Chapter 8 : Extracellular Matrix Interactions with Gram-Positive Pathogens

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Preview this chapter:
Zoom in

Extracellular Matrix Interactions with Gram-Positive Pathogens, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555816513/9781555813437_Chap08-1.gif /docserver/preview/fulltext/10.1128/9781555816513/9781555813437_Chap08-2.gif


This chapter discusses the interaction of extracellular matrix (ECM) components with gram-positive pathogens. It first describes the structure and function of ECM, and then deals with the interactions of gram-positive pathogens with ECM components and their biological consequences. The chapter explains binding of collagen, laminin, elastin, fibronectin, vitronectin, fibrinogen, and thrombospondin, to gram-positive bacteria in detail. Adherence and invasion are the important disease-causing mechanisms of gram-positive pathogens. As interaction of these pathogens with the components of host ECM is involved both in adherence and in invasion, the underlying mechanisms of this interaction are of utmost importance for designing novel therapeutic strategies. A classic example of the potential use of bacterial cell surface components interacting with ECM is documented with fibronectin-binding protein SfbI from . This and other examples clearly demonstrate the potential use of components involved in the interaction of ECM and gram-positive pathogens and justify further research in this field.

Citation: Chhatwal G, Preissner K. 2006. Extracellular Matrix Interactions with Gram-Positive Pathogens, p 89-99. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch8
Highlighted Text: Show | Hide
Loading full text...

Full text loading...


1. Allen, B. L.,, B. Katz,, and M. Hook. 2002. Streptococcus anginosus adheres to vascular endothelium basement membrane and purified extracellular matrix proteins. Microb. Pathog. 32: 191 204.
2. Bayer, A. S.,, P. M. Sullam,, M. Ramos,, C. Li,, A. L. Cheung,, and M. R. Yeaman. 1995. Staphylococcus aureus induces platelet aggregation via a fibrinogen-dependent mechanism which is independent of principal platelet glycoprotein IIb/IIIa fibrinogen-binding domains. Infect. Immun. 63: 3634 3641.
3. Beckmann, C.,, J. D. Waggoner,, T. O. Harris,, G. S. Tamura,, and C. E. Rubens. 2002. Identification of novel adhesins from Group B streptococci by use of phage display reveals that C5a peptidase mediates fibronectin binding. Infect. Immun. 70: 2869 2876.
4. Beg, A. M.,, M. N. Jones,, T. Miller-Torbert,, and R. G. Holt. 2002. Binding of Streptococcus mutans to extracellular matrix molecules and fibrinogen. Biochem. Biophys. Res. Commun. 298: 75 79.
5. Bergmann, S.,, M. Rohde,, G. S. Chhatwal,, and S. Hammerschmidt. 2001. alpha-Enolase of Streptococcus pneumonia is a plasmin(ogen)-binding protein displayed on the bacterial cell surface. Mol. Microbiol. 40: 1273 1287.
6. Bergmann, S.,, D. Wild,, O. Diekmann,, R. Frank,, D. Bracht,, G. S. Chhatwal,, and S. Hammerschmidt. 2003. Identification of a novel plasmin(ogen)-binding motif in surface displayed alpha-enolase of Streptococcus pneumoniae. Mol. Microbiol. 49: 411 423.
7. Border, C. C.,, R. Lottenberg,, G. O. von Mering,, K. H. Johnston,, and M. D. P. Boyle. 1991. Isolation of a prokaryotic plasmin receptor. Relationship to a plasminogen activator produced by the same micro-organism. J. Biol. Chem. 266: 4922 4928.
8. Bornstein, P. 1995. Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1. J. Cell Biol. 130: 503 506.
9. Carneiro, C. R.,, E. Postol,, R. Nomizo,, L. F. Reis,, and R. R. Brentani. 2004. Identification of enolase as a laminin-binding protein on the surface of Staphylococcus aureus. Microbes Infect. 6: 604 608.
10. Cheung, A. L.,, M. Krishnan,, E. A. Jaffe,, and V. A. Fischetti. 1991. Fibrinogen acts as a bridging molecule in the adherence of Staphylococcus aureus to cultured human endothelial cells. J. Clin. Invest. 87: 2236 2245.
11. Chhatwal, G. S. 2002. Anchorless adhesins and invasins of Gram-positive bacteria: a new class of virulence factors. Trends Microbiol. 10: 205 208.
12. Chhatwal, G. S.,, and H. Blobel. 1987. Heterogeneity of fibronectin reactivity among streptococci as revealed by binding of fibronectin fragments. Comp. Immunol. Microbiol. Infect. Dis. 10: 99 108.
13. Chhatwal, G. S.,, H. P. Müller,, and H. Blobel. 1983. Characterization of binding of human α 2-macroglobulin to group G streptococci. Infect. Immun. 41: 959 964.
14. Chhatwal, G. S.,, I. S. Dutra,, and H. Blobel. 1985. Fibrinogen binding inhibits the fixation of the third component of human complement on surface of groups A, B, C, and G streptococci. Microbiol. Immunol. 29: 973 980.
15. Chhatwal, G. S.,, G. Albohn,, and H. Blobel. 1987. Novel complex formed between a nonproteolytic cell wall protein of group A streptococci and α 2-macroglobulin. J. Bacteriol. 169: 3691 3695.
16. Chhatwal, G. S.,, K. T. Preissner,, G. Müller-Berghaus,, and H. Blobel. 1987. Specific binding of the human S protein (vitronectin) to streptococci, Staphylococcus aureus, and Escherichia coli. Infect. Immun. 55: 1878 1883.
17. Chhatwal, G. S.,, P. Valentin-Weigand,, and K. N. Timmis. 1990. Bacterial infection of wounds: fibronectin-mediated adherence of group A and C streptococci to fibrin thrombi in vitro. Infect. Immun. 58: 3015 3019.
18. Cho, S. H.,, I. Strickland,, M. Boguniewicz,, and D. Y. Leung. 2001. Fibronectin and fibrinogen contribute to the enhanced binding of Staphylococcus aureus to atopic skin. J. Allergy Clin. Immunol. 108: 269 274.
19. Chu, C. T.,, and S. V. Pizzo. 1994. Alpha-2-macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation. Lab. Invest. 71: 792 812.
20. Cunningham, M. W. 2000. Pathogenesis of group A streptococcal infections. Clin. Microbiol. Rev. 13: 470 511.
21. Cunningham, M. W. 2003. Autoimmunity and molecular mimicry in the pathogenesis of poststreptococcal heart disease. Front. Biosci. 8: 533 543.
22. Dickinson, R. B.,, J. A. Nagel,, D. McDevitt,, T. J. Foster,, R. A. Proctor,, and S. L. Cooper. 1995. Quantitative comparison of clumping factor- and coagulase-mediated Staphylococcus aureus adhesion to surface-bound fibrinogen under flow. Infect. Immun. 63: 3143 3150.
23. Dinkla, K.,, M. Rohde,, W. T. Jansen,, J. R. Carapetis,, G. S. Chhatwal,, and S. R. Talay. 2003. Streptococcus pyogenes recruits collagen via surface-bound fibronectin: a novel colonization and immune evasion mechanism. Mol. Microbiol. 47: 861 869.
24. Dinkla, K.,, M. Rohde,, W. T. Jansen,, E. L. Kaplan,, G. S. Chhatwal,, and S. R. Talay. 2003. Rheumatic fever-associated Streptococcus pyogenes isolates aggregate collagen. J. Clin. Invest. 111: 1905 1912.
25. Downer, R.,, F. Roche,, P. W. Park,, R. P. Mecham,, and T. J. Foster. 2002. The elastin-binding protein of Staphylococcus aureus (EbpS) is expressed at the cell surface as an integral membrane protein and not as a cell wall-associated protein. J. Biol. Chem. 277: 243 250.
26. Eberhard, T.,, and M. Ullberg. 2002. Interaction of vitronectin with Haemophilus influenzae. FEMS Immunol. Med. Microbiol. 34: 215 219.
27. Filippsen, L. F.,, P. Valentin-Weigand,, H. Blobel,, K. T. Preissner,, and G. S. Chhatwal. 1990. Role of complement S protein (vitronectin) in adherence of Streptococcus dysgalactiae to bovine epithelial cells. Am. J. Vet. Res. 51: 861 865.
28. Gailit, J.,, and R. A. F. Clark. 1994. Wound repair in the context of extracellular matrix. Curr. Opin. Cell Biol. 6: 717 725.
29. Godehardt, A. W.,, S. Hammerschmidt,, R. Frank,, and G. S. Chhatwal. 2004. Binding of alpha2-macroglobulin to GRAB (protein G-related alpha2-macroglobulin-binding protein), an important virulence factor of group A streptococci, is mediated by two charged motifs in the DeltaA region. Biochem. J. 381: 877 885.
30. Gutekunst, H.,, B. J. Eikmanns,, and D. J. Reinscheid. 2004. The novel fibrinogen-binding protein FbsB promotes Streptococcus agalactiae invasion into epithelial cells. Infect. Immun. 72: 3495 3504.
31. Guzmán, C. A.,, S. R. Talay,, G. Molinari,, E. Medina,, and G. S. Chhatwal. 1999. Protective immune response against Streptococcus pyogenes in mice after intranasal vaccination with the fibronectin binding protein SfbI. J. Infect. Dis. 179: 901 906.
32. Hall, C. E.,, and H. S. Slayter. 1959. The fibrinogen molecule: its size, shape, and mode of polymerization. J. Biophys. Biochem. Cytol. 5: 11 15.
33. Hanski, E.,, and M. Caparon. 1992. Protein F, a fibronectin-binding protein, is an adhesin of the group A Streptococcus pyogenes. Proc. Natl. Acad. Sci. USA 89: 6172 6176.
34. Heilmann, C.,, S. Niemann,, B. Sinha,, M. Herrmann,, B. E. Kehrel,, and G. Peters. 2004. Staphylococcus aureus fibronectin-binding protein (FnBP)-mediated adherence to platelets, and aggregation of platelets induced by FnBPA but not by FnBPB. J. Infect. Dis. 190: 321 329.
35. Henschen, A.,, F. Lottspeich,, E. Töpfer-Petersen,, and R. Warbinek. 1979. Primary structure of fibrinogen. Thromb. Haemost. 41: 662 670.
36. Herrmann, M.,, S. J. Suchard,, L. A. Boxer,, F. A. Waldvogel,, and D. P. Lew. 1991. Thrombospondin binds to Staphylococcus aureus and promotes staphylococcal adherence to surfaces. Infect. Immun. 59: 279 288.
37. Higazi, A. A. R.,, I. I. Barghouti,, and R. Abumuch. 1995. Identification of an inhibitor of tissue-type plasminogen activator-mediated fibrinolysis in human neutrophils—a role for defensin. J. Biol. Chem. 270: 9472 9477.
38. Holmes, A. R.,, R. McNab,, K. W. Millsap,, M. Rohde,, S. Hammerschmidt,, J. L. Mawdsley,, and H. F. Jenkinson. 2001. The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence. Mol. Microbiol. 41: 1395 1408.
39. Hostetter, M. K. 1996. An integrin-like protein in Candida albicans: implications for pathogenesis. Trends Microbiol. 4: 242 246.
40. Hynes, R. O.,, and K. M. Yamada. 1982. Fibronectins: multifunctional modular glycoproteins. J. Cell Biol. 95: 369 377.
41. Hytonen, J.,, S. Haataja,, D. Gerlach,, A. Podbielski,, and J. Finne. 2001. The SpeB virulence factor of Streptococcus pyogenes, a multifunctional secreted and cell surface molecule with strepadhesin, laminin-binding and cysteine protease activity. Mol. Microbiol. 39: 512 519.
42. Joh, J. J.,, K. House-Pompeo,, J. M. Patti,, S. Gurusiddappa,, and M. Höök. 1994. Fibronectin receptors from Gram-positive bacteria: comparison of active sites. Biochemistry 33: 6086 6092.
43. Kreikemeyer, B.,, S. R. Talay,, and G.S. Chhatwal. 1995. Characterization of a novel fibronectin-binding surface protein in group A streptococci. Mol. Microbiol. 17: 137 145.
44. Kreikemeyer, B.,, D. R. Martin,, and G. S. Chhatwal. 1999. SfbII protein, a fibronectin binding surface protein of group A streptococci, is a serum opacity factor with high serotype-specific apolipoproteinase activity. FEMS Microbiol. Lett. 178: 305 311.
45. Kreikemeyer, B.,, S. Oehmcke,, M. Nakata,, R. Hoffrogge,, and A. Podbielski. 2004. Streptococcus pyogenes fibronectin-binding protein F2: expression profile, binding characteristics, and impact on eukaryotic cell interactions. J. Biol. Chem. 279: 15850 15859.
46. Kreis, T.,, and R. Vale. 1993. Guidebook to the Extracellular Matrix and Adhesion Proteins. Oxford University Press, Oxford, United Kingdom.
47. Labat-Robert, J.,, M. Bihari-Varga,, and L. Robert. 1990. Extracellular matrix. FEBS Lett. 268: 386 393.
48. Lane, D. A.,, A. M. Flynn,, G. Pejler,, U. Lindahl,, J. Choay,, and K. T. Preissner. 1987. Structural requirements for the neutralization of heparin-like saccharides by complement S protein/vitronectin. J. Biol. Chem. 262: 16343 16349.
49. Lawler, J. W.,, and R. O. Hynes. 1987. Structure organization of the thrombospondin molecule. Semin. Thromb. Hemost. 13: 245 254.
50. Li, D. Q.,, F. Lundberg,, and A. Ljungh. 2001. Characterization of vitronectin-binding proteins of Staphylococcus epidermidis. Curr. Microbiol. 42: 361 367.
51. Liang, O. D.,, M. Maccarana,, J. I. Flock,, M. Paulsson,, K. T. Preissner,, and T. Wadström. 1993. Multiple interactions between human vitronectin and Staphylococcus aureus. Biochim. Biophys. Acta 374: 1 7.
52. Liang, O. D.,, K. T. Preissner,, and G. S. Chhatwal. 1997. The hemopexin-type repeats of human vitronectin are recognized by Streptococcus pyogenes. Biochem. Biophys. Res. Commun. 234: 445 449.
53. Lindgren, P.-E.,, P. Speziale,, M. McGavin,, H.-J. Monstein,, M. Höök,, L. Visai,, T. Kostiainen,, S. Bozzini,, and M. Lindberg. 1992. Cloning and expression of two different genes from Streptococcus dysgalactiae encoding fibronectin receptors. J. Biol. Chem. 267: 1924 1931.
54. Love, R. M.,, M. D. McMillan,, and H. F. Jenkinson. 1997. Invasion of dentinal tubules by oral streptococci is associated with collagen recognition mediated by the antigen I/II family of polypeptides. Infect. Immun. 65: 5157 5164.
55. Maeshima, Y.,, A. Sudhakar,, J. C. Lively,, K. Ueki,, S. Kharbanda,, C.R. Kahn,, N. Sonenberg,, R. O. Hynes,, and R. Kalluri. 2002. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science 295: 140 143.
56. Mamo, W.,, M. Boden,, and J. I. Flock. 1994. Vaccination with Staphylococcus aureus fibrinogen binding protein (FgBPs) reduces colonization of S. aureus in a mouse mastitis model. FEMS Immun. Med. Microbiol. 10: 47 53.
57. McDevitt, D.,, T. Nanavaty,, K. House-Pompeo,, E. Bell,, N. Turner,, L. McIntire,, T. Foster,, and M. Höök. 1997. Characterization of the interaction between the Staphylococcus aureus clumping factor (ClfA) and fibrinogen. Eur. J. Biochem. 247: 416 424.
58. McKay, F. C.,, J. D. McArthur,, M. L. Sanderson-Smith,, S. Gardam,, B. J. Currie,, K. S. Sriprakash,, P. K. Fagan,, R. J. Towers,, M. R. Batzloff,, G. S. Chhatwal,, M. Ranson,, and M. J. Walker. 2004. Plasminogen binding by group A streptococcal isolates from a region of hyperendemicity for streptococcal skin infection and a high incidence of invasive infection. Infect. Immun. 72: 364 370.
59. Medina, E.,, S. R. Talay,, G. S. Chhatwal,, and C. A. Guzmán. 1998. Fibronectin-binding protein I of Streptococcus pyogenes is a promising adjuvant for antigens delivered by mucosal route. Eur. J. Immunol. 28: 1069 1077.
60. Menzies, B. E. 2003. The role of fibronectin binding proteins in the pathogenesis of Staphylococcus aureus infections. Curr. Opin. Infect. Dis. 16: 225 229.
61. Molinari, G.,, S. R. Talay,, P. Valentin-Weigand,, M. Rohde,, and G. S. Chhatwal. 1997. The fibronectin-binding protein of Streptococcus pyogenes, SfbI, is involved in the internalization of group A streptococci by epithelial cells. Infect. Immun. 65: 1357 1363.
62. Molinari, G.,, and G. S. Chhatwal. 1998. Invasion and survival of Streptococcus pyogenes in eukaryotic cells correlates with the source of the clinical isolates. J. Infect. Dis. 177: 1600 1607.
63. Mosher, D. F.,, and R. A. Proctor. 1980. Binding of factor XIIIa-mediated cross-linking of a 27-kilodalton fragment of fibronectin to Staphylococcus aureus. Science 209: 927 929.
64. Mosher, D. F.,, J. Sottile,, C. Wu,, and J. A. McDonald. 1992. Assembly of extracellular matrix. Curr. Opin. Cell Biol. 4: 810 818.
65. Murphy-Ullrich, J. E.,, S. Gurusiddappa,, W. A. Frazier,, and M. Höök. 1993. Heparin-binding peptides from thrombospondin 1 and 2 contain focal adhesion-labilizing activity. J. Biol. Chem. 268: 26784 26789.
66. O’Reilly, M. S.,, T. Boehm,, Y. Shing,, N. Fukai,, G. Vasios,, W. S. Lane,, E. Flynn,, J. R. Birkhead,, B. R. Olsen,, and J. Folkman. 1997. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88: 277 285.
67. Ozeri, V.,, I. Rosenshine,, D. F. Mosher,, R. Fässler,, and E. Hanski. 1998. Roles of integrins and fibronectin in the entry of Streptococcus pyogenes into cells via protein F1. Mol. Microbiol. 30: 625 637.
68. Pancholi, V.,, and V. A. Fischetti. 1998. Alpha-enolase, a novel strong plasmin(ogen) binding protein on the surface of pathogenic streptococci. J. Biol. Chem. 273: 14503 14515.
69. Pancholi, V.,, P. Fontan,, and H. Jin. 2003. Plasminogen-mediated group A streptococcal adherence to and pericellular invasion of human pharyngeal cells. Microb. Pathog. 35: 293 303.
70. Park, P. W.,, D. D. Roberts,, L. E. Grosso,, W. C. Parks,, J. Rosenbloom,, W. R. Abrams,, and R. P. Mecham. 1991. Binding of elastin to Staphylococcus aureus. J. Biol. Chem. 266: 23399 23406.
71. Park, P.W.,, T. J. Broekelmann,, B. R. Mecham,, and R. P. Mecham. 1999. Characterization of the elastin binding domain in the cell-surface 25-kDa elastin-binding protein of Staphylococcus aureus (EbpS). J. Biol. Chem. 274: 2845 2850.
72. Patti, J. M.,, J. O. Boles,, and M. Höök. 1993. Identification and biochemical characterization of the ligand binding domain of the collagen adhesin from Staphylococcus aureus. Biochemistry 32: 11428 11435.
73. Patti, J. M.,, B. L. Allen,, M. J. McGavin,, and M. Höök. 1994. MSCRAMM-mediated adherence of microorganisms to host tissue. Annu. Rev. Microbiol. 48: 585 617.
74. Pierschbacher, M. D.,, and E. Ruoslahti. 1984. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309: 30 33.
75. Preissner, K. T. 1991. Structure and biological role of vitronectin. Annu. Rev. Cell Biol. 7: 275 310.
76. Preissner, K. T.,, and B. Pötzsch. 1995. Vessel wall-dependent metabolic pathways of the adhesive proteins, von-Willebrand-factor and vitronectin. Histol. Histopathol. 10: 239 251.
77. Preissner, K. T.,, A. E. May,, K. D. Wohn,, M. Germer,, and S. M. Kanse. 1997. Molecular crosstalk between adhesion receptors and proteolytic cascades in vascular remodeling. Thromb. Haemost. 78: 88 95.
78. Raghow, R. 1994. The role of extracellular matrix in post-inflammatory wound healing and fibrosis. FASEB J. 8: 823 831.
79. Rakonjac, J. V.,, J. C. Robbins,, and V. A. Fischetti. 1995. DNA sequence of the serum opacity factor of group A streptococci: identification of a fibronectin-binding repeat domain. Infect. Immun. 63: 622 631.
80. Ringdahl, U.,, M. Svensson,, A. C. Wistedt,, T. Renn,, R. Kellner,, W. Müller-Esterl,, and U. Sjöbring. 1998. Molecular co-operation between protein PAM and streptokinase for plasmin acquisition by Streptococcus pyogenes. J. Biol. Chem. 273: 6424 6430.
81. Rocha, C. L.,, and V. A. Fischetti. 1997. Identification and characterization of a new protein from Streptococcus pyogenes having homology with fibronectin and fibrinogen binding proteins. Adv. Exp. Med. Biol. 418: 737 739.
82. Rohde, M.,, E. Muller,, G. S. Chhatwal,, and S. R. Talay. 2003. Host cell caveolae act as an entry-port for group A streptococci. Cell Microbiol. 5: 323 342.
83. Rosenblatt, S.,, J. A. Bassuk,, C. E. Alpers,, E. H. Sage,, R. Timpl,, and K. T. Preissner. 1997. Differential modulation of cell adhesion by interaction between adhesive and counteradhesive proteins: characterization of the binding of vitronectin to osteonectin (BM40, SPARC). Biochem. J. 324: 311 319.
84. Sato, Y.,, K. Okamoto,, A. Kagami,, Y. Yamamoto,, T. Igarashi,, and H. Kizaki. 2004. Streptococcus mutans strains harboring collagen-binding adhesin. J. Dent. Res. 83: 534 539.
85. Schwarz-Linek, U.,, J. M. Werner,, A. R. Pickford,, S. Gurusiddappa,, J. H. Kim,, E. S. Pilka,, J. A. Briggs,, T. S. Gough,, M. Hook,, I. D. Campbell,, and J. R. Potts. 2003. Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper. Nature 423: 177 181.
86. Sommer, P.,, C. Gleyzal,, S. Guerret,, J. Etienne,, and J.-A. Grimaud. 1992. Induction of a putative laminin-binding protein of Streptococcus gordonii in human infective endocarditis. Infect. Immun. 60: 360 365.
87. Spellerberg, B.,, E. Rozdzinski,, S. Martin,, J. Weber-Heynemann,, N. Schnitzler,, R. Lutticken,, and A. Podbielski. 1999. Lmb, a protein with similarities to the LraI adhesin family, mediates attachment of Streptococcus agalactiae to human laminin. Infect. Immun. 67: 871 878.
88. Ständker, L.,, M. Schrader,, S. M. Kanse,, M. Jurgens,, W. G. Forssmann,, and K. T. Preissner. 1997. Isolation and characterization of the circulating form of human endostatin. FEBS Lett. 420: 129 133.
89. Sun, H.,, U. Ringdahl,, J. W. Homeister,, W. P. Fay,, N. C. Engleberg,, A. Y. Yang,, L. S. Rozek,, X. Wang,, U. Sjobring,, and D. Ginsburg. 2004. Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science 305: 1283 1286.
90. Svensson, M. D.,, U. Sjobring,, F. Luo,, and D. E. Bessen. 2002. Roles of the plasminogen activator streptokinase and the plasminogen-associated M protein in an experimental model for streptococcal impetigo. Microbiology 148: 3933 3945.
91. Switalski, L. M.,, P. Speziale,, M. Höök,, T. Wadström,, and R. Timpl. 1984. Binding of Streptococcus pyogenes to laminin. J. Biol. Chem. 259: 3734 3738.
92. Switalski, L. M.,, H. Murchinson,, R. Timpl,, R. Curtiss III,, and M. Höök. 1987. Binding of laminin to oral and endocarditis strains of viridans streptococci. J. Bacteriol. 169: 1095 1101.
93. Switalski, L. M.,, P. Speziale,, and M. Höök. 1989. Isolation and characterization of a putative collagen receptor from Staphylococcus aureus strain Cowan 1. J. Biol. Chem. 264: 21080 21086.
94. Switalski, L. M.,, W. G. Butcher,, P. C. Caufield,, and M. S. Lantz. 1993. Collagen mediates adhesion of Streptococcus mutans to human dentin. Infect. Immun. 61: 4119 4125.
95. Switalski, L. M.,, J. M. Patti,, W. Butcher,, A. G. Gristina,, P. Speziale,, and M. Höök. 1993. A collagen receptor in Staphylococcus aureus strains isolated from patients with septic arthritis mediates adhesion to cartilage. Mol. Microbiol. 7: 99 107.
96. Talay, S. R.,, E. Ehrenfeld,, G. S. Chhatwal,, and K. N. Timmis. 1991. Expression of the fibronectin-binding components of Streptococcus pyogenes in Escherichia coli demonstrates that they are proteins. Mol. Microbiol. 5: 1727 1734.
97. Talay, S. R.,, P. Valentin-Weigand,, P. G. Jerlström,, K. N. Timmis,, and G. S. Chhatwal. 1992. Fibronectin-binding protein of Streptococcus pyogenes: sequence of the binding domain involved in adherence of streptococci to epithelial cells. Infect. Immun. 60: 3837 3844.
98. Talay, S. R.,, P. Valentin-Weigand,, K. N. Timmis,, and G. S. Chhatwal. 1994. Domain structure and conserved epitopes of Sfb protein, the fibronectin-binding adhesin of Streptococcus pyogenes. Mol. Microbiol. 13: 531 539.
99. Talay, S. R.,, A. Zock,, M. Rohde,, G. Molinari,, M. Oggioni,, G. Pozzi,, C. A. Guzman,, and G. S. Chhatwal. 2000. Co-operative binding of human fibronectin to Sfbl protein triggers streptococcal invasion into respiratory epithelial cells. Cell Microbiol. 2: 521 535.
100. Terao, Y.,, S. Kawabata,, E. Kunitomo,, J. Murakami,, I. Nakagawa,, and S. Hamada. 2001. Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator. Mol. Microbiol. 42: 75 86.
101. Terao, Y.,, S. Kawabata,, E. Kunitomo,, I. Nakagawa,, and S. Hamada. 2002. Novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in adhesion to epithelial cells. Infect. Immun. 70: 993 997.
102. Terao, Y.,, S. Kawabata,, M. Nakata,, I. Nakagawa,, and S. Hamada. 2002. Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes strains isolated from toxic shock-like syndrome patients. J. Biol. Chem. 277: 47428 47435.
103. Timpl, R. 1989. Structure and biological activity of basement membrane proteins. Eur. J. Biochem. 180: 487 502.
104. Toppel, A. W.,, M. Rasmussen,, M. Rohde,, E. Medina,, and G. S. Chhatwal. 2003. Contribution of protein G-related alpha2-macroglobulin-binding protein to bacterial virulence in a mouse skin model of group A streptococcal infection. J. Infect. Dis. 187: 1694 1703.
105. Traore, M. Y.,, P. Valentin-Weigand,, G. S. Chhatwal,, and H. Blobel. 1991. Inhibitory effects of fibrinogen on phagocytic killing of streptococcal isolates from humans, cattle and horses. Vet. Microbiol. 28: 295 302.
106. Valentin-Weigand, P.,, J. Grulich-Henn,, G. S. Chhatwal,, G. Müller-Berghaus,, H. Blobel,, and K. T. Preissner. 1988. Mediation of adherence of streptococci to human endothelial cells by complement S-protein (vitronectin). Infect. Immun. 56: 2851 2855.
107. Valentin-Weigand, P.,, M. Y. Traore,, H. Blobel,, and G. S. Chhatwal. 1990. Role of α 2-macroglobulin in phagocytosis of group A and C streptococci. FEMS Microbiol. Lett. 58: 321 324.
108. Valentin-Weigand, P.,, K. N. Timmis,, and G. S. Chhatwal. 1993. Role of fibronectin in staphylococcal colonization of fibrin thrombi and plastic surfaces. J. Med. Microbiol. 38: 90 95.
109. Valentin-Weigand, P.,, S. R. Talay,, A. Kaufhold,, K. N. Timmis,, and G. S. Chhatwal. 1994. The fibronectin binding domain of the Sfb protein adhesin of Streptococcus pyogenes occurs in many group A streptococci and does not cross-react with heart myosin. Microb. Pathog. 17: 111 120.
110. van der Flier, M.,, N. Chhun,, T. M. Wizemann,, J. Min,, J. B. McCarthy,, and E. I. Tuomanen. 1995. Adherence of Streptococcus pneumoniae to immobilized fibronectin. Infect. Immun. 63: 4317 4322.
111. Vercellotti, G. M.,, D. Lussenhop,, P. K. Peterson,, L. T. Furcht,, J. B. McCarthy,, H. S. Jacob,, and C. F. Moldow. 1984. Bacterial adherence to fibronectin and endothelial cells: a possible mechanism for bacterial tissue tropism. J. Lab. Clin. Med. 103: 34 43.
112. Whitnack, E.,, and E. H. Beachy. 1985. Inhibition of complement-mediated opsonization and phagocytosis of Streptococcus pyogenes by D fragments of fibrinogen and fibrin bound to cell surface M protein. J. Exp. Med. 162: 1983 1997.
113. Wiestedt, A. C.,, U. Ringdahl,, W. Müller-Esterl,, and U. Sjöbring. 1995. Identification of a plasminogen-binding motif in PAM, a bacterial surface protein. Mol. Microbiol. 18: 569 578.
114. Yanagisawa, N.,, D. Q. Li,, and A. Ljungh. 2001. The N-terminal of thrombospondin-1 is essential for coagulase-negative staphylococcal binding. J. Med. Microbiol. 50: 712 719.


Generic image for table

Properties of ECM components involved in interaction with gram-positive pathogens

Citation: Chhatwal G, Preissner K. 2006. Extracellular Matrix Interactions with Gram-Positive Pathogens, p 89-99. In Fischetti V, Novick R, Ferretti J, Portnoy D, Rood J (ed), Gram-Positive Pathogens, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816513.ch8

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error