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Chapter 49 : Agents against Methicillin-Resistant Staphylococcus aureus
Author:
André Bryskier
Content Type: Reference
Publication Year:
2005
Category: Bacterial Pathogenesis
Book DOI:
10.1128/9781555815929
Chapter DOI:
10.1128/9781555815929.ch49
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Agents against Methicillin-Resistant Staphylococcus aureus, Page 1 of 2
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Abstract:
Infections due to methicillin-resistant Staphylococcus aureus (MRSA) are associated with a mortality rate of 15 to 60%. The first report of S. aureus resistant to penicillin occurred in 1942. A series of glycopeptides was prepared at Shionogi and displayed good in vitro anti-MRSA activity, with MICs ranging from 0.20 to 6.25 µg/ml. Daptomycin possesses an unusual amino acid, kynurenine. Modifications of this amino acid were attempted on the ketone and anilino groups. These modifications highlighted the importance of this amino acid for antibacterial activity. One of the most effective antibacterial strategies is to disrupt the integrity of bacterial cell wall formation. Peptidoglycan includes four steps in which amino acid residues are ligated to uridine-diphospho-N-acetylmuramic acid (UDP-MurNac). Benzylidene rhodamine is an inhibitor of MurC and is active against MRSA (MICs, 31 µM). A series of derivatives was synthesized, with the aim of improving logP and water solubility, as well as protein binding. Molecular iron is an essential factor for bacterial growth, iron being used during respiration, DNA replication, and other biological processes. One of the targets of a research was to improve water solubility, to obtain in vivo activity against MRSA, and to obtain both anti-MRSA activity and activity against gram-negative bacteria, including Pseudomonas aeruginosa. Deformylase is an essential bacterial metallo-enzyme responsible for the removal of the N-terminal formyl group from methionine following protein synthesis. Methionine aminopeptidases play a pivotal role in protein biosynthesis.
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
Key Concept Ranking
- Bacterial Proteins
- 1.0785233
- Antibacterial Agents
- 0.99282664
- Chemicals
- 0.5599055
- beta-Lactam Antibiotics
- 0.54171467
1.0785233
Figures
Agents against Methicillin-Resistant Staphylococcus aureus
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Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig01
Figure 1
Prevalence of MRSA in Europe, 1999 to 2000
10.1128/9781555815929/f1183-01_thmb.gif
10.1128/9781555815929/f1183-01.gif
Figure 1
Prevalence of MRSA in Europe, 1999 to 2000
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig02
Figure 2
Cyclic peptoid
10.1128/9781555815929/f1185-01_thmb.gif
10.1128/9781555815929/f1185-01.gif
Figure 2
Cyclic peptoid
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig03
Figure 3
Lipidated vancomycin derivatives with disulfide bonds
10.1128/9781555815929/f1185-02_thmb.gif
10.1128/9781555815929/f1185-02.gif
Figure 3
Lipidated vancomycin derivatives with disulfide bonds
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig04
Figure 4
AC-98 complex
10.1128/9781555815929/f1187-01_thmb.gif
10.1128/9781555815929/f1187-01.gif
Figure 4
AC-98 complex
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig05
Figure 5
Nocathiacin(s)
10.1128/9781555815929/f1188-01_thmb.gif
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Figure 5
Nocathiacin(s)
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig06
Figure 6
Laspartomycin
10.1128/9781555815929/f1190-01_thmb.gif
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Figure 6
Laspartomycin
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig07
Figure 7
WAP-8294A complex
10.1128/9781555815929/f1190-02_thmb.gif
10.1128/9781555815929/f1190-02.gif
Figure 7
WAP-8294A complex
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig08
Figure 8
LY-301621
10.1128/9781555815929/f1191-01_thmb.gif
10.1128/9781555815929/f1191-01.gif
Figure 8
LY-301621
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig09
Figure 9
Diperamycin
10.1128/9781555815929/f1191-02_thmb.gif
10.1128/9781555815929/f1191-02.gif
Figure 9
Diperamycin
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig10
Figure 10
TAN 1057 complex
10.1128/9781555815929/f1192-01_thmb.gif
10.1128/9781555815929/f1192-01.gif
Figure 10
TAN 1057 complex
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig11
Figure 11
GE 2270A
10.1128/9781555815929/f1193-01_thmb.gif
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Figure 11
GE 2270A
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig12
Figure 12
M-1396
10.1128/9781555815929/f1194-01_thmb.gif
10.1128/9781555815929/f1194-01.gif
Figure 12
M-1396
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig13
Figure 13
Epicatechin gallate
10.1128/9781555815929/f1195-01_thmb.gif
10.1128/9781555815929/f1195-01.gif
Figure 13
Epicatechin gallate
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig14
Figure 14
MC-21 A
10.1128/9781555815929/f1195-02_thmb.gif
10.1128/9781555815929/f1195-02.gif
Figure 14
MC-21 A
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig15
Figure 15
Sesquiterpenoids (A. gilvescens)
10.1128/9781555815929/f1195-03_thmb.gif
10.1128/9781555815929/f1195-03.gif
Figure 15
Sesquiterpenoids (A. gilvescens)
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig16
Figure 16
Xanthatin
10.1128/9781555815929/f1195-04_thmb.gif
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Figure 16
Xanthatin
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig17
Figure 17
Aaptamines
10.1128/9781555815929/f1195-05_thmb.gif
10.1128/9781555815929/f1195-05.gif
Figure 17
Aaptamines
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig18
Figure 18
ECO-0501
10.1128/9781555815929/f1196-01_thmb.gif
10.1128/9781555815929/f1196-01.gif
Figure 18
ECO-0501
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig19
Figure 19
Dichlorophenyl analogs
10.1128/9781555815929/f1196-02_thmb.gif
10.1128/9781555815929/f1196-02.gif
Figure 19
Dichlorophenyl analogs
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig20
Figure 20
Benzylidene rhodamine
10.1128/9781555815929/f1196-03_thmb.gif
10.1128/9781555815929/f1196-03.gif
Figure 20
Benzylidene rhodamine
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig21
Figure 21
Chorismate synthetase inhibitors
10.1128/9781555815929/f1197-01_thmb.gif
10.1128/9781555815929/f1197-01.gif
Figure 21
Chorismate synthetase inhibitors
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig22
Figure 22
A-358 (shikimate dehydroquinate synthase inhibitor)
10.1128/9781555815929/f1197-02_thmb.gif
10.1128/9781555815929/f1197-02.gif
Figure 22
A-358 (shikimate dehydroquinate synthase inhibitor)
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig23
Figure 23
Methanofusidic acid
10.1128/9781555815929/f1197-03_thmb.gif
10.1128/9781555815929/f1197-03.gif
Figure 23
Methanofusidic acid
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig24
Figure 24
Pol IIIC inhibitor (HBEMAU)
10.1128/9781555815929/f1198-01_thmb.gif
10.1128/9781555815929/f1198-01.gif
Figure 24
Pol IIIC inhibitor (HBEMAU)
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig25
Figure 25
Pol IIIC inhibitors
10.1128/9781555815929/f1198-02_thmb.gif
10.1128/9781555815929/f1198-02.gif
Figure 25
Pol IIIC inhibitors
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig26
Figure 26
Lydicamycin complex
10.1128/9781555815929/f1199-01_thmb.gif
10.1128/9781555815929/f1199-01.gif
Figure 26
Lydicamycin complex
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig27
Figure 27
Tetrahydroquinoline derivatives
10.1128/9781555815929/f1199-02_thmb.gif
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Figure 27
Tetrahydroquinoline derivatives
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig28
Figure 28
Phenylpiperidine derivatives
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10.1128/9781555815929/f1200-01.gif
Figure 28
Phenylpiperidine derivatives
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig29
Figure 29
Biaryl acid derivative
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10.1128/9781555815929/f1200-02.gif
Figure 29
Biaryl acid derivative
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig30
Figure 30
PDL 117230 and PDL 117229 (Biaryl derivatives)
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10.1128/9781555815929/f1200-03.gif
Figure 30
PDL 117230 and PDL 117229 (Biaryl derivatives)
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig31
Figure 31
PhenylalanyltRNA synthase inhibitors (spirocyclic furan and pyrrolidine derivatives)
10.1128/9781555815929/f1201-01_thmb.gif
10.1128/9781555815929/f1201-01.gif
Figure 31
PhenylalanyltRNA synthase inhibitors (spirocyclic furan and pyrrolidine derivatives)
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig32
Figure 32
CB 102930 (phenylalanyl-tRNA synthase inhibitor)
10.1128/9781555815929/f1201-02_thmb.gif
10.1128/9781555815929/f1201-02.gif
Figure 32
CB 102930 (phenylalanyl-tRNA synthase inhibitor)
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig33
Figure 33
Tyrosyl-tRNA synthetase inhibitor
10.1128/9781555815929/f1201-03_thmb.gif
10.1128/9781555815929/f1201-03.gif
Figure 33
Tyrosyl-tRNA synthetase inhibitor
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig34
Figure 34
Methionyl-tRNA synthase inhibitors
10.1128/9781555815929/f1202-01_thmb.gif
10.1128/9781555815929/f1202-01.gif
Figure 34
Methionyl-tRNA synthase inhibitors
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig35
Figure 35
Methionyl-tRNA synthase inhibitors
10.1128/9781555815929/f1202-02_thmb.gif
10.1128/9781555815929/f1202-02.gif
Figure 35
Methionyl-tRNA synthase inhibitors
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig36
Figure 36
REP 8839
10.1128/9781555815929/f1203-01_thmb.gif
10.1128/9781555815929/f1203-01.gif
Figure 36
REP 8839
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig37
Figure 37
SB 203207
10.1128/9781555815929/f1203-02_thmb.gif
10.1128/9781555815929/f1203-02.gif
Figure 37
SB 203207
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig38
Figure 38
Pantothenate kinase inhibitors
10.1128/9781555815929/f1203-03_thmb.gif
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Figure 38
Pantothenate kinase inhibitors
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig39
Figure 39
Benzoimidazole derivatives
10.1128/9781555815929/f1203-04_thmb.gif
10.1128/9781555815929/f1203-04.gif
Figure 39
Benzoimidazole derivatives
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig40
Figure 40
Vancoresmycin
10.1128/9781555815929/f1204-01_thmb.gif
10.1128/9781555815929/f1204-01.gif
Figure 40
Vancoresmycin
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig41
Figure 41
Flavonoid chalcone derivatives
10.1128/9781555815929/f1204-02_thmb.gif
10.1128/9781555815929/f1204-02.gif
Figure 41
Flavonoid chalcone derivatives
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig42
Figure 42
AR-100 (iclaprim)
10.1128/9781555815929/f1204-03_thmb.gif
10.1128/9781555815929/f1204-03.gif
Figure 42
AR-100 (iclaprim)
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig43
Figure 43
XRP 2868
10.1128/9781555815929/f1205-01_thmb.gif
10.1128/9781555815929/f1205-01.gif
Figure 43
XRP 2868
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig44
Figure 44
Benzopyran stilbene
10.1128/9781555815929/f1206-01_thmb.gif
10.1128/9781555815929/f1206-01.gif
Figure 44
Benzopyran stilbene
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig45
Figure 45
AVE 6971
10.1128/9781555815929/f1206-02_thmb.gif
10.1128/9781555815929/f1206-02.gif
Figure 45
AVE 6971
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig46
Figure 46
FabI inhibitor: 1,4-benzodiazepine derivative
10.1128/9781555815929/f1207-01_thmb.gif
10.1128/9781555815929/f1207-01.gif
Figure 46
FabI inhibitor: 1,4-benzodiazepine derivative
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig47
Figure 47
2-Mercaptoquinoline
10.1128/9781555815929/f1207-02_thmb.gif
10.1128/9781555815929/f1207-02.gif
Figure 47
2-Mercaptoquinoline
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig48
Figure 48
Coumarin derivative
10.1128/9781555815929/f1207-03_thmb.gif
10.1128/9781555815929/f1207-03.gif
Figure 48
Coumarin derivative
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig49
Figure 49
RU-79115
10.1128/9781555815929/f1208-01_thmb.gif
10.1128/9781555815929/f1208-01.gif
Figure 49
RU-79115
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig50
Figure 50
DNA gyrase B inhibitor: pyrazolo derivatives
10.1128/9781555815929/f1208-02_thmb.gif
10.1128/9781555815929/f1208-02.gif
Figure 50
DNA gyrase B inhibitor: pyrazolo derivatives
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig51
Figure 51
Cyclothialidine
10.1128/9781555815929/f1208-03_thmb.gif
10.1128/9781555815929/f1208-03.gif
Figure 51
Cyclothialidine
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig52
Figure 52
Novobiocin derivatives
10.1128/9781555815929/f1209-01_thmb.gif
10.1128/9781555815929/f1209-01.gif
Figure 52
Novobiocin derivatives
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig53
Figure 53
Indazole derivatives (DNA gyrase B inhibitor)
10.1128/9781555815929/f1209-02_thmb.gif
10.1128/9781555815929/f1209-02.gif
Figure 53
Indazole derivatives (DNA gyrase B inhibitor)
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig54
Figure 54
Mansonone F
10.1128/9781555815929/f1209-03_thmb.gif
10.1128/9781555815929/f1209-03.gif
Figure 54
Mansonone F
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig55
Figure 55
Indolquinoline
10.1128/9781555815929/f1210-01_thmb.gif
10.1128/9781555815929/f1210-01.gif
Figure 55
Indolquinoline
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig56
Figure 56
Isoquinoline
10.1128/9781555815929/f1210-02_thmb.gif
10.1128/9781555815929/f1210-02.gif
Figure 56
Isoquinoline
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig57
Figure 57
5S-penems: signal peptidase inhibitors
10.1128/9781555815929/f1210-03_thmb.gif
10.1128/9781555815929/f1210-03.gif
Figure 57
5S-penems: signal peptidase inhibitors
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig58
Figure 58
Isoxazolinones
10.1128/9781555815929/f1210-04_thmb.gif
10.1128/9781555815929/f1210-04.gif
Figure 58
Isoxazolinones
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig59
Figure 59
Pyrimido[4,5]pyrimidine derivatives
10.1128/9781555815929/f1211-01_thmb.gif
10.1128/9781555815929/f1211-01.gif
Figure 59
Pyrimido[4,5]pyrimidine derivatives
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig60
Figure 60
Netropsin and distamycin
10.1128/9781555815929/f1211-02_thmb.gif
10.1128/9781555815929/f1211-02.gif
Figure 60
Netropsin and distamycin
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig61
Figure 61
HARP analogs
10.1128/9781555815929/f1211-03_thmb.gif
10.1128/9781555815929/f1211-03.gif
Figure 61
HARP analogs
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig62
Figure 62
Nematophin
10.1128/9781555815929/f1212-01_thmb.gif
10.1128/9781555815929/f1212-01.gif
Figure 62
Nematophin
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig63
Figure 63
Pyrrolobenzodiazepines
10.1128/9781555815929/f1212-02_thmb.gif
10.1128/9781555815929/f1212-02.gif
Figure 63
Pyrrolobenzodiazepines
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig64
Figure 64
Cremimycin
10.1128/9781555815929/f1213-01_thmb.gif
10.1128/9781555815929/f1213-01.gif
Figure 64
Cremimycin
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig65
Figure 65
Benzothiazolyl cephems
10.1128/9781555815929/f1213-02_thmb.gif
10.1128/9781555815929/f1213-02.gif
Figure 65
Benzothiazolyl cephems
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig66
Figure 66
Classification, cephem group VI
10.1128/9781555815929/f1214-01_thmb.gif
10.1128/9781555815929/f1214-01.gif
Figure 66
Classification, cephem group VI
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig67
Figure 67
T-91825
10.1128/9781555815929/f1214-02_thmb.gif
10.1128/9781555815929/f1214-02.gif
Figure 67
T-91825
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig68
Figure 68
TAK-599
10.1128/9781555815929/f1215-01_thmb.gif
10.1128/9781555815929/f1215-01.gif
Figure 68
TAK-599
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig69
Figure 69
S-3578
10.1128/9781555815929/f1215-02_thmb.gif
10.1128/9781555815929/f1215-02.gif
Figure 69
S-3578
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig70
Figure 70
BAL 9141
10.1128/9781555815929/f1215-03_thmb.gif
10.1128/9781555815929/f1215-03.gif
Figure 70
BAL 9141
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig71
Figure 71
BMS-247243
10.1128/9781555815929/f1216-01_thmb.gif
10.1128/9781555815929/f1216-01.gif
Figure 71
BMS-247243
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig72
Figure 72
RWJ-54428
10.1128/9781555815929/f1216-02_thmb.gif
10.1128/9781555815929/f1216-02.gif
Figure 72
RWJ-54428
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig73
Figure 73
RWJ-333441 prodrugs
10.1128/9781555815929/f1217-01_thmb.gif
10.1128/9781555815929/f1217-01.gif
Figure 73
RWJ-333441 prodrugs
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig74
Figure 74
Water solubility of anti-MRSA cephems
10.1128/9781555815929/f1217-02_thmb.gif
10.1128/9781555815929/f1217-02.gif
Figure 74
Water solubility of anti-MRSA cephems
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig75
Figure 75
RWJ-442831, prodrug of RWJ-54428
10.1128/9781555815929/f1218-01_thmb.gif
10.1128/9781555815929/f1218-01.gif
Figure 75
RWJ-442831, prodrug of RWJ-54428
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig76
Figure 76
ME-1209 (CP-6679)
10.1128/9781555815929/f1218-02_thmb.gif
10.1128/9781555815929/f1218-02.gif
Figure 76
ME-1209 (CP-6679)
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig77
Figure 77
BC 1175
10.1128/9781555815929/f1218-03_thmb.gif
10.1128/9781555815929/f1218-03.gif
Figure 77
BC 1175
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig78
Figure 78
Imidazolopyridinium cephalosporin
10.1128/9781555815929/f1218-04_thmb.gif
10.1128/9781555815929/f1218-04.gif
Figure 78
Imidazolopyridinium cephalosporin
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig79
Figure 79
LB-11058
10.1128/9781555815929/f1219-01_thmb.gif
10.1128/9781555815929/f1219-01.gif
Figure 79
LB-11058
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig80
Figure 80
PGE-69337410 and PGE-69337410
10.1128/9781555815929/f1219-02_thmb.gif
10.1128/9781555815929/f1219-02.gif
Figure 80
PGE-69337410 and PGE-69337410
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig81
Figure 81
L-763863
10.1128/9781555815929/f1220-01_thmb.gif
10.1128/9781555815929/f1220-01.gif
Figure 81
L-763863
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig82
Figure 82
L-786392
10.1128/9781555815929/f1220-02_thmb.gif
10.1128/9781555815929/f1220-02.gif
Figure 82
L-786392
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig83
Figure 83
Cleavage of the carbapenem ring
10.1128/9781555815929/f1221-01_thmb.gif
10.1128/9781555815929/f1221-01.gif
Figure 83
Cleavage of the carbapenem ring
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig84
Figure 84
Dithiocarbamate (BO-3482)
10.1128/9781555815929/f1221-02_thmb.gif
10.1128/9781555815929/f1221-02.gif
Figure 84
Dithiocarbamate (BO-3482)
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig85
Figure 85
J-111,347 and analogs
10.1128/9781555815929/f1222-01_thmb.gif
10.1128/9781555815929/f1222-01.gif
Figure 85
J-111,347 and analogs
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig86
Figure 86
Pyrrolidinyl carbapenems
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10.1128/9781555815929/f1223-01.gif
Figure 86
Pyrrolidinyl carbapenems
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig87
Figure 87
β-Methyl carbapenems with oxime and imino moieties
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10.1128/9781555815929/f1223-02.gif
Figure 87
β-Methyl carbapenems with oxime and imino moieties
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig88
Figure 88
SM-216601
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10.1128/9781555815929/f1224-01.gif
Figure 88
SM-216601
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig89
Figure 89
CS-834
10.1128/9781555815929/f1224-02_thmb.gif
10.1128/9781555815929/f1224-02.gif
Figure 89
CS-834
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig90
Figure 90
CP-5068
10.1128/9781555815929/f1224-03_thmb.gif
10.1128/9781555815929/f1224-03.gif
Figure 90
CP-5068
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig91
Figure 91
Benzonaphthyridones
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10.1128/9781555815929/f1225-01.gif
Figure 91
Benzonaphthyridones
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig92
Figure 92
Saccharomicins
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10.1128/9781555815929/f1226-01.gif
Figure 92
Saccharomicins
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig93
Figure 93
PTK 0796
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10.1128/9781555815929/f1227-01.gif
Figure 93
PTK 0796
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig94
Figure 94
VIC-105555
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10.1128/9781555815929/f1227-02.gif
Figure 94
VIC-105555
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig95
Figure 95
DK-507k
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10.1128/9781555815929/f1228-01.gif
Figure 95
DK-507k
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig96
Figure 96
WCK 771
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10.1128/9781555815929/f1228-02.gif
Figure 96
WCK 771
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig97
Figure 97
DQ-113
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10.1128/9781555815929/f1229-01.gif
Figure 97
DQ-113
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig98
Figure 98
DX-619
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10.1128/9781555815929/f1229-02.gif
Figure 98
DX-619
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig99
Figure 99
AZD 2563
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Figure 99
AZD 2563
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig100
Figure 100
Oxazolidinones
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Figure 100
Oxazolidinones
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig101
Figure 101
BB-83698
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Figure 101
BB-83698
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
/content/10.1128/9781555815929.ch49.ch49fig102
Figure 102
Methionine aminopeptidase inhibitors
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Figure 102
Methionine aminopeptidase inhibitors
Citation:
Bryskier A.
2005.
Agents against Methicillin-Resistant Staphylococcus aureus,
p 1183-1238.
In
Bryskier, M.D. A (ed),
Antimicrobial Agents.
ASM Press, Washington, DC.
doi: 10.1128/9781555815929.ch49
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