Gram-Positive Pathogens, Second Edition

Editors: Vincent A. Fischetti1, Richard P. Novick2, Joseph J. Ferretti3, Daniel A. Portnoy4, Julian I. Rood5
Affiliations: 1: The Rockefeller University, New York, New York; 2: New York University Medical School, New York, New York; 3: University of Oklahoma Health Science Center, Oklahoma City, Oklahoma; 4: University of California, Berkeley; 5: Monash University, Melbourne, Victoria, Australia
Content Type: Reference
Format: Hardcover, Electronic
Publication Year: 2006

Category: Bacterial Pathogenesis

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The only work in the field offering comprehensive coverage of all gram-positive pathogens, this timely revision presents up-to-date research, incorporating the latest genome data on various pathogens. Written by experts, , will appeal to clinicians, infectious disease specialists, and instructors and students seeking a single reference source on gram-positive bacteria.

The new edition includes current theories on the mechanisms of gram-positive bacterial pathogenicity, examines current knowledge on gram-positive structure, and details mechanisms of antibiotic resistance. Similar to the original publication, streptococci, staphylococci, listeria, and spore-forming pathogens are emphasized, and a section is devoted to antibiotic and heavy metal resistance mechanisms.

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Doody Enterprises

23 June 2013

At A Glance

Gram-Positive Pathogens addresses the mechanisms of gram-positive bacterial pathogenicity, including the current knowledge on gram-positive structure and mechanisms of antibiotic resistance. Emphasizing streptococci, staphylococci, listeria, and spore-forming pathogens, it includes chapters written by many of the leading researchers in these areas. The chapters systematically dissect these organisms biologically, genetically, and immunologically in an attempt to understand the strategies used by these bacteria to cause human disease.


This is the second edition of a comprehensive work that describes the current information about gram-positive bacteria. The first edition was published in 2000 and since that time there has been a remarkable increase in information regarding the genomic sequences, protein structures and pathogenic strategies used by these ubiquitous pathogens. This edition will surely surpass the first in usefulness.


According to the editors this book is intended to "systematically dissect" the gram-positive pathogens "biologically, genetically and immunologically" in order to rationally address prevention and control of infections caused by these bacteria. This new volume has accomplished this remarkable goal and will lead others to follow the research cues left by this book.


This book is written primarily for the basic researcher. It will likely be used in graduate studies to teach the skills needed to further explore the gram-positive pathogens. The authors of each chapter are the leading researchers and authorities in their areas. Thus this volume contains a number of valuable pieces of information that would be difficult to find hidden in other texts.


There is a remarkable amount of information contained in this book. The first section discusses in general the cell wall of the gram-positive bacteria. The following sections cover the streptococci, enterococci, staphylococci, listeria, anthrax, clostridial toxins, actinomyces and finally the mechanisms used to evade antimicrobial agents. This book is very thorough and covers all aspects of each pathogen from the genomics, surface proteins, toxins, mechanisms of pathogenicity and vaccine strategies. This is likely the most complete text covering all aspects of research on gram-positive bacteria.


This is a top quality book and it is difficult to find a state-of-the-art comparison unless it is the first edition of Gram-Positive Pathogens. Overall this is a well organized and comprehensive contribution to researchers in microbiology.

Doody Enterprises

Reviewer: Rebecca Horvat, PhD, D(ABMM) (University of Kansas Medical Center)

Review Date: Unknown

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