Immune Responses to Viruses

Jonathan W. Yewdell; Theodore C. Pierson; Jack R. Bennink

doi:10.1128/9781555815981.ch14

Chapter 14 : Immune Responses to Viruses

Authors: Jonathan W. Yewdell, Theodore C. Pierson, Jack R. Bennink

Content Type: Reference

Publication Year: 2009

Category: Viruses and Viral Pathogenesis

Book DOI: 10.1128/9781555815981

Chapter DOI: 10.1128/9781555815981.ch14

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Abstract:

The vertebrate immune system has evolved in response to the threat posed by viruses. A number of viruses have evolved gene products for subverting specific elements of the immune system. Nonspecific immune mechanisms can be triggered by cellular sensing of viral invasion, viral destruction of cells, recognition of infected cells by natural killer (NK) cells, or direct interaction of complement with virions. Plasmacytoid dendritic cells (pDCs) are bone marrow-derived cells that are the source for most of the initial wave of type I interferons (IFNs) induced by many viruses. These cells reside in the T-cell regions of the spleen and lymph nodes and can be activated by noninfectious forms of viruses. Signals transduced through recognition of pattern recognition receptors (PRRs) at the onset of innate responses critically impact the development of adaptive immune responses. NK cells can directly interfere with viral reproduction by releasing cytokines with antiviral activity or by lysing virus-infected cells. Macrophages play a role in the destruction of antibodycoated virions, via Fc receptor-mediated internalization of immune complexes into lysosomes. The role of neutrophils in viral immunity is very poorly defined, even though neutrophils, like macrophages, are highly abundant phagocytic cells with Fc receptors and are recruited in large numbers to sites of viral infection. The most important result of T-cell receptor (TCR) stimulation of naive T cells is the increase in the transcription of interleukin-2 (IL-2) and the IL-2 receptor.

Citation: Yewdell J, Pierson T, Bennink J. 2009. Immune Responses to Viruses, p 295-331. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Third Edition. ASM Press, Washington, DC. doi: 10.1128/9781555815981.ch14

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Immune Responses to Viruses

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FIGURE 1

Genetic map of the HLA complex.

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FIGURE 1

Genetic map of the HLA complex.

References

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1. Amanna, I. J.,, M. K. Slifka, and, S. Crotty. 2006. Immunity and immunological memory following smallpox vaccination. Immunol. Rev. 211: 320– 337.

2. Beutler, B.,, Z. Jiang,, P. Georgel,, K. Crozat,, B. Croker,, S. Rutschmann,, X. Du, and, K. Hoebe. 2006. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu. Rev. Immunol. 24: 353– 389.

3. Bizebard, T.,, C. Barbey-Martin,, D. Fleury,, B. Gigant,, B. Barrere,, J. J. Skehel, and, M. Knossow. 2001. Structural studies on viral escape from antibody neutralization. Curr. Top. Microbiol. Immunol. 260: 55– 64.

4. Brandtzaeg, P. 2007. Induction of secretory immunity and memory at mucosal surfaces. Vaccine 25: 5467– 5484.

5. Burton, D. R. 2002. Antibodies, viruses and vaccines. Nat. Rev. Immunol. 2: 706– 713.

6. Burton, D. R.,, R. C. Desrosiers,, R. W. Doms,, W. C. Koff,, P. D. Kwong,, J. P. Moore,, G. J. Nabel,, J. Sodroski,, I. A. Wilson, and, R. T. Wyatt. 2004. HIV vaccine design and the neutralizing antibody problem. Nat. Immunol. 5: 233– 236.

7. Cao, W.,, and Y. J. Liu. 2007. Innate immune functions of plasmacytoid dendritic cells. Curr. Opin. Immunol. 19: 24– 30.

8. Fahraeus, R. 2005. Do peptides control their own birth and death? Nat. Rev. Mol. Cell Biol. 6: 263– 267.

9. Fremont, D. H.,, M. Matsumara,, E. A. Stura,, P. A. Peterson, and, I. A. Wilson. 1992. Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. Science 257: 919– 926.

10. Garcia, K. C.,, and E. J. Adams. 2005. How the T cell receptor sees antigen—a structural view. Cell 122: 333– 336.

11. Garcia-Sastre, A.,, and C. A. Biron. 2006. Type 1 interferons and the virus-host relationship: a lesson in detente. Science 312: 879– 882.

12. Gazit, R.,, R. Gruda,, M. Elboim,, T. I. Arnon,, G. Katz,, H. Achdout,, J. Hanna,, U. Qimron,, G. Landau,, E. Greenbaum,, Z. Zakay-Rones,, A. Porgador, and, O. Mandelboim. 2006. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat. Immunol. 7: 517– 523.

13. Gonzalez, S.,, V. Groh, and, T. Spies. 2006. Immunobiology of human NKG2D and its ligands. Curr. Top. Microbiol. Immunol. 298: 121– 138.

14. Guermonprez, P.,, and S. Amigorena. 2005. Pathways for antigen cross presentation. Springer Semin. Immunopathol. 26: 257– 271.

15. Haeryfar, S. M. M. 2005. The importance of being a pDC in antiviral immunity: the IFN mission versus Ag presentation? Trends Immunol. 26: 311– 317.

16. Hickman, H. D.,, K. Takeda,, C. N. Skon,, F. R. Murray,, S. E. Hensley,, J. Loomis,, G. N. Barber,, J. R. Bennink, and, J. W. Yewdell. 2008. Direct priming of antiviral CD8 + T cells in the peripheral interfollicular region of lymph nodes. Nat. Immunol. 9: 155– 163.

17. Hiscott, J. 2007. Triggering the innate antiviral response through IRF-3 activation. J. Biol. Chem. 282: 15325– 15329.

18. Jung, D.,, C. Giallourakis,, R. Mostoslavsky, and, F. W. Alt. 2006. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu. Rev. Immunol. 24: 541– 570.

19. Junt, T.,, E. A. Moseman,, M. Iannacone,, S. Massberg,, P. A. Lang,, M. Boes,, K. Fink,, S. E. Henrickson,, D. M. Shayakhmetov,, N. C. Di Paolo,, N. van Rooijen,, T. R. Mempel,, S. P. Whelan, and, U. H. von Andrian. 2007. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 450: 110– 114.

20. Kabelitz, D.,, and R. Medzhitov. 2007. Innate immunity—cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr. Opin. Immunol. 19: 1– 3.

21. Karre, K. 2002. NK cells, MHC class I molecules and the missing self. Scand. J. Immunol. 55: 221– 228.

22. Katze, M. G.,, Y. He, and, M. Gale, Jr. 2002. Viruses and interferon: a fight for supremacy. Nat. Rev. Immunol. 2: 675– 687.

23. Klotman, M. E.,, and T. L. Chang. 2006. Defensins in innate antiviral immunity. Nat. Rev. Immunol. 6: 447– 456.

24. Lee, H. K.,, J. M. Lund,, B. Ramanathan,, N. Mizushima, and, A. Iwasaki. 2007. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 315: 1398– 1401.

25. Lee, M. S.,, and Y. J. Kim. 2007. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu. Rev. Biochem. 76: 447– 480.

26. Lee, S. H.,, T. Miyagi, and, C. A. Biron. 2007. Keeping NK cells in highly regulated antiviral warfare. Trends Immunol. 28: 252– 259.

27. Levine, B.,, and V. Deretic. 2007. Unveiling the roles of autophagy in innate and adaptive immunity. Nat. Rev. Immunol. 7: 767– 777.

28. Marcenaro, S.,, F. Gallo,, S. Martini,, A. Santoro,, G. M. Griffiths,, M. Aricó,, L. Moretta, and, D. Pende. 2006. Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease. Blood 108: 2316– 2323.

29. Marshall, J. S.,, C. A. King, and, J. D. McCurdy. 2003. Mast cell cytokine and chemokine responses to bacterial and viral infection. Curr. Pharm. Des. 9: 11– 24.

30. Maruyama, M.,, K. P. Lam, and, K. Rajewsky. 2000. Memory B-cell persistence is independent of persisting immunizing antigen. Nature 407: 636– 642.

31. Meylan, E.,, and J. Tschopp. 2006. Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol. Cell 22: 561– 569.

32. Ochsenbein, A. F.,, and R. M. Zinkernagel. 2000. Natural antibodies and complement link innate and acquired immunity. Immunol. Today 21: 624– 630.

33. O’Leary, J. G.,, M. Goodarzi,, D. L. Drayton, and, U. H. Von Andrian. 2006. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat. Immunol. 7: 507– 516.

34. Orange, J. S.,, and Z. K. Ballas. 2006. Natural killer cells in human health and disease. Clin. Immunol. 118: 1– 10.

35. Orange, J. S.,, M. S. Fassett,, L. A. Koopman,, J. E. Boyson, and, J. L. Strominger. 2002. Viral evasion of natural killer cells. Nat. Immunol. 3: 1006– 1012.

36. Phan, T. G.,, I. Grigorova,, T. Okada, and, J. G. Cyster. 2007. Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nat. Immunol. 8: 992– 1000.

37. Pichlmair, A.,, and C. Reis e Sousa. 2007. Innate recognition of viruses. Immunity 27: 370– 383.

38. Poccia, F.,, C. Agrati,, F. Martini,, M. R. Capobianchi,, M. Wallace, and, M. Malkovsky. 2005. Antiviral reactivities of γδ T cells. Microbes Infect. 7: 518– 528.

39. Pozzi, L. A.,, J. W. Maciaszek, and, K. L. Rock. 2005. Both dendritic cells and macrophages can stimulate naive CD8 T cells in vivo to proliferate, develop effector function, and differentiate into memory cells. J. Immunol. 175: 2071– 2079.

40. Rammensee, H.,, J. Bachmann,, N. P. Emmerich,, O. A. Bachor, and, S. Stevanovic. 1999. SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics 50: 213– 219.

41. Reis e Sousa, C. 2004. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin. Immunol. 16: 27– 34.

42. Sacha, J. B.,, C. Chung,, E. G. Rakasz,, S. P. Spencer,, A. K. Jonas,, A. T. Bean,, W. Lee,, B. J. Burwitz,, J. J. Stephany,, J. T. Loffredo,, D. B. Allison,, S. Adnan,, A. Hoji,, N. A. Wilson,, T. C. Friedrich,, J. D. Lifson,, O. O. Yang, and, D. I. Watkins. 2007. Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression. J. Immunol. 178: 2746– 2754.

43. Savard, M.,, and J. Gosselin. 2006. Epstein-Barr virus immunosuppression of innate immunity mediated by phagocytes. Virus Res. 119: 134– 145.

44. Schmid, D.,, and C. Munz. 2007. Innate and adaptive immunity through autophagy. Immunity 27: 11– 21.

45. Shen, L.,, and K. L. Rock. 2006. Priming of T cells by exogenous antigen cross-presented on MHC class I molecules. Curr. Opin. Immunol. 18: 85– 91.

46. Shibata, K., I., M. Imarai,, G. M. Van Bleek,, S. Joyce, and, S. G. Nathenson. 1992. Vesicular stomatitis virus antigenic octapeptide N52-59 is anchored into the groove of the H-2Kb molecule by the side chains of three amino acids and the main-chain atoms of the amino terminus. Proc. Natl. Acad. Sci. USA 89: 3135– 3139.

47. Simon, I. D.,, J. Publicover, and, J. K. Rose. 2007. Replication and propagation of attenuated vesicular stomatitis virus vectors in vivo: vector spread correlates with induction of immune responses and persistence of genomic RNA. J. Virol. 81: 2078– 2082.

48. Stern, L. J.,, J. H. Brown,, T. S. Jardetzky,, J. C. Gorga,, R. G. Urban,, J. L. Strominger, and, D. C. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368: 215– 221.

49. Stern-Ginossar, N.,, N. Elefant,, A. Zimmermann,, D. G. Wolf,, N. Saleh,, M. Biton,, E. Horwitz,, Z. Prokocimer,, M. Prichard,, G. Hahn,, D. Goldman-Wohl,, C. Greenfield,, S. Yagel,, H. Hengel,, Y. Altuvia,, H. Margalit, and, O. Mandelboim. 2007. Host immune system gene targeting by a viral miRNA. Science 317: 376– 381.

50. Tewari, M. K.,, G. Sinnathamby,, D. Rajagopal, and, L. C. Eisenlohr. 2005. A cytosolic pathway for MHC class II-restricted antigen processing that is proteasome and TAP dependent. Nat. Immunol. 6: 287– 294.

51. Tortorella, D.,, B. E. Gewurz,, M. H. Furman,, D. J. Schust, and, H. L. Ploegh. 2000. Viral subversion of the immune system. Annu. Rev. Immunol. 18: 861– 926.

52. Turner, D. L.,, L. S. Cauley,, K. M. Khanna, and, L. Lefrancois. 2007. Persistent antigen presentation after acute vesicular stomatitis virus infection. J. Virol. 81: 2039– 2046.

53. van den Boorn, J. G.,, I. C. Le Poole, and, R. M. Luiten. 2006. T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity. Int. Rev. Immunol. 25: 235– 258.

54. Voigt, S.,, A. Mesci,, J. Ettinger,, J. H. Fine,, P. Chen,, W. Chou, and, J. R. Carlyle. 2007. Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis. Immunity 26: 617– 627.

55. Weber, F.,, and O. Haller. 2007. Viral suppression of the interferon system. Biochimie 89: 836– 842.

56. Whitton, J. L.,, M. K. Slifka,, F. Liu,, A. K. Nussbaum, and, J. K. Whitmire. 2004. The regulation and maturation of antiviral immune responses. Adv. Virus Res. 63: 181– 238.

57. Wiley, D. C.,, and J. J. Skehel. 1987. The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu. Rev. Biochem. 56: 365– 394.

58. Wilson, I. A.,, and N. J. Cox. 1990. Structural basis of immune recognition of influenza virus hemagglutinin. Annu. Rev. Immunol. 214: 737– 771.

59. Yewdell, J. W. 2006. Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responses. Immunity 25: 533– 543.

60. Yewdell, J. W.,, and J. R. Bennink. 1999. Mechanisms of viral interference with MHC class I antigen processing and presentation. Annu. Rev. Cell Dev. Biol. 15: 579– 606.

61. Yewdell, J. W.,, and A. B. Hill. 2002. Viral interference with antigen presentation. Nat. Immunol. 3: 1019– 1025.

62. Yewdell, J. W.,, and C. V. Nicchitta. 2006. The DRiP hypothesis decennial: support, controversy, refinement and extension. Trends Immunol. 27: 368– 373.

63. Yokoyama, W. M. 2005. Specific and non-specific natural killer cell responses to viral infection. Adv. Exp. Med. Biol. 560: 57– 61.

64. Zhou, T.,, L. Xu,, B. Dey,, A. J. Hessell,, D. Van Ryk,, S. H. Xiang,, X. Yang,, M. Y. Zhang,, M. B. Zwick,, J. Arthos,, D. R. Burton,, D. S. Dimitrov,, J. Sodroski,, R. Wyatt,, G. J. Nabel, and, P. D. Kwong. 2007. Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature 445: 732– 737.

65. zur Stadt, U.,, S. Schmidt,, B. Kasper,, K. Beutel,, A. S. Diler,, J.-I. Henter,, H. Kabisch,, R. Schneppenheim,, P. Nürnberg,, G. Janka, and, H. C. Hennies. 2005. Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11. Hum. Mol. Genet. 14: 827– 834.

Tables

Immune Responses to Viruses

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TABLE 1

Cytokines used in anti-inflammatory immune responses

TABLE 1

Cytokines used in anti-inflammatory immune responses

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TABLE 2

Chemokines used in anti-inflammatory immune responses

TABLE 2

Chemokines used in anti-inflammatory immune responses

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TABLE 3

Properties of human Ig subclasses

TABLE 3

Properties of human Ig subclasses

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TABLE 4

Human MHC class I-binding peptide motifs

TABLE 4

Human MHC class I-binding peptide motifs

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TABLE 5

Human MHC class II-binding peptide motifs a

TABLE 5

Human MHC class II-binding peptide motifs a

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TABLE 6

Viral proteins that interfere with host immunity a

TABLE 6

Viral proteins that interfere with host immunity a