Chapter 47 : Biology and Pathogenicity of Staphylococci Other than Staphylococcus aureus and Staphylococcus epidermidis

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This chapter focuses on species of non- species of staphylococci (NAS) selected for their pathogenic potential and those for which recent discoveries have had a significant outcome on the general knowledge of staphylococcal biology. is a human commensal more pathogenic than most other NAS, causing primary infections of the human. is known as a frequent cause of acute urinary tract infection among female outpatients. is regarded as an emerging nosocomial pathogen with a tendency to develop antibiotic resistance. is a rather genetically homogeneous species, since a very limited polymorphism is detected by pulsed-field gel electrophoresis (PFGE) or plasmid analysis. was originally isolated from goat milk; it is the most prevalent NAS in mastitis-free goat milk and has not been isolated from cow or sheep milk. has the usual characteristics of the NAS and can cause significant infection both in the community and in the hospital. strains are phenotypically similar to strains, but a clear-cut distinction between these two species may be obtained by comparing their rRNA gene restriction patterns. has been isolated as a rare cause of human infection including urinary tract, wound, bone, and joint infections; vertebral osteomyelitis; septicemia; and native valve endocarditis. is the most important NAS that produces coagulase; it is, however, taxonomically distinct from . It is the predominant coagulase-positive staphylococcus in the mouth and in skin infections of dogs.

Citation: Tristan A, Lina G, Etienne J, Vandenesch F. 2006. Biology and Pathogenicity of Staphylococci Other than Staphylococcus aureus and Staphylococcus epidermidis, p 572-586. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch47
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1. Abgrall, S.,, P. Meimoun,, A. Buu-Hoi,, J. P. Couetil,, L. Gutmann,, and J. L. Mainardi. 2001. Early prosthetic valve endocarditis due to Staphylococcus warneri with negative blood culture. J. Infect. 42: 166.
2. Adesiyun, A. A.,, S. R. Tatini,, and D. G. Hoover. 1984. Production of enterotoxin(s) by Staphylococcus hyicus. Vet. Microbiol. 9: 487 495.
3. Ahrens, P.,, and L. O. Andresen. 2004. Cloning and sequence analysis of genes encoding Staphylococcus hyicus exfoliative toxin types A, B, C, and D. J. Bacteriol. 186: 1833 1837.
4. Allaker, R. P.,, N. Garrett,, L. Kent,, W. C. Noble,, and D. H. Lloyd. 1993. Characterisation of Staphylococcus intermedius isolates from canine pyoderma and from healthy carriers by SDS-PAGE of exoproteins, immunoblotting and restriction endonuclease digest analysis. J. Med. Microbiol. 39: 429 433.
5. Allignet, J.,, S. Aubert,, K. G. Dyke,, and N. El Solh. 2001. Staphylococcus caprae strains carry determinants known to be involved in pathogenicity: a gene encoding an autolysin-binding fibronectin and the ica operon involved in biofilm formation. Infect. Immun. 69: 712 718.
6. Allignet, J.,, N. Liassine,, and N. El Solh. 1998. Characterization of a staphylococcal plasmid related to pUB110 and carrying two novel genes, vatC and vgbB, encoding resistance to streptogramins A and B and similar antibiotics. Antimicrob. Agents Chemother. 42: 1794 1798.
7. Almazan, J.,, R. de la Fuente,, E. Gomez-Lucia,, and G. Suarez. 1987. Enterotoxin production by strains of Staphylococcus intermedius and Staphylococcus aureus isolated from dog infections. Zentralbl. Bakteriol. Mikrobiol. Hyg. A 264: 29 32.
8. Andresen, L. O. 1998. Differentiation and distribution of three types of exfoliative toxin produced by Staphylococcus hyicus from pigs with exudative epidermitis. FEMS Immunol. Med. Microbiol. 20: 301 310.
9. Ayora, S.,, P. E. Lindgren,, and F. Gotz. 1994. Biochemical properties of a novel metalloprotease from Staphylococcus hyicus subsp. hyicus involved in extracellular lipase processing. J. Bacteriol. 176: 3218 3223.
10. Barcs, I.,, and L. Janosi. 1992. Plasmids encoding for erythromycin ribosomal methylase of Staphylococcus epidermidis and Staphylococcus simulans. Acta Microbiol. Hung. 39: 85 92.
11. Barnham, M.,, R. Horton,, J. M. P. Smith,, J. Richardson,, R. R. Marples,, and S. Reith. 1996. Methicillin-resistant Staphylococcus simulans masquerading as MRSA in a nursing home. J. Hosp. Infect. 34: 331 337.
12. Barriere, C.,, R. Bruckner,, D. Centeno,, and R. Talon. 2002. Characterisation of the katA gene encoding a catalase and evidence for at least a second catalase activity in Staphylococcus xylosus, bacteria used in food fermentation. FEMS Microbiol. Lett. 216: 277 283.
13. Barriere, C.,, D. Centeno,, A. Lebert,, S. Leroy-Setrin,, J. L. Berdague,, and R. Talon. 2001. Roles of superoxide dismutase and catalase of Staphylococcus xylosus in the inhibition of linoleic acid oxidation. FEMS Microbiol. Lett. 201: 181 185.
14. Bassias, J.,, and R. Bruckner. 1998. Regulation of lactose utilization genes in Staphylococcus xylosus. J. Bacteriol. 180: 2273 2279.
15. Bautista, L.,, P. Gaya,, M. Medina,, and M. Nunez. 1988. A quantitative study of enterotoxin production by sheep milk staphylococci. Appl. Environ. Microbiol. 54: 566 569.
16. Becker, K.,, B. Keller,, C. von Eiff,, M. Bruck,, G. Lubritz,, J. Etienne,, and G. Peters. 2001. Enterotoxigenic potential of Staphylococcus intermedius. Appl. Environ. Microbiol. 67: 5551 5557.
17. Benito, Y.,, G. Lina,, T. Greenland,, J. Etienne,, and F. Vandenesch. 1998. trans-complementation of Staphylococcus aureus agr mutant by S. lugdunensis agr RNAIII. J. Bacteriol. 180: 5780 5783.
18. Biberstein, E. L.,, S. Jang,, and D. C. Hirsh. 1984. Species distribution of coagulase-positive staphylococci in animals. J. Clin. Microbiol. 19: 610 615.
19. Billot-Klein, D.,, L. Gutmann,, D. Bryant,, D. Bell,, J. Van Heijenoort,, J. Grewal,, and D. M. Shlaes. 1996. Peptidoglycan synthesis and structure in Staphylococcus haemolyticus expressing increasing levels of resistance to glycopeptide antibiotics. J. Bacteriol. 178: 4696 4703.
20. Burriel, A. R. 1998. In vivo presence of capsular polysaccharide in coagulase-negative staphylococci of ovine origin. New Microbiol. 21: 49 54.
21. Buttery, J. P.,, M. Easton,, S. R. Pearson,, and G. G. Hogg. 1997. Pediatric bacteremia due to Staphylococcus warneri: microbiological, epidemiological, and clinical features. J. Clin. Microbiol. 35: 2174 2177.
22. Center, K. J.,, A. C. Reboli,, R. Hubler,, G. L. Rodgers,, and S. S. Long. 2003. Decreased vancomycin susceptibility of coagulase-negative staphylococci in a neonatal intensive care unit: evidence of spread of Staphylococcus warneri. J. Clin. Microbiol. 41: 4660 4665.
23. Chaouni, L.,, T. Greenland,, J. Etienne,, and F. Vandenesch. 1996. Nucleic acid sequence and affiliation of pLUG10, a novel cadmium resistance plasmid from Staphylococcus lugdunensis. Plasmid 36: 1 8.
24. Chesneau, O.,, A. Morvan,, F. Grimont,, H. Labischinski,, and N. El Solh. 1993. Staphylococcus pasteuri sp. nov., isolated from human, animal, and food specimens. Int. J. Syst. Bacteriol. 43: 237 244.
25. Cintas, L. M.,, P. Casaus,, H. Holo,, P. E. Hernandez,, I. F. Nes,, and L. S. Havarstein. 1998. Enterocins L50A and L50B, two novel bacteriocins from Enterococcus faecium L50, are related to staphylococcal hemolysins. J. Bacteriol. 180: 1988 1994.
26. Climo, M. W.,, R. L. Patron,, B. P. Goldstein,, and G. L. Archer. 1998. Lysostaphin treatment of experimental methicillin-resistant Staphylococcus aureus aortic valve endocarditis. Antimicrob. Agents Chemother. 42: 1355 1360.
27. Dacosta, A.,, H. Lelièvre,, G. Kirkorian,, M. Célard,, P. Chevalier,, F. Vandenesch,, J. Etienne,, and P. Touboul. 1998. Role of the preaxillary flora in pacemaker infections. A prospective study. Circulation 97: 1791 1795.
28. De Hondt, G.,, M. Ieven,, C. Vandermersch,, and J. Colaert. 1997. Destructive endocarditis caused by Staphylococcus lugdunensis. Case report and review of the literature. Acta Clin. Belg. 52: 27 30.
29. Donvito, B.,, J. Etienne,, L. Denoroy,, T. Greenland,, Y. Benito,, and F. Vandenesch. 1997. Synergistic hemolytic activity of Staphylococcus lugdunensis is mediated by three peptides encoded by a non- agr genetic locus. Infect. Immun. 65: 95 100.
30. Donvito, B.,, J. Etienne,, T. Greenland,, C. Mouren,, V. Delorme,, and F. Vandenesch. 1997. Distribution of the synergistic haemolysin genes hld and slush with respect to agr in human staphylococci. FEMS Microbiol. Lett. 151: 139 144.
31. Dziewanowska, K.,, V. M. Edwards,, J. R. Deringer,, G. A. Bohach,, and D. J. Guerra. 1996. Comparison of the beta-toxins from Staphylococcus aureus and Staphylococcus intermedius. Arch. Biochem. Biophys. 335: 102 108.
32. Edwards, V. M.,, J. R. Deringer,, S. D. Callantine,, C. F. Deobald,, P. H. Berger,, V. Kapur,, C. V. Stauffacher,, and G. A. Bohach. 1997. Characterization of the canine type C enterotoxin produced by Staphylococcus intermedius pyoderma isolates. Infect. Immun. 65: 2346 2352.
33. Fiegler, H.,, and R. Bruckner. 1997. Identification of the serine acetyltransferase gene of Staphylococcus xylosus. FEMS Microbiol. Lett. 148: 181 187.
34. Fthenakis, G. C.,, R. R. Marples,, J. F. Richardson,, and J. E. Jones. 1994. Some properties of coagulase-negative staphylococci isolated from cases of ovine mastitis. Epidemiol. Infect. 112: 171 176.
35. Gatermann, S.,, and R. Marre. 1989. Cloning and expression of Staphylococcus saprophyticus urease gene sequences in Staphylococcus carnosus and contribution of the enzyme to virulence. Infect. Immun. 57: 2998 3002.
36. Gatermann, S. G.,, and K. B. Crossley,. 1997. Urinary tract infections, p. 493 508. In K. B. Crosssley, and G. L. Archer (ed.), The Staphylococci in Human Disease. Churchill Livingstone, Inc., New York, N.Y.
37. Gerstadt, K.,, J. S. Daly,, M. Mitchell,, M. Wessolossky,, and S. H. Cheeseman. 1999. Methicillin-resistant Staphylococcus intermedius pneumonia following coronary artery bypass grafting. Clin. Infect. Dis. 29: 218 219.
38. Giovanetti, E.,, F. Biavasco,, A. Pugnaloni,, R. Lupidi,, G. Biagini,, and P. E. Varaldo. 1996. An electron microscopic study of clinical and laboratory-derived strains of teicoplanin-resistant Staphylococcus haemolyticus. Microb. Drug Resist. 2: 239 243.
39. Gotz, F.,, H. M. Verheij,, and R. Rosenstein. 1998. Staphylococcal lipases: molecular characterisation, secretion, and processing. Chem. Phys. Lipids 93: 15 25.
40. Greene, R. T.,, and C. Lammler. 1992. Isolation and characterization of immunoglobulin binding proteins from Staphylococcus intermedius and Staphylococcus hyicus. Zentralbl. Veterinarmed. B 39: 519 525.
41. Hajek, V.,, H. Meugnier,, M. Bes,, Y. Brun,, F. Fiedler,, Z. Chmela,, Y. Lasne,, J. Fleurette,, and J. Freney. 1996. Staphylococcus saprophyticus subsp. bovis subsp. nov., isolated from bovine nostrils. Int. J. Syst. Bacteriol. 46: 792 796.
42. Hébert, G. A. 1990. Hemolysins and other characteristics that help differentiate and biotype Staphylococcus lugdunensis and Staphylococcus schleiferi. J. Clin. Microbiol. 28: 2425 2431.
43. Hébert, G. A.,, C. G. Crowder,, G. A. Hancock,, W. R. Jarvis,, and C. Thornsberry. 1988. Characteristics of coagulase-negative staphylococci that help differentiate these species and other members of the family Micrococcaceae. J. Clin. Microbiol. 26: 1939 1949.
44. Hell, W.,, T. Kern,, and M. Klouche. 1999. Staphylococcus saprophyticus as an unusual agent of nosocomial pneumonia. Clin. Infect. Dis. 29: 685 686.
45. Hell, W.,, H. G. Meyer,, and S. G. Gatermann. 1998. Cloning of aas, a gene encoding a Staphylococcus saprophyticus surface protein with adhesive and autolytic properties. Mol. Microbiol. 29: 871 881.
46. Hernandez, J. L.,, J. Calvo,, R. Sota,, J. Aguero,, J. D. Garcia-Palomo,, and M. C. Farinas. 2001. Clinical and microbiological characteristics of 28 patients with Staphylococcus schleiferi infection. Eur. J. Clin. Microbiol. Infect. Dis. 20: 153 158.
47. Hirooka, E. Y.,, E. E. Muller,, J. C. Freitas,, E. Vicente,, Y. Yoshimoto,, and M. S. Bergdoll. 1988. Enterotoxigenicity of Staphylococcus intermedius of canine origin. Int. J. Food Microbiol. 7: 185 191.
48. Igimi, S.,, E. Takahashi,, and T. Mitsuoka. 1990. Staphylococcus schleiferi subsp. coagulans subsp. nov., isolated from the external auditory meatus of dogs with external ear otitis. Int. J. Syst. Bacteriol. 40: 409 411.
49. Jansen, B.,, F. Schumacher-Perdreau,, G. Peters,, G. Reinhold,, and J. Schonemann. 1992. Native valve endocarditis caused by Staphylococcus simulans. Eur. J. Clin. Microbiol. Infect. Dis. 11: 268 269.
50. Ji, G.,, R. Beavis,, and R. P. Novick. 1997. Bacterial interference caused by autoinducing peptide variants. Science 276: 2027 2030.
51. Jones, R. M.,, M. A. Jackson,, C. Ong,, and G. K. Lofland. 2002. Endocarditis caused by Staphylococcus lugdunensis. Pediatr. Infect. Dis. J. 21: 265 268.
52. Jose, J.,, S. Christians,, R. Rosenstein,, F. Gotz,, and H. Kaltwasser. 1991. Cloning and expression of various staphylococcal genes encoding urease in Staphylococcus carnosus. FEMS Microbiol. Lett. 64: 277 281.
53. Katayama, Y.,, T. Ito,, and K. Hiramatsu. 2001. Genetic organization of the chromosome region surrounding mecA in clinical staphylococcal strains: role of IS431-mediated mecI deletion in expression of resistance in mecA-carrying, low-level methicillin-resistant Staphylococcus haemolyticus. Antimicrob. Agents Chemother. 45: 1955 1963.
54. Katayama, Y.,, F. Takeuchi,, T. Ito,, X. X. Ma,, Y. Ui- Mizutani,, I. Kobayashi,, and K. Hiramatsu. 2003. Identification in methicillin-susceptible Staphylococcus hominis of an active primordial mobile genetic element for the staphylococcal cassette chromosome mec of methicillin-resistant Staphylococcus aureus. J. Bacteriol. 185: 2711 2722.
55. Kazembe, P.,, A. E. Simor,, A. E. Swarney,, L. G. Yap,, B. Kreiswirth,, J. Ng,, and D. E. Low. 1993. A study of the epidemiology of an endemic strain of Staphylococcus haemolyticus (TOR-35) in a neonatal intensive care unit. Scand. J. Infect. Dis. 25: 507 513.
56. Kerr, D. E.,, K. Plaut,, A. J. Bramley,, C. M. Williamson,, A. J. Lax,, K. Moore,, K. D. Wells,, and R. J. Wall. 2001. Lysostaphin expression in mammary glands confers protection against staphylococcal infection in transgenic mice. Nat. Biotechnol. 19: 66 70.
57. Khambarty, F. M.,, R. W. Bennett,, and D. B. Shah. 1994. Application of pulsed-field gel electrophoresis to the epidemiological characterization of Staphylococcus intermedius implicated in a food-related outbreak. Epidemiol. Infect. 113: 75 81.
58. Kiri, N.,, G. Archer,, and M. W. Climo. 2002. Combinations of lysostaphin with beta-lactams are synergistic against oxacillin-resistant Staphylococcus epidermidis. Antimicrob. Agents Chemother. 46: 2017 2020.
59. Kloos, W. E., 1986. Ecology of human skin, p. 37 50. In P. A. Mardh, and K. H. Schleifer (ed.), Coagulase-Negative Staphylococci. Almqvist & Wiksell International, Stockholm, Sweden.
60. Kloos, W. E.,, D. N. Ballard,, J. A. Webster,, R. J. Hubner,, A. Tomasz,, I. Couto,, G. L. Sloan,, H. P. Dehart,, F. Fiedler,, K. Schubert,, H. de Lencastre,, I. S. Sanches,, H. E. Heath,, P. A. Leblanc,, and A. Ljungh. 1997. Ribotype delineation and description of Staphylococcus sciuri subspecies and their potential as reservoirs of methicillin resistance and staphylolytic enzyme genes. Int. J. Syst. Bacteriol. 47: 313 323.
61. Kloos, W. E.,, and T. L. Bannerman. 1994. Update on clinical significance of coagulase-negative staphylococci. Clin. Microbiol. Rev. 7: 117 140.
62. Kloos, W. E.,, C. G. George,, J. S. Olgiate,, P. L. Van,, M. L. McKinnon,, B. L. Zimmer,, E. Muller,, M. P. Weinstein,, and S. Mirrett. 1998. Staphylococcus hominis subsp. novobiosepticus subsp. nov., a novel trehalose- and N-acetyl-D-glucosamine-negative, novobiocin- and multiple-antibiotic-resistant subspecies isolated from human blood cultures. Int. J. Syst. Bacteriol. 3: 799 812.
63. Kloos, W. E.,, and J. F. Wolfshohl. 1979. Evidence of desoxyribonucleotide sequence divergence between staphylococci living on human and other primate skin. Curr. Microbiol. 3: 167 172.
64. Kloos, W. E.,, and J. F. Wolfshohl. 1991. Staphylococcus cohnii subspecies: Staphylococcus cohnii subsp. cohnii subsp. nov. and Staphylococcus cohnii subsp. urealyticum subsp. nov. Int. J. Syst. Bacteriol. 41: 284 289.
65. Kluytmans, J.,, H. Berg,, P. Steegh,, F. Vandenesch,, J. Etienne,, and A. van Belkum. 1998. Outbreak of Staphylococcus schleiferi wound infections: strain characterization by randomly amplified polymorphic DNA analysis, PCR ribotyping, conventional ribotyping, and pulsed-field gel electrophoresis. J. Clin. Microbiol. 36: 2214 2219.
66. Kokai-Kun, J. F.,, S. M. Walsh,, T. Chanturiya,, and J. J. Mond. 2003. Lysostaphin cream eradicates Staphylococcus aureus nasal colonization in a cotton rat model. Antimicrob. Agents Chemother. 47: 1589 1597.
67. Krzeminski, Z.,, and A. Raczynska. 1990. Elastolytic activity of staphylococci isolated from human oral cavity. Med. Dosw. Mikrobiol. 42: 1 4.
68. Lambe, D. W.,, K. P. Fergusson,, J. L. Keplinger,, C. G. Gemmell,, and J. H. Kalbfleisch. 1990. Pathogenicity of Staphylococcus lugdunensis, Staphylococcus schleiferi, and three other coagulase-negative staphylococci in a mouse model and possible virulence factors. Can. J. Microbiol. 36: 455 463.
69. Latorre, M.,, P. M. Rojo,, R. Franco,, and R. Cisterna. 1993. Endocarditis due to Staphylococcus capitis subspecies ureolyticus. Clin. Infect. Dis. 16: 343 344.
70. Lee, J. 1994. Staphylococcus intermedius isolated from dog-bite wounds. J. Infect. 29: 105 118.
71. Liljeqvist, S.,, P. Samuelson,, M. Hansson,, T. N. Nguyen,, H. Binz,, and S. Stahl. 1997. Surface display of the cholera toxin B subunit on Staphylococcus xylosus and Staphylococcus carnosus. Appl. Environ. Microbiol. 63: 2481 2488.
72. Linehan, D.,, J. Etienne,, and D. Sheehan. 2003. Relationship between haemolytic and sphingomyelinase activities in a partially purified beta-like toxin from Staphylococcus schleiferi. FEMS Immunol. Med. Microbiol. 36: 95 102.
73. Long, J. P.,, J. Hart,, W. Albers,, and F. A. Kapral. 1992. The production of fatty acid modifying enzyme (FAME) and lipase by various staphylococcal species. J. Med. Microbiol. 37: 232 234.
74. Mahoudeau, I.,, X. Delabranche,, G. Prevost,, H. Monteil,, and Y. Piemont. 1997. Frequency of isolation of Staphylococcus intermedius from humans. J. Clin. Microbiol. 35: 2153 2154.
75. Marsou, R.,, M. Bes,, M. Boudouma,, Y. Brun,, H. Meugnier,, J. Freney,, F. Vandenesch,, and J. Etienne. 1999. Distribution of Staphylococcus sciuri subspecies among human clinical specimens, and profile of antibiotic resistance. Res. Microbiol. 150: 531 541.
76. Miedzobrodzki, J.,, A. S. Naidu,, J. L. Watts,, P. Ciborowski,, K. Palm,, and T. Wadstrom. 1989. Effect of milk on fibronectin and collagen type I binding to Staphylococcus aureus and coagulase-negative staphylococci isolated from bovine mastitis. J. Clin. Microbiol. 27: 540 544.
77. Minhas, T.,, H. A. Ludlam,, M. Wilks,, and S. Tabaqchali. 1995. Detection by PCR and analysis of the distribution of a fibronectin-binding protein gene ( fbn) among staphylococcal isolates. J. Med. Microbiol. 42: 96 101.
78. Nilsson, M.,, J. Bjerketorp,, A. Wiebensjo,, A. Ljungh,, L. Frykberg,, and B. Guss. 2004. A von Willebrand factor-binding protein from Staphylococcus lugdunensis. FEMS Microbiol. Lett. 234: 155 161.
79. Oh, B.,, H. Kim,, J. Lee,, S. Kang,, and T. Oh. 1999. Staphylococcus haemolyticus lipase: biochemical properties, substrate specificity and gene cloning. FEMS Microbiol. Lett. 179: 385 392.
80. Olszewski, W. L.,, S. Jamal,, G. Manokaran,, S. Pani,, V. Kumaraswami,, U. Kubicka,, B. Lukomska,, F. M. Tripathi,, E. Swoboda,, F. Meisel-Mikolajczyk,, E. Stelmach,, and M. Zaleska. 1999. Bacteriological studies of blood, tissue fluid, lymph and lymph nodes in patients with acute dermatolymphangioadenitis (DLA) in course of ‘filarial’ lymphedema. Acta Trop. 73: 217 224.
81. Orden, J. A.,, J. Goyache,, J. Hernandez,, A. Domenech,, G. Suarez,, and E. Gomez-Lucia. 1992. Production of staphylococcal enterotoxins and TSST-1 by coagulase negative staphylococci isolated from ruminant mastitis. Zentralbl. Veterinarmed. B 39: 144 148.
82. Ottenwalder, B.,, T. Kupke,, S. Brecht,, V. Gnau,, J. Metzger,, G. Jung,, and F. Gotz. 1995. Isolation and characterization of genetically engineered gallidermin and epidermin analogs. Appl. Environ. Microbiol. 61: 3894 3903.
83. Paulsonn, M.,, C. Petersson,, and A. Ljungh. 1993. Serum and tissue protein binding and cell surface properties of Staphylococcus lugdunensis. J. Med. Microbiol. 38: 96 102.
84. Paulsson, M.,, A. Ljungh,, and T. Wadstrom. 1992. Rapid identification of fibronectin, vitronectin, laminin, and collagen cell surface binding proteins on coagulase-negative staphylococci by particle agglutination assays. J. Clin. Microbiol. 30: 2006 2012.
85. Peacock, S. J.,, G. Lina,, J. Etienne,, and T. J. Foster. 1999. Staphylococcus schleiferi subsp. schleiferi expresses a fibronectin-binding protein. Infect. Immun. 67: 4272 4275.
86. Prevost, G.,, T. Bouakham,, Y. Piemont,, and H. Monteil. 1995. Characterisation of a synergohymenotropic toxin produced by Staphylococcus intermedius. FEBS Lett. 376: 135 140.
87. Raimundo, O.,, H. Heussler,, J. B. Bruhn,, S. Suntrarachun,, N. Kelly,, M. A. Deighton,, and S. M. Garland. 2002. Molecular epidemiology of coagulase-negative staphylococcal bacteraemia in a newborn intensive care unit. J. Hosp. Infect. 51: 33 42.
88. Raus, J.,, and D. N. Love. 1990. Comparison of the staphylocoagulase activities of Staphylococcus aureus and Staphylococcus intermedius on Chromozym-TH. J. Clin. Microbiol. 28: 207 210.
89. Razonable, R. R.,, D. G. Lewallen,, R. Patel,, and D. R. Osmon. 2001. Vertebral osteomyelitis and prosthetic joint infection due to Staphylococcus simulans. Mayo Clin. Proc. 76: 1067 1070.
90. Sandoe, J. A.,, K. G. Kerr,, G. W. Reynolds,, and S. Jain. 1999. Staphylococcus capitis endocarditis: two cases and review of the literature. Heart 82: e1.
91. Sato, H.,, K. Hirose,, R. Terauchi,, S. Abe,, I. Moromizato,, S. Kurokawa,, and N. Maehara. 2004. Purification and characterization of a novel Staphylococcus chromogenes exfoliative toxin. J. Vet. Med. B Infect. Dis. Vet. Public Health 51: 116 122.
92. Schleifer, K. H., 1986. Gram-positive cocci, p. 999 1103. In P. H. A. Sneath,, N. S. Mair,, M. E. Sharpe,, and J. G. Holt (ed.), Bergey’s Manual of Systematic Bacteriology, vol. 2. Williams & Wilkins, Baltimore, Md.
93. Schwarz, S.,, C. Kehrenberg,, and K. K. Ojo. 2002. Staphylococcus sciuri gene erm(33), encoding inducible resistance to macrolides, lincosamides, and streptogramin B antibiotics, is a product of recombination between erm(C) and erm(A). Antimicrob. Agents Chemother. 46: 3621 3623.
94. Schwarz, S.,, C. Werckenthin,, and C. Kehrenberg. 2000. Identification of a plasmid-borne chloramphenicolflorfenicol resistance gene in Staphylococcus sciuri. Antimicrob. Agents Chemother. 44: 2530 2533.
95. Shimizu, A.,, H. A. Berkhoff,, W. E. Kloos,, C. G. George,, and D. N. Ballard. 1996. Genomic DNA fingerprinting, using pulsed-field gel electrophoresis, of Staphylococcus intermedius isolated from dogs. Am. J. Vet. Res. 57: 1458 1462.
96. Shuttleworth, R.,, R. J. Behme,, A. McNabb,, and W. D. Colby. 1997. Human isolates of Staphylococcus caprae: association with bone and joint infections. J. Clin. Microbiol. 35: 2537 2541.
97. Stepanovic, S.,, D. Vukovicc,, V. Trajkovic,, T. Samardzic,, M. Cupic,, and M. Svabic-Vlahovic. 2001. Possible virulence factors of Staphylococcus sciuri. FEMS Microbiol. Lett. 199: 47 53.
98. Stout, R. D.,, Y. Li,, A. R. Miller,, and D. W. Lambe. 1994. Staphylococcal glycocalyx activates macrophage prostaglandin E2 and interleukin 1 production and modulates tumor necrosis factor alpha and nitric oxide production. Infect. Immun. 62: 4160 4166.
99. Sugai, M.,, T. Fujiwara,, K. Ohta,, H. Komatsuzawa,, M. Ohara,, and H. Suginaka. 1997. epr, which encodes glycylglycine endopeptidase resistance, is homologous to femAB and affects serine content of peptidoglycan cross bridges in Staphylococcus capitis and Staphylococcus aureus. J. Bacteriol. 179: 4311 4318.
100. Tabe, Y.,, A. Nakamura,, and J. Igari. 2001. Glycopeptide susceptibility profiles of nosocomial multiresistant Staphylococcus haemolyticus isolates. J. Infect. Chemother. 7: 142 147.
101. Talon, R.,, N. Dublet,, M. C. Montel,, and M. Cantonnet. 1995. Purification and characterization of extracellular Staphylococcus warneri lipase. Curr. Microbiol. 30: 11 16.
102. Tee, W. S.,, S. Y. Soh,, R. Lin,, and L. H. Loo. 2003. Staphylococcus lugdunensis carrying the mecA gene causes catheter-associated bloodstream infection in premature neonate. J. Clin. Microbiol. 41: 519 520.
103. Tegmark, K.,, E. Morfeldt,, and S. Arvidson. 1998. Regulation of agr-dependent virulence genes in Staphylococcus aureus by RNAIII from coagulase-negative staphylococci. J. Bacteriol. 180: 3181 3186.
104. Terauchi, R.,, H. Sato,, T. Hasegawa,, T. Yamaguchi,, C. Aizawa,, and N. Maehara. 2003. Isolation of exfoliative toxin from Staphylococcus intermedius and its local toxicity in dogs. Vet. Microbiol. 94: 19 29.
105. Thumm, G.,, and F. Gotz. 1997. Studies on prolysostaphin processing and characterization of the lysostaphin immunity factor (Lif) of Staphylococcus simulans biovar staphylolyticus. Mol. Microbiol. 23: 1251 1265.
106. Valle, J.,, E. Gomez-Lucia,, S. Piriz,, J. Goyache,, J. A. Orden,, and S. Vadillo. 1990. Enterotoxin production by staphylococci isolated from healthy goats. Appl. Environ. Microbiol. 56: 1323 1326.
107. Vandenesch, F.,, S. J. Eykyn,, M. Bes,, H. Meugnier,, J. Fleurette,, and J. Etienne. 1995. Identification and ribotypes of Staphylococcus caprae isolates isolated as human pathogens and from goat milk. J. Clin. Microbiol. 33: 888 892.
108. Vandenesch, F.,, S. J. Eykyn,, J. Etienne,, and J. Lemozy. 1995. Skin and post-surgical wound infections due to Staphylococcus lugdunensis. Clin. Microbiol. Infect. 1: 73 74.
109. Vandenesch, F.,, S. J. Eykyn,, and J. Etienne. 1995. Infections caused by newly-described species of coagulase-negative staphylococci. Rev. Med. Microbiol. 6: 94 100.
110. Vandenesch, F.,, C. Lebeau,, M. Bes,, G. Lina,, B. Lina,, T. Greenland,, Y. Benito,, Y. Brun,, J. Fleurette,, and J. Etienne. 1994. Clotting activity in Staphylococcus schleiferi subspecies from human patients. J. Clin. Microbiol. 32: 388 392.
111. Vandenesch, F.,, S. Projan,, B. Kreiswirth,, J. Etienne,, and R. P. Novick. 1993. agr related sequences in Staphylococcus lugdunensis. FEMS Microbiol. Lett. 111: 115 122.
112. Vandenesch, F.,, M. J. Storrs,, F. Poitevin-Later,, J. Etienne,, P. Courvalin,, and J. Fleurette. 1991. Delta-like haemolysin produced by Staphylococcus lugdunensis. FEMS Microbiol. Lett. 78: 65 68.
113. van der Mee-Marquet, N.,, A. Achard,, L. Mereghetti,, A. Danton,, M. Minier,, and R. Quentin. 2003. Staphylococcus lugdunensis infections: high frequency of inguinal area carriage. J. Clin. Microbiol. 41: 1404 1409.
114. Van Der Zwet, W. C.,, Y. J. Debets-Ossenkopp,, E. Reinders,, M. Kapi,, P. H. Savelkoul,, R. M. Van Elburg,, K. Hiramatsu,, and C. M. Vandenbroucke-Grauls. 2002. Nosocomial spread of a Staphylococcus capitis strain with heteroresistance to vancomycin in a neonatal intensive care unit. J. Clin. Microbiol. 40: 2520 2525.
115. van Kampen, M.,, J. W. Simons,, N. Dekker,, M. R. Egmond,, and H. M. Verheij. 1998. The phospholipase activity of Staphylococcus hyicus lipase strongly depends on a single Ser to Val mutation. Chem. Phys. Lipids 93: 39 45.
116. van Kampen, M. D.,, R. Rosenstein,, F. Gotz,, and M. R. Egmond. 2001. Cloning, purification and characterisation of Staphylococcus warneri lipase 2. Biochim. Biophys. Acta 1544: 229 241.
117. Vannuffel, P.,, M. Heusterspreute,, M. Bouyer,, B. Vandercam,, M. Philippe,, and J. L. Gala. 1999. Molecular characterization of femA from Staphylococcus hominis and Staphylococcus saprophyticus, and femA-based discrimination of staphylococcal species. Res. Microbiol. 150: 129 141.
118. Vernozy-Rozand, C.,, C. Mazuy,, G. Prevost,, C. Lapeyre,, M. Bes,, Y. Brun,, and J. Fleurette. 1996. Enterotoxin production by coagulase-negative staphylococci isolated from goats’ milk and cheese. Int. J. Food Microbiol. 30: 271 280.
119. Wagner, E.,, J. Doskar,, and F. Gotz. 1998. Physical and genetic map of the genome of Staphylococcus carnosus TM300. Microbiology 144: 509 517.
120. Watson, D. C.,, M. Yaguchi,, J. G. Bisaillon,, R. Beaudet,, and R. Morosoli. 1988. The amino acid sequence of a gonococcal growth inhibitor from Staphylococcus haemolyticus. Biochem. J. 252: 87 93.
121. Weiss, K.,, D. Rouleau,, and M. Laverdiere. 1996. Cystitis due to vancomycin-intermediate Staphylococcus saprophyticus. J. Antimicrob. Chemother. 37: 1039 1040.
122. Wu, S.,, H. de Lencastre,, and A. Tomasz. 1998. Genetic organization of the mecA region in methicillin-susceptible and methicillin-resistant strains of Staphylococcus sciuri. J. Bacteriol. 180: 236 242.
123. Wu, S. W.,, H. de Lencastre,, and A. Tomasz. 2001. Recruitment of the mecA gene homologue of Staphylococcus sciuri into a resistance determinant and expression of the resistant phenotype in Staphylococcus aureus. J. Bacteriol. 183: 2417 2424.


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Other extracellular factors produced by species other than S. and S.

SHT, synergohymenotropic toxin; NT, not tested; SCET, S. exfoliative toxin; ExhA, exfoliative toxin A from S. SHETA, S. exfoliative toxin A; SIET, S. exfoliative toxin.

Citation: Tristan A, Lina G, Etienne J, Vandenesch F. 2006. Biology and Pathogenicity of Staphylococci Other than Staphylococcus aureus and Staphylococcus epidermidis, p 572-586. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch47
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Binding of various species to extracellular matrix proteins

NT, not tested; PAA, particule agglutination assays; I-PBA, iodine-labeled protein-binding assays; PCR, PCR amplification of -like genes using primers based on conserved sequences of and ; WLAB, Western ligand affinity blotting; Fn, fibronectin; Vn, vitronectin; Lm, laminin; Cn, collagen; Fg, fibrinogen; *, low-affinity binding.

Citation: Tristan A, Lina G, Etienne J, Vandenesch F. 2006. Biology and Pathogenicity of Staphylococci Other than Staphylococcus aureus and Staphylococcus epidermidis, p 572-586. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch47
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Synergistic hemolysis and detection of , , and genes in species

NT, not tested.

Citation: Tristan A, Lina G, Etienne J, Vandenesch F. 2006. Biology and Pathogenicity of Staphylococci Other than Staphylococcus aureus and Staphylococcus epidermidis, p 572-586. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch47
Generic image for table

Superantigenic toxins produced by species other than and

NT, not tested.

Citation: Tristan A, Lina G, Etienne J, Vandenesch F. 2006. Biology and Pathogenicity of Staphylococci Other than Staphylococcus aureus and Staphylococcus epidermidis, p 572-586. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch47

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