Pathogenicity Factors in Group C and G Streptococci

Gursharan S. Chhatwal; David J. McMillan; Susanne R. Talay

doi:10.1128/9781555816513.ch17

Chapter 17 : Pathogenicity Factors in Group C and G Streptococci

Authors: Gursharan S. Chhatwal, David J. McMillan, Susanne R. Talay

Content Type: Reference

Publication Year: 2006

Category: Bacterial Pathogenesis

Book DOI: 10.1128/9781555816513

Chapter DOI: 10.1128/9781555816513.ch17

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Abstract:

Group C and G streptococci constitute a heterogeneous complex of streptococcal species that reside as apathogenic commensals in humans and animals or act as causative agents of severe infection and organ damage associated with high mortality rates. This chapter gives a short overview of the various group C and group G streptococcal species, the diseases they cause, and the major pathogenicity factors that contribute to the virulence of these organisms. It discusses the major factors that enable group C and G streptococci to infect their hosts and cause disease. Such factors include adhesive structures that initiate the infection process, antiphagocytic factors that enable the bacterium to evade the host’s immune system, factors that are potentially involved in spreading in tissues, and factors that specifically bind, degrade, or damage host components. Virulence factors that enable these bacteria to colonize the host, avoid immune responses, and cause disease have been characterized in some detail in Streptococcus dysgalactiae and S. equi. Analysis of the bacterial factors that specifically interact with components of the host has allowed insight into the biochemical principles as well as some functional strategies of these streptococci; analysis has also revealed interesting evolutionary aspects, including convergent development, horizontal spread, and module shuffling. As group C and group G streptococci-associated diseases are coming under greater scrutiny it has become apparent that in many instances the virulence factors of these species have close homologues in S. pyogenes.

Citation: Chhatwal G, McMillan D, Talay S. 2006. Pathogenicity Factors in Group C and G Streptococci, p 213-221. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch17

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1. Allen, B. L.,, and M. Hook. 2002. Isolation of a putative laminin binding protein from Streptococcus anginosus. Microb. Pathog. 33: 23– 31.

2. Allen, B. L.,, B. Katz,, and M. Hook. 2002. Streptococcus anginosus adheres to vascular endothelium basement membrane and purified extracellular matrix proteins. Microb. Pathog. 32: 191– 204.

3. Artiushin, S. C.,, J. F. Timoney,, A. S. Sheoran,, and S. K. Muthupalani. 2002. Characterization and immunogenicity of pyrogenic mitogens SePE-H and SePE-I of Streptococcus equi. Microb. Pathog. 32: 71– 85.

4. Balter, S.,, A. Benin,, S. W. Pinto,, L. M. Teixeira,, G. G. Alvim,, E. Luna,, D. Jackson,, L. LaClaire,, J. Elliott,, R. Facklam,, and A. Schuchat. 2000. Epidemic nephritis in Nova Serrana, Brazil. Lancet 355: 1776– 1780.

5. Barnham, M.,, J. Kerby,, R. S. Chandler,, and M. R. Millar. 1989. Group C streptococci in human infection: a study of 308 isolates with clinical correlations. Epidemiol. Infect. 102: 379– 390.

6. Ben Nasr, A.,, A. Wistedt,, U. Ringdahl,, and U. Sjobring. 1994. Streptokinase activates plasminogen bound to human group C and G streptococci through M-like proteins. Eur. J. Biochem. 222: 267– 276.

7. Bernal, A.,, T. Proft,, J. D. Fraser,, and D. N. Posnett. 1999. Superantigens in human disease. J. Clin. Immunol. 19: 149– 157.

8. Bert, F.,, and N. Lambert-Zechovsky. 1997. Septicemia caused by Streptococcus canis in a human. J. Clin. Microbiol. 35: 777– 779.

9. Bhakdi, S.,, J. Tranum-Jensen,, and A. Sziegoleit. 1985. Mechanism of membrane damage by streptolysin-O. Infect. Immun. 47: 52– 60.

10. Billington, S. J.,, B. H. Jost,, and J. G. Songer. 2000. Thiolactivated cytolysins: structure, function and role in pathogenesis. FEMS Microbiol. Lett. 182: 197– 205.

11. Bisno, A. L.,, and J. M. Gaviria. 1997. Murine model of recurrent group G streptococcal cellulitis: no evidence of protective immunity. Infect. Immun. 65: 4926– 4930.

12. Bisno, A. L.,, C. M. Collins,, and J. C. Turner. 1996. M proteins of group C streptococci isolated from patients with acute pharyngitis. J. Clin. Microbiol. 34: 2511– 2515.

13. Boschwitz, J. S.,, and J. F. Timoney. 1994. Inhibition of C3 deposition on Streptococcus equi subsp. equi by M protein: a mechanism for survival in equine blood. Infect. Immun. 62: 3515– 3520.

14. Bradford Kline, J.,, S. Xu,, A. L. Bisno,, and C. M. Collins. 1996. Identification of a fibronectin-binding protein (GfbA) in pathogenic group G streptococci. Infect. Immun. 64: 2122– 2129.

15. Bradley, S. F.,, J. J. Gordon,, D. D. Baumgartner,, W. A. Marasco,, and C. A. Kauffman. 1991. Group C streptococcal bacteremia: analysis of 88 cases. Rev. Infect. Dis. 13: 270– 280.

16. Bricker, A. L.,, C. Cywes,, C. D. Ashbaugh,, and M. R. Wessels. 2002. NAD+-glycohydrolase acts as an intracellular toxin to enhance the extracellular survival of group A streptococci. Mol. Microbiol. 44: 257– 269.

17. Byeon, I. J.,, J. M. Louis,, and A. M. Gronenborn. 2003. A protein contortionist: core mutations of GB1 that induce dimerization and domain swapping. J. Mol. Biol. 333: 141– 152.

18. Caballero, A. R.,, R. Lottenberg,, and K. H. Johnston. 1999. Cloning, expression, sequence analysis, and characterization of streptokinases secreted by porcine and equine isolates of Streptococcus equisimilis. Infect. Immun. 67: 6478– 6486.

19. Campo, R. E.,, D. R. Schultz,, and A. L. Bisno. 1995. M proteins of group G streptococci: mechanisms of resistance to phagocytosis. J. Infect. Dis. 171: 601– 606.

20. Carmeli, Y.,, and K. L. Ruoff. 1995. Report of cases of and taxonomic considerations for large-colony-forming Lancefield group C streptococcal bacteremia. J. Clin. Microbiol. 33: 2114– 2117.

21. Chanter, N.,, N. Collin,, N. Holmes,, M. Binns,, and J. Mumford. 1997. Characterization of the Lancefield group C streptococcus 16S-23S RNA gene intergenic spacer and its potential for identification and sub-specific typing. Epidemiol. Infect. 118: 125– 135.

22. Chhatwal, G. S.,, K. T. Preissner,, G. Muller-Berghaus,, and H. Blobel. 1987. Specific binding of the human S protein (vitronectin) to streptococci, Staphylococcus aureus, and Escherichia coli. Infect. Immun. 55: 1878– 1883.

23. Claridge, J. E., 3rd, S. Attorri, D. M. Musher, J. Hebert, and S. Dunbar. 2001. Streptococcus intermedius, Streptococcus constellatus, and Streptococcus anginosus (“ Streptococcus milleri group”) are of different clinical importance and are not equally associated with abscess. Clin. Infect. Dis. 32: 1511– 1515.

24. Cleary, P. P.,, J. Peterson,, C. Chen,, and C. Nelson. 1991. Virulent human strains of group G streptococci express a C5a peptidase enzyme similar to that produced by group A streptococci. Infect. Immun. 59: 2305– 2310.

25. Collins, C. M.,, A. Kimura,, and A. L. Bisno. 1992. Group G streptococcal M protein exhibits structural features analogous to those of class I M protein of group A streptococci. Infect. Immun. 60: 3689– 3696.

26. Cue, D.,, P. E. Dombek,, H. Lam,, and P. P. Cleary. 1998. Streptococcus pyogenes serotype M1 encodes multiple pathways for entry into human epithelial cells. Infect. Immun. 66: 4593– 4601.

27. Ding, K.,, J. M. Louis,, and A. M. Gronenborn. 2004. Insights into conformation and dynamics of protein GB1 during folding and unfolding by NMR. J. Mol. Biol. 335: 1299– 1307.

28. Dinkla, K.,, M. Rohde,, W. T. Jansen,, J. R. Carapetis,, G. S. Chhatwal,, and S. R. Talay. 2003. Streptococcus pyogenes recruits collagen via surface-bound fibronectin: a novel colonization and immune evasion mechanism. Mol. Microbiol. 47: 861– 869.

29. Dubost, J. J.,, M. Soubrier,, C. De Champs,, J. M. Ristori,, and B. Sauvezie. 2004. Streptococcal septic arthritis in adults. A study of 55 cases with a literature review. Joint Bone Spine 71: 303– 311.

30. Facklam, R. 2002. What happened to the streptococci: overview of taxonomic and nomenclature changes. Clin. Microbiol. Rev. 15: 613– 630.

31. Filippsen, L. F.,, P. Valentin-Weigand,, H. Blobel,, K. T. Preissner,, and G. S. Chhatwal. 1990. Role of complement S protein (vitronectin) in adherence of Streptococcus dysgalactiae to bovine epithelial cells. Am. J. Vet. Res. 51: 861– 865.

32. Fischetti, V. A. 1991. Streptococcal M protein. Sci. Am. 264: 58– 65.

33. Flanagan, J.,, N. Collin,, J. Timoney,, T. Mitchell,, J. A. Mumford,, and N. Chanter. 1998. Characterization of the haemolytic activity of Streptococcus equi. Microb. Pathog. 24: 211– 221.

34. Franken, C.,, G. Haase,, C. Brandt,, J. Weber-Heynemann,, S. Martin,, C. Lammler,, A. Podbielski,, R. Lutticken,, and B. Spellerberg. 2001. Horizontal gene transfer and host specificity of beta-haemolytic streptococci: the role of a putative composite transposon containing scpB and lmb. Mol. Microbiol. 41: 925– 935.

35. Gase, K.,, A. Gase,, H. Schirmer,, and H. Malke. 1996. Cloning, sequencing and functional overexpression of the Streptococcus equisimilis H46A gapC gene encoding a glyceraldehyde- 3-phosphate dehydrogenase that also functions as a plasmin(ogen)-binding protein. Purification and biochemical characterization of the protein. Eur. J. Biochem. 239: 42– 51.

36. Gonzalez Teran, B.,, M. P. Roiz,, T. Ruiz Jimeno,, J. Rosas,, and J. Calvo-Alen. 2001. Acute bacterial arthritis caused by group C streptococci. Semin. Arthritis Rheum. 31: 43– 51.

37. Gronenborn, A. M.,, D. R. Filpula,, N. Z. Essig,, A. Achari,, M. Whitlow,, P. T. Wingfield,, and G. M. Clore. 1991. A novel, highly stable fold of the immunoglobulin binding domain of streptococcal protein G. Science 253: 657– 661.

38. Guss, B.,, M. Eliasson,, A. Olsson,, M. Uhlen,, A. K. Frej,, H. Jornvall,, J. I. Flock,, and M. Lindberg. 1986. Structure of the IgG-binding regions of streptococcal protein G. EMBO J. 5: 1567– 1575.

39. Haidan, A.,, S. R. Talay,, M. Rohde,, K. S. Sriprakash,, B. J. Currie,, and G. S. Chhatwal. 2000. Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an aboriginal population. Lancet 356: 1167– 1169.

40. Harrington, D. J.,, I. C. Sutcliffe,, and N. Chanter. 2002. The molecular basis of Streptococcus equi infection and disease. Microbes Infect. 4: 501– 510.

41. Hashikawa, S.,, Y. Iinuma,, M. Furushita,, T. Ohkura,, T. Nada,, K. Torii,, T. Hasegawa,, and M. Ohta. 2004. Characterization of group C and G streptococcal strains that cause streptococcal toxic shock syndrome. J. Clin. Microbiol. 42: 186– 192.

42. Humar, D.,, V. Datta,, D. J. Bast,, B. Beall,, J. C. De Azavedo,, and V. Nizet. 2002. Streptolysin S and necrotising infections produced by group G streptococcus. Lancet 359: 124– 129.

43. Hynes, R. O.,, and K. M. Yamada. 1982. Fibronectins: multifunctional modular glycoproteins. J. Cell Biol. 95: 369– 377.

44. Igwe, E. I.,, P. L. Shewmaker,, R. R. Facklam,, M. M. Farley,, C. van Beneden,, and B. Beall. 2003. Identification of superantigen genes speM, ssa, and smeZ in invasive strains of beta-hemolytic group C and G streptococci recovered from humans. FEMS Microbiol. Lett. 229: 259– 264.

45. Ji, Y.,, L. McLandsborough,, A. Kondagunta,, and P. P. Cleary. 1996. C5a peptidase alters clearance and trafficking of group A streptococci by infected mice. Infect. Immun. 64: 503– 510.

46. Joh, D.,, P. Speziale,, S. Gurusiddappa,, J. Manor,, and M. Hook. 1998. Multiple specificities of the staphylococcal and streptococcal fibronectin-binding microbial surface components recognizing adhesive matrix molecules. Eur. J. Biochem. 258: 897– 905.

47. Joh, D.,, E. R. Wann,, B. Kreikemeyer,, P. Speziale,, and M. Hook. 1999. Role of fibronectin-binding MSCRAMMs in bacterial adherence and entry into mammalian cells. Matrix Biol. 18: 211– 223.

48. Jonsson, H.,, and H. P. Muller. 1994. The type-III Fc receptor from Streptococcus dysgalactiae is also an alpha 2-macroglobulin receptor. Eur. J. Biochem. 220: 819– 826.

49. Jonsson, H.,, L. Frykberg,, L. Rantamaki,, and B. Guss. 1994. MAG, a novel plasma protein receptor from Streptococcus dysgalactiae. Gene 143: 85– 89.

50. Jonsson, H.,, C. Burtsoff-Asp,, and B. Guss. 1995. Streptococcal protein MAG—a protein with broad albumin binding specificity. Biochim. Biophys. Acta 1249: 65– 71.

51. Jonsson, H.,, H. Lindmark,, and B. Guss. 1995. A protein G-related cell surface protein in Streptococcus zooepidemicus. Infect. Immun. 63: 2968– 2975.

52. Kalia, A.,, and D. E. Bessen. 2003. Presence of streptococcal pyrogenic exotoxin A and C genes in human isolates of group G streptococci. FEMS Microbiol. Lett. 219: 291– 295.

53. Katerov, V.,, P. E. Lindgren,, A. A. Totolian,, and C. Schalen. 2000. Streptococcal opacity factor: a family of bifunctional proteins with lipoproteinase and fibronectin-binding activities. Curr. Microbiol. 40: 149– 156.

54. Keiser, P.,, and W. Campbell. 1992. ‘Toxic strep syndrome’ associated with group C Streptococcus. Arch. Intern. Med. 152: 882, 884.

55. Kitada, K.,, M. Inoue,, and M. Kitano. 1997. Experimental endocarditis induction and platelet aggregation by Streptococcus anginosus, Streptococcus constellatus and Streptococcus intermedius. FEMS Immunol. Med. Microbiol. 19: 25– 32.

56. Kitada, K.,, M. Inoue,, and M. Kitano. 1997. Infective endocarditis-inducing abilities of “ Streptococcus milleri” group. Adv. Exp. Med. Biol. 418: 161– 163.

57. Korman, T. M.,, A. Boers,, T. M. Gooding,, N. Curtis,, and K. Visvanathan. 2004. Fatal case of toxic shock-like syndrome due to group C streptococcus associated with superantigen exotoxin. J. Clin. Microbiol. 42: 2866– 2869.

58. Lancefield, R. C.,, and R. Hare. 1935. The serological differentiation of pathogenic and nonpathogenic streptococci from parturient women. J. Exp. Med. 61: 335– 349.

59. Lannergard, J.,, L. Frykberg,, and B. Guss. 2003. CNE, a collagen-binding protein of Streptococcus equi. FEMS Microbiol. Lett. 222: 69– 74.

60. Lindgren, P. E.,, P. Speziale,, M. McGavin,, H. J. Monstein,, M. Hook,, L. Visai,, T. Kostiainen,, S. Bozzini,, and M. Lindberg. 1992. Cloning and expression of two different genes from Streptococcus dysgalactiae encoding fibronectin receptors. J. Biol. Chem. 267: 1924– 1931.

61. Lindgren, P. E.,, M. J. McGavin,, C. Signas,, B. Guss,, S. Gurusiddappa,, M. Hook,, and M. Lindberg. 1993. Two different genes coding for fibronectin-binding proteins from Streptococcus dysgalactiae. The complete nucleotide sequences and characterization of the binding domains. Eur. J. Biochem. 214: 819– 827.

62. Lindgren, P. E.,, C. Signas,, L. Rantamaki,, and M. Lindberg. 1994. A fibronectin-binding protein from Streptococcus equisimilis: characterization of the gene and identification of the binding domain. Vet. Microbiol. 41: 235– 247.

63. Lindmark, H.,, and B. Guss. 1999. SFS, a novel fibronectin-binding protein from Streptococcus equi inhibits the binding between fibronectin and collagen. Infect. Immun. 67: 2383– 2388.

64. Lindmark, H.,, K. Jacobsson,, L. Frykberg,, and B. Guss. 1996. Fibronectin-binding protein of Streptococcus equi subsp. zooepidemicus. Infect. Immun. 64: 3993– 3999.

65. Lindmark, H.,, M. Nilsson,, and B. Guss. 2001. Comparison of the fibronectin-binding protein FNE from Streptococcus equi subspecies equi with FNZ from S. equi subspecies zooepidemicus reveals a major and conserved difference. Infect. Immun. 69: 3159– 3163.

66. Lottenberg, R.,, D. Minning-Wenz,, and M. D. Boyle. 1994. Capturing host plasmin(ogen): a common mechanism for invasive pathogens? Trends Microbiol. 2: 20– 24.

67. Madden, J. C.,, N. Ruiz,, and M. Caparon. 2001. Cytolysin-mediated translocation (CMT): a functional equivalent of type III secretion in gram-positive bacteria. Cell 104: 143– 152.

68. Malke, H., 2000. Genetics and pathogenicity factors of group C and group G streptococci, p. 163– 176. In V. A. Fischetti,, R. P. Novick,, J. J. Ferretti,, D. A. Portnoy,, and J. I. Rood (ed.), Gram-Positive Pathogens. ASM Press, Washington, D.C.

69. McCoy, H. E.,, C. C. Broder,, and R. Lottenberg. 1991. Streptokinases produced by pathogenic group C streptococci demonstrate species-specific plasminogen activation. J. Infect. Dis. 164: 515– 521.

70. Meehan, M.,, P. Nowlan,, and P. Owen. 1998. Affinity purification and characterization of a fibrinogen-binding protein complex which protects mice against lethal challenge with Streptococcus equi subsp. equi. Microbiology 144: 993– 1003.

71. Meehan, M.,, D. A. Muldowney,, N. J. Watkins,, and P. Owen. 2000. Localization and characterization of the ligand-binding domain of the fibrinogen-binding protein (FgBP) of Streptococcus equi subsp. equi. Microbiology 146: 1187– 1194.

72. Meehan, M.,, Y. Lynagh,, C. Woods,, and P. Owen. 2001. The fibrinogen-binding protein (FgBP) of Streptococcus equi subsp. equi additionally binds IgG and contributes to virulence in a mouse model. Microbiology 147: 3311– 3322.

73. Meehl, M. A.,, and M. G. Caparon. 2004. Specificity of streptolysin O in cytolysin-mediated translocation. Mol. Microbiol. 52: 1665– 1676.

74. Miyoshi-Akiyama, T.,, J. Zhao,, H. Kato,, K. Kikuchi,, K. Totsuka,, Y. Kataoka,, M. Katsumi,, and T. Uchiyama. 2003. Streptococcus dysgalactiae-derived mitogen (SDM), a novel bacterial superantigen: characterization of its biological activity and predicted tertiary structure. Mol. Microbiol. 47: 1589– 1599.

75. Molinari, G.,, S.R. Talay,, P. Valentin-Weigand,, M. Rohde,, and G. S. Chhatwal. 1997. The fibronectin-binding protein of Streptococcus pyogenes, SfbI, is involved in the internalization of group A streptococci by epithelial cells. Infect. Immun. 65: 1357– 1363.

76. Morita, E.,, M. Narikiyo,, A. Yano,, E. Nishimura,, H. Igaki,, H. Sasaki,, M. Terada,, N. Hanada,, and R. Kawabe. 2003. Different frequencies of Streptococcus anginosus infection in oral cancer and esophageal cancer. Cancer Sci. 94: 492– 496.

77. Muller, H. P.,, and L. K. Rantamaki. 1995. Binding of native alpha 2-macroglobulin to human group G streptococci. Infect. Immun. 63: 2833– 2839.

78. Narikiyo, M.,, C. Tanabe,, Y. Yamada,, H. Igaki,, Y. Tachimori,, H. Kato,, M. Muto,, R. Montesano,, H. Sakamoto,, Y. Nakajima,, and H. Sasaki. 2004. Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers. Cancer Sci. 95: 569– 574.

79. Navarre, W. W.,, and O. Schneewind. 1999. Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope. Microbiol. Mol. Biol. Rev. 63: 174– 229.

80. Nicholson, M. L.,, L. Ferdinand,, J. S. Sampson,, A. Benin,, S. Balter,, S. W. Pinto,, S. F. Dowell,, R. R. Facklam,, G. M. Carlone,, and B. Beall. 2000. Analysis of immunoreactivity to a Streptococcus equi subsp. zooepidemicus M-like protein to confirm an outbreak of poststreptococcal glomerulonephritis, and sequences of M-like proteins from isolates obtained from different host species. J. Clin. Microbiol. 38: 4126– 4130.

81. Nizet, V. 2002. Streptococcal beta-hemolysins: genetics and role in disease pathogenesis. Trends Microbiol. 10: 575– 580.

82. Nizet, V.,, B. Beall,, D. J. Bast,, V. Datta,, L. Kilburn,, D. E. Low,, and J. C. De Azavedo. 2000. Genetic locus for streptolysin S production by group A streptococcus. Infect. Immun. 68: 4245– 4254.

83. Okumura, K.,, A. Hara,, T. Tanaka,, I. Nishiguchi,, W. Minamide,, H. Igarashi,, and T. Yutsudo. 1994. Cloning and sequencing the streptolysin O genes of group C and group G streptococci. DNA Seq. 4: 325– 328.

84. Patti, J. M.,, B. L. Allen,, M. J. McGavin,, and M. Hook. 1994. MSCRAMM-mediated adherence of microorganisms to host tissues. Annu. Rev. Microbiol. 48: 585– 617.

85. Preissner, K. T. 1991. Structure and biological role of vitronectin. Annu. Rev. Cell Biol. 7: 275– 310.

86. Proft, T.,, P. D. Webb,, V. Handley,, and J. D. Fraser. 2003. Two novel superantigens found in both group A and group C Streptococcus. Infect. Immun. 71: 1361– 1369.

87. Rantamaki, L. K.,, and H. P. Muller. 1995. Phenotypic characterization of Streptococcus dysgalactiae isolates from bovine mastitis by their binding to host derived proteins. Vet. Microbiol. 46: 415– 426.

88. Ruiz, N.,, B. Wang,, A. Pentland,, and M. Caparon. 1998. Streptolysin O and adherence synergistically modulate proinflammatory responses of keratinocytes to group A streptococci. Mol. Microbiol. 27: 337– 346.

89. Ruoff, K. L. 1988. Streptococcus anginosus (“ Streptococcus milleri”): the unrecognized pathogen. Clin. Microbiol. Rev. 1: 102– 108.

90. Sachse, S.,, P. Seidel,, D. Gerlach,, E. Gunther,, J. Rodel,, E. Straube,, and K. H. Schmidt. 2002. Superantigen-like gene(s) in human pathogenic Streptococcus dysgalactiae, subsp equisimilis: genomic localisation of the gene encoding streptococcal pyrogenic exotoxin G ( speG( dys)). FEMS Immunol. Med. Microbiol. 34: 159– 167.

91. Schnitzler, N.,, A. Podbielski,, G. Baumgarten,, M. Mignon,, and A. Kaufhold. 1995. M or M-like protein gene polymorphisms in human group G streptococci. J. Clin. Microbiol. 33: 356– 363.

92. Schroeder, B.,, M. D. Boyle,, B. R. Sheerin,, A. C. Asbury,, and R. Lottenberg. 1999. Species specificity of plasminogen activation and acquisition of surface-associated proteolytic activity by group C streptococci grown in plasma. Infect. Immun. 67: 6487– 6495.

93. Schwarz-Linek, U.,, M. Hook,, and J. R. Potts. 2004. The molecular basis of fibronectin-mediated bacterial adherence to host cells. Mol. Microbiol. 52: 631– 641.

94. Sela, S.,, A. Aviv,, A. Tovi,, I. Burstein,, M. G. Caparon,, and E. Hanski. 1993. Protein F: an adhesin of Streptococcus pyogenes binds fibronectin via two distinct domains. Mol. Microbiol. 10: 1049– 1055.

95. Shanley, T. P.,, D. Schrier,, V. Kapur,, M. Kehoe,, J. M. Musser,, and P. A. Ward. 1996. Streptococcal cysteine protease augments lung injury induced by products of group A streptococci. Infect. Immun. 64: 870– 877.

96. Simpson, W. J.,, J. M. Musser,, and P. P. Cleary. 1992. Evidence consistent with horizontal transfer of the gene ( emm12) encoding serotype M12 protein between group A and group G pathogenic streptococci. Infect. Immun. 60: 1890– 1893.

97. Sjobring, U.,, L. Bjorck,, and W. Kastern. 1991. Streptococcal protein G. Gene structure and protein binding properties. J. Biol. Chem. 266: 399– 405.

98. Skaar, I.,, P. Gaustad,, T. Tonjum,, B. Holm,, and H. Stenwig. 1994. Streptococcus phocae sp. nov., a new species isolated from clinical specimens from seals. Int. J. Syst. Bacteriol. 44: 646– 650.

99. Song, X. M.,, J. Perez-Casal,, A. Bolton,, and A. A. Potter. 2001. Surface-expressed Mig protein protects Streptococcus dysgalactiae against phagocytosis by bovine neutrophils. Infect. Immun. 69: 6030– 6037.

100. Song, X. M.,, J. Perez-Casal,, M. C. Fontaine,, and A. A. Potter. 2002. Bovine immunoglobulin A (IgA)-binding activities of the surface-expressed Mig protein of Streptococcus dysgalactiae. Microbiology 148: 2055– 2064.

101. Song, X. M.,, J. Perez-Casal,, and A. A. Potter. 2004. The Mig protein of Streptococcus dysgalactiae inhibits bacterial internalization into bovine mammary gland epithelial cells. FEMS Microbiol. Lett. 231: 33– 38.

102. Sriprakash, K. S.,, and J. Hartas. 1996. Lateral genetic transfers between group A and G streptococci for M-like genes are ongoing. Microb. Pathog. 20: 275– 285.

103. Sriprakash, K. S.,, and J. Hartas. 1997. Genetic mosaic upstream of scpG in human group G streptococci contains sequences from group A streptococcal virulence regulon. Adv. Exp. Med. Biol 418: 749– 751.

104. Stassen, M.,, C. Muller,, C. Richter,, C. Neudorfl,, L. Hultner,, S. Bhakdi,, I. Walev,, and E. Schmitt. 2003. The streptococcal exotoxin streptolysin O activates mast cells to produce tumor necrosis factor alpha by p38 mitogen-activated protein kinase- and protein kinase C-dependent pathways. Infect. Immun. 71: 6171– 6177.

105. Steiner, K.,, and H. Malke. 2002. Dual control of streptokinase and streptolysin S production by the covRS and fasCAX two-component regulators in Streptococcus dysgalactiae subsp. equisimilis. Infect. Immun. 70: 3627– 3636.

106. Talay, S. R.,, P. Valentin-Weigand,, P. G. Jerlstrom,, K. N. Timmis,, and G. S. Chhatwal. 1992. Fibronectin-binding protein of Streptococcus pyogenes: sequence of the binding domain involved in adherence of streptococci to epithelial cells. Infect. Immun. 60: 3837– 3844.

107. Tewodros, W.,, I. Karlsson,, and G. Kronvall. 1996. Allelic variation of the streptokinase gene in beta-hemolytic streptococci group C and G isolates of human origin. FEMS Immunol. Med. Microbiol. 13: 29– 34.

108. Timoney, J. F.,, J. Walker,, M. Zhou,, and J. Ding. 1995. Cloning and sequence analysis of a protective M-like protein gene from Streptococcus equi subsp. zooepidemicus. Infect. Immun. 63: 1440– 1445.

109. Timoney, J. F.,, S. C. Artiushin,, and J. S. Boschwitz. 1997. Comparison of the sequences and functions of Streptococcus equi M-like proteins SeM and SzPSe. Infect. Immun. 65: 3600– 3605.

110. Turner, J. C.,, F. G. Hayden,, M. C. Lobo,, C. E. Ramirez,, and D. Murren. 1997. Epidemiologic evidence for Lancefield group C beta-hemolytic streptococci as a cause of exudative pharyngitis in college students. J. Clin. Microbiol. 35: 1– 4.

111. Valentin-Weigand, P.,, J. Grulich-Henn,, G. S. Chhatwal,, G. Muller-Berghaus,, H. Blobel,, and K. T. Preissner. 1988. Mediation of adherence of streptococci to human endothelial cells by complement S protein (vitronectin). Infect. Immun. 56: 2851– 2855.

112. Vasi, J.,, L. Frykberg,, L. E. Carlsson,, M. Lindberg,, and B. Guss. 2000. M-like proteins of Streptococcus dysgalactiae. Infect. Immun. 68: 294– 302.

113. Visai, L.,, S. Bozzini,, G. Raucci,, A. Toniolo,, and P. Speziale. 1995. Isolation and characterization of a novel collagen-binding protein from Streptococcus pyogenes strain 6414. J. Biol. Chem. 270: 347– 353.

114. Visai, L.,, E. De Rossi,, V. Valtulina,, F. Casolini,, S. Rindi,, P. Guglierame,, G. Pietrocola,, V. Bellotti,, G. Riccardi,, and P. Speziale. 2003. Identification and characterization of a new ligand-binding site in FnbB, a fibronectin-binding adhesin from Streptococcus dysgalactiae. Biochim. Biophys. Acta 1646: 173– 183.

115. Vossen, A.,, A. Abdulmawjood,, C. Lammler,, R. Weiss,, and U. Siebert. 2004. Identification and molecular characterization of beta-hemolytic streptococci isolated from harbor seals ( Phoca vitulina) and grey seals ( Halichoerus grypus) of the German North and Baltic Seas. J. Clin. Microbiol. 42: 469– 473.

116. Wang, H.,, R. Lottenberg,, and M. D. Boyle. 1995. A role for fibrinogen in the streptokinase-dependent acquisition of plasmin(ogen) by group A streptococci. J. Infect. Dis. 171: 85– 92.

117. Welsh, R. D. 1984. The significance of Streptococcus zooepidemicus in the horse. Equine Practice 6: 6– 16.

118. Whiley, R. A.,, L. M. Hall,, J. M. Hardie,, and D. Beighton. 1999. A study of small-colony, beta-haemolytic, Lancefield group C streptococci within the anginosus group: description of Streptococcus constellatus subsp. pharyngis subsp. nov., associated with the human throat and pharyngitis. Int. J. Syst. Bacteriol. 49: 1443– 1449.

119. Woo, P. C.,, A. M. Fung,, S. K. Lau,, S. S. Wong,, and K. Y. Yuen. 2001. Group G beta-hemolytic streptococcal bacteremia characterized by 16S ribosomal RNA gene sequencing. J. Clin. Microbiol. 39: 3147– 3155.

120. Yoshikawa, H.,, T. Yasu,, H. Ueki,, T. Oyamada,, H. Oishi,, T. Anzai,, M. Oikawa,, and T. Yoshikawa. 2003. Pneumonia in horses induced by intrapulmonary inoculation of Streptococcus equi subsp. zooepidemicus. J. Vet. Med. Sci. 65: 787– 792.

121. Zaoutis, T.,, M. Attia,, R. Gross,, and J. Klein. 2004. The role of group C and group G streptococci in acute pharyngitis in children. Clin. Microbiol. Infect. 10: 37– 40.

Tables

Pathogenicity Factors in Group C and G Streptococci

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TABLE 1

Pathogenicity factors of group C and group G streptococci

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10.1128/9781555816513/tab17-1.gif

TABLE 1

Pathogenicity factors of group C and group G streptococci