Chapter 31 : Measles, Mumps, and Rubella

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The nucleoprotein, phosphoprotein, and large polymerase protein, in conjunction with the virion negative-strand RNA, comprise the ribonucleoprotein complex, the replicating and transcriptional unit of measles virus. Traditional antibody tests such as hemagglutination inhibition (HI), plaque reduction neutralization test (PRNT), and enzyme immunoassay (EIA) have been used extensively in the serologic diagnosis of measles. However, because of the availability of sensitive and specific commercial kits, EIAs have become the most widely used test format. The mumps genome is encapsidated by nucleoprotein, and as in the case of measles virus, the phosphoprotein and polymerase are associated with the encapsidated RNA to comprise the ribonucleoprotein complex. Enzyme-linked immunosorbent assay vary greatly in sensitivity (range, 24 to 51%), and the best specificity measured was 82%. Of considerable interest is the use of oral fluid rather than serum in the determination of Immunoglobulin M (IgM) for acute mumps infections and IgG for immune status for measles, mumps, and rubella. Rubella would be of little medical importance were it not for the profound defects rubella virus (RV) infection can cause in the unborn child. Mumps vaccine is given along with measles and rubella vaccines at 12 to 15 months of age and again at school entry. Laboratory diagnosis of both postnatal and congenital RV infections is by serologic and/or virus detection techniques.

Citation: Bellini W, Icenogle J, Sever J. 2009. Measles, Mumps, and Rubella, p 562-577. In Specter S, Hodinka R, Young S, Wiedbrauk D (ed), Clinical Virology Manual, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815974.ch31
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Interpretation of measles EIA results a

Citation: Bellini W, Icenogle J, Sever J. 2009. Measles, Mumps, and Rubella, p 562-577. In Specter S, Hodinka R, Young S, Wiedbrauk D (ed), Clinical Virology Manual, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815974.ch31

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