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Chapter 4 : Gastrointestinal Syndromes

Authors: Manish Patel, Roger I. Glass
Content Type: Reference
Publication Year: 2009

Category: Viruses and Viral Pathogenesis

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Abstract:

Gastroenteritis is one of the most common illnesses affecting infants, children, and adults and accounts for more than 2.5 million deaths annually in children under 5 years of age worldwide. This chapter concentrates on gastroenteritis and diarrhea caused specifically by viruses. The viral agents that are proven causes of gastroenteritis fall into four distinct families--rotaviruses (), human caliciviruses (), enteric adenoviruses (), and astroviruses (). All of these viruses cause clinical syndromes of diarrhea and vomiting that are generally similar, extraintestinal manifestations of disease are rare, and other disease syndromes associated with these viruses in humans have not been well documented. Some groups of people are at particularly high risk for disease with these agents by virtue of their age (the young and the old), their extent of exposure, or their host susceptibility, and hence special precautions for these groups are needed. The primary treatment of all these diseases is replacement of fluids and electrolytes. Prevention of the main childhood disease, rotavirus-induced diarrhea, rests with the recently introduced vaccines. Prevention of viral gastroenteritis epidemics will rest with the identification of the vehicle of infection, interruption of the mode of transmission, and the potential development of vaccines.

Citation: Patel M, Glass R. 2009. Gastrointestinal Syndromes, p 45-57. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch4

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Clinical and Public Health
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Severe Acute Respiratory Syndrome
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Traveler's Diarrhea
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Viral Gastroenteritis
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Gastrointestinal Bleeding
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Gastrointestinal Syndromes
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Citation: Patel M, Glass R. 2009. Gastrointestinal Syndromes, p 45-57. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch4
/content/10.1128/9781555815981.ch04.ch04fig01
FIGURE 1
Electron micrographs showing agents of viral gastroenteritis. (A) Rotavirus; (B) astrovirus; (C) adenovirus; (D and E) Norwalk-like viruses of the family
10.1128/9781555815981/f0048-01_thmb.gif
10.1128/9781555815981/f0048-01.gif
Image of FIGURE 1
FIGURE 1

Electron micrographs showing agents of viral gastroenteritis. (A) Rotavirus; (B) astrovirus; (C) adenovirus; (D and E) Norwalk-like viruses of the family

Citation: Patel M, Glass R. 2009. Gastrointestinal Syndromes, p 45-57. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch4
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References

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1. Ando, T.,, J. S. Noel, and, R. L. Fankhauser. 2000. Genetic classification of “Norwalk-like viruses.” J. Infect. Dis. 181 (Suppl. 2): S336– S348.
2. Baker, S. J.,, M. Mathan,, V. I. Mathan,, S. Jesudoss, and, S. P. Swaminathan. 1982. Chronic enterocyte infection with coronavirus. One possible cause of the syndrome of tropical sprue? Dig. Dis. Sci. 27: 1039– 1043.
3. Bartlett, A. V.,, M. Moore,, G. W. Gary,, K. M. Starko,, J. J. Erben, and, B. A. Meredith. 1985. Diarrheal illness among infants and toddlers in day care centers. I. Epidemiology and pathogens. J. Pediatr. 107: 495– 502.
4. Bartlett, A. V.,, M. Moore,, G. W. Gary,, K. M. Starko,, J. J. Erben, and, B. A. Meredith. 1985. Diarrheal illness among infants and toddlers in day care centers. II. Comparison with day care homes and households. J. Pediatr. 107: 503– 509.
5. Becker, K. M.,, C. L. Moe,, K. L. Southwick, and, J. N. MacCormack. 2000. Transmission of Norwalk virus during football game. N. Engl. J. Med. 343: 1223– 1227.
6. Beller, M.,, A. Ellis,, S. H. Lee,, M. A. Drebot,, S. A. Jenkerson,, E. Funk,, M. D. Sobsey,, O. D. Simmons III,, S. S. Monroe,, T. Ando,, J. Noel,, M. Petric,, J. P. Middaugh, and, J. S. Spika. 1997. Outbreak of viral gastroenteritis due to a contaminated well. International consequences. JAMA 278: 563– 568.
7. Bern, C.,, J. Lew,, P. McFeeley,, D. Ing,, R. T. Ing, and, R. I. Glass. 1993. Diarrheal deaths in children living in New Mexico: toward a strategy of preventive interventions. J. Pediatr. 122: 920– 922.
8. Bishop, R. F.,, G. P. Davidson,, I. H. Holmes, and, B. J. Ruck. 1973. Virus particles in epithelial cells of duodenal mucosa from children with acute nonbacterial gastroenteritis. Lancet ii: 1281– 1283.
9. Black, R. E. 1993. Persistent diarrhea in children of developing countries. Pediatr. Infect. Dis. J. 12: 751– 761.
10. Blacklow, N. R.,, and H. B. Greenberg. 1991. Viral gastroenteritis. N. Engl. J. Med. 325: 252– 264.
11. Blutt, S. E.,, C. D. Kirkwood,, V. Parreno,, K. L. Warfield,, M. Ciarlet,, M. K. Estes,, K. Bok,, R. F. Bishop, and, M. E. Conner. 2003. Rotavirus antigenaemia and viraemia: a common event? Lancet 362: 1445– 1449.
12. Bolivar, R.,, R. H. Conklin,, J. J. Vollet,, L. K. Pickering,, H. L. DuPont,, D. L. Walters, and, S. Kohl. 1978. Rotavirus in travelers’ diarrhea: study of an adult student population in Mexico. J. Infect. Dis. 137: 324– 327.
13. Brandt, C. D.,, H. W. Kim,, W. J. Rodriguez,, J. O. Arrobio,, B. C. Jeffries,, E. P. Stallings,, C. Lewis,, A. J. Miles,, M. K. Gardner, and, R. H. Parrott. 1985. Adenoviruses and pediatric gastroenteritis. J. Infect. Dis. 151: 437– 443.
14. Bresee, J. S.,, E. Hummelman,, E. A. Nelson, and, R. I. Glass. 2005. Rotavirus in Asia: the value of surveillance for informing decisions about the introduction of new vaccines. J. Infect. Dis. 192 (Suppl. 1): S1– S5.
15. Brown, D. W.,, L. Campbell,, D. S. Tomkins, and, M. H. Hambling. 1989. School outbreak of gastroenteritis due to atypical rotavirus. Lancet ii: 737– 738.
16. Caul, E. O.,, and S. I. Egglestone. 1977. Further studies on human enteric coronaviruses. Arch. Virol. 54: 107– 117.
17. Cheng, P. K.,, D. A. Wong,, L. K. Tong,, S. M. Ip,, A. C. Lo,, C. S. Lau,, E. Y. Yeung, and, W. W. Lim. 2004. Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome. Lancet 363: 1699– 1700.
18. Cubitt, W. D.,, and D. A. McSwiggan. 1987. Seroepidemiological survey of the prevalence of antibodies to a strain of human calicivirus. J. Med. Virol. 21: 361– 368.
19. Cunliffe, N. A.,, J. S. Gondwe,, C. D. Kirkwood,, S. M. Graham,, N. M. Nhlane,, B. D. Thindwa,, W. Dove,, R. L. Broadhead,, M. E. Molyneux, and, C. A. Hart. 2001. Effect of concomitant HIV infection on presentation and outcome of rotavirus gastroenteritis in Malawian children. Lancet 358: 550– 555.
20. Delage, G.,, B. McLaughlin, and, L. Berthiaume. 1978. A clinical study of rotavirus gastroenteritis. J. Pediatr. 93: 455– 457.
21. Dolin, R.,, N. R. Blacklow,, H. DuPont,, S. Formal,, R. F. Buscho,, J. A. Kasel,, R. P. Chames,, R. Hornick, and, R. M. Chanock. 1971. Transmission of acute infectious nonbacterial gastroenteritis to volunteers by oral administration of stool filtrates. J. Infect. Dis. 123: 307– 312.
22. Dowell, S. F.,, C. Groves,, K. B. Kirkland,, H. G. Cicirello,, T. Ando,, Q. Jin,, J. R. Gentsch,, S. S. Monroe,, C. D. Humphrey,, C. Slemp,, D. M. Dwyer,, R. A. Meriwether, and, R. I. Glass. 1995. A multistate outbreak of oyster-associated gastroenteritis: implications for interstate tracing of contaminated shellfish. J. Infect. Dis. 171: 1497– 1503.
23. Duggan, C.,, M. Santosham, and, R. I. Glass for the Centers for Disease Control and Prevention. 1992. The management of acute diarrhea in children: oral rehydration, maintenance, and nutritional therapy. Morb. Mortal. Wkly. Rep. Recomm. Rep. 41: 1– 20.
24. DuPont, H. L.,, and C. D. Ericsson. 1993. Prevention and treatment of traveler’s diarrhea. N. Engl. J. Med. 328: 1821– 1827.
25. Eichenwald, H. F.,, A. Ababio,, A. M. Arky, and, A. P. Hartman. 1958. Epidemic diarrhea in premature and older infants caused by ECHO virus type 18. JAMA 166: 1563– 1566.
26. Falkenhorst, G.,, L. Krusell,, M. Lisby,, S. B. Madsen,, B. Böttiger, and, K. Mølbak. 2005. Imported frozen raspberries cause a series of norovirus outbreaks in Denmark, 2005. Euro. Surveill. 10: E050922.2.
27. Figueroa-Quintanilla, D.,, E. Salazar-Lindo,, R. B. Sack,, R. Leon-Barua,, S. Sarabia-Arce,, M. Campos-Sanchez, and, E. Eyzaguirre-Maccan. 1993. A controlled trial of bismuth subsalicylate in infants with acute watery diarrheal disease. N. Engl. J. Med. 328: 1653– 1658.
28. Gaggero, A.,, L. F. Avendano,, J. Fernandez, and, E. Spencer. 1992. Nosocomial transmission of rotavirus from patients admitted with diarrhea. J. Clin. Microbiol. 30: 3294– 3297.
29. Gebhard, R. L.,, H. B. Greenberg,, N. Singh,, P. Henry,, H. L. Sharp,, L. Kaplan, and, A. Z. Kapikian. 1982. Acute viral enteritis and exacerbations of inflammatory bowel disease. Gastroenterology 83: 1207– 1209.
30. Gellert, G. A.,, S. H. Waterman,, D. Ewert,, L. Oshiro,, M. P. Giles,, S. S. Monroe,, L. Gorelkin, and, R. I. Glass. 1990. An outbreak of acute gastroenteritis caused by a small round structured virus in a geriatric convalescent facility. Infect. Control Hosp. Epidemiol. 11: 459– 464.
31. Gilger, M. A.,, D. O. Matson,, M. E. Conner,, H. M. Rosenblatt,, M. J. Finegold, and, M. K. Estes. 1992. Extraintestinal rotavirus infections in children with immunodeficiency. J. Pediatr. 120: 912– 917.
32. Glass, R. I.,, J. Noel,, T. Ando,, R. Fankhauser,, G. Belliot,, A. Mounts,, U. D. Parashar,, J. S. Bresee, and, S. S. Monroe. 2000. The epidemiology of enteric caliciviruses from humans: a reassessment using new diagnostics. J. Infect. Dis. 181 (Suppl. 2): S254– S261.
33. Gordon, I.,, H. S. Ingraham, and, R. F. Korns. 1947. Transmission of epidemic gastroenteritis to human volunteers by oral administration of fecal filtrates. J. Exp. Med. 86: 409– 422.
34. Gough, R. E.,, M. S. Collins,, E. Borland, and, L. F. Keymer. 1984. Astrovirus-like particles associated with hepatitis in ducklings. Vet. Rec. 114: 279.
35. Graham, D. Y.,, X. Jiang,, T. Tanaka,, A. R. Opekun,, H. P. Madore, and, M. K. Estes. 1994. Norwalk virus infection of volunteers: new insights based on improved assays. J. Infect. Dis. 170: 34– 43.
36. Green, K. Y.,, T. Ando,, M. S. Balayan,, T. Berke,, I. N. Clarke,, M. K. Estes,, D. O. Matson,, S. Nakata,, J. D. Neill,, M. J. Studdert, and, H. J. Thiel. 2000. Taxonomy of the caliciviruses. J. Infect. Dis. 181 (Suppl. 2): S322– S330.
37. Greenberg, H. B.,, J. Valdesuso,, A. Z. Kapikian,, R. M. Chanock,, R. G. Wyatt,, W. Szmuness,, J. Larrick,, J. Kaplan,, R. H. Gilman, and, D. A. Sack. 1979. Prevalence of antibody to the Norwalk virus in various countries. Infect. Immun. 26: 270– 273.
38. Grohmann, G. S.,, R. I. Glass,, H. G. Pereira,, S. S. Monroe,, A. W. Hightower,, R. Weber, and, R. T. Bryan for The Enteric Opportunistic Infections Working Group. 1993. Enteric viruses and diarrhea in HIV-infected patients. N. Engl. J. Med. 329: 14– 20.
39. Guarino, A.,, R. B. Canani,, S. Russo,, F. Albano,, M. B. Canani,, F. M. Ruggeri,, G. Donelli, and, A. Rubino. 1994. Oral immunoglobulins for treatment of acute rotaviral gastroenteritis. Pediatrics 93: 12– 16.
40. Guix, S.,, A. Bosch, and, R. M. Pinto. 2005. Human astrovirus diagnosis and typing: current and future prospects. Lett. Appl. Microbiol. 41: 103– 105.
41. Hall, G. A. 1987. Comparative pathology of infection by novel diarrhoea viruses. Ciba Found. Symp. 128: 192– 217.
42. Halvorsrud, J.,, and I. Orstavik. 1980. An epidemic of rotavirus-associated gastroenteritis in a nursing home for the elderly. Scand. J. Infect. Dis. 12: 161– 164.
43. Hedberg, C. W.,, and M. T. Osterholm. 1993. Outbreaks of food-borne and waterborne viral gastroenteritis. Clin. Microbiol. Rev. 6: 199– 210.
44. Herrmann, J. E.,, D. N. Taylor,, P. Echeverria, and, N. R. Blacklow. 1991. Astroviruses as a cause of gastroenteritis in children. N. Engl. J. Med. 324: 1757– 1760.
45. Ho, M. S.,, R. I. Glass,, S. S. Monroe,, H. P. Madore,, S. Stine,, P. F. Pinsky,, D. Cubitt,, C. Ashley, and, E. O. Caul. 1989. Viral gastroenteritis aboard a cruise ship. Lancet ii: 961– 965.
46. Ho, M. S.,, R. I. Glass,, P. F. Pinsky,, N. C. Young-Okoh,, W. M. Sappenfield,, J. W. Buehler,, N. Gunter, and, L. J. Anderson. 1988. Diarrheal deaths in American children. Are they preventable? JAMA 260: 3281– 3285.
47. Huang, P.,, T. Farkas,, W. Zhong,, M. Tan,, S. Thornton,, A. L. Morrow, and, X. Jiang. 2005. Norovirus and histoblood group antigens: demonstration of a wide spectrum of strain specificities and classification of two major binding groups among multiple binding patterns. J. Virol. 79: 6714– 6722.
48. Hung, T.,, G. M. Chen,, C. G. Wang,, H. L. Yao,, Z. Y. Fang,, T. X. Chao,, Z. Y. Chou,, W. Ye,, X. J. Chang, and, S. S. Den. 1984. Waterborne outbreak of rotavirus diarrhoea in adults in China caused by a novel rotavirus. Lancet i: 1139– 1142.
49. Hutson, A. M.,, R. L. Atmar,, D. Y. Graham, and, M. K. Estes. 2002. Norwalk virus infection and disease is associated with ABO histo-blood group type. J. Infect. Dis. 185: 1335– 1337.
50. Hyams, K. C.,, A. L. Bourgeois,, B. R. Merrell,, P. Rozmajzl,, J. Escamilla,, S. A. Thornton,, G. M. Wasserman,, A. Burke,, P. Echeverria,, K. Y. Green,, A. Z. Kapikian, and, J. N. Woody. 1991. Diarrheal disease during Operation Desert Shield. N. Engl. J. Med. 325: 1423– 1428.
51. Isakbaeva, E. T.,, M. A. Widdowson,, R. S. Beard,, S. N. Bulens,, J. Mullins,, S. S. Monroe,, J. Bresee,, P. Sassano,, E. H. Cramer, and, R. I. Glass. 2005. Norovirus transmission on cruise ship. Emerg. Infect. Dis. 11: 154– 158.
52. Jamieson, F. B.,, E. E. Wang,, C. Bain,, J. Good,, L. Duckmanton, and, M. Petric. 1998. Human torovirus: a new nosocomial gastrointestinal pathogen. J. Infect. Dis. 178: 1263– 1269.
53. Johnson, P. C.,, J. J. Mathewson,, H. L. DuPont, and, H. B. Greenberg. 1990. Multiple-challenge study of host susceptibility to Norwalk gastroenteritis in US adults. J. Infect. Dis. 161: 18– 21.
54. Kapikian, A. Z.,, H. W. Kim,, R. G. Wyatt,, W. L. Cline,, J. O. Arrobio,, C. D. Brandt,, W. J. Rodriguez,, D. A. Sack,, R. M. Chanock, and, R. H. Parrott. 1976. Human reovirus-like agent as the major pathogen associated with “winter” gastroenteritis in hospitalized infants and young children. N. Engl. J. Med. 294: 965– 972.
55. Kapikian, A. Z.,, R. G. Wyatt,, R. Dolin,, T. S. Thornhill,, A. R. Kalica, and, R. M. Chanock. 1972. Visualization by immune electron microscopy of a 27-nm particle associated with acute infectious nonbacterial gastroenteritis. J. Virol. 10: 1075– 1081.
56. Kaplan, J. E.,, G. W. Gary,, R. C. Baron,, N. Singh,, L. B. Schonberger,, R. Feldman, and, H. B. Greenberg. 1982. Epidemiology of Norwalk gastroenteritis and the role of Norwalk virus in outbreaks of acute nonbacterial gastroenteritis. Ann. Intern. Med. 96: 756– 761.
57. Kohn, M. A.,, T. A. Farley,, T. Ando,, M. Curtis,, S. A. Wilson,, Q. Jin,, S. S. Monroe,, R. C. Baron,, L. M. McFarland, and, R. I. Glass. 1995. An outbreak of Norwalk virus gastroenteritis associated with eating raw oysters. Implications for maintaining safe oyster beds. JAMA 273: 466– 471.
58. Konno, T.,, H. Suzuki,, T. Kutsuzawa,, A. Imai,, N. Katsushima,, M. Sakamoto, and, S. Kitaoka. 1977. Human rotavirus and intussusception. N. Engl. J. Med. 297: 945.
59. Koopmans, M.,, and M. C. Horzinek. 1994. Toroviruses of animals and humans: a review. Adv. Virus Res. 43: 233– 273.
60. Koopmans, M.,, M. Petric,, R. I. Glass, and, S. S. Monroe. 1993. Enzyme-linked immunosorbent assay reactivity of torovirus-like particles in fecal specimens from humans with diarrhea. J. Clin. Microbiol. 31: 2738– 2744.
61. Kordasti, S.,, H. Sjovall,, O. Lundgren, and, L. Svensson. 2004. Serotonin and vasoactive intestinal peptide antagonists attenuate rotavirus diarrhoea. Gut 53: 952– 957.
62. Kotler, D. P.,, H. P. Gaetz,, M. Lange,, E. B. Klein, and, P. R. Holt. 1984. Enteropathy associated with the acquired immunodeficiency syndrome. Ann. Intern. Med. 101: 421– 428.
63. Lawson, H. W.,, M. M. Braun,, R. I. Glass,, S. E. Stine,, S. S. Monroe,, H. K. Atrash,, L. E. Lee, and, S. J. Englender. 1991. Waterborne outbreak of Norwalk virus gastroenteritis at a southwest US resort: role of geological formations in contamination of well water. Lancet 337: 1200– 1204.
64. Leung, W. K.,, K. F. To,, P. K. Chan,, H. L. Chan,, A. K. Wu,, N. Lee,, K. Y. Yuen, and, J. J. Sung. 2003. Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology 125: 1011– 1017.
65. Lew, J. F.,, R. I. Glass,, R. E. Gangarosa,, I. P. Cohen,, C. Bern, and, C. L. Moe. 1991. Diarrheal deaths in the United States, 1979 through 1987. A special problem for the elderly. JAMA 265: 3280– 3284.
66. Lew, J. F.,, R. I. Glass,, M. Petric,, C. W. Lebaron,, G. W. Hammond,, S. E. Miller,, C. Robinson,, J. Boutilier,, M. Riepenhoff-Talty,, C. M. Payne,, R. Franklin,, L. Oshiro, and, M. Jaqua. 1990. Six-year retrospective surveillance of gastroenteritis viruses identified at ten electron microscopy centers in the United States and Canada. Pediatr. Infect. Dis. J. 9: 709– 714.
67. Lew, J. F.,, C. L. Moe,, S. S. Monroe,, J. R. Allen,, B. M. Harrison,, B. D. Forrester,, S. E. Stine,, P. A. Woods,, J. C. Hierholzer,, J. E. Herrmann,, N. R. Blacklow,, A. V. Bartlett, and, R. I. Glass. 1991. Astrovirus and adenovirus associated with diarrhea in children in day care settings. J. Infect. Dis. 164: 673– 678.
68. Li, S. T.,, D. C. Grossman, and, P. Cummings. 2007. Loperamide therapy for acute diarrhea in children: systematic review and meta-analysis. PLoS Med. 4: e98.
69. Lindesmith, L.,, C. Moe,, S. Marionneau,, N. Ruvoen,, X. Jiang,, L. Lindblad,, P. Stewart,, J. LePendu, and, R. Baric. 2003. Human susceptibility and resistance to Norwalk virus infection. Nat. Med. 9: 548– 553.
70. Liste, M. B.,, I. Natera,, J. A. Suarez,, F. H. Pujol,, F. Liprandi, and, J. E. Ludert. 2000. Enteric virus infections and diarrhea in healthy and human immunodeficiency virus-infected children. J. Clin. Microbiol. 38: 2873– 2877.
71. Lopman, B.,, H. Vennema,, E. Kohli,, P. Pothier,, A. Sanchez,, A. Negredo,, J. Buesa,, E. Schreier,, M. Reacher,, D. Brown,, J. Gray,, M. Iturriza,, C. Gallimore,, B. Bottiger,, K. O. Hedlund,, M. Torven,, C. H. von Bonsdorff,, L. Maunula,, M. Poljsak-Prijatelj,, J. Zimsek,, G. Reuter,, G. Szucs,, B. Melegh,, L. Svennson,, Y. van Duijnhoven, and, M. Koopmans. 2004. Increase in viral gastroenteritis outbreaks in Europe and epidemic spread of new norovirus variant. Lancet 363: 682– 688.
72. Lundgren, O.,, A. T. Peregrin,, K. Persson,, S. Kordasti,, I. Uhnoo, and, L. Svensson. 2000. Role of the enteric nervous system in the fluid and electrolyte secretion of rotavirus diarrhea. Science 287: 491– 495.
73. Lynch, M.,, B. Lee,, P. Azimi,, J. Gentsch,, C. Glaser,, S. Gilliam,, H. G. Chang,, R. Ward, and, R. I. Glass. 2001. Rotavirus and central nervous system symptoms: cause or contaminant? Case reports and review. Clin. Infect. Dis. 33: 932– 938.
74. Madeley, C. R.,, and B. P. Cosgrove. 1975. Letter: 28 nm particles in faeces in infantile gastroenteritis. Lancet ii: 451– 452.
75. Madeley, C. R.,, and B. P. Cosgrove. 1976. Letter: caliciviruses in man. Lancet i: 199– 200.
76. Mathan, M.,, V. I. Mathan,, S. P. Swaminathan, and, S. Yesudoss. 1975. Pleomorphic virus-like particles in human faeces. Lancet i: 1068– 1069.
77. Matsuno, S.,, E. Utagawa, and, A. Sugiura. 1983. Association of rotavirus infection with Kawasaki syndrome. J. Infect. Dis. 148: 177.
78. McCarthy, M.,, M. K. Estes, and, K. C. Hyams. 2000. Norwalk-like virus infection in military forces: epidemic potential, sporadic disease, and the future direction of prevention and control efforts. J. Infect. Dis. 181 (Suppl. 2): S387– S391.
79. Miller, S. E. 1986. Detection and identification of viruses by electron microscopy. J. Electron Microsc. 4: 265– 301.
80. Mitchell, D. K.,, R. Van,, A. L. Morrow,, S. S. Monroe,, R. I. Glass, and, L. K. Pickering. 1993. Outbreaks of astrovirus gastroenteritis in day care centers. J. Pediatr. 123: 725– 732.
81. Monroe, S. S.,, R. I. Glass,, N. Noah,, T. H. Flewett,, E. O. Caul,, C. I. Ashton,, A. Curry,, A. M. Field,, R. Madeley, and, P. J. Pead. 1991. Electron microscopic reporting of gastrointestinal viruses in the United Kingdom, 1985–1987. J. Med. Virol. 33: 193– 198.
82. Newburg, D. S.,, J. A. Peterson,, G. M. Ruiz-Palacios,, D. O. Matson,, A. L. Morrow,, J. Shults,, M. L. Guerrero,, P. Chaturvedi,, S. O. Newburg,, C. D. Scallan,, M. R. Taylor,, R. L. Ceriani, and, L. K. Pickering. 1998. Role of human-milk lactadherin in protection against symptomatic rotavirus infection. Lancet 351: 1160– 1164.
83. Oishi, I.,, K. Yamazaki,, T. Kimoto,, Y. Minekawa,, E. Utagawa,, S. Yamazaki,, S. Inouye,, G. S. Grohmann,, S. S. Monroe,, S. E. Stine,, C. Carcamo,, T. Ando, and, R. I. Glass. 1994. A large outbreak of acute gastroenteritis associated with astrovirus among students and teachers in Osaka, Japan. J. Infect. Dis. 170: 439– 443.
84. Owens, J. R.,, R. Broadhead,, R. G. Hendrickse,, O. P. Jaswal, and, R. N. Gangal. 1981. Loperamide in the treatment of acute gastroenteritis in early childhood. Report of a two centre, double-blind, controlled clinical trial. Ann. Trop. Paediatr. 1: 135– 141.
85. Pang, X. L.,, S. Honma,, S. Nakata, and, T. Vesikari. 2000. Human caliciviruses in acute gastroenteritis of young children in the community. J. Infect. Dis. 181 (Suppl. 2): S288– S294.
86. Pang, X. L.,, J. K. Preiksaitis, and, B. Lee. 2005. Multiplex real time RT-PCR for the detection and quantitation of norovirus genogroups I and II in patients with acute gastroenteritis. J. Clin. Virol. 33: 168– 171.
87. Parashar, U. D.,, E. G. Hummelman,, J. S. Bresee,, M. A. Miller, and, R. I. Glass. 2003. Global illness and deaths caused by rotavirus disease in children. Emerg. Infect. Dis. 9: 565– 572.
88. Parashar, U. D.,, J. F. Li,, R. Cama,, M. DeZalia,, S. S. Monroe,, D. N. Taylor,, D. Figueroa,, R. H. Gilman, and, R. I. Glass. 2004. Human caliciviruses as a cause of severe gastroenteritis in Peruvian children. J. Infect. Dis. 190: 1088– 1092.
89. Parrino, T. A.,, D. S. Schreiber,, J. S. Trier,, A. Z. Kapikian, and, N. R. Blacklow. 1977. Clinical immunity in acute gastroenteritis caused by Norwalk agent. N. Engl. J. Med. 297: 86– 89.
90. Parrott, R. H. 1957. The clinical importance of group A Coxsackie viruses. Ann. N. Y. Acad. Sci. 67: 230– 240.
91. Payne, C. M.,, C. G. Ray,, V. Borduin,, L. L. Minnich, and, M. D. Lebowitz. 1986. An eight-year study of the viral agents of acute gastroenteritis in humans: ultrastructural observations and seasonal distribution with a major emphasis on coronavirus-like particles. Diagn. Microbiol. Infect. Dis. 5: 39– 54.
92. Penaranda, M. E.,, W. D. Cubitt,, P. Sinarachatanant,, D. N. Taylor,, S. Likanonsakul,, L. Saif, and, R. I. Glass. 1989. Group C rotavirus infections in patients with diarrhea in Thailand, Nepal, and England. J. Infect. Dis. 160: 392– 397.
93. Pickering, L. K.,, A. V. Bartlett III,, R. R. Reves, and, A. Morrow. 1988. Asymptomatic excretion of rotavirus before and after rotavirus diarrhea in children in day care centers. J. Pediatr. 112: 361– 365.
94. Ramos-Alvarez, M.,, and A. B. Sabin. 1958. Enteropathogenic viruses and bacteria; role in summer diarrheal diseases of infancy and early childhood. JAMA 167: 147– 156.
95. Resta, S.,, J. P. Luby,, C. R. Rosenfeld, and, J. D. Siegel. 1985. Isolation and propagation of a human enteric coronavirus. Science 229: 978– 981.
96. Riepenhoff-Talty, M.,, K. Schaekel,, H. F. Clark,, W. Mueller,, I. Uhnoo,, T. Rossi,, J. Fisher, and, P. L. Ogra. 1993. Group A rotaviruses produce extrahepatic biliary obstruction in orally inoculated newborn mice. Pediatr. Res. 33: 394– 399.
97. Rodriguez, W. J.,, H. W. Kim,, C. D. Brandt,, R. H. Schwartz,, M. K. Gardner,, B. Jeffries,, R. H. Parrott,, R. A. Kaslow,, J. I. Smith, and, A. Z. Kapikian. 1987. Longitudinal study of rotavirus infection and gastroenteritis in families served by a pediatric medical practice: clinical and epidemiologic observations. Pediatr. Infect. Dis. J. 6: 170– 176.
98. Rosen, B. I.,, Z. Y. Fang,, R. I. Glass, and, S. S. Monroe. 2000. Cloning of human picobirnavirus genomic segments and development of an RT-PCR detection assay. Virology 277: 316– 329.
99. Rotbart, H. A.,, W. L. Nelson,, M. P. Glode,, T. C. Triffon,, S. J. Kogut,, R. H. Yolken,, J. A. Hernandez, and, M. J. Levin. 1988. Neonatal rotavirus-associated necrotizing enterocolitis: case control study and prospective surveillance during an outbreak. J. Pediatr. 112: 87– 93.
100. Ruiz-Palacios, G. M.,, I. Perez-Schael,, F. R. Velazquez,, H. Abate,, T. Breuer,, S. C. Clemens,, B. Cheuvart,, F. Espinoza,, P. Gillard,, B. L. Innis,, Y. Cervantes,, A. C. Linhares,, P. Lopez,, M. Macias-Parra,, E. Ortega-Barria,, V. Richardson,, D. M. Rivera-Medina,, L. Rivera,, B. Salinas,, N. Pavia-Ruz,, J. Salmeron,, R. Ruttimann,, J. C. Tinoco,, P. Rubio,, E. Nunez,, M. L. Guerrero,, J. P. Yarzabal,, S. Damaso,, N. Tornieporth,, X. Saez-Llorens,, R. F. Vergara,, T. Vesikari,, A. Bouckenooghe,, R. Clemens,, B. De Vos, and, M. O’Ryan. 2006. Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N. Engl. J. Med. 354: 11– 22.
101. Saavedra, J. M.,, N. A. Bauman,, I. Oung,, J. A. Perman, and, R. H. Yolken. 1994. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet 344: 1046– 1049.
102. Salmi, T. T.,, P. Arstila, and, A. Koivikko. 1978. Central nervous system involvement in patients with rotavirus gastroenteritis. Scand. J. Infect. Dis. 10: 29– 31.
103. Sanford, J. P.,, and S. E. Sulkin. 1959. The clinical spectrum of ECHO-virus infection. N. Engl. J. Med. 261: 1113– 1122.
104. Saulsbury, F. T.,, J. A. Winkelstein, and, R. H. Yolken. 1980. Chronic rotavirus infection in immunodeficiency. J. Pediatr. 97: 61– 65.
105. Sawyer, L. A.,, J. J. Murphy,, J. E. Kaplan,, P. F. Pinsky,, D. Chacon,, S. Walmsley,, L. B. Schonberger,, A. Phillips,, K. Forward,, C. Goldman,, J. Brunton,, R. A. Fralick,, A. O. Carter,, G. W. Gary,, R. I. Glass, and, D. E. Low. 1988. 25- to 30-nm virus particle associated with a hospital outbreak of acute gastroenteritis with evidence for airborne transmission. Am. J. Epidemiol. 127: 1261– 1271.
106. Schreiber, D. S.,, N. R. Blacklow, and, J. S. Trier. 1973. The mucosal lesion of the proximal small intestine in acute infectious nonbacterial gastroenteritis. N. Engl. J. Med. 288: 1318– 1323.
107. Simhon, A.,, and L. Mata. 1978. Anti-rotavirus antibody in human colostrum. Lancet i: 39– 40.
108. Smith, A. W.,, D. E. Skilling, and, S. Ridgway. 1983. Calicivirus-induced vesicular disease in cetaceans and probable interspecies transmission. J. Am. Vet. Med. Assoc. 183: 1223– 1225.
109. Steffen, R.,, F. Collard,, N. Tornieporth,, S. Campbell-Forrester,, D. Ashley,, S. Thompson,, J. J. Mathewson,, E. Maes,, B. Stephenson,, H. L. DuPont, and, F. von Sonnenburg. 1999. Epidemiology, etiology, and impact of traveler’s diarrhea in Jamaica. JAMA 281: 811– 817.
110. Szajewska, H.,, M. Kotowska,, J. Z. Mrukowicz,, M. Armanska, and, W. Mikolajczyk. 2001. Efficacy of Lactobacillus GG in prevention of nosocomial diarrhea in infants. J. Pediatr. 138: 361– 365.
111. Tacket, C. O.,, M. B. Sztein,, G. A. Losonsky,, S. S. Wasserman, and, M. K. Estes. 2003. Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers. Clin. Immunol. 108: 241– 247.
112. Turcios, R. M.,, M. A. Widdowson,, A. C. Sulka,, P. S. Mead, and, R. I. Glass. 2006. Reevaluation of epidemiological criteria for identifying outbreaks of acute gastroenteritis due to norovirus: United States, 1998–2000. Clin. Infect. Dis. 42: 964– 969.
113. Uhnoo, I.,, E. Olding-Stenkvist, and, A. Kreuger. 1986. Clinical features of acute gastroenteritis associated with rotavirus, enteric adenoviruses, and bacteria. Arch. Dis. Child. 61: 732– 738.
114. Uhnoo, I.,, G. Wadell,, L. Svensson, and, M. E. Johansson. 1984. Importance of enteric adenoviruses 40 and 41 in acute gastroenteritis in infants and young children. J. Clin. Microbiol. 20: 365– 372.
115. Ushijima, H.,, K. Q. Xin,, S. Nishimura,, S. Morikawa, and, T. Abe. 1994. Detection and sequencing of rotavirus VP7 gene from human materials (stools, sera, cerebrospinal fluids, and throat swabs) by reverse transcription and PCR. J. Clin. Microbiol. 32: 2893– 2897.
116. van Duynhoven, Y. T.,, C. M. de Jager,, L. M. Kortbeek,, H. Vennema,, M. P. Koopmans,, F. van Leusden,, W. H. van der Poel, and, M. J. van den Broek. 2005. A one-year intensified study of outbreaks of gastroenteritis in The Netherlands. Epidemiol. Infect. 133: 9– 21.
117. Vesikari, T.,, D. O. Matson,, P. Dennehy,, P. Van Damme,, M. Santosham,, Z. Rodriguez,, M. J. Dallas,, J. F. Heyse,, M. G. Goveia,, S. B. Black,, H. R. Shine-field,, C. D. Christie,, S. Ylitalo,, R. F. Itzler,, M. L. Coia,, M. T. Onorato,, B. A. Adeyi,, G. S. Marshall,, L. Gothefors,, D. Campens,, A. Karvonen,, J. P. Watt,, K. L. O’Brien,, M. J. DiNubile,, H. F. Clark,, J. W. Boslego,, P. A. Offit, and, P. M. Heaton. 2006. Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N. Engl. J. Med. 354: 23– 33.
118. Vonderfecht, S. L.,, R. L. Miskuff,, S. B. Wee,, S. Sato,, R. R. Tidwell,, J. D. Geratz, and, R. H. Yolken. 1988. Protease inhibitors suppress the in vitro and in vivo replication of rotavirus. J. Clin. Investig. 82: 2011– 2016.
119. Weinberg, A. D.,, and K. L. Minaker for the Council on Scientific Affairs, American Medical Association. 1995. Dehydration. Evaluation and management in older adults. JAMA 274: 1552– 1556.
120. Welsh, J. K.,, and J. T. May. 1979. Anti-infective properties of breast milk. J. Pediatr. 94: 1– 9.
121. Widdowson, M. A.,, R. Glass,, S. Monroe,, R. S. Beard,, J. W. Bateman,, P. Lurie, and, C. Johnson. 2005. Probable transmission of norovirus on an airplane. JAMA 293: 1859– 1860.
122. Widdowson, M. A.,, A. Sulka,, S. N. Bulens,, R. S. Beard,, S. S. Chaves,, R. Hammond,, E. D. Salehi,, E. Swanson,, J. Totaro,, R. Woron,, P. S. Mead,, J. S. Bresee,, S. S. Monroe, and, R. I. Glass. 2005. Norovirus and foodborne disease, United States, 1991–2000. Emerg. Infect. Dis. 11: 95– 102.
123. Yamashita, T. 1999. Biological and epidemiological characteristics of Aichi virus, as a new member of Picornaviridae. Virus (Nagoya) 49: 183– 191. (In Japanese.)
124. Yolken, R.,, E. Dubovi,, F. Leister,, R. Reid,, J. Almeido-Hill, and, M. Santosham. 1989. Infantile gastroenteritis associated with excretion of pestivirus antigens. Lancet i: 517– 520.
125. Yolken, R.,, and M. Murphy. 1982. Sudden infant death syndrome associated with rotavirus infection. J. Med. Virol. 10: 291– 296.
126. Yolken, R. H.,, C. A. Bishop,, T. R. Townsend,, E. A. Bolyard,, J. Bartlett,, G. W. Santos, and, R. Saral. 1982. Infectious gastroenteritis in bone-marrow-transplant recipients. N. Engl. J. Med. 306: 1010– 1012.
127. Yolken, R. H.,, H. W. Kim,, T. Clem,, R. G. Wyatt,, A. R. Kalica,, R. M. Chanock, and, A. Z. Kapikian. 1977. Enzyme-linked immunosorbent assay (ELISA) for detection of human reovirus-like agent of infantile gastroenteritis. Lancet ii: 263– 267.

Tables

Gastrointestinal Syndromes
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Citation: Patel M, Glass R. 2009. Gastrointestinal Syndromes, p 45-57. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch4
/content/10.1128/9781555815981.ch04.ch04tab01
TABLE 1
Historical advances in the identification of viral agents of gastroenteritis
Generic image for table
TABLE 1

Historical advances in the identification of viral agents of gastroenteritis

Citation: Patel M, Glass R. 2009. Gastrointestinal Syndromes, p 45-57. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch4
/content/10.1128/9781555815981.ch04.ch04tab02
TABLE 2
Microbiological and epidemiological characteristics of viral agents that cause gastroenteritis
Generic image for table
TABLE 2

Microbiological and epidemiological characteristics of viral agents that cause gastroenteritis

Citation: Patel M, Glass R. 2009. Gastrointestinal Syndromes, p 45-57. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch4
/content/10.1128/9781555815981.ch04.ch04tab03
TABLE 3
Contrasting epidemiological patterns of viral gastroenteritis
Generic image for table
TABLE 3

Contrasting epidemiological patterns of viral gastroenteritis

Citation: Patel M, Glass R. 2009. Gastrointestinal Syndromes, p 45-57. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch4
/content/10.1128/9781555815981.ch04.ch04tab04
TABLE 4
Groups at high risk for viral gastroenteritis
Generic image for table
TABLE 4

Groups at high risk for viral gastroenteritis

Citation: Patel M, Glass R. 2009. Gastrointestinal Syndromes, p 45-57. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch4

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