Tick-Borne Encephalitis

Patricia A. Nuttall; Milan Labuda

doi:10.1128/9781555816490.ch9

Chapter 9 : Tick-Borne Encephalitis

Authors: Patricia A. Nuttall¹, Milan Labuda²

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Affiliations: 1: Centre for Ecology and Hydrology, Mansfield Rd., Oxford OX1 3SR, United Kingdom; 2: Institute of Zoology, Slovak Academy of Sciences, Dubravska cesta 9, 845 06 Bratislava, Slovakia

Content Type: Monograph

Publication Year: 2005

Category: Clinical Microbiology

Book DOI: 10.1128/9781555816490

Chapter DOI: 10.1128/9781555816490.ch9

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Abstract:

The many synonyms for tick-borne encephalitis (TBE) chart the history of this important tick-borne viral disease. Many viruses isolated from ticks collected across Europe, Asia, and North America have been shown to be antigenically related to the virus species, Tick-borne encephalitis virus (TBEV). The life cycle of TBEV can be represented by a triangle of parasitic interactions. The interactions are between (i) virus-tick, (ii) virus-host, and (iii) tick-host. In virus-tick interactions, TBEV interacts with its tick vector, infecting and replicating within tick cells including those of the gut, hemocoel, and salivary glands. The goal of the virus is to infect the tick’s salivary glands so that it can be transmitted in saliva when the infected tick feeds. The ability of a particular tick species to act as a vector depends on whether TBEV can survive and overcome several barriers within the tick, e.g., the environment within the midgut where the virus is initially taken up in the blood meal, the gut infection barrier, and the salivary gland infection barrier. This chapter discusses summary of epidemiology and map of distribution of TBEV. Then, it presents clinical manifestations, diagnosis, treatment, and preventive measure of TBE.

Citation: Nuttall P, Labuda M. 2005. Tick-Borne Encephalitis, p 150-163. In Goodman J, Dennis D, Sonenshine D, Tick-Borne Diseases of Humans. ASM Press, Washington, DC. doi: 10.1128/9781555816490.ch9

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Tick-Borne Encephalitis

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Figure 1

Structure of TBEV. C, capsid protein; E, envelope protein; M, membrane protein; ssRNA, single-sided RNA.

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Figure 1

Structure of TBEV. C, capsid protein; E, envelope protein; M, membrane protein; ssRNA, single-sided RNA.

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Figure 2

Schematic life cycle of TBEV.

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Figure 2

Schematic life cycle of TBEV.

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Figure 3

Distribution map of TBEV. (Left) European, Crimean, and Caucasian region; (right) Asian region.

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Figure 3

Distribution map of TBEV. (Left) European, Crimean, and Caucasian region; (right) Asian region.

References

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1. Alekseev, A. N.,, and S. P. Chunikhin. 1990. Exchange of tick-borne encephalitis virus between Ixodidae simultaneously feeding on animals with subthreshold levels of viremia. Med. Parazitol. Parazit. Bolezni 2: 48– 50.

2. Alekseev, A. N.,, S. P. Chunikhin,, M. Y. Rukhkyan,, and L. F. Stefutkina. 1991. Possible role of Ixodidae salivary gland substrate as an adjuvant enhancing arbovirus transmission. Med. Parazitol. Parazit. Bolezni 1: 28– 31.

3. Artsob, H., 1988. Powassan encephalitis, p. 29– 49. In T. P. Monath (ed.), The Arboviruses: Epidemiology and Ecology, Vol. 4. CRC Press, Inc. , Boca Raton, Fla.

4. Balashov, Y. S. 1972. Bloodsucking ticks (Ixodoidea)—vectors of diseases of man and animals. Misc. Publ. Entomol. Soc. Am. 8: 161– 376.

5. Belozerov, V. N., 1982. Diapause and biological rhythms in ticks, p. 469– 500. In F. D. Obenchain, and R. Galun (ed.), Physiology of Ticks. Current Themes in Tropical Science, vol. 1. Pergamon Press , Oxford, United Kingdom.

6. Burke, D. S.,, and T. P. Monath,. 2001. Flaviviruses, p. 1043– 1125. In D. M. Knipe, , P. M. Howley, , D. E. Griffin, , S. R. A. Lamb, , M. A. Martin, , B. Roizman, , and S. E. Straus (ed.) , Fields Virology, 4th ed. Lippincott Williams and Wilkins, Philadelphia, Pa.

7. Calisher, C. H. 1988. Antigenic classification and taxonomy of flaviviruses (family Flaviviridae) emphasizing a universal system for the taxonomy of viruses causing tick-borne encephalitis. Acta Virol. 32: 469– 478.

8. Davidson, M. M.,, H. Williams,, and J. A. Macleod. 1991. Louping ill in man: a forgotten disease. J. Infect. 23: 241– 249.

9. Ebel, G. D.,, E. N. Campbell,, H. K. Goethert,, A. Spielman, , and S. R. Telford III. 1999. A focus of deer tick virus transmission in the northcentral United States. Emerg. Infect. Dis. 5: 570– 574.

10. Ebel, G. D.,, E. N. Campbell,, H. K. Goethert,, A. Spielman,, and S. R. Telford III. 2000. Enzootic transmission of deer tick virus in New England and Wisconsin sites. Am. J. Trop. Med. Hyg. 63: 36– 42.

11. Ebel, G. D.,, A. Spielman,, and S. R. Telford III. 2001. Phylogeny of North American Powassan virus. J. Gen. Virol. 82: 1657– 1665.

12. Ferlenghi, I.,, M. Clarke,, T. Ruttan,, S. I. Allison,, J. Schalich,, F. X. Heinz, et al. 2001. Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus. Mol. Cell 7: 593– 602.

13. Gao, G. F.,, W. R. Jiang,, M. H. Hussain,, K. Venugopal,, T. S. Gritsun,, H. W. Reid,, and E. A. Gould. 1993. Sequencing and antigenic studies of a Norwegian virus isolated from encephalomyelitic sheep confirm the existence of louping ill virus outside Great Britain and Ireland. J. Gen. Virol. 74: 109– 114.

14. Gholam, B. I.,, A. S. Puksa,, and J. P. Provias. 1999. Powassan encephalitis: a case report with neuropathology and literature review. Can. Med. Assoc. J. 161: 1419– 1422.

15. Gould, E. A.,, X. de Lamballerie,, P. M. A. Zanotto,, and E. C. Holmes. 2001. Evolution, epidemiology and dispersal of flaviviruses revealed by molecular phylogenies. Adv. Virus Res. 57: 71– 103.

16. Gray, J. S. 1991. The development and seasonal activity of the tick Ixodes ricinus: a vector of Lyme borreliosis. Rev. Med. Vet. Entomol. 79: 323– 333.

17. Gritsun, T. S.,, E. C. Holmes,, and E. A. Gould. 1995. Analysis of flavivirus envelope proteins reveals variable domains that reflect their antigenicity and may determine their pathogenesis. Virus Res. 35: 307– 321.

18. Gritsun, T. S.,, V. A. Lashkevich,, and E. A. Gould. 2003. Tick-borne encephalitis. Antiviral Res. 57: 129– 146.

19. Gritsun, T. S.,, P. A. Nuttall,, and E. A. Gould. 2004. Tick-borne flaviviruses. Adv. Virus Res. 61: 317– 371.

20. Hajnická, V.,, P. Kocáková,, M. Slovák,, M. Labuda,, N. Fuchsberger,, and P. A. Nuttall. 2000. Inhibition of the antiviral action of interferon by tick salivary gland extract. Parasite Immunol. 22: 201– 206.

21. Hajnická, V.,, P. Kocáková,, M. Sláviková,, M. Slovák,, J. Gšperík,, N. Fuchsberger,, and P. A. Nuttall. 2001. Antiinterleukin- 8 activity of tick salivary gland extracts. Parasite Immunol. 23: 483– 489.

22. Hajnická, V.,, I. Vancová,, P. Kocáková,, M. Slovák,, J. Gšperík,, M. Sláviková,, R. S. Hails,, M. Labuda,, and P. A. Nuttall. Manipulation of host cytokine network by ticks: a potential gateway for pathogen transmission. Parasitology, in press.

23. Hannier, S.,, J. Liversidge,, J. M. Sternberg,, and A. S. Bowman. 2003. Ixodes ricinus tick salivary gland extract inhibits IL-10 secretion and CD69 expression by mitogen-stimulated murine splenocytes and induces hyporesponsiveness in B lymphocytes. Parasite Immunol. 25: 27– 37.

24. Heinz, F. X. 2003. Molecular aspects of TBE virus research. Vaccine 21( Suppl. 1): S3– S10.

25. Heinz, F. X.,, M. S. Collett,, R. H. Purcell,, E. A. Gould,, C. R. Howard,, M. Houghton,, R. J. M. Moormann,, C. M. Rice,, and H. J. Thiel,. 2000. Family Flaviviridae, p. 859– 878. In M. H. V. Regenmortel, , C. M. Fauquet, , D. H. L. Bishop, , E. Carstens, , M. K. Estes, , S. Lemon, , J. Maniloff, , M. A. Mayo, , D. Mc–Geogch, , C. R. Pringle, , and R. B. Wickner (ed.) , Virus taxonomy. 7th Report of the International Committee on Taxonomy of Viruses. Academic Press, San Diego, Calif.

26. Hoffmann, A.,, P. Walsmann,, G. Riesener,, M. Paintz,, and F. Markwardt. 1991. Isolation and characterization of a thrombin inhibitor from the tick Ixodes ricinus. Pharmazie 46: 209– 212.

27. Holzmann, H. 2003. Diagnosis of tick-borne encephalitis. Vaccine 21( Suppl. 1): 36– 40.

28. Jones, L. D.,, M. Gaunt,, R. S. Hails,, K. Laurenson,, P. J. Hudson,, H. Reid,, P. Henbest,, and E. A. Gould. 1997. Transmission of louping-ill virus between infected and uninfected ticks co-feeding on mountain hares. Med. Vet. Entomol. 11: 172– 176.

29. Korenberg, E. I.,, and T. V. Kovalevskii. 1999. Main features of tick-borne encephalitis eco-epidemiology in Russia. Zentralbl. Bakteriol. 289: 525– 539.

30. Kuno, G.,, H. Artsob,, N. Karabatsos,, K. R. Tsuchiya,, and G. J. J. Chang. 2001. Genomic sequencing of deer tick virus and phylogeny of Powassan-related viruses of North America. Am. J. Trop. Med. Hyg. 65: 671– 676.

31. Kunz, C. 2003. TBE vaccination and the Austrian experience. Vaccine 21: 50– 55.

32. Labuda, M.,, V. Danielova,, L. D. Jones,, and P. A. Nuttall. 1993. Amplification of tick-borne encephalitis virus infection during co-feeding of ticks. Med. Vet. Entomol. 7: 339– 342.

33. Labuda, M.,, L. D. Jones,, T. Williams,, V. Danielova,, and P. A. Nuttall. 1993. Efficient transmission of tick-borne encephalitis virus between cofeeding ticks. J. Med. Entomol. 30: 295– 299.

34. Labuda, M.,, L. D. Jones,, T. Williams,, and P. A. Nuttall. 1993. Enhancement of tick-borne encephalitis virus transmission by tick salivary gland extracts. Med. Vet. Entomol. 7: 193– 196.

35. Labuda, M.,, P. A. Nuttall,, O. Kozuch,, E. Eleckova,, T. Williams,, E. Zuffova,, and A. Sabo. 1993. Non-viremic transmission of tick-borne encephalitis virus: a mechanism for arbovirus survival in nature. Experientia 49: 802– 805.

36. Labuda, M.,, J. Austyn,, E. Zuffova,, O. Kozuch,, N. Fuchsberger,, J. Lysy,, and P. Nuttall. 1996. Importance of localized skin infection in tick-borne encephalitis virus transmission. Virology 219: 357– 366.

37. Labuda, M.,, O. Kozuch,, E. Zuffova,, E. Eleckova,, R. S. Hails,, and P. A. Nuttall. 1997. Tick-borne encephalitis virus transmission between ticks co-feeding on specific immune natural rodent hosts. Virology 235: 138– 143.

38. Lawrie, C. H.,, S. E. Randolph,, and P. A. Nuttall. 1999. Ixodes ticks: serum species sensitivity of anti-complement activity. Exp. Parasitol. 93: 207– 214.

39. Lawrie, C. H.,, R. B. Sim,, and P. A. Nuttall. 2005. Investigation of the mechanisms of anti-complement activity in Ixodes ticks. Mol. Immunol. 42: 31– 38.

40. Leboulle, G.,, M. Crippa,, Y. Decrem,, N. Mejri,, M. Brossard,, A. Bollen,, and E. Godfroid. 2002. Characterization of a novel salivary immunosuppressive protein from Ixodes ricinus ticks. J. Biol. Chem. 277: 10083– 10089.

41. Lindenbach, B. D.,, and C. M. Rice,. 2001. Flaviviridae: the viruses and their replication , p. 991– 1041. In D. M. Knipe, , P. M. Howley, , D. E. Griffin, , S. R. A. Lamb, , M. A. Martin, , B. Roizman, , and S. E. Straus (ed.) , Fields Virology, vol. 1, 4th ed. Lippincott Williams and Wilkins, Philadelphia, Pa.

42. Norman, R.,, D. Ross,, M. K. Laurenson,, and P. J. Hudson. 2004. The role of non-viraemic transmission on the persistence and dynamics of a tick borne virus—Louping ill in red grouse ( Lagopus lagopus scoticus) and mountain hares ( Lepus timidus). J. Math. Biol. 48: 119– 134.

43. Nuttall, P. A.,, and M. Labuda. 2003. Dynamics of infection in tick vectors and at the tick-host interface. Adv. Virus Res. 60: 233– 272.

44. Nuttall, P. A.,, and M. Labuda. Tick-host interactions: saliva-activated transmission. Parasitology (Supplement), in press.

45. Nuttall, P. A.,, L. D. Jones,, M. Labuda,, and W. R. Kaufman. 1994. Adaptations of arboviruses to ticks. J. Med. Entomol. 31: 1– 9.

46. Porterfield, J. S. 1975. The basis of arbovirus classification. Med. Biol. 53: 400– 405.

47. Randolph, S. E.,, D. Miklisova,, J. Lysy,, D. J. Rogers,, and M. Labuda. 1999. Incidence from coincidence: patterns of tick infestations on rodents facilitate transmission of tick-borne encephalitis virus. Parasitology 118: 177– 186.

48. Randolph, S. E.,, L. Gern,, and P. A. Nuttall. 1996. Co-feeding ticks: epidemiological significance for tick-borne pathogen transmission. Parasitol. Today 12: 472– 479.

49. Řeháček, F. 1962. Transovarial transmission of tick-borne encephalitis virus by ticks. Acta Virol. 6: 220– 226.

50. Reid, H.W. 1984. Epidemiology of louping-ill, p. 161– 178. In M. A. Mayo and K. A. Harrap (ed.), Vectors in Virus Biology. Academic Press, London, England.

51. Reid, H. W., 1988. Louping-ill, p. 117– 135. In T. P. Monath (ed.), The Arboviruses: Epidemiology and Ecology, vol. 3. CRC Press, Inc. , Boca Raton, Fla.

52. Rey, F. A.,, F. X. Heinz,, C. Mandl,, C. Kunz,, and S. C. Harrison. 1995. The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution. Nature 375: 291– 298.

53. Smith, C. E. G.,, and M. G. R. Varma,. 1981. Louping ill, p. 191– 200. In G. W. Beran (ed.), CRC Handbook Series in Zoonoses, Section B. Viral Zoonoses, vol. 1. CRC Press, Inc., Boca Raton, Fla.

54. Süss, J. 2003. Epidemiology and ecology of TBE relevant to the production of effective vaccines. Vaccine 21( Suppl. 1): 19– 35.

55. Telford, S. R., III, P. M. Armstrong, P. Katavolos, I. Foppa, A. S. Garcia, M. L.Wilson, and A. Spielman. 1997. A new tick-borne encephalitis-like virus infecting New England deer ticks, Ixodes dammini. Emerg. Infect. Dis. 3: 165– 170.

56. Wang, H.,, and P. A. Nuttall. 1999. Immunoglobulin binding proteins in ticks: new target for vaccine development against a blood-feeding parasite. Cell. Mol. Life Sci. 56: 286– 295.

57. Zanotto, P. M.,, G. F. Gao,, T. Gritsun,, M. S. Marin,, W. R. Jiang,, K. Venugopal,, H. W. Reid,, and E. A. Gould. 1995. An arbovirus cline across the northern hemisphere. Virology 210: 152– 159.

58. Zlobin, V. I.,, and O. Z. Gorin. 1996. Tick-Borne Encephalitis: Etiology, Epidemiology and Prophylactics in Siberia. Nauka, Novosibirsk, Russia.

Tables

Tick-Borne Encephalitis

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Table 1

Synonyms for TBE

Table 1

Synonyms for TBE

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Table 2

TBEV and related viruses causing encephalitis in humans

Table 2

TBEV and related viruses causing encephalitis in humans

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Table 3

Pharmacopeia of adult I. ricinus

Table 3

Pharmacopeia of adult I. ricinus

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