Chapter 71 : Susceptibility Test Methods: Fastidious Bacteria

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Most fastidious bacteria do not grow satisfactorily in standard in vitro susceptibility test systems that use unsupple-mented media. Clinical and Laboratory Standards Institute (CLSI) has also published an approved guideline for testing infrequently isolated or fastidious bacteria including spp., spp., spp., spp., spp. (not ), , spp., , the HACEK group, spp., spp., , , spp., spp., and spp. In addition to conventional MIC test methods (e.g., agar dilution or broth dilution methods), the Etest MIC determination method has been used to test many types of fastidious bacteria. The limitations of this method include its cost and lack of clearance by the U.S. Food and Drug Administration (FDA) for testing many less commonly encountered fastidious bacteria. This chapter summarizes the standard methods recommended by CLSI for antimicrobial susceptibility testing of spp. (including ), , , and . Methods for testing the infrequently isolated or fastidious bacteria included in the CLSI M45 guideline are summarized to include testing potential agents of bioterrorism. The incidence of resistance, test methods, and indications for testing and the reporting of results are provided.

Citation: Hindler J, Jorgensen J. 2011. Susceptibility Test Methods: Fastidious Bacteria , p 1180-1203. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch71
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