Clinical Virology, Third Edition

Editors: Douglas D. Richman1, Richard J. Whitley2, Frederick G. Hayden3
Affiliations: 1: Departments of Pathology and Medicine, University of California, San Diego School of Medicine, La Jolla, California, and Veterans Affairs San Diego Healthcare System, San Diego, California; 2: Division of Infectious Diseases, Department of Pediatrics, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; 3: Departments of Medicine and Pathology, University of Virginia School of Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia
Content Type: Reference
Format: Hardcover, Electronic
Publication Year: 2009

Category: Viruses and Viral Pathogenesis

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Virology is currently one of the most dynamic and rapidly changing fields of clinical medicine. The new third edition of this essential reference has been extensively revised and updated to incorporate the latest developments and relevant research. Covering novel viruses, pathogenesis, epidemiology, diagnosis, treatment, and prevention, informs scientists and health care professionals about all the medically relevant aspects of this rapidly evolving field.

This landmark volume is organized into two major sections. The first addresses infections and syndromes related to particular organ systems, as well as the fundamentals of modern medical virology. This section includes crucial information on immune responses and vaccinology, diagnostics, antivirals, and the nascent field of gene therapy. The second section provides agent-specific chapters that detail the virology, epidemiology, pathogenesis, clinical manifestations, and prevention and treatment of important viral pathogens. All of the chapters are written by internationally recognized experts.

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Doody Enterprises

23 June 2013


This is the third edition of a classic reference that reviews the current condition of clinical virology. The book is divided into two sections: the first reviews the clinical syndromes caused by viruses and the second contains chapters on specific viral pathogens. The last edition was published in 2002 and much has changed in clinical virology in those seven years.


The purpose is to provide a comprehensive resource for "scientists and health care providers" on the changing nature of known viral pathogens and the discovery of new viral pathogens. It also provides reliable information on the rapid evolution of new methods used for testing, treatment, and prevention of viral diseases. This resource is clearly needed during a time of global travel and increasing recognition of new pathogens.


This book is written for professionals who work in the area of infectious disease. This would include scientists developing new antiviral agents and vaccines as well as practitioners making a diagnosis of infection in an increasingly vulnerable population. The authors of each chapter are respected authorities in virology and their contribution to this resource is clearly visible.


Chapters in the first section review the clinical viral syndromes by organ system and illustrate the complexity of diagnosing viral diseases that can manifest with similar symptoms. This section also addresses the increased opportunity for viral infections in vulnerable populations, such as cancer and transplant patients, as well as neonatal patients. The large second section is classically organized by viral agents. These chapters provide details on the basic life cycle of the viruses, and the epidemiology and pathogenesis of viral infections in various hosts. Most of these chapters discuss diagnostic methods and treatment. Each chapter is packed with good references, diagrams of the disease process, and diagnostic markers used to determine the stage of viral disease.


This is clearly one of the classic, need to have books for any scientist or healthcare provider who works in the area of viral infections. A large book, it weighs in at more than seven pounds, so would not be convenient to have available at the bedside. This is a reference that would be useful in an electronic format to provide this type of access.

Doody Enterprises

Reviewer: Rebecca Horvat, PhD, D(ABMM) (University of Kansas Medical Center)

Review Date: Unknown

©Doody’s Review Service

Microbiology Today

10 May 2013

Since its first edition in 1997, Clinical Virology has become a classic textbook for this rapidly growing speciality. Not only are new viruses causing disease in humans continuously discovered, the discipline spans a wide area of knowledge, reaching from basic virology over pathogenesis, immunology, clinical symptoms and diagnosis to antiviral treatment, epidemiology and prevention of epidemics by vaccines and other measures of outbreak control.

The book is organized in two parts: Part I deals with clinical symptoms and syndromes, and various aspects of general virology; Part II contains chapters on individual viruses/virus families. All chapters are written by internationally recognized leaders in their field; often several authors with special expertise in basic and in clinical virology combine forces. Obviously, in Part I the presentation of syndromes and their differential diagnosis play a major role. The chapters on general virology are adapted to issues important for clinical virology. Special chapters are devoted to viral infections in organ transplant recipients, viral haemorrhagic fevers, the role of viruses as vectors for gene therapy and the syndrome of viral post-infective fatigue with its multiple proposed aetiologies. Antiviral treatment is reviewed in two big chapters, one devoted to the large number of antiretrovirals, and one to all the other compounds. Antiviral treatment, including antiviral susceptibility testing, has really come of age. Nowadays viral diagnosis goes far beyond the identification of a virus as cause of a clinical disease. Serological typing/subtyping and other traditional virological techniques are complemented or replaced by a vast array of nucleic acid-based tests, including genotyping assays and quantitation ("viral load'). The results of many such tests are very important for clinical management, prognosis and epidemiological tracing. The large spectrum of innate immune responses has been recognized as a crucial network of early defenses to viral infections. Of the specific immune responses, the factors determining the specificity and efficacy of cell-mediated immunity are extensively reviewed. Viral proteins instrumental in evading the host's immune responses are identified at a steeply increasing rate.

Part II of the book contains 40 chapters on the major viruses or groups of viruses pathogenic for humans. Each chapter is divided into sections on core virology, viral replication, epidemiology and evolution (phylogeny), pathogenesis, specific immune responses, clinical symptoms, diagnosis, treatment and prevention by vaccination wherever possible. The epidemiology which is not discussed in detail in the general part of the book, finds its proper space in the special chapters of Part II. The plethora of information and details forbids comments on individual chapters. Suffice it to say that the emphasis given to the different sections varies from one chapter to the next. An excellent balance of conveying and discussing all the relevant facts and issues is achieved in most chapters. Based on all the data, the following conclusions seem to be warranted: a remarkably high number of emerging/re-emerging viruses causing human disease has been discovered since 2002 (year of the 2nd edition), the significance of proper phylogenies for epidemiological tracing, including tracking down of zoonotic transmission pathways, is apparent, progress in practically all areas of rapid viral diagnosis has been achieved, the power of rational antiviral treatment is increasing, outbreak management based on detailed knowledge of particular epidemiologies has improved, etc. The references are updated and well researched up to 2006/07.

The 3rd edition of Clinical Virology is a diligent, globally relevant and valuable synopsis of the specialty. This reviewer wishes the book a wide distribution into the hands of clinical virologists/microbiologists, infectious disease and general physicians, transplant surgeons, epidemiologists, vaccinologists, public health physicians and, last but not least, all interested students of biomedical sciences.

Society for General Microbiology: Microbiology Today

Reviewer: Ulrich Desselberger, Cambridge

Review Date: No Date

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