Chapter 2 : The Ontogeny of the Cells of the Innate and the Adaptive Immune System

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The ontogeny of erythrocytes, megakaryocytes, and blood platelets of different types of blood cells, the cells of the innate and the adaptive immune system, is very complex. Embryonic stem (ES) cells can be induced in vitro to differentiate to various cell lineages, notably also to hematopoietic cells and, more specifically, to cells of the innate and the adaptive immune system. Since B lymphocytes can be stimulated to develop into cells that no longer deposit their B-cell receptors (BcRs) (Ig) as antigen-specific receptors into the surface membrane but rather secrete this Ig as so-called plasma cells into the blood stream, antigen specificity of a B cell can be transferred to the innate immune system. By the time newly generated lymphocytes have been deposited in their peripheral, mature compartments of all the T cells and a large part of the B1 cells have been auto- antigen-ligand selected even before a foreign antigen can select “its” specific lymphocytes for a response.

Citation: Melchers F. 2011. The Ontogeny of the Cells of the Innate and the Adaptive Immune System, p 21-39. In Kaufmann S, Rouse B, Sacks D (ed), The Immune Response to Infection. ASM Press, Washington, DC. doi: 10.1128/9781555816872.ch2
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