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Chapter 18 :

Author: Eric A. Johnson1
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Affiliations: 1: Department of Food Microbiology and Toxicology and Bacteriology, Food Research Institute, University of Wisconsin, 1925 Willow Dr., Madison, WI 53706
Content Type: Reference
Publication Year: 2007

Category: Applied and Industrial Microbiology; Food Microbiology

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Abstract:

Botulism is a neuroparalytic disease in humans and animals, resulting from the actions of neurotoxins produced by and rare strains of and . This chapter talks about historical features of and botulism, and biochemistry and pharmacology of botulinal neurotoxins. The hallmark clinical symptoms of botulism are a bilateral and descending weakening and paralysis of skeletal muscles. Currently there is no treatment for botulism except for passive administration of antibodies at early stages in the disease before botulinal neurotoxin has begun internalization into nerves. The major treatment of botulism is supportive nursing care, with specific attention given to respiratory ability and the need for mechanical ventilation. The chapter discusses epidemiology of foodborne botulism. The defining feature of botulinogenic clostridia is that they produce botulinal neurotoxin. Prevention of botulinal neurotoxin formation in foods can be achieved by avoiding contamination of foods by spores; inactivating spores that are present in foods; preventing spores from germination and vegetative cell growth resulting in botulinal neurotoxin formation; and inactivation of botulinal neurotoxins in food. The primary factors that control growth of in foods are temperature, pH and acidity, water activity, redox potential, nutrient sufficiency, the presence of antimicrobials, and competitive microflora. The chapter describes the use of predictive modeling and challenge studies for evaluation of neurotoxin formation, and genomics of . Remarkable advances have been achieved during the past decade in elucidating the biochemistry, structure, and pharmacological mechanisms of botulinum neurotoxins.

Citation: Johnson E. 2007. , p 401-421. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch18

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Acute Flaccid Paralysis
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Food Microbiology
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Enzyme-Linked Immunosorbent Assay
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Clostridium botulinum
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Citation: Johnson E. 2007. , p 401-421. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch18
/content/10.1128/9781555815912.ch18.ch18fig01
Figure 18.1
Portrayal of a person with the flaccid paralysis symptoms characteristic of botulism. Drawing prepared by James K. Archer, Centers for Disease Control and Prevention, Atlanta, Ga.
10.1128/9781555815912/f0403-01_thmb.gif
10.1128/9781555815912/f0403-01.gif
Image of Figure 18.1
Figure 18.1

Portrayal of a person with the flaccid paralysis symptoms characteristic of botulism. Drawing prepared by James K. Archer, Centers for Disease Control and Prevention, Atlanta, Ga.

Citation: Johnson E. 2007. , p 401-421. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch18
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References

/content/book/10.1128/9781555815912.ch18
1. Alberts, B. 2005. Modeling attacks on the food supply. Proc. Natl. Acad. Sci. USA 102: 9737– 9738.
2. Angulo, F. J.,, J. Getz,, J. P. Taylor,, K. A. Hendricks,, C. L. Hatheway,, S. S. Barth,, H. M. Solomon,, A. E. Larson,, E. A. Johnson,, L. N. Nickey, and, A. A. Ries. 1998. A large outbreak of botulism: the hazardous baked potato. J. Infect. Dis. 178: 172– 177.
3. Anne, C.,, F. Cornille, and, C. Lenoir. 2001. High-throughput fluorogenic assay for determination of botulinum type B protease activity. Anal. Biochem. 291: 253– 261.
4. Arnon, S. S. 2004. Infant botulism, p. 1758– 1766. In R. D. Feigen and, J. D. Cherry (ed.), Textbook of Pediatric Infectious Diseases, 5th ed. W. B. Saunders, Philadelphia, Pa.
5. Arnon, S. S.,, K. Damus, and, J. Chin. 1981. Infant botulism: epidemiology and relation to sudden infant death syndrome. Epidemiol. Rev. 3: 45– 66.
6. Arnon, S. S.,, R. Schechter,, T. V. Inglesby,, D. A. Henderson,, J. G. Bartlett,, M. Ascher,, E. Eitzen,, A. D. Fine,, J. Hauer,, M. Layton,, S. Lillibridge,, M. T. Osterholm,, E. O’Toole,, G. Parker,, T. M. Perl,, P. K. Russell,, D. L. Swerdlow,, K. Tonat, and the Working Group on Civilian Biodefense. 2001. Botulinum toxin as a biological weapon. Medical and public health management. JAMA 285: 1059– 1070.
7. Arnon, S. S.,, R. Schechter,, S. E. Maslanka,, N. P. Jewell, and, C. L. Hatheway. 2006. Human botulism immune globulin for the treatment of infant botulism. N. Engl. J. Med. 354: 462– 471.
8. Aureli, P.,, M. Di Cunto,, A. Maffei,, G. De Chiara,, G. Franciosa,, L. Accorinti,, A. M. Gambardella, and, D. Greco. 2000. An outbreak in Italy of botulism associated with a dessert made with mascarpone cream cheese. Eur. J. Epidemiol. 16: 913– 918.
9. Baird-Parker, A. C., and, B. Freame. 1967. Combined effect of water activity, spores, and temperature on the growth of Clostridium botulinum from spores and vegetative cell inocula. J. Appl. Bacteriol. 30: 420– 429.
10. Baranyi, J., and, T. A. Roberts. 2000. Principles and applications of predictive modeling of the effects of preservative factors on microorganisms, p. 342– 358. In B. M. Lund,, T. C. Baird-Parker, and, G. W. Gould (ed.), The Microbiological Safety and Quality of Foods, vol. 1. Aspen Publishers, Gaithersburg, Md.
11. Barr, J.,, H. Moura,, A. E. Boyer,, A. R. Wollfitt,, S. R. Kalb,, A. Pavlopoulos,, L. G. McWilliams,, J. G. Schmidt,, R. A. Martinez, and, D. L. Ashley. 2005. Botulinum neurotoxin detection and differentiation by mass spectroscopy. Emerg. Infect. Dis. 10: 1578– 1583.
12. Bell, C., and, A. Kyriades. 2000. Clostridium botulinum. A Practical Approach to Its Control in Foods. Blackwell Science, Oxford, United Kingdom.
13. Bradshaw, M.,, S. S. Dineen,, N. D. Maks, and, E. A. Johnson. 2004. Regulation of neurotoxin complex expression in Clostridium botulinum strains 62A, Hall A- hyper, and NCTC 2916. Anaerobe 10: 321– 333.
14. Cato, E. P.,, W. L. George, and, S. M. Finegold. 1986. Genus Clostridium, p. 1141– 1200. In P. H. A. Sneath,, N. S. Mair,, M. E. Sharpe, and, J. G. Holt (ed.), Bergey’s Manual of Systematic Bacteriology, vol. 2. The Williams & Wilkins Co., Baltimore, Md.
15. Caya, J. G. 2001. Clostridium botulinum and the ophthalmologist: a review of botulism, including biological warfare ramifications of botulinum toxin. Surv. Ophthamol. 56: 25– 34.
16. Centers for Disease Control and Prevention. 1998. Botulism in the United States, 1899–1996. In Handbook for Epidemiologists, Clinicians, and Laboratory Workers. Centers for Disease Control and Prevention, Atlanta, Ga.
17. Cherington, M. 1998. Clinical spectrum of botulism. Muscle Nerve 21: 701– 710.
18. Cherington, M. 2004. Botulism: update and review. Semin. Neurol. 24: 155– 163.
19. DasGupta, B. R. 1989. Structure of botulinum neurotoxin, p. 53– 67. In L. L. Simpson (ed.), Botulinum Neurotoxin and Tetanus Toxin. Academic Press, San Diego, Calif.
20. Dickson, E. C. 1918. Botulism. A clinical and experimental study. Rockefeller Inst. Med. Res. Monog. No. 8: 1– 117.
21. Dineen, S. S.,, M. Bradshaw, and, E. A. Johnson. 2003. Neurotoxin gene clusters in Clostridium botulinum type A strains: sequence comparison and evolutionary implications. Curr. Microbiol. 46: 345– 352.
22. Dineen, S. S.,, M. Bradshaw,, C. Karasek, and, E. A. Johnson. 2004. Nucleotide sequence and transcriptional analysis of the type A2 neurotoxin gene cluster in Clostridium botulinum. FEMS Microbiol. Lett. 235: 9– 16.
23. Dixit, A.,, R. K. Dhaked,, S. I. Alam, and, L. Singh. 2005. Characterization of Clostridium sp. RKD producing botulinum-like neurotoxin. Syst. Appl. Microbiol. 28: 405– 414.
24. Dodds, K. L. 1993. Clostridium botulinum in the environment, p. 21– 51. In A. H. W. Hauschild and, K. L. Dodds (ed.), Clostridium botulinum: Ecology and Control in Foods. Marcel Dekker, New York, N.Y.
25. Dodds, K. L. 1993. Clostridium botulinum in foods, p. 53– 68. In A. H. W. Hauschild and, K. L. Dodds (ed.), Clostridium botulinum: Ecology and Control in Foods. Marcel Dekker, New York, N.Y.
26. Dolman, E. C. 1964. Botulism as a world health problem. In K. H. Lewis and, K. Cassel (ed.), Botulism. U.S. Public Health Service, Washington, D.C.
27. Dong, M.,, D. A. Richards,, M. C. Goodnough,, W. H. Tepp,, E. A. Johnson, and, E. R. Chapman. 2003. Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells. J. Cell Biol. 162: 1293– 1303.
28. Dong, M.,, F. Yeh,, W. H. Tepp,, C. Dean,, E. A. Johnson,, R. Janz, and, E. R. Chapman. 2006. Receptor for botulinum neurotoxin type A. Science 312: 592– 596.
29. Dong, M.,, W. H. Tepp,, E. A. Johnson, and, E. R. Chapman. 2004. Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells. Proc. Natl. Acad. Sci. USA 101: 14701– 14706.
30. Doyle, M. P. 1991. Evaluating the potential risk from extended-shelf-life refrigerated foods by Clostridium botulinum inoculation studies. Food Technol. 45( 4): 154– 156.
31. Dürre, P. (ed.). 2005. Handbook of Clostridia. CRC Press, Boca Raton, Fla.
32. Eklund, M. W.,, D. I. Wieler, and, F. T. Poysky. 1967. Outgrowth and toxin production of non-proteolytic type B Clostridium botulinum at 3.3 to 5.6°C. J. Bacteriol. 93: 1461– 1462.
33. Eklund, M. W., and, V. R. Dowell. Jr. (ed.). 1987. Avian Botulism: An International Perspective. Charles C Thomas, Springfield, Ill.
34. Eleopra, R.,, V. Tugnoli,, O. Rossetto,, D. De Grandis, and, C. Monteucco. 1998. Different time courses in recovery after poisoning neurotoxin serotypes A and E in humans. Neurosci. Lett. 256: 135– 138.
35. Esty, J. R., and, K. F. Meyer. 1922. The heat resistance of the spores of B. botulinus and allied anaerobes. XI. J. Infect. Dis. 31: 650– 653.
36. Ferracci, G.,, R. Miquelis,, S. Kozaki,, M. Seagar, and, C. Leveque. 2005. Synaptic vesicle chips to assay botulinum neurotoxin. Biochem. J. 391: 659– 666.
37. Ferreira, J. L.,, S. Maslanka,, E. Johnson, and, M. Good-nough. 2003. Detection of botulinal neurotoxins A, B, E, and F by amplified enzyme-linked immunosorbent assay: collaborative assay. J. Assoc. Off. Agric. Chem. Int. 86: 314– 331.
38. Foran, P. G.,, N. Mohammed,, G. O. Lisk,, S. Nagwaney,, G. W. Lawrence,, E. Johnson,, L. Smith,, K. R. Aoki, and, J. O. Dolly. 2003. Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A-Basis for distinct durations of inhibition of exocytosis in central neurons. J. Biol. Chem. 278: 1363– 1371.
39. Foster, E. M. 1997. Historical overview of key issues in food safety. Emerg. Infect. Dis. 3: 481– 482.
40. Fox, C. K.,, C. A. Keet, and, J. B. Strober. 2004. Recent advances in infant botulism. Pediatr. Neurol. 32: 149– 154.
41. Franciosa, G.,, J. L. Ferreira, and, C. L. Hatheway. 1994. Detection of type-A, type-B, and type-E botulism neurotoxin genes in Clostridium botulinum and other Clostridium species by PCR-evidence of unexpressed type-B toxin genes in type-A toxigenic organisms. J. Clin. Microbiol. 32: 1911– 1917.
42. Franciosa, G.,, P. Aureli, and, R. Schechter. 2003. Clostridium botulinum, p. 61– 89. In M. D. Miliotis and, J. W. Bier (ed.), International Handbook of Foodborne Pathogens. Marcel Dekker, New York, N.Y.
43. Giménez, D. F., and, J. A. Giménez. 1993. Serological subtypes of botulinal neurotoxins, p. 421– 431. In B. R. Dasgupta (ed.), Botulism and Tetanus Neurotoxins: Neurotransmission and Biomedical Aspects. Plenum Press, New York, N.Y.
44. Glass, K. A., and, E. A. Johnson. 2002. Formulating low-acid foods for botulinal safety, p. 323– 350. In V. K. Juneja and, J. N. Sofos (ed.), Control of Foodborne Microorganisms. Marcel Dekker, New York, N.Y.
45. Gupta, A.,, C. J. Sumner,, M. Castor,, S. Maslanka, and, J. Sobel. 2005. Adult botulism type F in the United States, 1981–2002. Neurology 65: 1694– 1700.
46. Hall, Y. H. J.,, J. A. Chaddock,, H. J. Moulsdale,, E. R. Kirby,, F. C. G. Alexander,, J. D. Marks, and, K. A. Foster. 2004. Novel application of an in vitro technique to the detection and quantification of botulinum neurotoxin antibodies. J. Immunol. Methods 288: 55– 60.
47. Hallis, B.,, B. A. F. James, and, C. C. Shone. 1996. Development of novel assays for botulinum type A and B neurotoxins based on their endopeptidase activity. J. Clin. Microbiol. 34: 1934– 1938.
48. Hammes, W. P., and, P. S. Tichaczek. 1994. The potential of lactic acid bacteria for the production of safe and wholesome food. Z. Lebensm. Unters. Forsch. 198: 193– 201.
49. Hatheway, C. L. 1988. Botulism, p. 111– 133. In A. Balows, et al. (ed.), Laboratory Diagnosis of Infectious Diseases: Principles and Practice. Springer-Verlag, New York, N.Y.
50. Hatheway, C. L. 1993. Clostridium botulinum and other organisms that produce botulinum neurotoxin, p. 3– 20. In A. H. W. Hauschild and, K. L. Dodds (ed.), Clostridium botulinum: Ecology and Control in Foods. Marcel Dekker, New York, N.Y.
51. Hatheway, C. L., and, E. A. Johnson. 1998. Clostridium: the spore-bearing anaerobes, p. 731– 782. In L. Collier,, A. Balows, and, M. Sussman (ed.), Topley & Wilson’s Microbiology and Microbial Infections, 9th ed., vol. 2. Systematic Bacteriology. Arnold, London, United Kingdom.
52. Hauschild, A. H. W. 1993. Epidemiology of foodborne botulism, p. 69– 104. In A. H. W. Hauschild and, K. L. Dodds (ed.), Clostridium botulinum: Ecology and Control in Foods. Marcel Dekker, New York, N.Y.
53. Hauschild, A. H. W. 1989. Clostridium botulinum, p. 111– 189. In M. P. Doyle (ed.), Foodborne Bacterial Pathogens. Marcel Dekker, New York, N.Y.
54. Hauschild, A. H. W., and, K. L. Dodds (ed.). 1993. Clostridium botulinum: Ecology and Control in Foods. Marcel Dekker, New York, N.Y.
55. Hauschild, A. H. W.,, R. Hilsheimer,, K. F. Weiss, and, R. B. Burke. 1988. Clostridium botulinum in honey, syrups, and dry infant cereals. J. Food Prot. 51: 892– 894.
56. Hines, H. B.,, F. Lebeda,, M. Hale, and, E. E. Brueggemann. 2005. Characterization of botulinum progenitor toxins by mass spectrometry. Appl. Environ. Microbiol. 71: 4478– 4486.
57. Holdeman, L. V.,, E. P. Cato, and, W. E. C. Moore. 1979. Anaerobe Laboratory Manual, 4th ed. Virginia Polytechnic Institute and State University, Blacksburg.
58. International Commission on Microbiological Specifications for Foods. 1996. Microorganisms in Foods. 5. Characteristics of Microbial Pathogens. Blackie Academic & Professional, London, United Kingdom.
59. Ito, K. A.,, D. J. Seslar,, W. A. Mercern, and, K. F. Meyer. 1967. The thermal and chlorine resistance of Cl. botulinum types A, B, and E. spores, p. 108– 122. In M. Ingram and, T. A. Roberts (ed.), Botulism 1966. Chapman and Hall, London, United Kingdom.
60. Johnson, E. A. 2005. Clostridial neurotoxins. In P. Dürre (ed.), Handbook of Clostridia. CRC Press, Inc., Boca Raton, Fla.
61. Johnson, E. A. 2005. Clostridium botulinum and Clostridium tetani, p. 1035– 1088. In P. Murray (ed.), Topley and Wilson’s Microbiology and Microbial Infections, 8th ed. Hodder Arnold, London, United Kingdom.
62. Johnson, E. A., and, M. Bradshaw. 2001. Clostridium botulinum: a metabolic and cellular perspective. Toxicon 39: 1703– 1722.
63. Johnson, E. A., and, M. C. Goodnough. 1998. Botulism, p. 723– 741. In L. Collier,, A. Balows, and, M. Sussman (ed.), Topley & Wilson’s Microbiology and Microbial Infections, 9th ed., vol. 2. Systematic Bacteriology. Arnold, London, United Kingdom.
64. Johnson, E. A.,, W. H. Tepp,, M. Bradshaw,, R. J. Gilbert,, P. E. Cooke, and, E. D. G. McIntosh. 2005. Characterization of Clostridium botulinum strains associated with an infant botulism case in the United Kingdom. J. Clin. Microbiol. 43: 2602– 2607.
65. Johnson, E. A.,, P. San, and, S. M. Finegold. 2007. Clostridium, p. 889– 910. In P. R. Murray,, E. J. Baron,, J. H. Jorgensen,, M. L. Landry, and, M. A. Pfaller (ed.), Manual of Clinical Microbiology, 9th ed. ASM Press, Washington, D.C.
66. Jousimies-Somer, H. R.,, P. Summanen,, D. M. Citron,, E. J. Baron,, H. M. Wexler, and, S. M. Finegold. 2002. Anaerobic Laboratory Manual, 6th ed. Star Publishing Company, Belmont, Calif.
67. Kalluri, P.,, C. Crowe,, M. Reller,, L. Gaul,, J. Hayslett,, S. Barth,, S. Eliasvberg,, J. Ferreira,, K. Holt,, S. Bengston,, K. Hendricks, and, J. Sobel. 2003. An outbreak of foodborne botulism associated with food sold at a salvage store in Texas. Clin. Infect. Dis. 37: 1490– 1495.
68. Kautter, D. A.,, S. M. Harmon,, R. Y. Lynt, and, T. Lilly. 1966. Antagonistic effect on Clostridium botulinum by organisms resembling it. Appl. Microbiol. 14: 616– 622.
69. Kempner, W. 1897. Further contributions to the knowledge of meat poisoning. The antitoxin to botulism. Z. Hyg. Infektionskrankh. 26: 481– 500. (In German.)
70. Lacy, D. B.,, W. Tepp,, A. C. Cohen,, B. R. DasGupta, and, R. C. Stevens. 1998. Crystal structure of botulinum neurotoxin type A and implications for toxicity. Nat. Struct. Biol. 5: 898– 902.
71. Lalli, G.,, S. Bohnert,, K. Deinhardt,, C. Verastegui, and, G. Schiavo. The journey of tetanus and botulinum neurotoxins in neurons. Trends Microbiol. 11: 431– 437.
72. Larson, A. E., and, E. A. Johnson. 1999. Evaluation of botulinal toxin production in packaged fresh-cut cantaloupe and honeydew melons. J. Food Prot. 62: 948– 952.
73. Lindler, L. E.,, F. J. Lebeda, and, G. W. Korch (ed.). 2005. Biological Weapons Defense. Infectious Diseases and Counterbioterrorism. Humana Press, Totowa, N.J.
74. Lindstrom, M.,, M. Nevas,, K. Kurki,, R. Sauna-Aho,, A. Latvala-Kiesila,, I. Polonen, and, H. Korkeala. 2004. Type C botulism due to toxic feed affecting 52,000 farmed foxes and minks in Finland. J. Clin. Microbiol. 42: 4718– 4725.
75. Lynt, R. K.,, D. A. Kautter, and, R. B. Read, Jr. 1975. Botulism in commercially canned foods. J. Milk Food Technol. 38: 546– 550.
76. MacDonald, K. L.,, M. L. Cohen, and, P. A. Blake. 1986. The changing epidemiology of adult botulism in the United States. Am. J. Epidemiol. 124: 794– 799.
77. Malizio, C. J.,, M. C. Goodnough, and, E. A. Johnson. 2000. Purification of botulinum type A neurotoxin. Methods Mol. Biol. 145: 27– 39.
78. Margosch, D.,, M. A. Ehrmann,, M. G. Gänzle, and, R. F. Vogel. 2004. Comparison of pressure and heat resistance of Clostridium botulinum and other endospores in mashed carrots. J. Food Prot. 67: 2530– 2537.
79. McKellar, R. C., and, X. Lu (ed.). 2004. Modeling Microbial Responses in Foods. CRC Press, Boca Raton, Fla.
80. Meyer, K. F. 1956. The status of botulism as a world health problem. Bull. W. H. O. 15: 281– 298.
81. Meyer, K. F., and, B. Eddie. 1950. Fifty Years of Botulism in the United States and Canada. George Williams Hooper Foundation, San Francisco, Calif.
82. Montecucco, C., and, G. Schiavo. 1995. Structure and function of tetanus and botulinum neurotoxins. Q. Rev. Biophys. 28: 423– 472.
83. Moorthy, J.,, G. A. Mensing,, D. Kim,, S. Mohanty,, D. T. Eddington,, W. H. Tepp,, E. A. Johnson, and, D. J. Beebe. 2004. Microfluidic tectonics platform: a colorimetric, disposable botulinum toxin enzyme-linked immunosorbent assay system. Electrophoresis 25: 1705– 1713.
84. Morse, D. L.,, L. K. Pickard,, J. J. Buzewich,, B. D. Devine, and, M. Sharyegani. 1990. Garlic-in-oil associated botulism: episode leads to product modification. Am. J. Public Health 80: 1372– 1373.
85. Nevas, M.,, M. Lindström,, A. Virtanen,, S. Hielm,, M. Kuusi,, S. S. Arnon,, E. K. Vuori, and, H. Korkeala. 2005. Infant botulism acquired from household dust presenting as sudden infant death syndrome. J. Clin. Microbiol. 43: 511– 513.
86. NFPA/CMI Container Integrity Task Force, Microbiological Assessment Group Report. 1984. Botulism risk from post-processing contamination of commercially canned foods in metal containers. J. Food Prot. 47: 801– 816.
87. Odlaug, T. E., and, I. J. Pflug. 1978. Clostridium botulinum and acid foods. J. Food Prot. 41: 566– 573.
88. Paredes, C. J.,, K. V. Alsaker, and, E. T. Papoutsakis. 2005. A comparative genomic view of clostridial sporulation and physiology. Nat. Rev. Microbiol. 3: 969– 978.
89. Pitt, M. L. M., and, R. D. LeClaire. 2005. Pathogenesis by aerosol, p. 65– 78. In L. E. Lindler,, F. J. Lebeda, and, G. W. Korch (ed.), Biological Weapons Defense. Infectious Diseases and Counterbioterrorism. Humana Press, Totowa, N.J.
90. Reddy, N. R.,, H. M. Solomon,, G. A. Fingerhut, and, E. J. Rhodehamel. 1999. Inactivation of Clostridium botulinum spores by high pressure processing. J. Food Safety 19: 277– 288.
91. Reddy, N. R.,, H. M. Solomon,, R. C. Tetzloff, and, E. J. Rhodehamel. 2003. Inactivation of Clostridium botulinum type A spores by high-pressure processing at elevated temperatures. J. Food Prot. 66: 1402– 1407.
92. Rhodehamel, E. J.,, N. R. Reddy, and, M. D. Pierson. 1992. Botulism: the causative agent and its control in foods. Food Control 3: 125– 143.
93. Roberts, T. A. 1997. Maximizing the usefulness of food microbiology research. Emerg. Infect. Dis. 3: 523– 528.
94. Rodgers, S. 2004. Novel approaches in controlling safety of cook-chill meals. Trends Food Sci. Technol. 15: 366– 372.
95. Sakaguchi, G. 1983. Clostridium botulinum toxins. Pharmacol. Ther. 19: 165– 194.
96. Schantz, E. J., and, E. A. Johnson. 1992. Properties and use of botulinum toxin and other microbial neurotoxins in medicine. Microbiol. Rev. 56: 80– 99.
97. Schmidt, R. H., and, G. E. Rodrick (ed.). 2003. Food Safety Handbook. Wiley-Interscience, Hoboken, N.J.
98. Sesardic, D. 2002. Alternatives in testing of bacterial toxins and antitoxins. Dev. Biol. (Basel) 111: 101– 108.
99. Sesardic, D.,, R. G. Jones,, T. Leung,, T. Alsop, and, R. Tierney. 2004. Detection of antibodies against botulinum toxins. Mov. Disord. 19( Suppl. 8): S85– S91.
100. Shapiro, R. L.,, C. L. Hatheway, and, D. L. Swerdlow. 1998. Botulism in the United States: a clinical and epidemiologic review. Ann. Intern. Med. 129: 221– 228.
101. Sharma, S. K., and, R. C. Whiting. 2005. Methods for detection of Clostridium botulinum toxin in foods. J. Food Prot. 68: 1256– 1263.
102. Siegel, L. S. 1992. Destruction of botulinum toxins in food and water, p. 323– 342. In A. H. W. Hauschild and, K. L. Dodds (ed.), Clostridium botulinum. Ecology and Control in Foods. Marcel Dekker, Inc., New York, N.Y.
103. Smeldt, J. P. P. M.,, P. C. Hellemons,, P. C. Wouters, and, S. J. C. van Gerwen. 2002. Physiological and mathematical aspects in setting criteria for decontamination of foods by physical means. Int. J. Food Microbiol. 78: 57– 77.
104. Smith, L. D. S. 1977. Botulism. The Organism, Its Toxins, the Disease. Charles C Thomas, Springfield, Ill.
105. Smith, L. D. S., and, H. Sugiyama. 1988. Botulism. The Organism, Its Toxins, the Disease, 2nd ed. Charles C. Thomas, Springfield, Ill.
106. Smith, T. J.,, J. Lou,, I. N. Geren,, C. M. Forsyth,, R. Tsai,, S. L. LaPorte,, W. H. Tepp,, M. Bradshaw,, E. A. Johnson,, L. A. Smith, and, J. D. Marks. 2005. Sequence variation with botulinum neurotoxin serotypes impacts antibody binding and neutralization. Infect. Immun. 73: 5450– 5457.
107. Sobel, J.,, N. Tucker,, A. Sulka,, J. McLaughlin, and, S. Maslanka. 2004. Foodborne botulism in the United States, 1990–2004. Emerg. Infect. Dis. 10: 1606– 1611.
108. Solomon, H. A., and, D. A. Kautter. 1988. Outgrowth and toxin production by Clostridium botulinum in bottled, chopped garlic. J. Food Prot. 51: 862– 865.
109. Solomon, H. M.,, E. A. Johnson,, D. T. Bernard,, S. S. Arnon, and, J. L. Ferreira. 2001. Clostridium botulinum and its toxins, p. 317– 324. In F. P. Downes and, K. Ito (ed.), Compendium for the Microbiological Examination of Foods, 4th ed. American Public Health Association, Washington, D.C.
110. Sugiyama, H. 1980. Clostridium botulinum neurotoxin. Microbiol. Rev. 44: 419– 448.
111. Sugiyama, H. 1990. Botulism, p. 107– 125. In D. O. Cliver (ed.), Foodborne Diseases. Academic Press, San Diego, Calif.
112. Sugiyama, H., and, K. S. Rutledge. 1978. Failure of Clostridium botulinum to grow in fresh mushrooms packaged in plastic film overwraps with holes. J. Food Prot. 41: 348– 350.
113. Swaminathan, S.,, S. Eswaramoorthy, and, D. Kumaran. 2004. Structure and activity of botulinum neurotoxins. Mov. Disord. 19( Suppl. 8): S17– S22.
114. Tanaka, N.,, E. Traisman,, P. Plantinga,, L. Finn,, W. Flom,, L. Meske, and, J. Guggisberg. 1986. Evaluation of factors involved in antibotulinal properties of pasteurized process cheese spreads. J. Food Prot. 49: 526– 531.
115. Townes, J. M.,, P. R. Cieslak,, C. L. Hatheway,, H. M. Solomon,, J. T. Holloway,, M. P. Baker,, C. F. Keller,, L. M. McCroskey, and, P. M. Griffin. 1996. An outbreak of type A botulism associated with a commercial cheese sauce. Ann. Intern. Med. 125: 558– 563.
116. Tsukamoto, K.,, M. Mikamoto,, T. Kohda,, H. Ihara,, S. Wang,, T. Maegawa,, S. Nakamura,, T. Karasawa, and, S. Kozaki. 2002. Characterization of Clostridium butyricum neurotoxin associated with food-borne botulism. Microb. Pathog. 33: 177– 184.
117. U.S. Food and Drug Adminstration. 2001. Bacteriological Analytical Manual. [Online.] http://www.cfsan.fda.gov/∼ebam/bam-toc.html. Accessed 10 February 2006.
118. van Ermengem, E. 1979. Classics in infectious disease. A new anaerobic bacillus and its relation to botulism. Rev. Infect. Dis. 1: 701– 719. (Originally published in 1897 as: Ueber einen neuen anaeroben Bacillus und seine Beziehungen zum Botulismus. Z. Hyg. Infektionskr. 26: 1– 56.)
119. Villar, R. G.,, R. L. Shapiro,, S. Busto,, C. Riva-Posse,, G. Verdejo,, M. I. Farace,, R. Rossetti,, J. A. San Juan,, C. M. Julia,, J. Becher,, S. E. Maslanka, and, D. L. Swerdlow. 1999. Outbreak of type A botulism and development of a botulism surveillance and antitoxin release system in Argentina. JAMA 281: 1334– 1338.
120. von Holzer, E. 1962. Botulismus durch Inhalation. Med. Klin. (München) 57: 1735– 1738.
121. Wein, L. M., and, Y. Liu. 2005. Analyzing a bioterror attack on the food supply: the case of botulinum toxin in milk. Proc. Natl. Acad. Sci. USA 102: 9984– 9989.
122. Whiting, R. C., and, K. A. Naftulin. 1992. Effect of head-space oxygen concentration on growth and toxin production by proteolytic strains of Clostridium botulinum. J. Food Prot. 55: 23– 27.
123. Whitmer, M. E., and, E. A. Johnson. 1988. Development of improved defined media for Clostridium botulinum serotypes A, B, and E. Appl. Environ. Microbiol. 54: 753– 759.
124. Woodruff, B. A.,, P. M. Griffin,, L. M. McCroskey,, J. F. Smart,, R. B. Wainright,, R. G. Bryant,, L. C. Hutwagner, and, C. L. Hatheway. 1992. Clinical and laboratory features of botulism from toxin types A, B, and E in the United States, 1975–1988. J. Infect. Dis. 166: 1281– 1286.
125. Wörner, K.,, H. Szurmant,, C. Chiang, and, J. A. Hoch. 2005. Phosphorylation and functional analysis of the sporulation initiation factor Spo0A from Clostridium botulinum. Mol. Microbiol. 59: 1000– 1012.

Tables

Clostridium botulinum
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Citation: Johnson E. 2007. , p 401-421. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch18
/content/10.1128/9781555815912.ch18.ch18tab01
Table 18.1
Groupings and relevant growth and resistance properties of botulinogenic clostridia
Generic image for table
Table 18.1

Groupings and relevant growth and resistance properties of botulinogenic clostridia

Citation: Johnson E. 2007. , p 401-421. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch18
/content/10.1128/9781555815912.ch18.ch18tab02
Table 18.2
Primary physical treatments and antimicrobials used in formulation of botulism-safe foods
Generic image for table
Table 18.2

Primary physical treatments and antimicrobials used in formulation of botulism-safe foods

Citation: Johnson E. 2007. , p 401-421. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch18
/content/10.1128/9781555815912.ch18.ch18tab03
Table 18.3
Nutritional substrates metabolized by botulinogenic clostridia
Generic image for table
Table 18.3

Nutritional substrates metabolized by botulinogenic clostridia

Citation: Johnson E. 2007. , p 401-421. In Doyle M, Beuchat L (ed), Food Microbiology: Fundamentals and Frontiers, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815912.ch18

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