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Chapter 4 : Development of an Antibiotic: Microbiology

Author: A. Bryskier
Content Type: Reference
Publication Year: 2005

Category: Bacterial Pathogenesis

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Abstract:

This chapter deals with the antibacterial agent that is only one molecule among a series of compounds prepared by chemists before becoming a drug. Preselection is a crucial stage in the life of a new drug. Once a molecule is synthesized, its in vitro activity against a panel of strains belonging to selected bacterial genera and species is determined. Activity against producing penicillinase is added, as well as that against and . Strains resistant to clindamycin and cephamycins must be included for gram-negative bacilli. Nondiscriminatory models are prepared during the preselection phase of a molecule. After determining the in vitro activity, it is essential to determine the in vivo activity parenterally and orally. In fact, the in vitro activity is not necessarily correlated with good in vivo activity. In these systemic infection models, activity is tested against gram-positive cocci, , and . The susceptibility of the bacterial strain considered responsible for the infection is determined in the clinical microbiology laboratory of the center in which the study is being conducted. However, semiautomatic devices related to the antibiotic sensitivity test are used by some microbiology laboratories. Determination of breakpoints is one of the major factors for an antibiotic. The mechanism of resistance is an important factor for determining breakpoints for given bacteria. The MIC at which these bacterial species are shown to be resistant is the cutoff and can be considered as the concentration under which the strain is considered susceptible.

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
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References

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1. Agouridas C,, Bonnefoy A,, Chantot JF, 1994, Ketolides, a new distinct semi-synthetic class of macrolides: in vitro and in vivo antibacterial activity, 34th Intersci Conf Antimicrob Agents Chemother, abstract F-168.
2. Akoun G,, Bertrand A, Cambarrère I,, Constans P,, Dumont R,, Guibout P,, Kamarec J,, Marsac J,, Robillard M,, Sauvaget J,, Thibault P,, Voisin C,, Safran C, 1986, Clinical evaluation of roxithromycin (RU 28965) in the treatment of hospitalized patients with lower respiratory tract infections, in Butzler JP,, Kobayashi H, ed, Macrolides: a Review with an Outlook on Future Development, Excerpta Medica, p 95– 99.
3. Allen JL,, Sprunt K, 1978, Discrepancy between minimum inhibitory and minimum bactericidal concentrations of penicillin for group A and group B β-hemolytic streptococci, J Pediatr, 93, 69– 71.
4. Baquero F, 1990, European standards for antibiotic susceptibility testing: towards a theoretical consensus, Eur J Clin Microbiol Infect Dis, 9, 492– 495.
5. Barrière JC,, Bouanchaud DH,, Desnottes JF,, Paris JM, 1994, Streptogramin analogues, Expert Opin Investig Drugs, 32, 115– 131.
6. Barry A,, Bryskier A,, Traczewski M,, Brown S, 2004, Preparation of stock solutions of macrolide and ketolide compounds for antimicrobial susceptibility tests, Clin Microbiol Infect, 10, 78– 83.
7. Bauer AW,, Kirby WMM,, Sherris JC,, Turck M, 1966, Antibiotic susceptibility testing by a standardized single disc method, Am J Clin Pathol, 45, 493– 496.
8. Beam TR Jr,, Gilbert DN,, Kunin CM, 1993, European guidelines for anti-infective drug products. Introduction, Clin Infect Dis, 17, 787– 788.
9. British Society for Antimicrobial Chemotherapy, 1991, A guide to sensitivity testing, J Antimicrob Chemother, 27, suppl D, 1– 47.
10. Bryskier A, 1993, Fluoroquinolones: mechanisms of action and resistance, Int J Antimicrob Chemother, 2, 151– 184.
11. Bryskier A,, Veyssier P,, Kazmierczak A, 1994, Fluoroquinolones, propriétés physico chimiques et microbiologiques, Encyclopédie médico-chirurgicales-maladies infectieuses, 8-004-B-10.
12. Chabbert YA, 1982, Sensibilité bactérienne aux antibiotiques , in Le Minor L,, Veron M, ed, Bactériologie médicale, Flammarion, Paris, p 204– 212.
13. Chantot JF,, Bryskier A, 1985, Antibacterial activity of ofloxacin and other 4-quinolone derivatives: in vitro and in vivo comparison, J Antimicrob Chemother, 16, 475– 484.
14. Chantot J-F,, Bryskier A,, Gasc J-C, 1986, Antibacterial activity of roxithromycin: a laboratory evaluation, J Antibiot, 39, 660– 668.
15. Cooper GL,, Louie A,, Baltch AL,, Chu RC,, Smith RP,, Ritz WJ,, Michelsen P, 1993, Influence of zinc on Pseudomonas aeruginosa susceptibilities to imipenem, J Clin Microbiol, 31, 2366– 2370.
16. De Cross AJ,, Marschall BJ,, McCallum RW,, Hoffman SR,, Barrett LJ,, Guerrant RL, 1993, Metronidazole susceptibility testing for Helicobacter pylori: comparison of disk, broth, and agar dilution methods and their clinical relevance, J Clin Microbiol, 31, 1971– 1974.
17. Deutsche Institut für Normung, 1984, Methoden zur Empfindlichkeitsprüfung von Bakteriellen Krankenheitseregern (ausser Mycobacterien) gegen Chemotherapeutika, DIN 58940.
18. Dickinson JM,, Mitchison DA, 1990, In vitro activities against mycobacteria of two long-acting rifamycins, FCE 22807 and CGP 40/469 A (SPA-S-565), Tubercle, 71, 109– 115.
19. Doern GV, 1992, In vitro susceptibility testing of Haemophilus influenzae: review of new National Committee for Clinical Laboratory Standards recommendations, J Clin Microbiol, 30, 3035– 3038.
20. Dublanchet A,, Caillou J,, Emond JP,, Chardon H,, Drugeon HB, 1986, Isolation of Bacteroides strains with reduced susceptibility to 5-nitroimidazole, Eur J Clin Microbiol, 5, 346– 347.
21. Eagle H,, Fleishman R,, Musselman AD, 1950, Effect of schedule of administration on the therapeutic efficacy of penicillin, Am J Med, 9, 280– 289.
22. Edlund C,, Nord CE, 1993, Ecological impact of antimicrobial agents on human intestinal microflora, Alpa Adria Microbiol J, 3, 137– 164.
23. Ellner PD,, Neu HC, 1981, The inhibitory quotient: a method for interpreting minimum inhibitory concentration data, J Am Med Assoc, 246, 1575– 1578.
24. Eng RHK,, Cherubin C,, Smith SM,, Buccini F, 1985, Inoculum effect of beta-lactam antibiotics on Enterobacteriaceae, Antimicrob Agents Chemother, 28, 601– 606.
25. Ericsson HM,, Sherris JC, 1971, Antibiotic sensitivity testing—report of an international collaborative study, Acta Pathol Microbiol Immunol Scand Sect B, 217, suppl 217, 1– 90.
26. Erwin ME,, Jones RN, 1993, Roxithromycin in vitro susceptibility testing of Haemophilus influenzae by NCCLS methods, J Antimicrob Chemother, 32, 652– 654.
27. Farrell DJ,, Felmingham D, 2004, Activities of telithromycin against 13,874 Streptococcus pneumoniae isolates collected between 1999 and 2003, Antimicrob Agents Chemother, 48, 1882– 1884.
28. Felmingham D,, Robbins MJ,, Marais R,, Ridgway GL,, Grüneberg RN, 1987, The effect of carbon dioxide on the in vitro activity of erythromycin and RU 28965 against anaerobic bacteria, Drugs Exp Clin Res, 13, 195– 199.
29. Felmingham D,, Solomonides K,, O’Hare MD,, Wilson APR,, Grüneberg RN, 1987, The effect of medium and inoculum on the activity of vancomycin and teicoplanin against coagulase-negative staphylococci, J Antimicrob Chemother, 20, 609– 619.
30. Forrest A,, Nix DE,, Ballow CH,, Goss TF,, Birmingham MC,, Schentag JJ, 1993, Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients, Antimicrob Agents Chemother, 37, 1073– 1081.
31. Foster JK,, Lentino JR,, Strodtman R,, DiVincenzo C, 1986, Comparison of in vitro activity of quinolone antibiotics and vancomycin against gentamicin- and methicillin-resistant Staphylococcus aureus by time-kill kinetic studies, Antimicrob Agents Chemother, 30, 823– 827.
32. Frémaux A,, Sissia G,, Rosembaum M,, Geslin P, 1992, In vitro activity of cefpirome (HR 810), a new parenteral cephalosporin, against penicillin-susceptible and resistant pnemococci, 32nd Intersci Conf Antimicrob Agents Chemother, abstract 102.
33. Garau J,, Vercken JB, 1994, Efficacy of sparfloxacin in the treatment of 312 cases of pneumococcal community-acquired pneumonia: a pool data analysis, 5th Int Symp New Quinolones.
34. Gasc J-C,, Gouin d’Ambriere S,, Lutz A,, Chantot J-F, 1991, New ether oxime derivative of erythromycin A. A structure activity relationship study, J Antibiot, 44, 651– 668.
35. Goessens WHF, 1990, Basic mechanisms of bacterial tolerance of antimicrobial agents, Eur J Clin Microbiol Infect Dis, 9, 9– 12.
36. Graig W, 1990, Pharmacodynamics of antimicrobial agents as a basis for determining dosage regimens, Eur J Clin Microbiol Infect Dis, 9, 6– 8.
37. Greub G,, Raoult D, 2002, Parachlamydiaceae: potential emerging pathogens, Emerg Infect Dis, 8, 625– 630.
38. Hammerschlag MR, 1994, Antimicrobial susceptibility and therapy of infections caused by Chlamydia pneumoniae, Antimicrob Agents Chemother, 38, 1873– 1878.
39. Jabès D,, Rossi R,, Della, Bruna C,, Perrone E,, Alpegiani M,, Andreini BP,, Visenti G,, Zarini F,, Francheschi G, 1993, Activity of new penems against defined MRSA strains, Bioorg Med Chem Lett, 3, 2165– 2170.
40. James PA,, Hossain FK,, Lewis DA,, White DG, 1993, β-Lactam susceptibility of Haemophilus influenzae strains showing reduced susceptibility to cefuroxime, J Antimicrob Chemother, 32, 239– 246.
41. Jarlier V,, Nicolas MH,, Fournier G,, Phillipon A, 1988, Extended broad-spectrum β-lactamases conferring transferable resistance to newer β-lactam antibiotics in Enterobacteriaceae: hospital prevalence and susceptibility pattern, Rev Infect Dis, 10, 867– 878.
42. Jones RN,, Barry AL,, Thornsberry C, 1982, Antimicrobial activity of desacetylcefotaxime alone and in combination with cefotaxime: evidence of synergy, Rev Infect Dis, 4, suppl, S366– S373.
43. Jones RN,, Doern GV,, Gerlach HE,, Hindler J,, Erwin ME, 1994, Validation of NCCLS macrolide (azithromycin, clarithromycin, and erythromycin) interpretive criteria for Haemophilus influenzae tested with the Haemophilus Test Medium, Diagn Microbiol Infect Dis, 18, 243– 249.
44. Kabir I,, Butler T,, Khanam A, 1986, Comparative efficacies of single intravenous doses of ceftriaxone and ampicillin for shigellosis in a placebo-controlled trial, Antimicrob Agents Chemother, 29, 645– 648.
45. Kahlmeter G,, Brown D,, Goldstein F,, MacGowan AP,, Mouton JW,, Osterlund A,, Rodolf A,, Steinback M,, Urbaskova P,, Vatopoulos A, 2003, European harmonization of MIC breakpoints for antimicrobial susceptibility testing of bacteria, J Antimicrob Chemother, 52, 145– 148.
46. Kenny GE,, Cartwright FD, 1993, Effect of pH, inoculum size, and incubation time on the susceptibility of Ureaplasma urealyticum to erythromycin in vitro, Clin Infect Dis, 17, suppl 1, S215– S218.
47. Kenny GE,, Cartwright FD,, Roberts MC, 1986, Agar dilution method for determination of antibiotic susceptibility of Ureaplasma urealyticum, Pediatr Infect Dis J, 6, suppl 5, S332– S334.
48. Kilian M, 1976, A taxonomic study of the genus Haemophilus with the proposal of a new species, J Gen Microbiol, 93, 9– 62.
49. King A,, Phillips I, 1993, Standardization of Iso-Sensitest agar, J Antimicrob Chemother, 32, 339.
50. Klugman KP,, Saunders J, 1994, In vitro susceptibility of penicillin-susceptible and penicillin-resistant pneumococci to parenteral third and fourth generation cephalosporins, 6th Int Congr Infect Dis.
51. Knapp JS,, Washington JA,, Doyle LJ,, Neul SW,, Parekh MC,, Rice RJ, 1994, Persistence of Neisseria gonorrhoeae strains with decreased susceptibilities to ciprofloxacin and ofloxacin in Cleveland, Ohio, from 1992 through 1993, Antimicrob Agents Chemother, 38, 2194– 2196.
52. La Scola B,, Boyadjiev I,, Greub G,, Khamis A,, Martin C,, Raoult D, 2003, Amoeba-resisting bacteria and ventilator-associated pneumonia, Emerg Infect Dis, 9, 815– 821.
53. La Scola B,, Bryskier A,, Raoult D, 2004, Comparison of the in vitro efficacy of telithromycin (HMR 3647) and levofloxacin with 22 antibiotic compounds against Bosea and Afipia species, J Antimicrob Chemother, 53, 683– 685.
54. Lee BL,, Sachdeva M,, Chambers HF, 1991, Effect of protein binding of daptomycin on MIC and antibacterial activity, Antimicrob Agents Chemother, 35, 2505– 2508.
55. Loleka S,, Vibulbandhikit S,, Poouyarit P, 1991, Response to antimicrobial therapy for shigellosis in Thailand, Rev Infect Dis, 13, suppl 4, S42– S46.
56. Lukehart SA,, Fohn MJ,, Baker-Zander SA, 1990, Efficacy of azithromycin for therapy of active syphilis in the rabbit model, J Antimicrob Chemother, 25, suppl A, 91– 99.
57. Marrie TJ,, Durant H,, Yates L, 1984, Community-acquired pneumonia requiring hospitalization: 5 years prospective study, Rev Infect Dis, 11, 586– 599.
58. Miller GH,, Aminoglycoside Resistance Study Group, 1994, Resistance to aminoglycosides in Pseudomonas, Trends Microbiol, 2, 347– 352.
59. Moore RD,, Smith CR,, Lietman PS, 1984a, The association of aminoglycoside plasma levels with mortality in patients with gramnegative bacteria, J Infect Dis, 149, 443– 448.
60. Moore RD,, Smith CR,, Lietman PS, 1984b, Association of amino-glycoside plasma levels with therapeutic outcome in gram-negative pneumonia, Am J Med, 77, 657– 662.
61. National Committee for Clinical Laboratory Standards, 1993, Development of in vitro susceptibility testing criteria and quality control parameters—tentative guideline, document M23-T, NCCLS, Villanova, Pa.
62. Nickolai DJ,, Lammel CJ,, Byford BA,, Morris JH,, Kaplan EB,, Hadley WK,, Brooks GF, 1985, Effects of storage temperature and pH on the stability of eleven β-lactam antibiotics in MIC trays, J Clin Microbiol, 21, 366– 370.
63. Peloux I,, Le Noc P,, Bryskier A,, Le Noc D, 1994, In vitro activity of cefpirome and five other cephems against enteric pathogens, 34th Intersci Conf Antimicrob Agents Chemother, abstract E-28.
64. Periti P,, Sueri L,, Tosi M,, Ciammarughi R,, Cadco P,, Milanesi B, 1984, Cefotaxime in the cerebral fluid and serum in patients with purulent meningitis, J Antimicrob Chemother, 14, suppl B, 117– 123.
65. Péter O,, Bretz AG, 1992, Polymorphism of outer surface proteins of Borrelia burgdorferi as a tool for classification, Zentbl Bakteriol, 277, 28– 33.
66. Péter O,, Bretz AG, 1994, In vitro susceptibility of Borrelia burgdorferi, Borrelia garinii and Borrelia afzelii to 7 antimicrobial agents, in Cevenini R,, Sambri V,, La Placa M, ed, Advances in Lyme Borreliosis Research, p 167– 170.
67. Philipon A,, Arlet G,, Lagrange PH, 1994, Origin and impact of plasmid-mediated extended-spectrum beta-lactamases, Eur J Clin Microbiol Infect Dis, 13, suppl 1, 17– 29.
68. Putnam SD,, Lavin BS,, Stone JR,, Oldfield III EC,, Hooper DG, 1992, Evaluation of the standardized disk diffusion and agar dilution antibiotic susceptibility test methods by using strains of Neisseria gonorrhoeae from the United States and Southeast Asia, J Clin Microbiol, 30, 974– 980.
69. Raoult D,, Birg ML,, La, Scola B, et al, 2000, Cultivation of the bacillus of Whipple disease, N Engl J Med, 342, 620– 625.
70. Saez-Nieto JA,, Vasquez JA,, Marcos C, 1990, Meningococci moderately resistant to penicillin, Lancet, 336, 54.
71. Sahm DF,, Baker CN,, Jones RN,, Thornsberry C, 1984, Influence of growth medium on the in vitro activities of second- and third-generation cephalosporins against Streptococcus faecalis, Antimicrob Agents Chemother, 20, 561– 567.
72. Schentag J, 1991, Correlation of pharmacokinetic parameters to efficacy of antibiotics: relationships between serum concentrations, MIC values and bacterial eradication in patients with Gramnegative pneumonia, Scand J Infect Dis, suppl 74, 218– 234.
73. Siebor E,, Kazmierczak A, 1993, Factors influencing the activity of macrolide antibiotics in vitro, in Bryskier AJ,, Butzler J-P,, Neu HC,, Tulkens PM, ed, Macrolides, Chemistry, Pharmacology and Clinical Use, Blackwell-Arnette, Paris, p 197– 203.
74. Simpson IN,, Hunter R,, Govan JRW,, Nelson JW, 1993, Do all Pseudomonas cepacia produce carbapenemases? J Antimicrob Chemother, 32, 339– 341.
75. Smith JT,, Levin CS, 1988, Chemistry and mechanisms of action of the quinolone antibacterials, in Andriole VT, ed, The Quinolones, Academic Press, p 23– 82.
76. Snell JJS,, George RC,, Perry SF,, Erdman YJ, 1988, Antimicrobial susceptibility testing of Streptococcus pneumoniae: quality assessment results, J Clin Pathol, 41, 384– 387.
77. Soussy CJ,, Cluzel R,, Courvalin P,, Comité de l’antibiogramme de la société française de microbiologie, 1984, Definition and determination of in vitro antibiotic susceptibility breakpoints for bacteria in France, Eur J Clin Microbiol Infect Dis, 13, 238– 246.
78. Stamm LV,, Stapleton JT,, Bassford PJ, 1988, In vitro assay to demonstrate high-level erythromycin resistance of a clinical isolate of Treponema pallidum, Antimicrob Agents Chemother, 32, 164– 169.
79. Stokes EJ, 1955, Antibacterial drugs, in Clinical Bacteriology, Edward Arnold, London, p 157– 192.
80. Stokes EJ,, Ridgway GL,, Wren MWD, 1993, Clinical Microbiology, 7th ed, Edward Arnold, London, p 234– 278.
81. Swedish Reference Group for Antibiotics, 1981, A revised system for antibiotic sensitivity testing, Scand J Infect Dis, 13, 148– 152.
82. Täuber MG,, Kunz S,, Zak O,, Sande MA, 1989, Influence of antibiotic dose, dosing interval, and duration of therapy on outcome in experimental pneumococcal meningitis in rabbits, Antimicrob Agents Chemother, 33, 418– 423.
83. Täuber MG,, Zak O,, Scheld WM,, Hengsler B,, Sande MA, 1984, The postantibiotic effect in the treatment of experimental meningitis caused by Streptococcus pneumoniae in rabbits, J Infect Dis, 149, 575– 583.
84. Tomasz A,, Nachman S,, Leaf H, 1991, Stable classes of phenotypic expression in methicillin-resistant clinical isolates of staphylococci, Antimicrob Agents Chemother, 35, 124– 129.
85. Verdon MS,, Handsfield HH,, Johnson RB, 1994, Pilot study of azithromycin for treatment of primary and secondary syphilis, Clin Infect Dis, 19, 486– 488.
86. Vogelman BS,, Craig WA, 1985, Postantibiotic effects, J Anti-microb Chemother, 15, suppl A, 37– 46.
87. Wallace RJ,, Steele LC, 1988, Susceptibility testing of Nocardia species for the clinical laboratory, Diagn Microbiol Infect Dis, 9, 155– 166.
88. Werkgroep Richtlijnen Govoeligheidsbepalingen, 1981, Report, Standaardisatie van govoeligheidsbepalingen, Werkgroep Richtlijnen Govoeligheidsbepalingen, Bilthoven, The Netherlands.
89. White RL,, Kays MB,, Friederich LV,, Brown EW,, Koonce JR, 1991, Pseudoresistance of Pseudomonas aeruginosa resulting from degradation of imipenem in an automated susceptibility testing system with predried panels, J Clin Microbiol, 29, 398– 400.
90. Wilkins TD,, Chalgren S, 1976, Medium for use in antibiotic susceptibility testing of anaerobic bacteria, Antimicrob Agents Chemother, 10, 926– 928.
91. Williams JD, 1990, Prospects for standardisation of methods and guidelines for disc susceptibility testing, Eur J Clin Microbiol Infect Dis, 9, 496– 501.
92. Xia H,, Keane CT,, Beattie S,, O’Morain CA, 1994, Standardization of disk diffusion and its clinical significance for susceptibility testing of metronidazole against Helicobacter pylori, Antimicrob Agents Chemother, 38, 2357– 2361.
93. Yabuuchi E,, Kosako Y,, Oyaizu H,, Yano I,, Hotta H,, Hashimoto Y, et al, 1992, Proposal of Burkholderia gen. nov. and transfer of seven species of the genus Pseudomonas homology group II to the new genus with the type species Burkholderia cepacia (Palirini and Holmes, 1981) comb. nov. 1992, Microbiol Immunol, 36, 1251– 1275.
94. Zak O,, O’Reilly T, 1990, Animal models as predictors of the safety and efficacy of antibiotics, Eur J Clin Microbiol Infect Dis, 9, 472– 478.

Tables

Development of an Antibiotic: Microbiology
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Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab01
Table 1
In vitro activities of cephalosporins against
Generic image for table
Table 1

In vitro activities of cephalosporins against

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab02
Table 2
Generic image for table
Table 2

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab03
Table 3
Generic image for table
Table 3

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab04
Table 4
Generic image for table
Table 4

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab05
Table 5
Generic image for table
Table 5

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab06
Table 6
Stability of ansamycins in 7 H9 medium with or without Tween 80
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Table 6

Stability of ansamycins in 7 H9 medium with or without Tween 80

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab07
Table 7
Generic image for table
Table 7

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab08
Table 8
Generic image for table
Table 8

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab09
Table 9
Effect of urine on the activities of ofloxacin and norfloxacin
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Table 9

Effect of urine on the activities of ofloxacin and norfloxacin

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab10
Table 10
Radius for levofloxacin according to Joan Stokes’s method
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Table 10

Radius for levofloxacin according to Joan Stokes’s method

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab11
Table 11
In vitro activities of combination of cefotaxime and its main metabolite
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Table 11

In vitro activities of combination of cefotaxime and its main metabolite

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab12
Table 12
In vitro activities of carbapenems against MRSA strains
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Table 12

In vitro activities of carbapenems against MRSA strains

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab13
Table 13
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Table 13

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab14
Table 14
Breakpoints of metronidazole against
Generic image for table
Table 14

Breakpoints of metronidazole against

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab15
Table 15
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Table 15

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab16
Table 16
Zone of inhibition for 50% of clinical isolates resistant to aminoglycosides (1989 to 1991)
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Table 16

Zone of inhibition for 50% of clinical isolates resistant to aminoglycosides (1989 to 1991)

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab17
Table 17
Activities of β-lactams against ampicillin-resistant and non-β-lactamase-producing
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Table 17

Activities of β-lactams against ampicillin-resistant and non-β-lactamase-producing

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4
/content/10.1128/9781555815929.ch04.ch04tab18
Table 18
Performance of telithromycin when microdilution panels were prepared with eight different types of working solutions of telithromycin
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Table 18

Performance of telithromycin when microdilution panels were prepared with eight different types of working solutions of telithromycin

Citation: Bryskier A. 2005. Development of an Antibiotic: Microbiology, p 93-112. In Bryskier, M.D. A (ed), Antimicrobial Agents. ASM Press, Washington, DC. doi: 10.1128/9781555815929.ch4

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