Chapter 23 : The Humoral Immune Response to

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Antibody specific for both bacterial polysaccharide and protein can be protective against extracellular bacteria, including . In this regard, polysaccharide- and protein-specific Ig isotype responses to the intact bacterium could more closely resemble those observed using conjugate vaccines consisting of covalently linked polysaccharide and protein, as opposed to purified antigens. It remains to be determined which B-cell subpopulation(s) plays the major role in IgG antipolysaccharide responses to intact extracellular bacteria, where the role may depend on cognate CD4-T-cell help. Dendritic cells (DCs) in turn can directly stimulate activated B cells to secrete Ig in vitro and can play an active role in stimulating in vivo T-cell-independent (TI) and T-cell-dependent (TD) antipolysaccharide, as well as antiprotein, responses to intact . In vivo studies so far suggest only a limited role for endogenous NK cells in augmenting a humoral immune response, by demonstrating their ability to selectively stimulate trinitrophenyl (TNP)-specific IgG2a in response to the soluble TI antigen TNP-LPS. It is demonstrated instead that a critical balance exists between signals mediated by derived pathogen-associated molecular patterns and DC-derived interleukin-10 (IL-10) for optimization of DC induction of an in vivo humoral immune response. induces the early release of proinflammatory cytokines, the anti-inflammatory cytokine IL-10, and the type 2 cytokine IL-4. The use of intact as an immunogen to study the regulation of in vivo antipolysaccharide and antiprotein responses has revealed levels of complexity and distinct mechanistic pathways not anticipated from studies using isolated soluble antigens.

Citation: Snapper W, Colino J, Khan A, Wu Z. 2004. The Humoral Immune Response to , p 367-381. In Tuomanen E, Mitchell T, Morrison D, Spratt B (ed), The Pneumococcus. ASM Press, Washington, DC. doi: 10.1128/9781555816537.ch23
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1. AlonsoDeVelasco, E.,, A. F. M. Verheul,, J. Verhoef,, and H. Snippe. 1995. Streptococcus pneumoniae: virulence factors, pathogenesis, and vaccines. Microbiol. Rev. 59: 591 603.
2. Ashany, D.,, A. Savir,, N. Bhardwaj,, and K. B. Elkon. 1999. Dendritic cells are resistant to apoptosis through the Fas (CD95/APO-1) pathway. J. Immunol. 163: 5303 5311.
3. Balazs, M.,, F. Martin,, T. Zhou,, and J. Kearney. 2002. Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity 17: 341 352.
4. Banchereau, J.,, F. Briere,, C. Caux,, J. Davoust,, S. Lebecque,, Y. Liu,, B. Pulendran,, and K. Palucka. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18: 767 811.
5. Barrett, D. J.,, and E. M. Ayoub. 1986. IgG2 subclass restriction of antibody to pneumococcal polysaccharides. Clin. Exp. Immunol. 63: 127 134.
6. Berney, C.,, S. Herren,, C. A. Power,, S. Gordon,, L. Martinez-Pomares,, and M. H. Kosco-Vilbois. 1999. A member of the dendritic cell family that enters B cell follicles and stimulates primary antibody responses identified by a mannose receptor fusion protein. J. Exp. Med. 190: 851 860.
7. Blanca, I. R.,, E. W. Bere,, H. A. Young,, and J. R. Ortaldo. 2001. Human B cell activation by autologous NK cells is regulated by CD40-CD40 ligand interaction: role of memory B cells and CD5+ B cells. J. Immunol. 167: 6132 6139.
8. Boswell, H. S.,, S. O. Sharrow,, and A. Singer. 1980. Role of accessory cells in B cell activation. I. Macrophage presentation of TNP-Ficoll: evidence for macrophage-B cell interaction. J. Immunol. 124: 989 996.
9. Braun, D. G.,, B. Kindred,, and E. B. Jacobson. 1972. Streptococcal group A carbohydrate antibodies in mice: evidence for strain differences in magnitude and restriction of the response, and for thymus dependence. Eur. J. Immunol. 2: 138 143.
10. Briles, D. E.,, M. Nahm,, N. Marion,, R. M. Perlmutter,, and J. M. Davie>. 1982. Streptococcal group-A carbohydrate has properties of both a thymus-independent (TI-2) and a thymus-dependent antigen. J. Immunol. 128: 2032 2035.
11. Brunswick, M.,, F. D. Finkelman,, P. F. Highet,, J. K. Inman,, H. M. Dintzis,, and J. J. Mond. 1988. Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation. J. Immunol. 140: 3364 3372.
12. Carroll, M. C. 1998. The role of complement and complement receptors in induction and regulation of immunity. Annu. Rev. Immunol. 16: 545 568.
13. Claflin, J. L.,, R. Lieberman,, and J. M. Davie. 1974. Clonal nature of the immune response to phosphorylcholine. J. Exp. Med. 139: 58 73.
14. Colino, J.,, and C. M. Snapper. 2003. Opposing signals from pathogen-associated molecular patterns and IL-10 are critical for optimal dendritic cell induction of in vivo humoral immunity to Streptococcus pneumoniae. J. Immunol. 171: 3508 3519.
15. Colino, J.,, and C. M. Snapper. 2003. Two distinct mechanisms for induction of dendritic cell apoptosis in response to intact Streptococcus pneumoniae. J. Immunol. 171: 2354 2365.
16. Colino, J.,, Y. Shen,, and C. M. Snapper. 2002. Dendritic cells pulsed with intact Streptococcus pneumoniae elicit both protein- and polysaccharide- specific immunoglobulin isotype responses in vivo through distinct mechanisms. J. Exp. Med. 195: 1 13.
17. Corinti, S.,, C. Albanesi,, A. la Sala,, S. Pastore,, and G. Girolomoni. 2001. Regulatory activity of autocrine IL-10 on dendritic cell functions. J. Immunol. 166: 4312 4318.
18. Cosenza, H.,, J. Quintans,, and I. Lefkovits. 1975. Antibody response to phosphorylcholine in vitro. I. Studies on the frequency of precursor cells, average clone size, and cellular cooperation. Eur. J. Immunol. 5: 343 349.
19. der Balian, G. P.,, J. Slack,, B. L. Clevinger,, H. Bazin,, and J. M. Davie. 1980. Subclass restriction of murine antibodies. III. Antigens that stimulate IgG3 in mice stimulate IgG2c in rats. J. Exp. Med. 152: 209 218.
20. De Smedt, T.,, M. Van Mechelen,, G. De Becker,, J. Urbain,, O. Leo,, and M. Moser. 1997. Effect of interleukin-10 on dendritic cell maturation and function. Eur. J. Immunol. 27: 1229 1235.
21. Dockrell, D. H.,, M. Lee,, D. H. Lynch,, and R. C. Read. 2001. Immune-mediated phagocytosis and killing of Streptococcus pneumoniae are associated with direct and bystander macrophage apoptosis. J. Infect. Dis. 184: 713 722.
22. Dubois, B.,, B. Vanbervliet,, J. Fayette,, C. Massacrier,, C. V. Kooten,, F. Briere,, J. Banchereau,, and C. Caux. 1997. Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes. J. Exp. Med. 185: 941 951.
23. Fernandez, N. C.,, A. Lozier,, C. Flament,, P. Ricciardi-Castagnoli,, D. Bellet,, M. Suter,, M. Perricaudet,, T. Tursz,, E. Maraskovsky,, and L. Zitvogel. 1999. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nat. Med. 5: 405 411.
24. Fischer, W., 2000. Pneumococcal lipoteichoic acid and teichoic acid, p. 155 177. In A. Tomasz (ed.), Streptococcus pneumoniae. Molecular Biology and Mechanisms of Disease. Mary Ann Liebert, Inc., Larchmont, N.Y.
25. Foy, T. M.,, D. M. Shepherd,, F. H. Durie,, A. Aruffo,, J. A. Ledbetter,, and R. J. Noelle. 1993. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39. J. Exp. Med. 178: 1567 1575.
26. Gao, N.,, T. Dang,, and D. Yuan. 2001. IFN-gamma- dependent and -independent initiation of switch recombination by NK cells. J. Immunol. 167: 2011 2018.
27. Gerosa, F.,, B. Baldani-Guerra,, C. Nisii,, V. Marchesini,, G. Carra,, and G. Trinchieri. 2002. Reciprocal activating interaction between natural killer cells and dendritic cells. J. Exp. Med. 195: 327 333.
28. Greenfield, E.,, K. Nguyen,, and V. Kuchroo. 1998. CD28/B7 costimulation: a review. Crit. Rev. Immunol. 18: 389 418.
29. Grewal, I. S.,, and R. A. Flavell. 1998. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16: 111 135.
30. Guzman, C. A.,, E. Domann,, M. Rohde,, D. Bruder,, A. Darji,, S. Weiss,, J. Wehland,, T. Chakraborty,, and K. N. Timmis. 1996. Apoptosis of mouse dendritic cells is triggered by listeriolysin, the major virulence determinant of Listeria monocytogenes. Mol. Microbiol. 20: 119 126.
31. Harding, C. V.,, R. W. Roof,, P. M. Allen,, and E. R. Unanue. 1991. Effects of pH and polysaccharides on peptide binding to class II major histocompatibility complex molecules. Proc. Natl. Acad. Sci. USA 88: 2740 2744.
32. Harnett, W.,, and M. M. Harnett. 2000. Phosphorylcholine: an immunomodulator present on glycoproteins secreted by filarial nematodes. Mod. Asp. Immunobiol. 1: 40 42.
33. Hayashi, R. J.,, and O. Kanagawa. 1999. Unique CD4(+) T cells in TCR alpha chain-deficient class I MHC-restricted TCR transgenic mice: role in a superantigen-mediated disease process. Int. Immunol. 11: 1581 1590.
34. Hayday, A. C. 2000. Ag cells: a right time and a right place for a conserved third way of protection. Annu. Rev. Immunol. 18: 975 1026.
35. Iezzi, G.,, K. Karjalainen,, and A. Lanzavecchia. 1998. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8: 89 95.
36. Igietseme, J. U.,, G. A. Ananaba,, J. Bolier,, S. Bowers,, T. Moore,, T. Belay,, F. O. Eko,, D. Lyn,, and C. M. Black. 2000. Suppression of endogenous IL-10 gene expression in dendritic cells enhances antigen presentation for specific Th1 induction: potential for cellular vaccine development. J. Immunol. 164: 4212 4219.
37. Inaba, K.,, M. Inaba,, M. Naito,, and R. M. Steinman. 1993. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette- Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J. Exp. Med. 178: 479 488.
38. Inaba, K.,, J. P. Metlay,, M. T. Crowley,, and R. M. Steinman. 1990. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J. Exp. Med. 172: 631 640.
39. Ingulli, E.,, A. Mondino,, A. Khoruts,, and M. K. Jenkins. 1997. In vivo detection of dendritic cell antigen presentation to CD4(+) T cells. J. Exp. Med. 185: 2133 2141.
40. Ishioka, G. Y.,, A. G. Lamont,, D. Thomson,, N. Bulbow,, F. C. A. Gaeta,, A. Sette,, and H. M. Grey. 1992. MHC interaction and T cell recognition of carbohydrates and glycopeptides. J. Immunol. 148: 2446 2451.
41. Kalka-Moll, W. M.,, A. O Tzianabos,, P. W. Bryant,, M. Niemeyer,, H. L. Ploegh,, and D. L. Kasper. 2002. Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions. J. Immunol. 169: 6149 6153.
42. Kamboj, K.,, H. L. Kirchner,, R. Kimmel,, N. Greenspan,, and J. R. Schreiber. 2003. Significant variation in serotype-specific immunogenicity of the seven valent Streptococcus pneumoniae- CRM 197 conjugate vaccine occurs despite vigorous T cell help induced by the carrier protein. J. Infect. Dis. 187: 1629 1638.
43. Khan, A. Q.,, A. Lees,, and C. M. Snapper. 2003. Differential regulation of IgG anti-capsular polysaccharide and anti-protein responses to intact Streptococcus pneumoniae in the presence of cognate CD4 + T cell help. J. Immunol. 172: 532 539.
44. Khan, A. Q.,, Y. Shen,, Z. Q. Wu,, T. A. Wynn,, and C. M. Snapper. 2002. Endogenous pro- and anti-inflammatory cytokines differentially regulate an in vivo humoral response to Streptococcus pneumoniae. Infect. Immun. 70: 749 761.
45. Kleindienst, P.,, and T. Brocker. 2003. Endogenous dendritic cells are required for amplification of T cell responses induced by dendritic cell vaccines in vivo. J. Immunol. 170: 2817 2823.
46. Koh, C. Y.,, and D. Yuan. 1997. The effect of NK cell activation by tumor cells on antigen-specific antibody responses. J. Immunol. 159: 4745 4752.
47. Kopf, M.,, S. Herren,, M. V. Wiles,, M. B. Pepys,, and M. H. Kosco-Vilbois. 1998. Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component. J. Exp. Med. 188: 1895.
48. Lam, K. P.,, and K. Rajewsky. 1999. B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development. J. Exp. Med. 190: 471 477.
49. Leenen, P. J.,, K. Radosevic,, J. S. Voerman,, B. Salomon,, N. van Rooijen,, D. Klatzmann,, and W. van Ewijk. 1998. Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover. J. Immunol. 160: 2166 2173.
50. Leonard, E. G.,, D. H. Canaday,, C. V. Harding,, and J. R. Schreiber. 2003 Antigen processing of the heptavalent pneumococcal conjugate vaccine carrier protein CRM197 differs depending on the serotype of the attached polysaccharide. Infect. Immun. 71: 4186 4189.
51. Leverkus, M.,, H. Walczak,, A. McLellan,, H. W. Fries,, G. Terbeck,, E. B. Brocker,, and E. Kampgen. 2000. Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis. Blood 96: 2628 2631.
52. Lundqvist, A.,, T. Nagata,, R. Kiessling,, and P. Pisa. 2002. Mature dendritic cells are protected from Fas/CD95-mediated apoptosis by upregulation of Bcl-X(L). Cancer Immunol. Immunother. 51: 139 144.
53. MacLennan, I. C. M.,, and C. G. Vinuesa. 2002. Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses. Immunity 17: 235 238.
54. Martin, F.,, and J. F. Kearney. 2002. Marginal-zone B cells. Nat. Rev. Immunol. 2: 323 335.
55. Martin, F.,, and J. F. Kearney. 2001. B1 cells: similarities and differences with other B cell subsets. Curr. Opin. Immunol. 13: 195 201.
56. Martin, F.,, A. M. Oliver,, and J. F. Kearney. 2001. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 14: 617 629.
57. Mawas, F.,, I. M. Feavers,, and M. J. Corbel. 2000. Serotype of Streptococcus pneumoniae capsular polysaccharide can modify the Th1/Th2 cytokine profile and IgG subclass response to pneumococcal- CRM(197) conjugate vaccines in a murine model. Vaccine 19: 1159 1166.
58. Mbow, M. L.,, N. Zeidner,, N. Panella,, R. G. Titus,, and J. Piesman. 1997. Borrelia burgdorferi-pulsed dendritic cells induce a protective immune response against tick-transmitted spirochetes. Infect. Immun. 65: 3386 3390.
59. Medzhitow, R.,, and C. A. J. Janeway. 1997. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91: 295 298.
60. Melamed, I.,, G. P. Downey,, K. Aktories,, and C. M. Roifman. 1991. Microfilament assembly is required for antigen-receptor-mediated activation of human B lymphocytes. J. Immunol. 147: 1139 1146.
61. Mond, J. J.,, A. Lees,, and C. M. Snapper. 1995. T cell independent antigens type 2. Annu. Rev. Immunol. 13: 655 692.
62. Murphy, K. M.,, and S. L. Reiner. 2002. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2: 933 944.
63. Noelle, R. J.,, M. Roy,, D. M. Shepherd,, I. Stamenkovic,, J. A. Ledbetter,, and A. Aruffo. 1992. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc. Natl. Acad. Sci. USA 89: 6550 6554.
64. Oliver, A. M.,, F. Martin,, and J. F. Kearney. 1999. IgM highCD21high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells. J. Immunol. 162: 7198 7207.
65. Pepys, M. B. 1974. Role of complement in induction of antibody production in vivo. Effect of cobra venom factor and other C3-reactive agents on thymus-dependent and thymus-independent antibody responses. J. Exp. Med. 140: 126 145.
66. Pryjma, J.,, J. H. Humphrey,, and G. G. B. Klaus. 1974. C3 activation and T-independent B cell stimulation. Nature 252: 505 506.
67. Qian, Y.,, C. Santiago,, M. Borrero,, T. F. Tedder,, and S. H. Clarke. 2001. Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds. J. Immunol. 166: 2412 2419.
68. Robbins, J. B.,, and R. Schneerson. 1990. Polysaccharide-protein conjugates: a new generation of vaccines. J. Infect. Dis. 161: 821 832.
69. Satoskar, A.,, L. Stamm,, X. Zhang,, M. Okano,, J. David,, C. Terhorst,, and B. Wang. 1999. NK cell-deficient mice develop a Th1-like response but fail to mount an efficient antigen-specific IgG2a antibody response. J. Immunol. 163: 5298 5302.
70. Schnare, M.,, G. M. Barton,, A. C. Holt,, K. Takeda,, S. Akira,, and R. Medzhitov. 2001. Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2: 947 950.
71. Shaw, P. X.,, S. Horkko,, M. K. Chang,, L. K. Curtiss,, W. Palinski,, G. J. Silverman,, and J. L. Witztum. 2000. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J. Clin. Investig. 105: 1731 1740.
72. Shi, G.-P.,, J. A. Villadangos,, G. Dranoff,, C. Small,, L. Gu,, K. J. Haley,, R. Riese,, H. L. Ploegh,, and H. A. Chapman. 1999. Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity 10: 197 206.
73. Sinha, A. A.,, C. Guidos,, K. C. Lee,, and E. Diener. 1987. Functions of accessory cells in B cell responses to thymus-independent antigens. J. Immunol. 138: 4143 4149.
74. Slack, J.,, G. P. Der-Balian,, M. Nahm,, and J. M. Davie. 1980. Subclass restriction of murine antibodies. II. The IgG plaque-forming cell response to thymus-independent type I and type 2 antigens in normal mice and mice expressing an X-linked immunodeficiency. J. Exp. Med. 151: 853 862.
75. Snapper, C. M.,, Y. Shen,, A. Q. Khan,, J. Colino,, P. Zelazowski,, J. J. Mond,, W. C. Gause,, and Z.-Q. Wu. 2001. Distinct types of T-cell help for the induction of a humoral immune response to Streptococcus pneumoniae. Trends Immunol. 22: 308 311.
76. Snapper, C. M.,, and F. D. Finkelman,. 1997. Immunoglobulin class switching, p. 831 861. In W. E. Paul (ed.), Fundamental Immunology, 4th ed. Raven Press, New York, N.Y.
77. Snapper, C. M.,, and J. J. Mond. 1996. A model for induction of T cell-independent humoral immunity in response to polysaccharide antigens. J. Immunol. 157: 2229 2233.
78. Snapper, C. M.,, H. Yamaguchi,, M. A. Moorman,, and J. J. Mond. 1994. An in vitro model for T cell-independent induction of humoral immunity. A requirement for NK cells. J. Immunol. 152: 4884 4892.
79. Snapper, C. M.,, H. Yamaguchi,, M. A. Moorman,, R. Sneed,, D. Smoot,, and J. J. Mond. 1993. Natural killer cells induce activated murine B cells to secrete Ig. J. Immunol. 151: 5251 5260.
80. Snapper, C. M.,, H. Yamada,, D. Smoot,, R. Sneed,, A. Lees,, and J. J. Mond. 1993. Comparative in vitro analysis of proliferation, Ig secretion, and Ig class switching by murine marginal zone and follicular B cells. J. Immunol. 150: 2737 2745.
81. Snapper, C. M.,, and W. E. Paul. 1987. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236: 944 947.
82. Su, H.,, R. Messer,, W. Whitmire,, E. Fischer,, J. C. Portis,, and H. D. Caldwell. 1998. Vaccination against chlamydial genital tract infection after immunization with dendritic cells pulsed ex vivo with nonviable Chlamydiae. J. Exp. Med. 188: 809 818.
83. Svensson, M.,, B. Stockinger,, and M. J. Wick. 1997. Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells. J. Immunol. 158: 4229 4236.
84. Takeda, K.,, T. Kaisho,, and S. Akira. 2003. Toll-like receptors. Annu. Rev. Immunol. 21: 335 376.
85. Taniguchi, M.,, M. Harada,, S. Kojo,, T. Nakayama,, and H. Wakao. 2003. The regulatory role of Vα14 NKT cells in innate and acquired immune response. Annu. Rev. Immunol. 21: 483 513.
86. Vinay, D. S.,, and B. S. Kwon. 1998. Role of 4-1BB in immune responses. Semin. Immunol. 10: 481 489.
87. Vos, Q.,, C. M. Snapper,, and J. J. Mond. 1999. Heterogeneity in the ability of cytotoxic murine NK cell clones to enhance Ig secretion in vitro. Int. Immunol. 11: 159 168.
88. Watts, T. H.,, and M. A. DeBenedette. 1999. T cell costimulatory molecules other than CD28. Curr. Opin. Immunol. 11: 286 293.
89. Wilder, J. A.,, C. Y. Koh,, and D. Yuan. 1996. The role of NK cells during in vivo antigen-specific antibody responses. J. Immunol. 156: 146 152.
90. Wu, Z. Q.,, A. Q. Khan,, Y. Shen,, K. M. Wolcott,, W. Dawicki,, T. H. Watts,, R. S. Mittler,, and C. M. Snapper. 2003. 4-1BB (CD137) differentially regulates murine in vivo protein- and polysaccharide-specific immunoglobulin isotype responses to Streptococcus pneumoniae. Infect. Immun. 71: 196 204.
91. Wu, Z. Q.,, Y. Shen,, A. Q. Khan,, C. L. Chu,, R. Riese,, H. A. Chapman,, O. Kanagawa,, and C. M. Snapper. 2002. The mechanism underlying T cell help for induction of an antigen-specific in vivo humoral immune response to intact Streptococcus pneumoniae is dependent on the type of antigen. J. Immunol. 168: 5551 5557.
92. Wu, Z. Q.,, A. Q. Khan,, Y. Shen,, J. Schartman,, R. Peach,, A. Lees,, J. J. Mond,, W. C. Gause,, and C. M. Snapper. 2000. B7 requirements for primary and secondary protein- and polysaccharide-specific Ig isotype responses to Streptococcus pneumoniae. J. Immunol. 165: 6840 6848.
93. Wu, Z.-Q.,, Q. Vos,, Y. Shen,, A. Lees,, S. R. Wilson,, D. E. Briles,, W. C. Gause,, J. J. Mond,, and C. M. Snapper. 1999. In vivo polysaccharide-specific IgG isotype responses to intact Streptococcus pneumoniae are T cell dependent and require CD40- and B7-ligand interactions. J. Immunol. 163: 659 667.
94. Wykes, M.,, A. Pombo,, C. Jenkins,, and G. G. MacPherson. 1998. Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response. J. Immunol. 161: 1313 1319.
95. Yuan, D.,, J. Wilder,, T. Dang,, M. Bennett,, and V. Kumar. 1992. Activation of B lymphocytes by NK cells. Int. Immunol. 4: 1373 1380.


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Regulation of antiprotein and antipolysaccharide responses

Citation: Snapper W, Colino J, Khan A, Wu Z. 2004. The Humoral Immune Response to , p 367-381. In Tuomanen E, Mitchell T, Morrison D, Spratt B (ed), The Pneumococcus. ASM Press, Washington, DC. doi: 10.1128/9781555816537.ch23

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