Chapter 93 : Arboviruses

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Important antigenic determinants have been elucidated for the most important arboviruses, and virus- and group-specific monoclonal antibodies are available for taxonomic and diagnostic purposes. Serologic cross-relationships are most evident in hemagglutination inhibition and binding assays, e.g., enzyme-linked immunosorbent assay (ELISA) and immunofluorescent antibody tests, and occur to a lesser extent in complement fixation tests. The epidemiologic and clinical characteristics of the medically important arboviruses are summarized in this chapter. Immunoglobulin M capture ELISAs for arboviral central nervous system infections transmitted in the United States are offered by several reference and some state public health laboratories. A number of nucleic acid amplification strategies have been developed for the detection and identification of medically important arboviruses, including standard RT-PCR (with agarose gel analysis), real-time RT-PCR using fluorescent probes, nucleic acid sequence-based amplification (NASBA), and the recently developed reverse transcription-loop-mediated isothermal amplification (LAMP) method. Novel arboviruses continue to be discovered, usually as orphan viruses first identified in vector surveys but, remarkably, also from human clinical specimens. The majority of arboviruses are lethal to suckling (2 to 3-day-old) mice, which exhibit signs of illness, paralysis, and death within days to 2 weeks after intracerebral inoculation. While identification of arboviral isolates previously depended upon their antigenic characterization, PCR and other molecular tests are now available for many of the medically important arboviruses.

Citation: Lanciotti R, Tsai T. 2011. Arboviruses , p 1488-1503. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch93
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1. Balachandra, K.,, K. Chimabutra,, P. Supromajakr,, C. Wasi,, T. Yamamoto,, T. Mukai,, T. Okuno,, and K. Yamanishi. 1994. High rate of reactivation of human herpesvirus 6 in children with dengue hemorrhagic fever. J. Infect. Dis. 170: 746 748.
2. Beaty, B. J.,, C. H. Calisher,, and R. E. Shope,. 1995. Arboviruses, p. 189 212. In E. H. Lennette,, P. A. Lennette,, and E. T. Lennette (ed.), Diagnostic Procedures for Viral, Rickettsial, and Chlamydial Infections, 7th ed. American Public Health Association, Washington, DC.
3. Blacksell, S. D.,, P. N. Newton,, D. Bell,, J. Kelley,, M. P. Mammen, Jr.,, D. W. Vaughn,, V. Wuthiekanun,, A. Sungkakum,, A. Nisalak,, and N. P. J. Day. 2006. The comparative accuracy of 8 commercial rapid immunochromatographic assays for the diagnosis of acute dengue infection. Clin. Infect. Dis. 42: 1127 1134.
4. Blitvich, B. J.,, R. A. Bowen,, N. L. Marlenee,, R. A. Hall,, M. L. Bunning,, and B. J. Beaty. 2003. Epitope-blocking enzyme-linked immunosorbent assays for detection of West Nile virus antibodies in domestic mammals. J. Clin. Microbiol. 41: 2676 2679.
5. Burke, D. S.,, and T. P. Monath,. 2001. Flaviviruses, p. 1043 1125. In D. M. Knipe,, P. M. Howley,, D. E. Griffin,, R. A. Lamb,, M. A. Martin,, B. Roizman,, and S. E. Straus (ed.), Fields Virology, 4th ed., vol. 1. Lippincott Williams & Wilkins, Philadelphia, PA.
6. Burke, D. S.,, A. Nisalak,, and M. K. Gentry. 1987. Detection of flavivirus antibodies in human serum by epitope blocking immunoassay. J. Med. Virol. 23: 165 173.
7. Burke, D. S.,, A. Nisalak,, M. A. Ussery,, T. Laorakpongse,, and S. Chantavibul. 1985. Kinetics of IgM and IgG responses to Japanese encephalitis virus in human serum and cerebrospinal fluid. J. Infect. Dis. 151: 1093 1099.
8. Busch, M. P.,, S. Caglioti,, E. F. Robertson,, J. D. McAuley,, L. H. Tobler,, H. Kamel,, J. M. Linnen,, V. Shyamala,, P. Tomasulo,, and S. H. Kleinman. 2005. Screening the blood supply for West Nile virus RNA by nucleic acid amplification testing. N. Engl. J. Med. 353: 460 467.
9. Carter, I. W. J.,, J. R. E. Fraser,, and M. J. Cloonan. 1987. Specific IgA antibody response in Ross River virus infection. Immunol. Cell Biol. 65: 511 513.
10. Chan, K. H.,, W. C. Yam,, C. M. Pang,, K. M. Chan,, S. Y. Lam,, K. F. Lo,, L. L. Poon,, and J. S. Peiris. 2008. Comparison of the NucliSens easyMAG and Qiagen BioRobot 9604 nucleic acid extraction systems for detection of RNA and DNA respiratory viruses in nasopharyngeal aspirate samples. J. Clin. Microbiol. 46: 2195 2199.
11. Chang, G. J.,, D. W. Trent,, A. V. Vorndam,, E. Vergene,, R. M. Kinney,, and C. J. Mitchell. 1994. An integrated target sequence and signal amplification assay, reverse transcriptase- PCR-enzyme-linked immunosorbent assay, to detect and characterize flaviviruses. J. Clin. Microbiol. 32: 477 483.
12. Chu, C. T.,, D. N. Howell,, J. C. Morgenleander,, C. M. Hulette,, R. E. McLendon,, and S. E. Miller. 1999. Electron microscopic diagnosis of human flavivirus encephalitis: use of confocal microscopy as an aid. Am. J. Surg. Pathol. 23: 1217 1226.
13. Cuzzubbo, A. J.,, T. P. Endy,, D. W. Vaughn,, T. Solomon,, A. Nisalak,, S. Kalayanarooj,, N. M. Dung,, D. Warrilow,, J. Aaskov,, and P. L. Devine. 1999. Evaluation of a new commercially available immunoglobulin M capture enzyme-linked immunosorbent assay for diagnosis of Japanese encephalitis infections. J. Clin. Microbiol. 37: 3738 3741.
14. Cuzzubbo, A. J.,, D. W. Vaughn,, A. Nisalak,, T. Solomon,, S. Kalayanarooj,, J. Aaskov,, N. M. Dung,, and P. L. Devine. 2000. Comparison of PanBio Dengue Duo IgM and IgG capture ELISA and Venture Technologies dengue IgM and IgG dot blot. J. Clin. Virol. 16: 135 144.
15. De Brito, T.,, S. A. C. Siqueira,, R. T. M. Santos,, E. S. Nassar,, T. L. M. Coimbra,, and V. A. F. Alves. 1992. Human fatal yellow fever. Immunohistochemical detection of viral antigens in the liver, kidney and heart. Pathol. Res. Pract. 188: 177 181.
16. Fang, M. Y.,, H. S. Chen,, C. H. Chen,, X. D. Tian,, and H. Jiang. 1997. Detection of flaviviruses by reverse transcriptasepolymerase chain reaction with the universal primer set. Microbiol. Immunol. 41: 209 213.
17. Fauquet, C. M.,, M. A. Mayo,, J. Maniloff,, U. Desselberger,, and L. A. Ball. 2005. Virus Taxonomy: Classification and Nomenclature of Viruses, 8th ed. Elsevier, Academic Press, San Diego, CA.
18. Feigin, R. D.,, J. D. Cherry,, G. J. Demmier,, and S. L. Kaplan (ed.). 2004. Textbook of Pediatric Infectious Diseases, 5th ed., vol. 2. Saunders, Philadelphia, PA.
19. Fitzgibbon, J. E.,, and J. L. Sagripanti. 2006. Simultaneous identification of orthopoxviruses and alphaviruses by oligonucleotide macroarray with special emphasis on detection of variola and Venezuelan equine encephalitis viruses. J. Virol. Methods 131: 160 167.
20. Gritsun, T. S.,, T. V. Frolova,, A. I. Zhankov,, M. Armesto,, S. L. Turner,, M. P. Frolova,, V. V. Pogodina,, V. A. Lashkevich,, and E. A. Gould. 2003. Characterization of a Siberian virus isolated from a patient with progressive chronic tick-borne encephalitis. J. Virol. 77: 25 36.
21. Groen, J.,, P. Koraka,, J. Velzing,, C. Copra,, and A. D. Osterhaus. 2000. Evaluations of six immunoassays for detection of dengue virus-specific immunoglobulin M and G antibodies. Clin. Diagn. Lab. Immunol. 7: 867 871.
22. Hall, W. C.,, T. P. Crowell,, D. M. Watts,, V. L. R. Barros,, H. Kruger,, F. Pinheiro,, and C. L. Peters. 1991. Demonstration of yellow fever and dengue antigens in formalin-fixed paraffin-embedded human liver by immunohistochemical analysis. Am. J. Trop. Med. Hyg. 45: 408 417.
23. Hang, V. T.,, N. M. Nguyet,, D. T. Trung,, V. Tricou,, S. Yoksan,, N. M. Dung,, T. Van Ngoc,, T. T. Hien,, J. Farrar,, B. Wills,, and C. P. Simmons. 2009. Diagnostic accuracy of NS1 ELISA and lateral flow rapid tests for dengue sensitivity, specificity and relationship to viraemia and antibody responses. PLoS Negl. Trop. Dis. 3: e360.
24. Hayes, E. B.,, J. J. Sejvar,, S. Zaki,, R. S. Lanciotti,, A. V. Bode,, and G. L. Campbell. 2005. Virology, pathology and clinical manifestations of West Nile virus disease. Emerg. Infect. Dis. 11: 1174 1179.
25. Hsiung, G. D., 1994. Hemagglutination and hemagglutination- inhibition test, p. 69–75. In G. D. Hsiung,, C. K. Y. Fong,, and M. L. Landry (ed.), Hsiung’s Diagnostic Virology, 4th ed. Yale University Press, New Haven, CT.
26. Hsiung, G. D., 1994. Virus assay, neutralization test and antiviral assay, p. 46-55. In G. D. Hsiung,, C. K. Y. Fong,, and M. L. Landry (ed.), Hsiung’s Diagnostic Virology, 4th ed. Yale University Press, New Haven, CT.
27. Hunsperger, E. A.,, S. Yoksan,, P. Buchy,, V. C. Nguyen,, S. D. Sekaran,, D. A. Enria,, J. L. Pelegrino,, S. Vázquez,, H. Artsob,, M. Drebot,, D. J. Gubler,, S. B. Halstead,, M. G. Guzmán,, H. S. Margolis,, C. M. Nathanson,, N. R. Rizzo Lic,, K. E. Bessoff,, S. Kliks,, and R. W. Peeling. 2009. Evaluation of commercially available anti-dengue virus immunoglobulin M tests. Emerg. Infect. Dis. 15: 436 440.
28. Hunt, A. R.,, R. A. Hall,, A. J. Kerst,, R. S. Nasci,, H. M. Savage,, N. A. Panella,, K. L. Gottfried,, K. L. Burkhalter,, and J. T. Roehrig. 2002. Detection of West Nile virus antigen in mosquitoes and avian tissues by a monoclonal antibody-based capture enzyme immunoassay. J. Clin. Microbiol. 40: 2023 2030.
29. Iwamoto, M.,, D. B. Jernigan,, A. Guasch,, M. J. Trepka,, C. G. Blackmore,, W. C. Hellinger,, S. M. Pham,, S. Zaki,, R. S. Lanciotti,, S. E. Lance-Parker,, C. A. Diaz-Granados,, A. G. Winquist,, C. A. Perlino,, S. Wiersma,, K. L. Hillyer,, J. L. Goodman,, A. A. Marfin,, M. E. Chamberland,, L. R. Petersen, and the West Nile Virus in Transplant Recipients Investigation Team. 2003. Transmission of West Nile virus from an organ donor to four transplant recipients. N. Engl. J. Med. 348: 2196 2203.
30. Karabatsos, N. 1985. International Catalogue of Arboviruses 1985, Including Certain Other Viruses of Vertebrates, 3rd ed. American Society of Tropical Medicine and Hygiene, San Antonio, TX.
31. Kuno, G. 1998. Universal diagnostic RT-PCR protocol for arboviruses. J. Virol. Methods 72: 27 41.
32. Kuno, G.,, C. J. Mitchell,, G. J. Chang,, and G. C. Smith. 1996. Detecting bunyaviruses of the Bunyamwera and California serogroups by a PCR technique. J. Clin. Microbiol. 34: 1184 1188.
33. Lambert, A. J.,, O. Kosoy,, J. O. Velez,, B. J. Russell,, and R. S. Lanciotti. 2007. Detection of Colorado tick fever viral RNA in acute human serum samples by a quantitative realtime RT-PCR assay. J. Virol. Methods 140: 43 48.
34. Lambert, A. J.,, and R. S. Lanciotti. 2009. Consensus amplification and novel multiplex sequencing method for S segment species identification of 47 viruses of the Orthobunyavirus, Phlebovirus, and Nairovirus genera of the family Bunyaviridae. J. Clin. Microbiol. 47: 2398 2404.
35. Lambert, A. J.,, D. A. Martin,, and R. S. Lanciotti. 2003. Detection of North American Eastern and Western equine encephalitis viruses by nucleic acid amplification assays. J. Clin. Microbiol. 41: 379 385.
36. Lambert, A. J.,, R. S. Nasci,, B. C. Cropp,, D. A. Martin,, B. C. Rose,, B. J. Russell,, and R. S. Lanciotti. 2005. Nucleic acid amplification assays for detection of La Crosse virus RNA. J. Clin. Microbiol. 43: 1885 1889.
37. Lanciotti, R. S.,, and A. J. Kerst. 2001. Nucleic acid sequence-based amplification assays for the rapid detection of West Nile and St. Louis encephalitis viruses. J. Clin. Microbiol. 39: 4506 4513.
38. Lanciotti, R. S.,, A. J. Kerst,, R. S. Nasci,, M. S. Godsey,, C. J. Mitchell,, H. M. Savage,, N. Komar,, N. A. Panella,, B. C. Allen,, K. E. Volpe,, B. S. Davis,, and J. T. Roehrig. 2000. Rapid detection of West Nile virus from human clinical specimens, field-collected mosquitoes, and avian samples by a TaqMan reverse transcriptase PCR assay. J. Clin. Microbiol. 38: 4066 4071.
39. Lanciotti, R. S.,, O. L. Kosoy,, J. J. Laven,, J. O. Velez,, A. J. Lambert,, A. J. Johnson,, S. M. Stanfield,, and M. R. Duffy. 2008. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg. Infect. Dis. 14: 1232 1239.
40. Landry, M. L.,, and G. D. Hsiung,. 2000. Primary isolation of viruses, p. 27 42. In S. Specter,, R. L. Hodinka,, and S. A. Young (ed.), Clinical Virology Manual, 3rd ed. ASM Press, Washington, DC.
41. Leiby, D. A.,, and J. E. Gill. 2004. Transfusion-transmitted tick-borne infections: a cornucopia of threats. Transfus. Med. Rev. 18: 293 306.
42. Le Roux, C. A.,, T. Kubo,, A. A. Grobbelaar,, P. J. van Vuren,, J. Weyer,, L. H. Nel,, R. Swanepoel,, K. Morita,, and J. T. Paweska. 2009. Development and evaluation of a real-time reverse transcription-loop-mediated isothermal amplification assay for rapid detection of Rift Valley fever virus in clinical specimens. J. Clin. Microbiol. 47: 645 651.
43. Levett, P. N.,, K. Sonnenberg,, F. Sidaway,, S. Shead,, M. Niedrig,, K. Steinhagen,, G. B. Horsman,, and M. A. Drebot. 2005. Use of immunoglobulin G avidity assays for differentiation of primary from previous infections with West Nile virus. J. Clin. Microbiol. 43: 5873 5875.
44. Lotric-Furlan, S.,, M. Petrovec,, T. Avsic-Zupanc,, and F. Srle. 2005. Concomitant tickborne encephalitis and human granulocytic ehrlichiosis. Emerg. Infect. Dis. 11: 485 488.
45. Malan, A. K.,, P. J. Stipanovich,, T. B. Martins,, H. R. Hill,, and C. M. Litwin. 2003. Detection of IgG and IgM to West Nile virus. Development of an immunofluorescence assay. Am. J. Clin. Pathol. 119: 508 515.
46. Matheus, S.,, X. Deparis,, B. Labeau,, J. Lelarge,, J. Morvan,, and P. Dussart. 2005. Discrimination between primary and secondary dengue virus infection by an immunoglobulin G avidity test using a single acute-phase serum sample. J. Clin. Microbiol. 43: 2793 2797.
47. Monath, T. P. (ed.). 1988. The Arboviruses: Epidemiology and Ecology, vol. I to V. CRC Press, Inc., Boca Raton, FL.
48. Pancharoen, C.,, and U. Thisyakorn. 1998. Coinfections in dengue patients. Pediatr. Infect. Dis. J. 17: 81 82.
49. Parida, M.,, S. Sannarangaiah,, P. K. Dash,, P. V. Rao,, and K. Morita. 2008. Loop mediated isothermal amplification (LAMP): a new generation of innovative gene amplification technique; perspectives in clinical diagnosis of infectious diseases. Rev. Med. Virol. 18: 407 421.
50. Pastorino, B.,, M. Bessaud,, M. Grandadam,, S. Murri,, H. J. Tolou,, and C. N. Peyrefitte. 2005. Development of a TaqMan RT-PCR assay without RNA extraction step for the detection and quantification of African Chikungunya viruses. J. Virol. Methods 124: 65 71.
51. Pealer, L. N.,, A. A. Marfin,, R. S. Petersen,, L. R. Lanciotti,, P. L. Page,, S. L. Stramer,, M. G. Stobierski,, K. Signs,, B. Newman,, H. Kapoor,, J. L. Goodman,, M. E. Chamberland, and the West Nile Virus Transmission Investigation Team. 2003. Transmission of West Nile virus through blood transfusion in the United States in 2002. N. Engl. J. Med. 349: 1236 1245.
52. Peters, C. J.,, P. B. Jahrling,, and A. S. Khan. 1996. Patients infected with high-hazard viruses: scientific basis for infection control. Arch. Virol. 11( Suppl. 1): 141 158.
53. Pfeffer, M.,, B. Proebster,, R. M. Kinney,, and O. R. Kaaden. 1997. Genus-specific detection of alphaviruses by a seminested reverse transcription-polymerase chain reaction. Am. J. Trop. Med. Hyg. 57: 709 718.
54. Pogodina, V. V.,, M. P. Frolova,, G. V. Malenko,, G. I. Fokina,, L. S. Levina,, L. L. Mamonenko,, G. V. Koreshkova,, and N. M. Ralf. 1981. Persistence of tick-borne encephalitis virus in monkeys. 1. Features of experimental infection. Acta Virol. 25: 337 343.
55. Prince, H. E.,, M. Lape-Nixon,, R. J. Moore,, and W. R. Hogrefe. 2004. Utility of the Focus Technologies West Nile virus immunoglobulin M capture enzyme-linked immunosorbent assay for testing cerebrospinal fluid. J. Clin. Microbiol. 42: 12 15.
56. Rasmussen, T. B.,, A. Uttenthal,, M. Hakhverdyan,, S. Belák,, P. R. Wakeley,, S. M. Reid,, K. Ebert,, and D. P. King. 2009. Evaluation of automated nucleic acid extraction methods for virus detection in a multicenter comparative trial. J. Virol. Methods 155: 87 90.
57. Ravi, V.,, A. S. Desai,, P. K. Shenoy,, P. Satishchandra,, A. Chandramuki,, and M. Gourie-Devi. 1993. Persistence of Japanese encephalitis virus in the human nervous system. J. Med. Virol. 40: 326 329.
58. Ravindra, K. V.,, A. G. Freifeld,, A. C. Kalil,, D. F. Mercer,, W. J. Grant,, J. F. Botha,, L. E. Wrenshall,, and R. B. Stevens. 2004. West Nile virus-associated encephalitis in recipients of renal and pancreas transplants: case series and literature review. Clin. Infect. Dis. 38: 1257 1260.
59. Richman, D. D.,, R. J. Whitley,, and F. G. Hayden (ed.). 2002. Clinical Virology, 2nd ed. ASM Press, Washington, DC.
60. Roehrig, J. T.,, D. Nash,, B. Maldin,, A. Laborvitz,, D. A. Martin,, R. S. Lanciotti,, and G. L. Campbell. 2003. Persistence of virus-reactive serum immunoglobulin M antibody in confirmed West Nile encephalitis cases. Emerg. Infect. Dis. 9: 376 379.
61. Rosen, L. 1984. Use of mosquitoes to detect and propagate viruses. Methods Virol. 8: 281 292.
62. Scaramozzino, N.,, J. M. Crance,, A. Jouan,, D. A. DeBriel,, F. Stoll,, and D. Garin. 2001. Comparison of flavivirus universal primer pairs and development of a rapid, highly sensitive heminested reverse transcription-PCR assay for detection of flaviviruses targeted to a conserved region of the NS5 gene sequences. J. Clin. Microbiol. 39: 1922 1927.
63. Sharma, S.,, A. Mathur,, R. Prakash,, R. Kulshreshtha,, R. Kumar,, and U. C. Chaturvedi. 1991. Japanese encephalitis virus latency in peripheral blood lymphocytes and recurrence of infection in children. Clin. Exp. Immunol. 85: 85 89.
64. Shi, P. Y.,, E. B. Kauffman,, P. Ren,, A. Felton,, J. H. Tai,, A. P. Dupuis II,, S. A. Jones,, A. Ngo,, D. C. Nicholas,, J. Maffei,, G. D. Ebel,, K. A. Bernard,, and L. D. Kramer. 2001. High-throughput detection of West Nile virus RNA. J. Clin. Microbiol. 39: 1264 1271.
65. Sibailly, T. S.,, S. Z. Wiktor,, T. F. Tsai,, B. C. Cropp,, E. R. Ekpini,, G. Adjorlolo-Johnson,, E. Gnaore,, K. M. DeCock,, and A. E. Greenberg. 1997. Poor antibody response to yellow fever vaccination in children infected with human immunodeficiency virus type 1. Pediatr. Infect. Dis. J. 16: 1177 1179.
66. Stark, L. M.,, and A. L. Lewis,. 2000. Complement fixation test, p. 112 126. In S. Spector,, R. L. Hodinka,, and S. A. Young (ed.), Clinical Virology Manual, 3rd ed. ASM Press, Washington, DC.
67. Stramer, S. L.,, C. T. Fang,, G. A. Foster,, A. G. Wagner,, J. P. Brodsky,, and R. Y. Dodd. 2005. West Nile virus among blood donors in the United States, 2003 and 2004. N. Engl. J. Med. 353: 451 459.
68. Telles, J. N.,, K. Leroux,, P. Grivard,, G. Vernet,, and A. Michault. 2009. Evaluation of real-time nucleic acid sequencebased amplification for detection of Chikungunya virus in clinical samples. J. Med. Microbiol. 58: 1168 1172.
69. Tesh, R. B. 1979. A method for the isolation of dengue viruses, using mosquito cell cultures. Am. J. Trop. Med. Hyg. 28: 1053 1059.
70. Tesh, R. B. 1982. Arthritides caused by mosquito-borne viruses. Annu. Rev. Med. 33: 31 40.
71. Tesh, R. B.,, M. Siirin,, H. Guzman,, A. P. A. Travassos da Rosa,, X. Wu,, T. Duan,, H. Lei,, M. R. Nunes,, and S. Y. Xiao. 2005. Persistent West Nile virus infection in the golden hamster: studies on its mechanism and possible implications for other flavivirus infections. J. Infect. Dis. 192: 287 295.
72. Tilley, P. A. G.,, R. Walle,, A. Chow,, G. C. Jayuaraman,, K. Fonseca,, M. A. Drebot,, J. Preiksaitis,, and J. Fox. 2005. Clinical utility of commercial enzyme immunoassays during the inaugural season of West Nile virus activity, Alberta, Canada. J. Clin. Microbiol. 43: 4691 4695.
72a. Tilley, P. A.,, J. D. Fox,, G. C. Jayaraman,, and J. K. Preiksaitis. 2006. Nucleic acid testing for West Nile virus RNA in plasma enhances rapid diagnosis of acute infection in symptomatic patients. J. Infect. Dis. 193: 1361 1364.
73. Tonry, J. H.,, C. B. Brown,, C. B. Cropp,, J. K. G. Co,, S. N. Bennett,, V. R. Nerurkar,, T. Kuberski,, and D. J. Gubler. 2005. West Nile virus detection in urine. Emerg. Infect. Dis. 11: 1294 1296.
74. Tsai, T. F.,, R. A. Bolin,, M. Montoya,, R. E. Bailey,, D. B. Francy,, M. Jozan,, and J. T. Roehrig. 1987. Detection of St. Louis encephalitis virus antigen in mosquitoes by capture enzyme immunoassay. J. Clin. Microbiol. 25: 370 376.
75. Tsai, T. F. 2006. Congenital arboviral infections: something new, something old. Pediatrics 117: 936 939.
76. U.S. Department of Health and Human Services. 2007. Biosafety in Microbiological and Biomedical Laboratories, 5th ed. U.S. Government Printing Office, Washington, DC.
77. Vaughn, D. W.,, S. Greens,, S. Kalayanarooj,, B. L. Innis,, S. Nimmannitya,, S. Suntayakom,, A. L. Rothman,, F. A. Ennis,, and A. Nisalak. 1997. Dengue in the early febrile phase: viremia and antibody response. J. Infect. Dis. 176: 322 330.
78. Vaughn, D. W.,, A. Nisalak,, S. Kalayanarooj,, T. Solomon,, N. M. Dung,, A. Cuzzubboo,, and P. L. Devine. 1998. Evaluation of a rapid immunochromatographic test for diagnosis of dengue virus infection. J. Clin. Microbiol. 36: 234 238.
79. Wicki, R.,, P. Sauter,, C. Mettler,, A. Natsch,, T. Enzler,, N. Pusterla,, P. Kuhnert,, G. Egli,, M. Bernasconi,, R. Lienhard,, H. Lutz,, and C. M. Leutenegger. 2000. Swiss Army survey in Switzerland to determine the prevalence of Francisella tularensis, members of the Ehrlichia phagocytophila genogroup, Borrelia burgdorferi sensu lato, and tick-borne encephalitis virus in ticks. Eur. J. Clin. Microbiol. Infect. Dis. 19: 427 432.
80. Wong, J. K., 2002. Colorado tick fever virus and other arthropod-borne Reoviridae, p. 731 741. In D. O. Richman,, R. J. Whitley,, and F. G. Hayden (ed.), Clinical Virology, 2nd ed. ASM Press, Washington, DC.
81. Wong, S. J.,, V. L. Demarest,, R. H. Doyle,, T. Wang,, M. Ledizet,, K. Kar,, L. D. Kramer,, E. Fikrig,, and R. A. Koski. 2004. Detection of human anti-flavivirus antibodies with a West Nile virus recombinant antigen microsphere immunoassay. J. Clin. Microbiol. 42: 65 72.
82. Wu, S. J.,, E. M. Lee,, R. Putvatana,, R. N. Shurtliff,, K. R. Porter,, W. Suharyono,, D. M. Watts,, C. C. King,, G. S. Murphy,, C. G. Hayes,, and J. W. Romano. 2001. Detection of dengue viral RNA using a nucleic acid sequence-based amplification assay. J. Clin. Microbiol. 39: 2794 2798.
83. Zainah, S.,, A. H. Wahab,, M. Mariam,, M. K. Fauziah,, A. H. Khairul,, I. Roslina,, A. Sairulakhma,, S. S. Kadimon,, M. S. Jais,, and K. B. Chua. 2009. Performance of a commercial rapid dengue NS1 antigen immunochromatography test with reference to dengue NS1 antigen-capture ELISA. J. Virol. Methods 155: 157 160.


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Charactertistics of arboviruses

Citation: Lanciotti R, Tsai T. 2011. Arboviruses , p 1488-1503. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch93
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TABLE 2 Arboviruses associated with human illness by geographic region, mode of transmission, and clinical syndrome

Key: ○, rare or sporadic; ●, frequent, epidemic. Only arboviruses causing illness after natural infection are listed; viruses causing illness after laboratory exposure only are excluded.

Perinatal illness following third-trimester infection has also been described.

Transmissible by ingestion of infected milk products.

Transmissible through meat of infected animals.

Syndrome reported only after laboratory-acquired infection.

Citation: Lanciotti R, Tsai T. 2011. Arboviruses , p 1488-1503. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch93
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Serologic assays commercially available in the United States for diagnosis of arbovirus infections

IVD, for in vitro diagnostics; ASR, analyte-specific reagent; RUO, for research use only. Additional products available for sale outside the United States include IFAs for WN, VEE, JE, YF, and DEN viruses; rapid lateral-flow and strip immunochromatographic tests for DEN virus, and IgM and IgG ELISAs for JE virus.

Citation: Lanciotti R, Tsai T. 2011. Arboviruses , p 1488-1503. In Versalovic J, Carroll K, Funke G, Jorgensen J, Landry M, Warnock D (ed), Manual of Clinical Microbiology, 10th Edition. ASM Press, Washington, DC. doi: 10.1128/9781555816728.ch93

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