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Chapter 17 : Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function
Authors:
Charles N. Serhan1,
Julio Aliberti2
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Affiliations:
1: Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115;
2: Divisions of Molecular Immunology and Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229
Content Type: Monograph
Publication Year:
2009
Category: Microbial Genetics and Molecular Biology; Bacterial Pathogenesis
Book DOI:
10.1128/9781555816650
Chapter DOI:
10.1128/9781555816650.ch17
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Abstract:
Several novel enzymatic pathways were recently identified that are activated during the resolution phase and initiated from precursors eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The protectin family name signifies their formation, potent anti-inflammatory, as well as protective actions demonstrated for the novel and potent DHA-derived 10,17-docasatriene in animal models of stroke and Alzheimer’s disease. Both families, the resolvins and protectins, are potent local-acting agonists of endogenous anti-inflammation and promote resolution-specific processes. The connection(s) of these new lipid mediators to the control of an acute inflammation and its timely resolution are illustrated in this chapter. The chapter focuses on biosynthesis of proresolving mediators via cyclooxygenases and lipoxygenases. COX-2 also plays a key role in the biosynthesis of PGD2, which is a precursor to the cyclopentenones. Precursors are transformed via enzymatic mechanisms to bioactive compounds such as lipoxins, resolvins, and protectins that regulate the duration and magnitude of inflammation. The most likely human cell types and pathways that biosynthesize the bioactive mediators within the resolving exudates were reconstructed in vitro, which involved cell-cell interactions in vivo within the exudates. Emerging evidence indicates that the immunomodulatory actions of several lipid mediators are exploited by pathogens, including fungi and helminths. In such cases, it seems that modulation of immunity by suppressing host proinflammatory responses is the aim. The interplay between these mediators, the induction of 5-LO, and the control of immune responses in vivo await further investigation.
Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17
Key Concept Ranking
- Omega-3 Fatty Acids
- 0.5817793
- Liquid Chromatography-Tandem Mass Spectrometry
- 0.4718558
- Gastrointestinal Diseases
- 0.44929397
- Cardiovascular Diseases
- 0.4473791
- Chemicals
- 0.44622576
- Fatty Acids
- 0.42615488
0.5817793
Figures
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function
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Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17
/content/10.1128/9781555816650.ch17.ch17fig01
FIGURE 1
Lipid mediators during the initiation and resolution of acute inflammation.
10.1128/9781555816650/f0268-01_thmb.gif
10.1128/9781555816650/f0268-01.gif
FIGURE 1
Lipid mediators during the initiation and resolution of acute inflammation.
Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17
/content/10.1128/9781555816650.ch17.ch17fig02
FIGURE 2
Eicosanoids and their proinflammatory and proresolution actions.
10.1128/9781555816650/f0270-01_thmb.gif
10.1128/9781555816650/f0270-01.gif
FIGURE 2
Eicosanoids and their proinflammatory and proresolution actions.
Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17
/content/10.1128/9781555816650.ch17.ch17fig03
FIGURE 3
Biosynthesis of E-series resolvins.
10.1128/9781555816650/f0273-01_thmb.gif
10.1128/9781555816650/f0273-01.gif
FIGURE 3
Biosynthesis of E-series resolvins.
Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17
/content/10.1128/9781555816650.ch17.ch17fig04
FIGURE 4
Biosynthesis of D-series resolvins.
10.1128/9781555816650/f0274-01_thmb.gif
10.1128/9781555816650/f0274-01.gif
FIGURE 4
Biosynthesis of D-series resolvins.
Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17
/content/10.1128/9781555816650.ch17.ch17fig05
FIGURE 5
Protectin D1/neuro-protectin D1 biosynthesis and related dihydroxydocosatrienes.
10.1128/9781555816650/f0275-01_thmb.gif
10.1128/9781555816650/f0275-01.gif
FIGURE 5
Protectin D1/neuro-protectin D1 biosynthesis and related dihydroxydocosatrienes.
Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17
/content/10.1128/9781555816650.ch17.ch17fig06
FIGURE 6
Leukocyte- and pathogen-mediated synthesis of lipoxins.
10.1128/9781555816650/f0276-01_thmb.gif
10.1128/9781555816650/f0276-01.gif
FIGURE 6
Leukocyte- and pathogen-mediated synthesis of lipoxins.
Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17
References
/content/book/10.1128/9781555816650.ch17
1.
Aliberti, J.,, S. Hieny,, C. Reis e Sousa,, C. N. Serhan, and, A. Sher. 2002a. Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. Nat. Immunol. 3: 76– 82.
2.
Aliberti, J.,, C. Serhan, and, A. Sher. 2002b. Parasite-induced lipoxin A(4) is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection. J. Exp. Med. 196: 1253– 1262.
3.
Ariel, A.,, G. Fredman,, Y.-P. Sun,, A. Kantarci,, T. E. Van Dyke,, A. D. Luster, and, C. N. Serhan. 2006. Apoptotic neutrophils and T cells sequester chemokines during immune response resolution via modulation of CCR5 expression. Nat. Immunol. 7: 1209– 1216.
4.
Ariel, A.,, P.-L. Li,, W. Wang,, W.-X. Tang,, G. Fredman,, S. Hong,, K. H. Gotlinger, and, C. N. Serhan. 2005. The docosatriene protectin D1 is produced by T H2 skewing and promotes human T cell apoptosis via lipid raft clustering. J. Biol. Chem. 280: 43079– 43086.
5.
Arita, M.,, F. Bianchini,, J. Aliberti,, A. Sher,, N. Chiang,, S. Hong,, R. Yang,, N. A. Petasis, and, C. N. Serhan. 2005a. Stereochemical assignment, anti-inflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J. Exp. Med. 201: 713– 722.
6.
Arita, M.,, T. Ohira,, Y. P. Sun,, S. Elangovan,, N. Chiang, and, C. N. Serhan. 2007. Resolvin E1 selectively interacts with leukotriene B 4 receptor BLT1 and ChemR23 to regulate inflammation. J. Immunol. 178: 3912– 3917.
7.
Arita, M.,, M. Yoshida,, S. Hong,, E. Tjonahen,, J. N. Glickman,, N. A. Petasis,, R. S. Blumberg, and, C. N. Serhan. 2005b. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc. Natl. Acad. Sci. USA 102: 7671– 7676.
8.
Bafica, A.,, C. A. Scanga,, C. Serhan,, F. Machado,, S. White,, A. Sher, and, J. Aliberti. 2005. Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production. J. Clin. Invest. 115: 1601– 1606.
9.
Bandeira-Melo, C.,, M. F. Serra,, B. L. Diaz,, R. S. B. Cordeiro,, P. M. R. Silva,, H. L. Lenzi,, Y. S. Bakhle,, C. N. Serhan, and, M. A. Martins. 2000. Cyclooxygenase-2-derived prostaglandin E 2 and lipoxin A 4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. J. Immunol. 164: 1029– 1036.
10.
Bannenberg, G. L.,, J. Aliberti,, S. Hong,, A. Sher, and, C. N. Serhan. 2004. Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A 4 biosynthesis. J. Exp. Med. 199: 515– 523.
11.
Bannenberg, G. L.,, N. Chiang,, A. Ariel,, M. Arita,, E. Tjonahen,, K. H. Gotlinger,, S. Hong, and, C. N. Serhan. 2005. Molecular circuits of resolution: formation and actions of resolvins and protectins. J. Immunol. 174: 4345– 4355.
12.
Bazan, N. G. 2006. Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerations. Adv. Exp. Med. Biol. 572: 531– 540.
13.
Bonnans, C.,, B. Mainprice,, P. Chanez,, J. Bousquet, and, V. Urbach. 2003. Lipoxin A4 stimulates a cytosolic Ca2+ increase in human bronchial epithelium. J. Biol. Chem. 278: 10879– 10884.
14.
Brezinski, D. A.,, R. W. Nesto, and, C. N. Serhan. 1992. Angioplasty triggers intracoronary leukotrienes and lipoxin A 4. Impact of aspirin therapy. Circulation 86: 56– 63.
15.
Burr, G. O.,, and M. M. Burr. 1929. A new deficiency disease produced by the rigid exclusion of fat from the diet. J. Biol. Chem. 82: 345– 367.
16.
Calder, P. C. 2006a. Long-chain polyunsaturated fatty acids and inflammation. Scand. J. Food Nutr. 50( S2) : 54– 61.
17.
Calder, P. C. 2006b. n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am. J. Clin. Nutr. 83( Suppl.) : 1505S– 1519S.
18.
Chan, J.,, and J. Flynn. 2004. The immunological aspects of latency in tuberculosis. Clin. Immunol. 110: 2– 12.
19.
Chiang, N.,, C. N. Serhan,, S.-E. Dahlén,, J. M. Drazen,, D. W. P. Hay,, G. E. Rovati,, T. Shimizu,, T. Yokomizo, and, C. Brink. 2006. The lipoxin receptor ALX: potent ligandspecific and stereoselective actions in vivo. Pharmacol. Rev. 58: 463– 487.
20.
Colgan, S. P.,, C. N. Serhan,, C. A. Parkos,, C. Delp-Archer, and, J. L. Madara. 1993. Lipoxin A 4 modulates transmigration of human neutrophils across intestinal epithelial mono-layers. J. Clin. Investig. 92: 75- 82.
21.
Connor, K. M.,, J. P. SanGiovanni,, C. Lofqvist,, C. M. Aderman,, J. Chen,, A. Higuchi,, S. Hong,, E. A. Pravda,, S. Majchrzak,, D. Carper,, A. Hellstrom,, J. X. Kang,, E. Y. Chew,, N. N. Salem, Jr.,, C. N. Serhan, and, L. E. H. Smith. 2007. Increased dietary intake of omega-3 PUFA reduces pathological retinal angiogenesis. Nat. Med. 13: 868– 873.
22.
Cotran, R. S.,, V. Kumar, and, T. Collins (ed.). 1999. Robbins Pathologic Basis of Disease, 6th ed. W.B. Saunders Co., Philadelphia, PA.
23.
Devchand, P. R.,, M. Arita,, S. Hong,, G. Bannenberg,, R.-L. Moussignac,, K. Gronert, and, C. N. Serhan. 2003. Human ALX receptor regulates neutrophil recruitment in transgenic mice: roles in inflammation and host-defense. FASEB J. 17: 652– 659.
24.
Duffield, J. S.,, S. Hong,, V. Vaidya,, Y. Lu,, G. Fredman,, C. N. Serhan, and, J. V. Bonventre. 2006. Resolvin D series and protectin D1 mitigate acute kidney injury. J. Immunol. 177: 5902– 5911.
25.
Fiorucci, S.,, J. L. Wallace,, A. Mencarelli,, E. Distrutti,, G. Rizzo,, S. Farneti,, A. Morelli,, J.-L. Tseng,, B. Suramanyam,, W. J. Guilford, and, J. F. Parkinson. 2004. A beta-oxidation-resistant lipoxin A 4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction. Proc. Natl. Acad. Sci. USA 101: 15736– 15741.
26.
Flynn, J. L.,, and J. Chan. 2003. Immune evasion by Mycobacterium tuberculosis: living with the enemy. Curr. Opin. Immunol. 15: 450– 455.
27.
Freire-de-Lima, C. G.,, Y. Q. Xiao,, S. J. Gardai,, D. L. Bratton,, W. P. Schiemann, and, P. M. Henson. 2006. Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages. J. Biol. Chem. 281: 38376– 38384.
28.
Gewirtz, A. T.,, B. McCormick,, A. S. Neish,, N. A. Petasis,, K. Gronert,, C. N. Serhan, and, J. L. Madara. 1998. Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A 4 analogs. J. Clin. Investig. 101: 1860– 1869.
29.
Gilroy, D. W.,, P. R. Colville-Nash,, D. Willis,, J. Chivers,, M. J. Paul-Clark, and, D. A. Willoughby. 1999. Inducible cyclooxygenase may have anti-inflammatory properties. Nat. Med. 5: 698– 701.
30.
Gilroy, D. W.,, T. Lawrence,, M. Perretti, and, A. G. Rossi. 2004. Inflammatory resolution: new opportunities for drug discovery. Nat. Rev. Drug Discov. 3: 401– 416.
31.
Gilroy, D. W.,, and M. Perretti. 2005. Aspirin and steroids: new mechanistic findings and avenues for drug discovery. Curr. Op. Pharmacol. 5: 405– 411.
32.
GISSI-Prevenzione Investigators. 1999. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto miocardico. Lancet 354: 447– 455.
33.
Godson, C.,, S. Mitchell,, K. Harvey,, N. A. Petasis,, N. Hogg, and, H. R. Brady. 2000. Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages. J. Immunol. 164: 1663– 1667.
34.
González-Périz, A.,, A. Planagumà,, K. Gronert,, R. Miquel,, M. López-Parra,, E. Titos,, R. Horrillo,, N. Ferré,, R. Deulofeu,, V. Arroyo,, J. Rodés, and, J. Clària. 2006. Docosahexanenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17 S-hydroxyDHA. FASEB J. 20: 2537– 2539.
35.
Gronert, K.,, A. Gewirtz,, J. L. Madara, and, C. N. Serhan. 1998. Identification of a human enterocyte lipoxin A 4 receptor that is regulated by IL-13 and IFN-γ and inhibits TNF-α-induced IL-8 release. J. Exp. Med. 187: 1285– 1294.
36.
Gronert, K.,, N. Maheshwari,, N. Khan,, I. R. Hassan,, M. Dunn, and, M. L. Schwartzman. 2005. A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. J. Biol. Chem. 280: 15267– 15278.
37.
Guilford, W. J., and J. F. Parkinson. 2005. Second-generation beta-oxidation resistant 3-oxa-lipoxin A 4 analogs. Prostaglandins Leukot. Essent. Fatty Acids 73: 245– 250.
38.
Hachicha, M.,, M. Pouliot,, N. A. Petasis, and, C. N. Serhan. 1999. Lipoxin (LX)A 4 and aspirin-triggered 15-epi-LXA 4 inhibit tumor necrosis factor 1α-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis. J. Exp. Med. 189: 1923– 1929.
39.
Hamazaki, K.,, M. Itomura,, S. Sawazaki, and, T. Hamazaki. 2006. Fish oil reduces tooth loss mainly through its anti-inflammatory effects? Med. Hypotheses 67: 868– 870.
40.
Harris, W. S.,, K. J. Reid,, S. A. Sands, and, J. A. Spertus. 2007. Blood omega-3 and trans fatty acids in middle-aged acute coronary syndrome patients. Am. J. Cardiol. 99: 154– 158.
41.
Hashimoto, A.,, Y. Murakami,, H. Kitasato,, I. Hayashi, and, H. Endo. 2007. Glucocorticoids co-interact with lipoxin A 4 via lipoxin A 4 receptor (ALX) up-regulation. Biomed. Pharmacother. 61: 81– 85.
42.
Hasturk, H.,, A. Kantarci,, T. Ohira,, M. Arita,, N. Ebrahimi,, N. Chiang,, N. A. Petasis,, B. D. Levy,, C. N. Serhan, and, T. E. Van Dyke. 2006. RvE1 protects from local inflammation and osteoclast mediated bone destruction in periodontitis. FASEB J. 20: 401– 403.
43.
Hong, S.,, K. Gronert,, P. Devchand,, R.-L. Moussignac, and, C. N. Serhan. 2003. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood and glial cells: autacoids in anti-inflammation. J. Biol. Chem. 278: 14677– 14687.
44.
Hudert, C. A.,, K. H. Weylandt,, J. Wang,, Y. Lu,, S. Hong,, A. Dignass,, C. N. Serhan, and, J. X. Kang. 2006. Transgenic mice rich in endogenous n-3 fatty acids are protected from colitis. Proc. Natl. Acad. Sci. USA 103: 11276– 11281.
45.
Jain, A.,, E. L. Batista, Jr.,, C. Serhan,, G. L. Stahl, and, T. E. Van Dyke. 2003. Role for periodontitis in the progression of lipid deposition in an animal model. Infect. Immun. 71: 6012– 6018.
46.
James, M. J.,, S. M. Proudman, and, L. G. Cleland. 2003. Dietary n-3 fats as adjunctive therapy in a prototypic inflammatory disease: issues and obstacles for use in rheumatoid arthritis. Prostaglandins Leukot. Essent. Fatty Acids 68: 399– 405.
47.
Karp, C. L.,, L. M. Flick,, K. W. Park,, S. Softic,, T. M. Greer,, R. Keledjian,, R. Yang,, J. Uddin,, W. B. Guggino,, S. F. Atabani,, Y. Belkaid,, Y. Xu,, J. A. Whitsett,, F. J. Accurso,, M. Wills-Karp, and, N. A. Petasis. 2004. Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway. Nat. Immunol. 5: 388– 392.
48.
Kasuga, K.,, T. Porter, and, C. N. Serhan. 2007. Novel mechanisms in resolution: rapid appearance of EPA and DHA in murine exudates for resolvins and protectins (abstract). 6th Biennial Arthritis Research Conference, Stone Mountain, GA, 20 to 22 April 2007.
49.
Kieran, N. E.,, P. P. Doran,, S. B. Connolly,, M.-C. Greenan,, D. F. Higgins,, M. Leonard,, C. Godson,, C. T. Taylor,, A. Henger,, M. Kretzler,, M. J. Burne,, H. Rabb, and, H. R. Brady. 2003. Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog. Kidney Int. 64: 480– 492.
50.
Kieran, N. E.,, P. Maderna, and, C. Godson. 2004. Lipoxins: potential anti-inflammatory, proresolution, and antifibrotic mediators in renal disease. Kidney Int. 65: 1145– 1154.
51.
Lee, T. H.,, C. E. Horton,, U. Kyan-Aung,, D. Haskard,, A. E. Crea, and, B. W. Spur. 1989. Lipoxin A 4 and lipoxin B 4 inhibit chemotactic responses of human neutrophils stimulated by leukotriene B 4 and N-formyl-L-methionyl-L-leucylL-phenylalanine. Clin. Sci. 77: 195– 203.
52.
Levy, B. D.,, C. B. Clish,, B. Schmidt,, K. Gronert, and, C. N. Serhan. 2001. Lipid mediator class switching during acute inflammation: signals in resolution. Nat. Immunol. 2: 612– 619.
53.
Levy, B. D.,, G. T. De Sanctis,, P. R. Devchand,, E. Kim,, K. Ackerman,, B. Schmidt,, W. Szczeklik,, J. M. Drazen, and, C. N. Serhan. 2003. Lipoxins and aspirin-triggered lipoxins in airway responses. Adv. Exp. Med. Biol. 525: 19– 23.
54.
Levy, B. D.,, G. T. De Sanctis,, P. R. Devchand,, E. Kim,, K. Ackerman,, B. A. Schmidt,, W. Szczeklik,, J. M. Drazen, and, C. N. Serhan. 2002. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A 4. Nat. Med. 8: 1018– 1023.
55.
Levy, B. D.,, P. Kohli,, K. Gotlinger,, O. Haworth,, S. Hong,, S. Kazani,, E. Israel,, K. J. Haley, and, C. N. Serhan. 2007. Protectin D1 is generated in asthma and dampens airway inflammation and hyper-responsiveness. J. Immunol. 178: 496– 502.
56.
Libby, P. 2002. Atherosclerosis: the new view. Sci. Am. 286: 46– 55.
57.
Lukiw, W. J.,, J. G. Cui,, V. L. Marcheselli,, M. Bodker,, A. Botkjaer,, K. Gotlinger,, C. N. Serhan, and, N. G. Bazan. 2005. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J. Clin. Investig. 115: 2774– 2783.
58.
Maddox, J. F.,, M. Hachicha,, T. Takano,, N. A. Petasis,, V. V. Fokin, and, C. N. Serhan. 1997. Lipoxin A 4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein linked lipoxin A 4 receptor. J. Biol. Chem. 272: 6972– 6978.
59.
Maddox, J. F.,, and C. N. Serhan. 1996. Lipoxin A 4 and B 4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction. J. Exp. Med. 183: 137– 146.
60.
Majno, G.,, and I. Joris. 2004. Cells, Tissues, and Disease: Principles of General Pathology, 2nd ed. Oxford University Press, New York, NY.
61.
Mangino, M. J.,, L. Brounts,, B. Harms, and, C. Heise. 2006. Lipoxin biosynthesis in inflammatory bowel disease. Prostaglandins Other Lipid Mediat. 79: 84– 92.
62.
Marcheselli, V. L.,, S. Hong,, W. J. Lukiw,, X. Hua Tian,, K. Gronert,, A. Musto,, M. Hardy,, J. M. Gimenez,, N. Chiang,, C. N. Serhan, and, N. G. Bazan. 2003. Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J. Biol. Chem. 278: 43807– 43817.
63.
Marchioli, R.,, F. Barzi,, E. Bomba,, C. Chieffo,, D. Di Gregorio,, R. Di Mascio,, M. G. Franzosi,, E. Geraci,, G. Levantesi,, A. P. Maggioni,, L. Mantini,, R. M. Marfisi,, G. Mastrogiuseppe,, N. Mininni,, G. L. Nicolosi,, M. Santini,, C. Schweiger,, L. Tavazzi,, G. Tognoni,, C. Tucci, and, F. Valagussa. 2002. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione. Circulation 105: 1897– 1903.
64.
Menezes-de-Lima, O., Jr.,, C. A. Kassuya,, A. F. Nascimento,, M. G. Henriques, and, J. B. Calixto. 2006. Lipoxin A 4 inhibits edema in mice: implications for the anti-edematogenic mechanism induced by aspirin. Prostaglandins Other Lipid Mediat. 80: 123– 135.
65.
Mitchell, S.,, G. Thomas,, K. Harvey,, D. Cottell,, K. Reville,, G. Berlasconi,, N. A. Petasis,, L. Erwig,, A. J. Rees,, J. Savill,, H. R. Brady, and, C. Godson. 2002. Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo. J. Am. Soc. Nephrol. 13: 2497– 2507.
66.
Morris, T.,, R. Rajakariar,, M. Stables, and, D. W. Gilroy. 2006. Not all eicosanoids are bad. Trends Pharmacol. Sci. 27: 609– 611.
67.
Mukherjee, P. K.,, V. L. Marcheselli,, C. N. Serhan, and, N. G. Bazan. 2004. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc. Natl. Acad. Sci. USA 101: 8491– 8496.
68.
Munger, K. A.,, A. Montero,, M. Fukunaga,, S. Uda,, T. Yura,, E. Imai,, Y. Kaneda,, J. M. Valdivielso, and, K. F. Badr. 1999. Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis. Proc. Natl. Acad. Sci. USA 96: 13375– 13380.
69.
Parkinson, J. F. 2006. Lipoxin and synthetic lipoxin analogs: an overview of anti-inflammatory functions and new concepts in immunomodulation. Inflamm. Allergy Drug Targets 5: 91– 106.
70.
Pouliot, M.,, C. B. Clish,, N. A. Petasis,, T. E. Van Dyke, and, C. N. Serhan. 2000. Lipoxin A 4 analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. Biochemistry 39: 4761– 4768.
71.
Rajakariar, R.,, M. M. Yaqoob, and, D. W. Gilroy. 2006. COX-2 in inflammation and resolution. Mol. Interv. 6: 199– 207.
72.
Rossi, A. G.,, and D. A. Sawatzky (ed.). 2008. The Resolution of Inflammation. Birkhäuser Verlag AG, Basel, Switzerland.
73.
Samuelsson, B.,, S. E. Dahlen,, J. A. Lindgren,, C. A. Rouzer, and, C. N. Serhan. 1987. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 237: 1171– 1176.
74.
Serhan, C. N. 1989. On the relationship between leukotriene and lipoxin production by human neutrophils: evidence for differential metabolism of 15-HETE and 5-HETE. Biochim. Biophys. Acta 1004: 158– 168.
75.
Serhan, C. N. 2005a. Mediator lipidomics. Prostaglandins Other Lipid Mediat. 77: 4– 14.
76.
Serhan, C. N. (Guest Ed.). 2005b. Special Issue on Lipoxins and Aspirin-Triggered Lipoxins. Prostaglandins Leukot. Essent. Fatty Acids 73( 3-4) : 139– 321.
77.
Serhan, C. N. 2007. Resolution phases of inflammation: novel endogenous anti-inflammatory and pro-resolving lipid mediators and pathways. Annu. Rev. Immunol. 25: 101– 137.
78.
Serhan, C. N.,, S. D. Brain,, C. D. Buckley,, D. W. Gilroy,, C. Haslett,, L. A. J. O’Neill,, M. Perretti,, A. G. Rossi, and, J. L. Wallace. 2007. Resolution of inflammation: state of the art, definitions and terms. FASEB J. 21: 325– 332.
79.
Serhan, C. N.,, C. B. Clish,, J. Brannon,, S. P. Colgan,, N. Chiang, and, K. Gronert. 2000. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J. Exp. Med. 192: 1197– 1204.
80.
Serhan, C. N.,, I. M. Fierro,, N. Chiang, and, M. Pouliot. 2001. Nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A 4. J. Immunol. 166: 3650– 3654.
81.
Serhan, C. N.,, K. Gotlinger,, S. Hong,, Y. Lu,, J. Siegelman,, T. Baer,, R. Yang,, S. P. Colgan, and, N. A. Petasis. 2006. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. J. Immunol. 176: 1848– 1859.
82.
Serhan, C. N.,, S. Hong,, K. Gronert,, S. P. Colgan,, P. R. Devchand,, G. Mirick, and, R.-L. Moussignac. 2002. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter pro-inflammation signals. J. Exp. Med. 196: 1025– 1037.
83.
Serhan, C. N.,, A. Jain,, S. Marleau,, C. Clish,, A. Kantarci,, B. Behbehani,, S. P. Colgan,, G. L. Stahl,, A. Merched,, N. A. Petasis,, L. Chan, and, T. E. Van Dyke. 2003. Reduced inflammation and tissue damage in transgenic rabbits overex-pressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J. Immunol. 171: 6856– 6865.
84.
Serhan, C. N.,, J. F. Maddox,, N. A. Petasis,, I. Akritopoulou-Zanze,, A. Papayianni,, H. R. Brady,, S. P. Colgan, and, J. L. Madara. 1995. Design of lipoxin A 4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry 34: 14609– 14615.
85.
Serhan, C. N.,, and J. Savill. 2005. Resolution of inflammation: the beginning programs the end. Nat. Immunol. 6: 1191– 1197.
86.
Shen, J.,, E. Herderick,, J. F. Cornhill,, E. Zsigmond,, H.-S. Kim,, H. Kühn,, N. V. Guevara, and, L. Chan. 1996. Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development. J. Clin. Investig. 98: 2201– 2208.
87.
Sun, Y.-P.,, S. F. Oh,, J. Uddin,, R. Yang,, K. Gotlinger,, E. Campbell,, S. P. Colgan,, N. A. Petasis, and, C. N. Serhan. 2007. Resolvin D1 and its aspirin-triggered 17 R epimer: stereochemical assignments, anti-inflammatory properties and enzymatic inactivation. J. Biol. Chem. 282: 9323– 9334.
88.
Svensson, C. I.,, M. Zattoni, and, C. N. Serhan. 2007. Lipoxins and aspirin-triggered lipoxin stop inflammatory pain processing. J. Exp. Med. 204: 245– 252.
89.
Takano, T.,, C. B. Clish,, K. Gronert,, N. Petasis, and, C. N. Serhan. 1998. Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A 4 and novel lipoxin B 4 stable analogues. J. Clin. Investig. 101: 819– 826.
90.
Takano, T.,, S. Fiore,, J. F. Maddox,, H. R. Brady,, N. A. Petasis, and, C. N. Serhan. 1997. Aspirin-triggered 15-epilipoxin A 4 and LXA 4 stable analogs are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J. Exp. Med. 185: 1693– 1704.
91.
Thomas, E.,, J. L. Leroux,, F. Blotman, and, C. Chavis. 1995. Conversion of endogenous arachidonic acid to 5,15-diHETE and lipoxins by polymorphonuclear cells from patients with rheumatoid arthritis. Inflamm. Res. 44: 121– 124.
92.
Tjonahen, E.,, S. F. Oh,, J. Siegelman,, S. Elangovan,, K. B. Percarpio,, S. Hong,, M. Arita, and, C. N. Serhan. 2006. Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. Chem. Biol. 13: 1193– 1202.
93.
Vance, R. E.,, S. Hong,, K. Gronert,, C. N. Serhan, and, J. J. Mekalanos. 2004. The opportunistic pathogen Pseudomonas aeruginosa carries a novel secretable arachidonate 15-lipoxygenase. Proc. Natl. Acad. Sci. USA 101: 2135– 2139.
94.
Van Dyke, T. E.,, and C. N. Serhan. 2006. A novel approach to resolving inflammation. Sci. Am. Oral and Whole Body Health 42– 45.
95.
Wada, K.,, M. Arita,, A. Nakajima,, K. Katayama,, C. Kudo,, Y. Kamisaki, and, C. N. Serhan. 2006. Leukotriene B 4 and lipoxin A 4 are regulatory signals for neural stem cell proliferation and differentiation. FASEB J. 20: 1785– 1792.
96.
Wallace, J. L.,, and S. Fiorucci. 2003. A magic bullet for mucosal protection, and aspirin is the trigger! Trends Pharmacol. Sci. 24: 323– 326.
97.
Ward, C.,, I. Dransfield,, E. R. Chilvers,, C. Haslett, and, A. G. Rossi. 1999. Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets. Trends Pharmacol. Sci. 20: 503– 509.
Tables
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function
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Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17
/content/10.1128/9781555816650.ch17.ch17tab01
TABLE 1
Lipoxins reduce inflammation and promote resolution
TABLE 1
Lipoxins reduce inflammation and promote resolution
Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17
/content/10.1128/9781555816650.ch17.ch17tab02
TABLE 2
Lipoxin deficiencies in human disease and proresolving actions after lipoxin analog treatment in animal disease models
TABLE 2
Lipoxin deficiencies in human disease and proresolving actions after lipoxin analog treatment in animal disease models
Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17
/content/10.1128/9781555816650.ch17.ch17tab03
TABLE 3
Resolvins in models of human diseases
TABLE 3
Resolvins in models of human diseases
Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17
/content/10.1128/9781555816650.ch17.ch17tab04
TABLE 4
Protectins in models of human diseases
TABLE 4
Protectins in models of human diseases
Citation:
Serhan C, Aliberti J.
2009.
Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function,
p 267-280.
In
Russell D, Gordon S (ed),
Phagocyte-Pathogen Interactions.
ASM Press, Washington, DC.
doi: 10.1128/9781555816650.ch17