Human Immunodeficiency Virus-Associated Malignancies

Nathan T. Connell; Jeremy S. Abramson

doi:10.1128/9781555816803.ch8

Chapter 8 : Human Immunodeficiency Virus-Associated Malignancies

Authors: Nathan T. Connell¹, Jeremy S. Abramson²

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Affiliations: 1: Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903; 2: Harvard Medical School, Massachusetts General Hospital Cancer Center, Boston, MA 02114

Content Type: Monograph

Publication Year: 2010

Category: Clinical Microbiology; Bacterial Pathogenesis

Book DOI: 10.1128/9781555816803

Chapter DOI: 10.1128/9781555816803.ch8

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Abstract:

Immunodeficiency associated with the human immunodeficiency virus (HIV) has been associated with an increased risk of malignancy since the dawn of the AIDS epidemic. Non-Hodgkin lymphoma (NHL) and invasive cervical cancer were subsequently identified to be increased among HIV-infected individuals and were classified along with Kaposi sarcoma (KS) as AIDS-defining illnesses, though numerous additional malignancies have since been found to be enriched among patients living with HIV/AIDS but are not considered AIDS-defining illnesses. The association of NHL with HIV infection was evident early in the AIDS epidemic, when an unusually high number of lymphomas appeared among young men in cancer registries in California. The majority of patients with AIDS-related lymphoma (ARL) will present with a majority of these risk factors present, placing most in the high-risk category. Multicentric Castleman disease (MCD) is uniformly associated with HHV-8, and though pathologically benign, may occur concurrently with or progress to lymphoma or independently demonstrate rapid progression and result in death. Anogenital squamous cell neoplasms are the third most common subtype of HIV-associated malignancies and are uniformly associated with oncogenic serotypes of HPV, most commonly HPV-16, -18, and -19. A number of other malignancies, including cancers of the lung, liver, prostate, testes, and skin, among others, occur with increased frequency in HIV-positive patients, and this trend continues since the introduction of highly active antiretroviral therapy (HAART).

Citation: Connell N, Abramson J. 2010. Human Immunodeficiency Virus-Associated Malignancies, p 169-183. In Scheld W, Grayson M, Hughes J (ed), Emerging Infections 9. ASM Press, Washington, DC. doi: 10.1128/9781555816803.ch8

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References

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1. Aboulafia, D. 1998. Regression of AIDS-related pulmonary Kaposi’s sarcoma after highly active antiretroviral therapy. Mayo Clin. Proc. 73: 439– 443.

2. Ahdieh-Grant, L.,, R. Li,, A. M. Levine,, L. S. Massad,, H. D. Strickler,, H. Minkoff,, M. Moxley,, J. Palefsky,, H. Sacks,, R. D. Burk, and, S. J. Gange. 2004. Highly active antiretroviral therapy and cervical squamous intraepithelial lesions in human immunodeficiency virus-positive women. J. Natl. Cancer Inst. 96: 1070– 1076.

3. Albini, A.,, R. Soldi,, D. Giunciuglio,, E. Giraudo,, R. Benelli,, L. Primo,, D. Noonan,, M. Salio,, G. Camussi,, W. Rockl, and, F. Bussolino. 1996. The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells. Nat. Med. 2: 1371– 1375.

4. Ambrosino, C.,, M. R. Ruocco,, X. Chen,, M. Mallardo,, F. Baudi,, S. Trematerra,, I. Quinto,, S. Venuta, and, G. Scala. 1997. HIV-1 Tat induces the expression of the interleukin-6 (IL6) gene by binding to the IL6 leader RNA and by interacting with CAAT enhancer-binding protein beta (NF-IL6) transcription factors. J. Biol. Chem. 272: 14883– 14892.

5. Andrieu, J. M.,, S. Roithmann,, J. M. Tourani,, R. Levy,, B. Desablens,, C. le Maignan,, J. A. Gastaut,, P. Brice,, M. Raphael,, B. Taillan, et al. 1993. Hodgkin’s disease during HIV1 infection: the French registry experience. Ann. Oncol. 4: 635– 641.

6. Aoki, Y.,, E. S. Jaffe,, Y. Chang,, K. Jones,, J. Teruya-Feldstein,, P. S. Moore, and, G. Tosato. 1999. Angiogenesis and hematopoiesis induced by Kaposi’s sarcoma-associated herpesvirus-encoded interleukin-6. Blood 93: 4034– 4043.

7. Aoki, Y.,, G. Tosato,, T. W. Fonville, and, S. Pittaluga. 2001. Serum viral interleukin-6 in AIDS-related multicentric Castleman disease. Blood 97: 2526– 2527.

8. Baumgartner, J. E.,, J. R. Rachlin,, J. H. Beckstead,, T. C. Meeker,, R. M. Levy,, W. M. Wara, and, M. L. Rosenblum. 1990. Primary central nervous system lymphomas: natural history and response to radiation therapy in 55 patients with acquired immunodeficiency syndrome. J. Neurosurg. 73: 206– 211.

9. Bedimo, R. J.,, K. A. McGinnis,, M. Dunlap,, M. C. Rodriguez-Barradas, and, A. C. Justice. 2009. Incidence of non-AIDS-defining malignancies in HIV-infected versus noninfected patients in the HAART era: impact of immunosuppression. J. Acquir. Immune Defic. Syndr. 52: 203– 208.

10. Biggar, R. J.,, A. K. Chaturvedi,, J. J. Goedert, and, E. A. Engels. 2007. AIDS-related cancer and severity of immunosuppression in persons with AIDS. J. Natl. Cancer Inst. 99: 962– 972.

11. Boue, F.,, J. Gabarre,, C. Gisselbrecht,, J. Reynes,, A. Cheret,, F. Bonnet,, E. Billaud,, M. Raphael,, R. Lancar, and, D. Costagliola. 2006. Phase II trial of CHOP plus rituximab in patients with HIV-associated non-Hodgkin’s lymphoma. J. Clin. Oncol. 24: 4123– 4128.

12. Buchbinder, S. P.,, S. D. Holmberg,, S. Scheer,, G. Colfax,, P. O’Malley, and, E. Vittinghoff. 1999. Combination antiretroviral therapy and incidence of AIDS-related malignancies. J. Acquir. Immune Defic. Syndr. 21( Suppl. 1): S23– S26.

13. Burgi, A.,, S. Brodine,, S. Wegner,, M. Milazzo,, M. R. Wallace,, K. Spooner,, D. L. Blazes,, B. K. Agan,, A. Armstrong,, S. Fraser, and, N. F. Crum. 2005. Incidence and risk factors for the occurrence of non-AIDS-defining cancers among human immunodeficiency virus-infected individuals. Cancer 104: 1505– 1511.

14. Burkhardt, A. L.,, J. B. Bolen,, E. Kieff, and, R. Longnecker. 1992. An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases. J. Virol. 66: 5161– 5167.

15. Carbone, A.,, R. Dolcetti,, A. Gloghini,, R. Maestro,, E. Vaccher,, D. di Luca,, U. Tirelli, and, M. Boiocchi. 1996. Immunophenotypic and molecular analyses of acquired immune deficiency syndrome-related and Epstein-Barr virus-associated lymphomas: a comparative study. Hum. Pathol. 27: 133– 146.

16. Carbone, A.,, and A. Gloghini. 2005. AIDS-related lymphomas: from pathogenesis to pathology. Br. J. Haematol. 130: 662– 670.

17. Carbone, A.,, A. Gloghini,, G. Gaidano,, A. M. Cilia,, P. Bassi,, P. Polito,, E. Vaccher,, G. Saglio, and, U. Tirelli. 1995. AIDS-related Burkitt’s lymphoma. Morphologic and immunophenotypic study of biopsy specimens. Am. J. Clin. Pathol. 103: 561– 567.

18. Carbone, A.,, L. M. Weiss,, A. Gloghini, and, A. Ferlito. 1996. Hodgkin’s disease: old and recent clinical concepts. Ann. Otol. Rhinol. Laryngol. 105: 751– 758.

19. Cattani, P.,, F. Cerimele,, D. Porta,, R. Graffeo,, S. Ranno,, S. Marchetti,, R. Ricci,, N. Capodicasa,, L. Fuga,, R. Amico,, G. Cherchi,, M. Gazzilli,, S. Zanetti, and, G. Fadda. 2003. Age-specific seroprevalence of human herpesvirus 8 in Mediterranean regions. Clin. Microbiol. Infect. 9: 274– 279.

20. Centers for Disease Control. 1981. Kaposi’s sarcoma and Pneumocystis pneumonia among homosexual men—New York City and California. MMWR Morb. Mortal. Wkly. Rep. 30: 305– 308.

21. Centers for Disease Control. 1983. Update: acquired immunodeficiency syndrome (AIDS)—United States. MMWR Morb. Mortal. Wkly. Rep. 32: 465– 467.

22. Centers for Disease Control and Prevention. 1995. First 500,000 AIDS cases—United States, 1995. MMWR Morb. Mortal. Wkly. Rep. 44: 849– 853.

23. Cesarman, E.,, Y. Chang,, P. S. Moore,, J. W. Said, and, D. M. Knowles. 1995. Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332: 1186– 1191.

24. Cesarman, E.,, R. G. Nador,, F. Bai,, R. A. Bohenzky,, J. J. Russo,, P. S. Moore,, Y. Chang, and, D. M. Knowles. 1996. Kaposi’s sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi’s sarcoma and malignant lymphoma. J. Virol. 70: 8218– 8223.

25. Chang, Y.,, E. Cesarman,, M. S. Pessin,, F. Lee,, J. Culpepper,, D. M. Knowles, and, P. S. Moore. 1994. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 266: 1865– 1869.

26. Chaturvedi, A. K.,, M. M. Madeleine,, R. J. Biggar, and, E. A. Engels. 2009. Risk of human papilloma-virus-associated cancers among persons with AIDS. J. Natl. Cancer Inst. 101: 1120– 1130.

27. Clifford, G. M.,, J. Polesel,, M. Rickenbach,, L. Dal Maso,, O. Keiser,, A. Kofler,, E. Rapiti,, F. Levi,, G. Jundt,, T. Fisch,, A. Bordoni,, D. De Week, and, S. Franceschi. 2005. Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy. J. Natl. Cancer Inst. 97: 425– 432.

28. Dong, H. Y.,, D. T. Scadden,, L. de Leval,, Z. Tang,, P. G. Isaacson, and, N. L. Harris. 2005. Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm. Am. J. Surg. Pathol. 29: 1633– 1641.

29. Du, M. Q.,, C. M. Bacon, and, P. G. Isaacson. 2007. Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disorders. J. Clin. Pathol. 60: 1350– 1357.

30. Engels, E. A.,, M. V. Brock,, J. Chen,, C. M. Hooker,, M. Gillison, and, R. D. Moore. 2006. Elevated incidence of lung cancer among HIV-infected individuals. J. Clin. Oncol. 24: 1383– 1388.

31. Engels, E. A.,, R. M. Pfeiffer,, J. J. Goedert,, P. Virgo,, T. S. McNeel,, S. M. Scoppa, and, R. J. Biggar. 2006. Trends in cancer risk among people with AIDS in the United States 1980–2002. AIDS 20: 1645– 1654.

32. Epstein, L.,, F. DiCarlo,, V. Joshi, et al. 1988. Primary lymphoma of the CNS in children with AIDS. Pediatrics 82: 355.

33. Feng, H.,, M. Shuda,, Y. Chang, and, P. S. Moore. 2008. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319: 1096– 1100.

34. Franceschi, S.,, L. Dal Maso,, S. Arniani,, P. Crosignani,, M. Vercelli,, L. Simonato,, F. Falcini,, R. Zanetti,, A. Barchielli,, D. Serraino, and, G. Rezza for the Cancer and AIDS Registry Linkage Study. 1998. Risk of cancer other than Kaposi’s sarcoma and non-Hodgkin’s lymphoma in persons with AIDS in Italy. Br. J. Cancer 78: 966– 970.

35. Frisch, M.,, R. J. Biggar,, E. A. Engels, and, J. J. Goedert. 2001. Association of cancer with AIDS-related immunosuppression in adults. JAMA 285: 1736– 1745.

36. Frisch, M.,, R. J. Biggar, and, J. J. Goedert. 2000. Human papillomavirus-associated cancers in patients with human immunodeficiency virus infection and acquired immunodeficiency syndrome. J. Natl. Cancer Inst. 92: 1500– 1510.

37. Gao, S. J.,, L. Kingsley,, M. Li,, W. Zheng,, C. Parravicini,, J. Ziegler,, R. Newton,, C. R. Rinaldo,, A. Saah,, J. Phair,, R. Detels,, Y. Chang, and, P. S. Moore. 1996. KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi’s sarcoma. Nat. Med. 2: 925– 928.

38. Gill, P. S.,, B. Akil,, P. Colletti,, M. Rarick,, C. Loureiro,, M. Bernstein-Singer,, M. Krailo, and, A. M. Levine. 1989. Pulmonary Kaposi’s sarcoma: clinical findings and results of therapy. Am. J. Med. 87: 57– 61.

39. Gill, P. S.,, R. A. Graham,, W. Boswell,, P. Meyer,, M. Krailo, and, A. M. Levine. 1986. A comparison of imaging, clinical, and pathologic aspects of space-occupying lesions within the brain in patients with acquired immune deficiency syndrome. Am. J. Physiol. Imaging 1: 134– 141.

40. Gill, P. S.,, A. M. Levine,, P. R. Meyer,, W. D. Boswell,, R. L. Burkes,, J. W. Parker,, F. M. Hofman,, R. L. Dworsky, and, R. J. Lukes. 1985. Primary central nervous system lymphoma in homosexual men. Clinical, immunologic, and pathologic features. Am. J. Med. 78: 742– 748.

41. Glesby, M. J.,, D. R. Hoover,, S. Weng,, N. M. Graham,, J. P. Phair,, R. Detels,, M. Ho, and, A. J. Saah. 1996. Use of antiherpes drugs and the risk of Kaposi’s sarcoma: data from the Multicenter AIDS Cohort Study. J. Infect. Dis. 173: 1477– 1480.

42. Goldie, S. J.,, K. M. Kuntz,, M. C. Weinstein,, K. A. Freedberg,, M. L. Welton, and, J. M. Palefsky. 1999. The clinical effectiveness and cost-effectiveness of screening for anal squamous intraepithelial lesions in homosexual and bisexual HIV-positive men. JAMA 281: 1822– 1829.

43. Gregory, C. D.,, C. Dive,, S. Henderson,, C. A. Smith,, G. T. Williams,, J. Gordon, and, A. B. Rickinson. 1991. Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Nature 349: 612– 614.

44. Guiguet, M.,, F. Boue,, J. Cadranel,, J. M. Lang,, E. Rosenthal, and, D. Costagliola. 2009. Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study. Lancet Oncol. 10: 1152– 1159.

45. Hamilton-Dutoit, S. J.,, G. Pallesen,, M. B. Franzmann,, J. Karkov,, F. Black,, P. Skinhoj, and, C. Pedersen. 1991. AIDS-related lymphoma. Histopathology, immunophenotype, and association with Epstein-Barr virus as demonstrated by in situ nucleic acid hybridization. Am. J. Pathol. 138: 149– 163.

46. Hamilton-Dutoit, S. J.,, G. Pallesen,, J. Karkov,, P. Skinhoj,, M. B. Franzmann, and, C. Pedersen. 1989. Identification of EBV-DNA in tumour cells of AIDS-related lymphomas by in-situ hybridisation. Lancet i: 554– 555.

47. Harrington, W.,, Jr., L. Sieczkowski,, C. Sosa,, S. Chan-a-Sue,, J. P. Cai,, L. Cabral, and, C. Wood. 1997. Activation of HHV-8 by HIV-1 tat. Lancet 349: 774– 775.

48. Hoffmann, C.,, S. Tabrizian,, E. Wolf,, C. Eggers,, A. Stoehr,, A. Plettenberg,, T. Buhk,, H. J. Stellbrink,, H. A. Horst,, H. Jager, and, T. Rosenkranz. 2001. Survival of AIDS patients with primary central nervous system lymphoma is dramatically improved by HAART-induced immune recovery. AIDS 15: 2119– 2127.

49. Howard, M.,, and A. O’Garra. 1992. Biological properties of interleukin 10. Immunol. Today 13: 198– 200.

50. Huen, D. S.,, S. A. Henderson,, D. Croom-Carter, and, M. Rowe. 1995. The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-kappa B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain. Oncogene 10: 549– 560.

51. Jacobson, L. P.,, T. E. Yamashita,, R. Detels,, J. B. Margolick,, J. S. Chmiel,, L. A. Kingsley,, S. Melnick, and, A. Munoz. 1999. Impact of potent antiretroviral therapy on the incidence of Kaposi’s sarcoma and non-Hodgkin’s lymphomas among HIV-1-infected individuals. Multicenter AIDS Cohort Study. J. Acquir. Immune Defic. Syndr. 21( Suppl. 1): S34– S41.

52. Jacomet, C.,, P. M. Girard,, M. G. Lebrette,, V. L. Farese,, L. Monfort, and, W. Rozenbaum. 1997. Intravenous methotrexate for primary central nervous system non-Hodgkin’s lymphoma in AIDS. AIDS 11: 1725– 1730.

53. Kaplan, L. D.,, J. Y. Lee,, R. F. Ambinder,, J. A. Sparano,, E. Cesarman,, A. Chadburn,, A. M. Levine, and, D. T. Scadden. 2005. Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010. Blood 106: 1538– 1543.

54. Kaposi, M. 1872. Idiopathisches multiples Pigmentsarkom der Haut. Arch. Dermatol. Syph. 4: 265– 273.

55. Karcher, D. S.,, and S. Alkan. 1997. Human herpesvirus-8-associated body cavity-based lymphoma in human immunodeficiency virus-infected patients: a unique B-cell neoplasm. Hum. Pathol. 28: 801– 808.

56. Kedes, D. H.,, E. Operskalski,, M. Busch,, R. Kohn,, J. Flood, and, D. Ganem. 1996. The seroepidemiology of human herpesvirus 8 (Kaposi’s sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat. Med. 2: 918– 924.

57. Kieff, E. 1998. Current perspectives on the molecular pathogenesis of virus-induced cancers in human immunodeficiency virus infection and acquired immunodeficiency syndrome. J. Natl. Cancer Inst. Monogr. 23: 7– 14.

58. Kishimoto, T.,, S. Akira,, M. Narazaki, and, T. Taga. 1995. Interleukin-6 family of cytokines and gp130. Blood 86: 1243– 1254.

59. Klein, G. 1989. Viral latency and transformation: the strategy of Epstein-Barr virus. Cell 58: 5– 8.

60. Knecht, H.,, M. Raphael,, C. McQuain,, S. Rothenberger,, G. Pihan,, S. Camilleri-Broet,, E. Bachmann,, G. R. Kershaw,, S. Ryan,, E. L. Kittler,, P. J. Quesenberry,, D. Schlaifer,, B. A. Woda, and, P. Brousset. 1996. Deletion variants within the NF-kappa B activation domain of the LMP1 oncogene prevail in acquired immunodeficiency syndrome-related large cell lymphomas and human immunodeficiency virus-negative atypical lymphoproliferations. Blood 87: 876– 881.

61. Knowles, D. M. 1996. Etiology and pathogenesis of AIDS-related non-Hodgkin’s lymphoma. Hematol. Oncol. Clin. N. Am. 10: 1081– 1109.

62. Knowles, D. M. 1977. Molecular pathology of acquired immunodeficiency syndrome-related non-Hodgkin’s lymphoma. Semin. Diagn. Pathol. 14: 67– 82.

63. Krown, S. E.,, J. Y. Lee, and, D. P. Dittmer. 2008. More on HIV-associated Kaposi’s sarcoma. N. Engl. J. Med. 358: 535– 536.

64. Levine, A. M. 1998. Hodgkin’s disease in the setting of human immunodeficiency virus infection. J. Natl. Cancer Inst. Monogr. 23: 37– 42.

65. Levine, A. M.,, P. Li,, T. Cheung,, A. Tulpule,, J. Von Roenn,, B. N. Nathwani, and, L. Ratner. 2000. Chemotherapy consisting of doxorubicin, bleomycin, vinblastine, and dacarbazine with granulocyte-colony-stimulating factor in HIV-infected patients with newly diagnosed Hodgkin’s disease: a prospective, multi-institutional AIDS clinical trials group study (ACTG 149). J. Acquir. Immune Defic. Syndr. 24: 444– 450.

66. Liebowitz, D. 1998. Epstein-Barr virus and a cellular signaling pathway in lymphomas from immunosuppressed patients. N. Engl. J. Med. 338: 1413– 1421.

67. Lim, S. T.,, R. Karim,, B. N. Nathwani,, A. Tulpule,, B. Espina, and, A. M. Levine. 2005. AIDS-related Burkitt’s lymphoma versus diffuse large-cell lymphoma in the pre-highly active antiretroviral therapy (HAART) and HAART eras: significant differences in survival with standard chemotherapy. J. Clin. Oncol. 23: 4430– 4438.

68. Liu, M.,, O. Matinez-Maza,, M. Johnson,, J. Fan,, T. Kishimoto, and, S. Plaeger. 1995. IL-6 induces target cell resistance to HIV-specific cytotoxic lysis. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 9: 321– 331.

69. MacMahon, E. M.,, J. D. Glass,, S. D. Hayward,, R. B. Mann,, P. S. Becker,, P. Charache,, J. C. McArthur, and, R. F. Ambinder. 1991. Epstein-Barr virus in AIDS-related primary central nervous system lymphoma. Lancet 338: 969– 973.

70. Martin, D. F.,, B. D. Kuppermann,, R. A. Wolitz,, A. G. Palestine,, H. Li, and, C. A. Robinson. 1999. Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. N. Engl. J. Med. 340: 1063– 1070.

71. Martin, J. N.,, D. E. Ganem,, D. H. Osmond,, K. A. Page-Shafer,, D. Macrae, and, D. H. Kedes. 1998. Sexual transmission and the natural history of human herpesvirus 8 infection. N. Engl. J. Med. 338: 948– 954.

72. Maurer, T.,, M. Ponte, and, K. Leslie. 2007. HIV-associated Kaposi’s sarcoma with a high CD4 count and a low viral load. N. Engl. J. Med. 357: 1352– 1353.

73. Mbulaiteye, S. M.,, R. M. Pfeiffer,, D. Whitby,, G. R. Brubaker,, J. Shao, and, R. J. Biggar. 2003. Human herpesvirus 8 infection within families in rural Tanzania. J. Infect. Dis. 187: 1780– 1785.

74. Mocroft, A.,, M. Youle,, B. Gazzard,, J. Morcinek,, R. Halai,, A. N. Phillips, et al. 1996. Anti-herpesvirus treatment and risk of Kaposi’s sarcoma in HIV infection. AIDS 10: 1101– 1105.

75. Montaner, S. 2007. Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi’s sarcoma. Cell Cycle 6: 438– 443.

76. Moore, K. W.,, A. O’Garra,, R. de Waal Malefyt,, P. Vieira, and, T. R. Mosmann. 1993. Interleukin-10. Annu. Rev. Immunol. 11: 165– 190.

77. Moore, K. W.,, P. Vieira,, D. F. Fiorentino,, M. L. Trounstine,, T. A. Khan, and, T. R. Mosmann. 1990. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science 248: 1230– 1234. (Erratum, 250: 494.)

78. Mosialos, G.,, M. Birkenbach,, R. Yalamanchilli,, T. VanArsdale,, C. Ware, and, E. Kieff. 1995. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80: 389– 399.

79. Murphy, M.,, D. Armstrong,, K. A. Sepkowitz,, R. N. Ahkami, and, P. L. Myskowski. 1997. Regression of AIDS-related Kaposi’s sarcoma following treatment with an HIV-1 protease inhibitor. AIDS 11: 261– 262.

80. Nathan, M.,, N. Singh,, N. Garrett,, N. Hickey,, T. Prevost, and, M. Sheaff. 2010. Performance of anal cytology in a clinical setting when measured against histology and high-resolution anoscopy findings. AIDS 24: 373– 379.

81. Northfelt, D. W.,, B. J. Dezube,, J. A. Thommes,, B. J. Miller,, M. A. Fischl,, A. Friedman-Kien,, L. D. Kaplan,, C. Du Mond,, R. D. Mamelok, and, D. H. Henry. 1998. Pegylated-liposomal doxorubicin versus doxorubicin, bleomycin, and vincristine in the treatment of AIDS-related Kaposi’s sarcoma: results of a randomized phase III clinical trial. J. Clin. Oncol. 16: 2445– 2451.

82. Palefsky, J. M.,, E. A. Holly,, J. T. Efirdc,, M. Da Costa,, N. Jay,, J. M. Berry, and, T. M. Darragh. 2005. Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with men. AIDS 19: 1407– 1414.

83. Palefsky, J. M.,, E. A. Holly,, M. L. Ralston,, S. P. Arthur,, N. Jay,, J. M. Berry,, M. M. DaCosta,, R. Botts, and, T. M. Darragh. 1998. Anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual and bisexual men: prevalence and risk factors. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 17: 320– 326.

84. Palefsky, J. M.,, E. A. Holly,, M. L. Ralston, and, N. Jay. 1998. Prevalence and risk factors for human papillomavirus infection of the anal canal in human immunodeficiency virus (HIV)-positive and HIV-negative homosexual men. J. Infect. Dis. 177: 361– 367.

85. Palella, F. J.,, Jr., K. M. Delaney,, A. C. Moorman,, M. O. Loveless,, J. Fuhrer,, G. A. Satten,, D. J. Aschman, and, S. D. Holmberg. 1998. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N. Engl. J. Med. 338: 853– 860.

86. Pauk, J.,, M. L. Huang,, S. J. Brodie,, A. Wald,, D. M. Koelle,, T. Schacker,, C. Celum,, S. Selke, and, L. Corey. 2000. Mucosal shedding of human herpesvirus 8 in men. N. Engl. J. Med. 343: 1369– 1377.

87. Pellett, P. E.,, D. J. Wright,, E. A. Engels,, D. V. Ablashi,, S. C. Dollard,, B. Forghani,, S. A. Glynn,, J. J. Goedert,, F. J. Jenkins,, T. H. Lee,, F. Neipel,, D. S. Todd,, D. Whitby,, G. J. Nemo, and, M. P. Busch. 2003. Multicenter comparison of serologic assays and estimation of human herpesvirus 8 seroprevalence among US blood donors. Transfusion 43: 1260– 1268.

88. Rabkin, C. S.,, M. A. Testa,, J. Huang, and, J. H. Von Roenn. 1999. Kaposi’s sarcoma and non-Hodgkin’s lymphoma incidence trends in AIDS Clinical Trial Group study participants. J. Acquir. Immune Defic. Syndr. 21( Suppl. 1): S31– S33.

89. Raphael, M.,, O. Gentilhomme,, M. Tulliez,, P. A. Byron,, J. Diebold, et al. 1991. Histopathologic features of high-grade non-Hodgkin’s lymphomas in acquired immunodeficiency syndrome. Arch. Pathol. Lab. Med. 115: 15– 20.

90. Serrano, M.,, C. Bellas,, E. Campo,, J. Ribera,, C. Martin,, R. Rubio,, C. Ruiz,, I. Ocana,, L. Buzon,, M. Yebra, et al. 1990. Hodgkin’s disease in patients with antibodies to human immunodeficiency virus. A study of 22 patients. Cancer 65: 2248– 2254.

91. Shibata, D.,, L. M. Weiss,, A. M. Hernandez,, B. N. Nathwani,, L. Bernstein, and, A. M. Levine. 1993. Epstein-Barr virus-associated non-Hodgkin’s lymphoma in patients infected with the human immunodeficiency virus. Blood 81: 2102– 2109.

92. Simpson, G. R.,, T. F. Schulz,, D. Whitby,, P. M. Cook,, C. Boshoff,, L. Rainbow,, M. R. Howard,, S. J. Gao,, R. A. Bohenzky,, P. Simmonds,, C. Lee,, A. de Ruiter,, A. Hatzakis,, R. S. Tedder,, I. V. Weller,, R. A. Weiss, and, P. S. Moore. 1996. Prevalence of Kaposi’s sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet 348: 1133– 1138.

93. Sparano, J. A.,, J. Y. Lee,, L. D. Kaplan,, A. M. Levine,, J. C. Ramos,, R. F. Ambinder,, W. Wachsman,, D. Aboulafia,, A. Noy,, D. H. Henry,, J. Von Roenn,, B. J. Dezube,, S. C. Remick,, M. H. Shah,, L. Leichman,, L. Ratner,, E. Cesarman,, A. Chadburn, and, R. Mitsuyasu. 2010. Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma. Blood 115: 3008– 3016.

94. Spina, M.,, S. Sandri, and, U. Tirelli. 1999. Hodgkin’s disease in HIV-infected individuals. Curr. Opin. Oncol. 11: 522– 526.

95. Stewart, S.,, H. Jablonowski,, F. D. Goebel,, K. Arasteh,, M. Spittle,, A. Rios,, D. Aboulafia,, J. Galleshaw,, B. J. Dezube, et al. 1998. Randomized comparative trial of pegylated liposomal doxorubicin versus bleomycin and vincristine in the treatment of AIDS-related Kaposi’s sarcoma. J. Clin. Oncol. 16: 683– 691.

96. Sun, X. W.,, L. Kuhn,, T. V. Ellerbrock,, M. A. Chiasson,, T. J. Bush, and, T. C. Wright, Jr. 1997. Human papillomavirus infection in women infected with the human immunodeficiency virus. N. Engl. J. Med. 337: 1343– 1349.

97. Wang, D.,, D. Liebowitz, and, E. Kieff. 1985. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 43: 831– 840.

98. Wang, E. S.,, D. J. Straus,, J. Teruya-Feldstein,, J. Qin,, C. Portlock,, C. Moskowitz,, A. Goy,, E. Hedrick,, A. D. Zelenetz, and, A. Noy. 2003. Intensive chemotherapy with cyclophosphamide, doxorubicin, high-dose methotrexate/ifosfamide, etoposide, and high-dose cytarabine (CODOX-M/IVAC) for human immunodeficiency virus-associated Burkitt lymphoma. Cancer 98: 1196– 1205.

99. Whitby, D.,, M. R. Howard,, M. Tenant-Flowers,, N. S. Brink,, A. Copas,, C. Boshoff,, T. Hatzioannou,, F. E. Suggett,, D. M. Aldam,, A. S. Denton, et al. 1995. Detection of Kaposi sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi’s sarcoma. Lancet 346: 799– 802.

100. Xicoy, B.,, J. M. Ribera,, P. Miralles,, J. Berenguer,, R. Rubio,, B. Mahillo,, M. E. Valencia,, E. Abella,, A. Lopez-Guillermo,, A. Sureda,, M. Morgades,, J. T. Navarro, and, H. Esteban. 2007. Results of treatment with doxorubicin, bleomycin, vinblastine and dacarbazine and highly active antiretroviral therapy in advanced stage, human immunodeficiency virus-related Hodgkin’s lymphoma. Haematologica 92: 191– 198.

101. Yoshizaki, K.,, T. Matsuda,, N. Nishimoto,, T. Kuritani,, L. Taeho,, K. Aozasa,, T. Nakahata,, H. Kawai,, H. Tagoh,, T. Komori, et al. 1989. Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman’s disease. Blood 74: 1360– 1367.

102. Zeng, Y.,, X. Zhang,, Z. Huang,, L. Cheng,, S. Yao,, D. Qin,, X. Chen,, Q. Tang,, Z. Lv,, L. Zhang, and, C. Lu. 2007. Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi’s sarcoma-associated herpesvirus: role of JAK/STAT signaling. J. Virol. 81: 2401– 2417.