Chapter 49 : Epidemiology and Clinical Manifestations of Listeria monocytogenes Infection

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Enhancement of organism specific virulence factors may play a role in epidemic disease, although all isolates of have the constitutive ability to produce all the virulence factors characteristic of the species. The current understanding of the epidemiology of human listeriosis suggests that the organism is a common contaminant of food products and that ingestion of small numbers of occurs frequently in human populations. A wide variety of clinical syndromes have been associated with infection in both animals and humans. The clinical syndromes associated with listeriosis in humans have been more recently elucidated. Autopsy findings in cases of early-onset listeriosis show significant chorioamnionitis in placental remnants and granulomas in multiple organs, particularly the liver and spleen, of infected infants. is an uncommon cause of bacterial meningitis in adults. There are two major clinical presentations. The first is a typical subacute bacterial meningitis characterized by fever, headache, and neck stiffness. The second form of central nervous system listeriosis in adults is a rhombencephalitis that has features characteristic of the same illness in animals described as circling disease. , or bacteremia without central nervous system involvement, represents one-third of adult cases of invasive listeriosis. The chapter also talks about other clinical syndromes.

Citation: Schlech, III W. 2006. Epidemiology and Clinical Manifestations of Listeria monocytogenes Infection, p 601-608. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch49
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Magnetic resonance imaging of the cerebellum and midbrain of a 72-year-old, previously healthy man. Spinal fluid and blood cultures demonstrated . Wellformed microabscesses typical of listeriosis can be seen within the brain parenchyma.

Citation: Schlech, III W. 2006. Epidemiology and Clinical Manifestations of Listeria monocytogenes Infection, p 601-608. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch49
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Generic image for table

Some foods implicated in published reports of food-borne listeriosis

Citation: Schlech, III W. 2006. Epidemiology and Clinical Manifestations of Listeria monocytogenes Infection, p 601-608. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch49
Generic image for table

Major clinical syndromes associated with

Citation: Schlech, III W. 2006. Epidemiology and Clinical Manifestations of Listeria monocytogenes Infection, p 601-608. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch49

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