Extracellular Matrix Interactions with Gram-Positive Pathogens

Gursharan S. Chhatwal; Klaus T. Preissner

doi:10.1128/9781555816513.ch8

Chapter 8 : Extracellular Matrix Interactions with Gram-Positive Pathogens

Authors: Gursharan S. Chhatwal, Klaus T. Preissner

Content Type: Reference

Publication Year: 2006

Category: Bacterial Pathogenesis

Book DOI: 10.1128/9781555816513

Chapter DOI: 10.1128/9781555816513.ch8

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Abstract:

This chapter discusses the interaction of extracellular matrix (ECM) components with gram-positive pathogens. It first describes the structure and function of ECM, and then deals with the interactions of gram-positive pathogens with ECM components and their biological consequences. The chapter explains binding of collagen, laminin, elastin, fibronectin, vitronectin, fibrinogen, and thrombospondin, to gram-positive bacteria in detail. Adherence and invasion are the important disease-causing mechanisms of gram-positive pathogens. As interaction of these pathogens with the components of host ECM is involved both in adherence and in invasion, the underlying mechanisms of this interaction are of utmost importance for designing novel therapeutic strategies. A classic example of the potential use of bacterial cell surface components interacting with ECM is documented with fibronectin-binding protein SfbI from Streptococcus pyogenes. This and other examples clearly demonstrate the potential use of components involved in the interaction of ECM and gram-positive pathogens and justify further research in this field.

Citation: Chhatwal G, Preissner K. 2006. Extracellular Matrix Interactions with Gram-Positive Pathogens, p 89-99. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch8

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Tables

Extracellular Matrix Interactions with Gram-Positive Pathogens

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TABLE 1

Properties of ECM components involved in interaction with gram-positive pathogens

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TABLE 1

Properties of ECM components involved in interaction with gram-positive pathogens