexican children younger than two years of age. Pediatr. Infect. Dis. J. 13: 597– 602.
51. Hall, P. A. 1994. Scope for rapid microbiological methods in modern food production, p. 255– 267. In P. Patel (ed.), Rapid Analysis Techniques in Food Microbiology. Blackie Academic & Professional, New York, N.Y.
52. Haltalin, K.,, J. Nelson, and, R. Ring. 1967. Double-blind treatment study of shigellosis comparing ampicillin, sulfa-diazone and placebo. J. Pediatr. 70: 970– 981.
53. Hedberg, C. W.,, W. C. Levine,, K. E. White,, R. H. Carlson,, D. K. Winsor,, D. N. Cameron,, K. L. MacDonald, and, M. T. Osterholm. 1992. An international foodborne outbreak of shigellosis associated with a commercial airline. JAMA 268: 3208– 3212.
54. High, N.,, J. Mounier,, M. C. Prevost, and, P. J. Sansonetti. 1992. IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole. EMBO J. 11: 1991– 1999.
55. Hoge, C. W.,, J. M. Gambel,, A. Srijan,, C. Pitarangsi, and, P. Echeverria. 1998. Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years. Clin. Infect. Dis. 26: 341– 345.
56. Hossain, M. A.,, K. Z. Hasan, and, M. J. Albert. 1994. Shigella carriers among non-diarrhoeal children in an endemic area of shigellosis in Bangladesh. Trop. Geogr. Med. 46: 40– 42.
57. Hyams, K. C.,, A. L. Bourgeois,, B. R. Merrell,, P. Rozmajzl,, J. Escamilla,, S. A. Thornton,, G. M. Wasserman,, A. Burke,, P. Echeverria,, K. Y. Green,, A. Z. Kapikian, and, J. N. Woody. 1991. Diarrheal disease during Operation Desert Shield. N. Engl. J. Med. 325: 1423– 1428.
58. International Commission on Microbiological Specifications for Foods of the International Union of Biological Societies. 1996. Shigella, p. 280– 298. In Microorganisms in Foods, vol 5. Microbiological Specifications of Food Pathogens. Blackie Academic & Professional, New York, N.Y.
59. Jiang, Y.,, F. Yang,, X. Zhang,, J. Yang,, L. Chen,, Y. Yan,, H. Nie,, Z. Xiong,, J. Wang,, J. Dong,, Y. Xue,, X. Xu,, Y. Zhu,, S. Chen, and, Q. Jin. 2005. The complete sequence and analysis of the large virulence plasmid pSS of Shigella sonnei. Plasmid 54: 149– 159.
60. Jin, Q.,, Z. Yuan,, J. Xu,, Y. Wang,, Y. Shen,, W. Lu,, J. Wang,, H. Liu,, J. Yang,, F. Yang,, X. Zhang,, J. Zhang,, G. Yang,, H. Wu,, D. Qu,, J. Dong,, L. Sun,, Y. Xue,, A. Zhao,, Y. Gao,, J. Zhu,, B. Kan,, K. Ding,, S. Chen,, H. Cheng,, Z. Yao,, B. He,, R. Chen,, D. Ma,, B. Qiang,, Y. Wen,, Y. Hou, and, J. Yu. 2002. Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 30: 4432– 4441.
61. Jouihri, N.,, M. P. Sory,, A. L. Page,, P. Gounon,, C. Parsot, and, A. Allaoui. 2003. MxiK and MxiN interact with the Spa47 ATPase and are required for transit of the needle components MxiH and MxiI, but not of Ipa proteins, through the type III secretion apparatus of Shigella flexneri. Mol. Microbiol. 49: 755– 767.
62. Kalluri, P.,, K. C. Cummings,, S. Abbott,, G. B. Malcolm,, K. Hutcheson,, A. Beall,, K. Joyce,, C. Polyak,, D. Woodward,, R. Caldeira,, F. Rodgers,, E. D. Mintz, and, N. Strockbine. 2004. Epidemiological features of a newly described serotype of Shigella boydii. Epidemiol. Infect. 132: 579– 583.
63. Kane, C. D.,, R. Schuch,, W. A. Day, Jr., and, A. T. Maurelli. 2002. MxiE regulates intracellular expression of factors secreted by the Shigella flexneri 2a type III secretion system. J. Bacteriol. 184: 4409– 4419.
64. Kapperud, G.,, L. M. Rorvik,, V. Hasseltvedt,, E. A. Hoiby,, B. G. Iversen,, K. Staveland,, G. Johnsen,, J. Leitao,, H. Herikstad,, Y. Andersson,, G. Langeland,, B. Gondrosen, and, J. Lassen. 1995. Outbreak of Shigella sonnei infection traced to imported iceberg lettuce. J. Clin. Microbiol. 33: 609– 614.
65. Karmali, M. A.,, M. Petric,, C. Lim,, P. C. Fleming,, G. S. Arbus, and, H. Lior. 1985. The association between idiopathic hemolytic syndrome and infection by verotoxin-producing Escherichia coli. J. Infect. Dis. 151: 775– 782.
66. Kennedy, F. M.,, J. Astbury,, J. R. Needham, and, T. Cheasty. 1993. Shigellosis due to occupational contact with non-human primates. Epidemiol. Infect. 110: 247– 257.
67. Kim, D. W.,, G. Lenzen,, A. L. Page,, P. Legrain,, P. J. Sansonetti, and, C. Parsot. 2005. The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. Proc. Natl. Acad. Sci. USA 102: 14046– 14051.
68. Kinsey, M. D.,, S. B. Formal,, G. J. Dammin, and, R. A. Giannella. 1976. Fluid and electrolyte transport in rhesus monkeys challenged intracecally with Shigella flexneri 2a. Infect. Immun. 14: 368– 371.
69. Kolavic, S. A.,, A. Kimura,, S. L. Simons,, L. Slutsker,, S. Barth, and, C. E. Haley. 1997. An outbreak of Shigella dysenteriae type 2 among laboratory workers due to intentional food contamination. JAMA 278: 396– 398.
70. Kotloff, K. L.,, J. P. Winickoff,, B. Ivanoff,, J. D. Clemens,, D. L. Swerdlow,, P. J. Sansonetti,, G. K. Adak, and, M. M. Levine. 1999. Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull. W. H. O. 77: 651– 666.
71. LaBrec, E. H.,, H. Schneider,, T. J. Magnani, and, S. B. Formal. 1964. Epithelial cell penetration as an essential step in the pathogenesis of bacillary dysentery. J. Bacteriol. 88: 1503– 1518.
72. Lawlor, K. M.,, P. A. Daskeleros,, R. E. Robinson, and, S. M. Payne. 1987. Virulence of iron-transport mutants of Shigella flexneri and utilization of host iron compounds. Infect. Immun. 55: 594– 599.
73. Lee, L. A.,, S. M. Ostroff,, H. B. McGee,, D. R. Johnson,, F. P. Downes,, D. N. Cameron,, N. H. Bean, and, P. M. Griffin. 1991. An outbreak of shigellosis at an outdoor music festival. Am. J. Epidemiol. 133: 608– 615.
74. Le Gall, T.,, M. Mavris,, M. C. Martino,, M. L. Bernardini,, E. Denamur, and, C. Parsot. 2005. Analysis of virulence plasmid gene expression defines three classes of effectors in the type III secretion system of Shigella flexneri. Microbiology 151: 951– 962.
75. Levine, M. M., and, O. S. Levine. 1994. Changes in human ecology and behavior in relation to the emergence of diarrheal diseases, including cholera. Proc. Natl. Acad. Sci. USA 91: 2390– 2394.
76. Lew, J. F.,, D. L. Swerdlow,, M. E. Dance,, P. M. Griffin,, C. A. Bopp,, M. J. Gillenwater,, T. Mercatante, and, R. I. Glass. 1991. An outbreak of shigellosis aboard a cruise ship caused by a multiple-antibiotic-resistant strain of Shigella flexneri. Am. J. Epidemiol. 134: 413– 420.
77. Lopez, E. L.,, M. Diaz,, S. Grinstein,, S. Dovoto,, F. Mendila-Harzu,, B. E. Murray,, S. Ashkenazi,, E. Rubeglio,, M. Woloj,, M. Vasquez,, M. Turco,, L. K. Pickering, and, T. G. Cleary. 1989. Hemolytic uremic syndrome and diarrhea in Argentine children: the role of Shiga-like toxins. J. Infect. Dis. 160: 469– 475.
78. Magdalena, J.,, A. Hachani,, M. Chamekh,, N. Jouihri,, P. Gounon,, A. Blocker, and, A. Allaoui. 2002. Spa32 regulates a switch in substrate specificity of the type III secreton of Shigella flexneri from needle components to Ipa proteins. J. Bacteriol. 184: 3433– 3441.
79. Makino, S.,, C. Sasakawa,, K. Kamata,, T. Kurata, and, M. Yoshikawa. 1986. A genetic determinant required for continuous reinfection of adjacent cells on large plasmid in Shigella flexneri 2a. Cell 46: 551– 555.
80. Maurelli, A. T. 1989. Temperature regulation of virulence genes in pathogenic bacteria: a general strategy for human pathogens? Microb. Pathog. 7: 1– 10.
81. Maurelli, A. T.,, B. Baudry,, H. d’Hauteville,, T. L. Hale, and, P. J. Sansonetti. 1985. Cloning of virulence plasmid DNA sequences involved in invasion of HeLa cells by Shigella flexneri. Infect. Immun. 49: 164– 171.
82. Maurelli, A. T.,, B. Blackmon, and, R. Curtiss III. 1984. Temperature-dependent expression of virulence genes in Shigella species. Infect. Immun. 43: 195– 201.
83. Maurelli, A. T.,, R. E. Fernández,, C. A. Bloch,, C. K. Rode, and, A. Fasano. 1998. “Black holes” and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli. Proc. Natl. Acad. Sci. USA 95: 3943– 3948.
84. Maurelli, A. T., and, K. A. Lampel. 2001. Shigella, p. 323– 343. In Y. H. Hui,, M. D. Pierson, and, J. R. Gorham (ed.), Foodborne Disease Handbook, vol. 1, 2nd ed. Marcel Dekker Publishers, New York, N.Y.
85. Maurelli, A. T., and, P. J. Sansonetti. 1988. Identification of a chromosomal gene controlling temperature regulated expression of Shigella virulence. Proc. Natl. Acad. Sci. USA 85: 2820– 2824.
86. Mavris, M.,, A. L. Page,, R. Tournebize,, B. Demers,, P. Sansonetti, and, C. Parsot. 2002. Regulation of transcription by the activity of the Shigella flexneri type III secretion apparatus. Mol. Microbiol. 43: 1543– 1553.
87. Mavris, M.,, P. J. Sansonetti, and, C. Parsot. 2002. Identification of the cis-acting site involved in activation of promoters regulated by activity of the type III secretion apparatus in Shigella flexneri. J. Bacteriol. 184: 6751– 6759.
88. McKenna, S.,, C. Beloin, and, C. J. Dorman. 2003. In vitro DNA-binding properties of VirB, the Shigella flexneri virulence regulatory protein. FEBS Lett. 545: 183– 187.
89. Mead, P. S.,, L. Slutkser,, V. Dietz,, L. F. McCaig,, J. S. Bresee,, C. Shapiro,, P. M. Griffin, and, R. V. Tauxe. 1999. Food-related illness and death in the United States. Emerg. Infect. Dis. 5: 607– 625.
90. Ménard, R.,, M.-C. Prévost,, P. Gounon,, P. Sansonetti, and, C. Dehio. 1996. The secreted Ipa complex of Shigella flexneri promotes entry into mammalian cells. Proc. Natl. Acad. Sci. USA 93: 1254– 1258.
91. Ménard, R.,, P. J. Sansonetti, and, C. Parsot. 1993. Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells. J. Bacteriol. 175: 5899– 5906.
92. Ménard, R.,, P. J. Sansonetti, and, C. Parsot. 1994. The secretion of the Shigella flexneri Ipa invasins is induced by the epithelial cell and controlled by IpaB and IpaD. EMBOJ. 13: 5293– 5302.
93. Ménard, R.,, P. J. Sansonetti,, C. Parsot, and, T. Vasselon. 1994. The IpaB and IpaC invasins of Shigella flexneri associate in the extracellular medium and are partitioned in the cytoplasm by a specific chaperon. Cell 76: 829– 839.
94. Morita-Ishihara, T.,, M. Ogawa,, H. Sagara,, M. Yoshida,, E. Katayama, and, C. Sasakawa. 2006. Shigella Spa33 is an essential C-ring component of type III secretion machinery. J. Biol. Chem. 281: 599– 607.
95. Moss, J. E.,, T. J. Cardozo,, A. Zychlinsky, and, E. A. Groisman. 1999. The selC-associated SHI-2 pathogenicity island of Shigella flexneri. Mol. Microbiol. 33: 74– 83.
96. Nassif, X.,, M. C. Mazert,, J. Mounier, and, P. J. Sansonetti. 1987. Evaluation with an iuc::Tn 10 mutant of the role of aerobactin production in the virulence of Shigella flexneri. Infect. Immun. 55: 1963– 1969.
97. Nataro, J. P.,, J. Seriwatana,, A. Fasano,, D. R. Maneval,, L. D. Guers,, F. Noriega,, F. Dubovsky,, M. M. Levine, and, J. G. Morris, Jr. 1995. Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains. Infect. Immun. 63: 4721– 4728.
98. Oaks, E. V.,, T. L. Hale, and, S. B. Formal. 1986. Serum immune response to Shigella protein antigens in rhesus monkeys and humans infected with Shigella spp. Infect. Immun. 53: 57– 63.
99. O’Brien, A. D., and, R. K. Holmes. 1995. Protein toxins of Escherichia coli and Salmonella. In F. C. Neidhardt,, R. Curtiss III,, C. A. Gross,, J. I. Ingraham,, E. C. Lin,, K. B. Low, Jr.,, B. Magasanik,, W. Reznikoff,, M. Riley,, M. Schaechter, and, H. E. Umbarger (ed.), Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology, 2nd ed. American Society for Microbiology, Washington, D.C.
100. Ochman, H.,, T. S. Whittam,, D. A. Caugant, and, R. K. Selander. 1983. Enzyme polymorphism and genetic population structure in Escherichia coli and Shigella. J. Gen. Microbiol. 129: 2715– 2726.
101. O’Connell, C. M. C.,, R. C. Sandlin, and, A. T. Maurelli. 1995. Signal transduction and virulence gene regulation in Shigella spp.: temperature and (maybe) a whole lot more, p. 111– 127. In R. Rappuoli (ed.), Signal Transduction and Bacterial Virulence. R.G. Landes Company, Austin, Tex.
102. Ogawa, M.,, T. Yoshimori,, T. Suzuki,, H. Sagara,, N. Mizushima, and, C. Sasakawa. 2005. Escape of intracellular Shigella from autophagy. Science 307: 727– 731.
103. Parsot, C.,, E. Ageron,, C. Penno,, M. Mavris,, K. Jamoussi,, H. d’Hauteville,, P. Sansonetti, and, B. Demers. 2005. A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri. Mol. Microbiol. 56: 1627– 1635.
104. Parsot, C.,, R. Ménard,, P. Giunon, and, P. J. Sansonetti. 1995. Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structures. Mol. Microbiol. 16: 291– 300.
105. Parsot, C., and, P. J. Sansonetti. 1996. Invasion and the pathogenesis of Shigella infections. Curr. Top. Microbiol. Immunol. 209: 25– 42.
106. Pickering, L. K.,, A. V. Bartlett, and, W. E. Woodward. 1986. Acute infectious diarrhea among children in day-care: epidemiology and control. Rev. Infect. Dis. 8: 539– 547.
107. Picking, W. L.,, H. Nishioka,, P. D. Hearn,, M. A. Baxter,, A. T. Harrington,, A. Blocker, and, W. D. Picking. 2005. IpaD of Shigella flexneri is independently required for regulation of Ipa protein secretion and efficient insertion of IpaB and IpaC into host membranes. Infect. Immun. 73: 1432– 1440.
108. Raghupathy, P.,, A. Date,, J. C. M. Shastry,, A. Sudarsanam, and, M. Jadhav. 1978. Haemolytic-uraemic syndrome complicating shigella dysentery in south Indian children. Br. Med. J. 1: 1518– 1521.
109. Rajakumar, K.,, C. Sasakawa, and, B. Adler. 1997. Use of a novel approach, termed island probing, identifies the Shigella flexneri she pathogenicity island which encodes a homolog of the immunoglobulin A protease-like family of proteins. Infect. Immun. 65: 4606– 4614.
110. Reller, M. E.,, J. M. Nelson,, K. Mølbak,, D. M. Ackman,, D. J. Schoonmaker-Bopp,, T. P. Root, and, E. D. Mintz. 2006. A large, multiple-restaurant outbreak of infection with Shigella flexneri serotype 2a traced to tomatoes. Clin. Infect. Dis. 42: 163– 169.
111. Roberts, T. 1989. Human illness costs of foodborne bacteria. Am. J. Agric. Econ. 71: 468– 474.
112. Rout, W. R.,, S. B. Formal,, R. A. Giannella, and, G. J. Dammin. 1975. Pathophysiology of Shigella diarrhea in the rhesus monkey: intestinal transport, morphological, and bacteriological studies. Gastroenterology 68: 270– 278.
113. Sakai, T.,, C. Sasakawa, and, M. Yoshikawa. 1988. Expression of four virulence antigens of Shigella flexneri is positively regulated at the transcriptional level by the 30 kilodalton virF protein. Mol. Microbiol. 2: 589– 597.
114. Sandlin, R. C.,, K. A. Lampel,, S. P. Keasler,, M. B. Goldberg,, A. L. Stolzer, and, A. T. Maurelli. 1995. Avirulence of rough mutants of Shigella flexneri: requirement of O-antigen for correct unipolar localization of IcsA in bacterial outer membrane. Infect. Immun. 63: 229– 237.
115. Sandlin, R. C., and, A. T. Maurelli. 1999. Establishment of unipolar localization of IcsA in Shigella flexneri 2a is not dependent on virulence plasmid determinants. Infect. Immun. 67: 350– 356.
116. Sansonetti, P. J.,, H. d’Hauteville,, C. Ecobichon, and, C. Pourcel. 1983. Molecular comparison of virulence plasmids in Shigella and enteroinvasive Escherichia coli. Ann. Microbiol. (Paris) 134A: 295– 318.
117. Sansonetti, P. J.,, T. L. Hale, and, E. V. Oaks. 1985. Genetics of virulence in enteroinvasive Escherichia coli, p. 74– 77. In D. Schlessinger (ed.), Microbiology—1985. American Society for Microbiology, Washington, D.C.
118. Sansonetti, P. J.,, D. J. Kopecko, and, S. B. Formal. 1981. Shigella sonnei plasmids: evidence that a large plasmid is necessary for virulence. Infect. Immun. 34: 75– 83.
119. Sansonetti, P. J.,, D. J. Kopecko, and, S. B. Formal. 1982. Involvement of a plasmid in the invasive ability of Shigella flexneri. Infect. Immun. 35: 852– 860.
120. Sasakawa, C.,, K. Komatsu,, T. Tobe,, T. Suzuki, and, M. Yoshikawa. 1993. Eight genes in region 5 that form an operon are essential for invasion of epithelial cells by Shigella flexneri 2a. J. Bacteriol. 175: 2334– 2346.
121. Schuch, R., and, A. T. Maurelli. 2000. The type III secretion pathway: dictating the outcome of bacterial-host interactions, p. 203– 223. In K. A. Brogden,, J. A. Roth,, T. B. Stanton,, C. A. Bolin,, F. C. Minion, and, M. J. Wannemuehler (ed.), Virulence Mechanisms of Bacterial Pathogens, 3rd ed. ASM Press, Washington, D.C.
122. Schuch, R., and, A. T. Maurelli. 2001. MxiM and MxiJ, base elements of the Mxi-Spa type III secretion system of Shigella, interact with and stabilize the MxiD secretin in the cell envelope. J. Bacteriol. 183: 6991– 6998.
123. Schuch, R., and, A. T. Maurelli. 2001. Spa33, a cell surface-associated subunit of the Mxi-Spa type III secretory pathway of Shigella flexneri, regulates Ipa protein traffic. Infect. Immun. 69: 2180– 2189.
124. Sharp, T. W.,, S. A. Thornton,, M. R. Wallace,, R. F. Defraites,, J. L. Sanchez,, R. A. Batchelor,, P. J. Rozmajzl,, R. K. Hanson,, P. Echeverria,, A. Z. Kapikian,, X. J. Xiang,, M. K. Estes, and, J. P. Burans. 1995. Diarrheal disease among military personnel during Operation Restore Hope, Somalia, 1992–1993. Am J. Trop. Med. Hyg. 52: 188– 193.
125. Shere, K. D.,, S. Sallustio,, A. Manessis,, T. G. D’Aversa, and, M. B. Goldberg. 1997. Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility. Mol. Microbiol. 25: 451– 462.
126. Simon, D. G.,, R. A. Kaslow,, J. Rosenbaum,, R. L. Kaye, and, A. Calin. 1981. Reiter’s syndrome following epidemic shigellosis. J. Rheumatol. 8: 969– 973.
127. Small, P.,, D. Blankenhorn,, D. Welty,, E. Zinser, and, J. L. Slonczewski. 1994. Acid and base resistance in Escherichia coli and Shigella flexneri: role of rpoS and growth pH. J. Bacteriol. 176: 1729– 1737.
128. Smith, J. L. 1987. Shigella as a foodborne pathogen. J. Food Prot. 50: 788– 801.
129. Snyder, O. P. 1992. HACCP—an industry food safety self-control program. IV. Dairy Food Environ. Sanit. 12: 230– 232.
130. Tamano, K.,, S. Aizawa,, E. Katayama,, T. Nonaka,, S. Imajoh-Ohmi,, A. Kuwae,, S. Nagai, and, C. Sasakawa. 2000. Supramolecular structure of the Shigella type III secretion machinery: the needle part is changeable in length and essential for delivery of effectors. EMBO J. 19: 3876– 3887.
131. Tesh, V. L., and, A. D. O’Brien. 1991. The pathogenic mechanisms of Shiga toxin and the Shiga-like toxins. Mol. Microbiol. 5: 1817– 1822.
132. Tobe, T.,, S. Nagai,, N. Okada,, B. Adler,, M. Yoshikawa, and, C. Sasakawa. 1991. Temperature-regulated expression of invasion genes in Shigella flexneri is controlled through the transcriptional activation of the virB gene on the large plasmid. Mol. Microbiol. 5: 887– 893.
133. Tobe, T.,, M. Yoshikawa,, T. Mizuno, and, C. Sasakawa. 1993. Transcriptional control of the invasion regulatory gene virB of Shigella flexneri: activation by VirF and repression by H-NS. J. Bacteriol. 175: 6142– 6149.
134. Tran Van Nhieu, G.,, A. Ben-Ze’ev, and, P. J. Sansonetti. 1997. Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin. EMBO J. 16: 2717– 2729.
135. Tran Van Nhieu, G.,, E. Caron,, A. Hall, and, P. J. Sansonetti. 1999. IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells. EMBO J. 18: 3249– 3262.
136. Van Gijsegem, F.,, S. Genin, and, C. Boucher. 1993. Conservation of secretion pathways for pathogenicity determinants of plant and animal bacteria. Trends Microbiol. 1: 175– 180.
137. Venkatesan, M. M.,, J. M. Buysse, and, E. V. Oaks. 1992. Surface presentation of Shigella flexneri invasion plasmid antigens requires the products of the spa locus. J. Bacteriol. 174: 1990– 2001.
138. Venkatesan, M. M.,, M. B. Goldberg,, D. J. Rose,, E. J. Grotbeck,, V. Burland, and, F. R. Blattner. 2001. Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri. Infect. Immun. 69: 3271– 3285.
139. Vokes, S. A.,, S. A. Reeves,, A. G. Torres, and, S. M. Payne. 1999. The aerobactin iron transport system genes in Shigella flexneri are present within a pathogenicity island. Mol. Microbiol. 33: 63– 73.
140. Watarai, M.,, T. Tobe,, M. Yoshikawa, and, C. Sasakawa. 1995. Contact of Shigella with host cells triggers release of Ipa invasins and is an essential function of invasiveness. EMBO J. 14: 2461– 2470.
141. Watarai, M.,, S. Funato, and, C. Sasakawa. 1996. Interaction of Ipa proteins of Shigella flexneri with α5-β1 integrin promotes entry of the bacteria into mammalian cells. J. Exp. Med. 183: 991– 999.
142. Weissman, J. B.,, A. Schmerler,, P. Weiler,, G. Filice,, N. Godby, and, I. Hansen. 1974. The role of preschool children and day-care centers in the spread of shigellosis in urban communities. J. Pediatr. 84: 797– 802.
143. Wetherington, J.,, J. L. Bryant,, K. A. Lampel, and, J. M. Johnson. 2000. PCR screening and isolation of Shigella sonnei from layered party dip. Lab. Inf. Bull. 16: 1– 8.
144. Wharton, M.,, R. A. Spiegel,, J. M. Horan,, R. V. Tauxe,, J. G. Wells,, N. Barg,, J. Herndon,, R. A. Meriwether,, J. N. MacCormack, and, R. H. Levine. 1990. A large outbreak of antibiotic-resistant shigellosis at a mass gathering. J. Infect. Dis. 162: 1324– 1328.
145. Yagupsky, P.,, M. Loeffelholz,, K. Bell, and, M. A. Menegus. 1991. Use of multiple markers for investigation of an epidemic of Shigella sonnei infections in Monroe County, New York. J. Clin. Microbiol. 29: 2850– 2855.
146. Yang, F.,, J. Yang,, X. Zhang,, L. Chen,, Y. Jiang,, Y. Yan,, X. Tang,, J. Wang,, Z. Xiong,, J. Dong,, Y. Xue,, Y. Zhu,, X. Xu,, L. Sun,, S. Chen,, H. Nie,, J. Peng,, J. Xu,, Y. Wang,, Z. Yuan,, Y. Wen,, Z. Yao,, Y. Shen,, B. Qiang,, Y. Hou,, J. Yu, and, Q. Jin. 2005. Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery. Nucleic Acids Res. 33: 6445– 6458.
147. Zychlinsky, A.,, B. Kenny,, R. Mènard,, M. C. Prevost,, I. B. Holland, and, P. J. Sansonetti. 1994. IpaB mediates macrophage apoptosis induced by Shigella flexneri. Mol. Microbiol. 11: 619– 627.

Tables

Shigella Species
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Citation: Lampel K, Maurelli A. 2007. Species, p 323-341. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch15
/content/10.1128/9781555815912.ch15.ch15tab01
Table 15.1
Examples of foodborne outbreaks caused by spp.
Generic image for table
Table 15.1

Examples of foodborne outbreaks caused by spp.

Citation: Lampel K, Maurelli A. 2007. Species, p 323-341. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch15
/content/10.1128/9781555815912.ch15.ch15tab02
Table 15.2
Virulence-associated loci of
Generic image for table
Table 15.2

Virulence-associated loci of

Citation: Lampel K, Maurelli A. 2007. Species, p 323-341. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch15

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