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Chapter 5 : Comparative Genomics of : Biology and Applications

Authors: Lien-I Hor1, Hung-Yu Shu2, Keh-Ming Wu3, Shih-Feng Tsai4
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Affiliations: 1: Department of Microbiology and Immunology, College of Medicine, National Cheng-Kung University, Tainan 701, Taiwan; 2: Department of Bioscience Technology, College of Health Science, Chang Jung Christian University, Tainan County 711, Taiwan; 3: Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli 350, Taiwan; 4: Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli 350, Taiwan
Content Type: Monograph
Publication Year: 2011

Category: Applied and Industrial Microbiology; Food Microbiology

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Abstract:

, a gram-negative marine bacterium, has been recognized as an important pathogen of both humans and eels for decades. infection is characterized by the rapid spread of this organism from intestine or skin into deeper tissue and even the bloodstream to result in septicemia and/or necrotic skin lesions. One of gene regions, region XII, was found to be associated with one of the two lineages of divided based on the multilocus sequence typing (MLST) data of six housekeeping genes. The superintegron is unique to each Vibrio species, containing different kinds of gene cassettes. The functions of gene cassettes and open reading frames (ORFs) in superintegrons remain largely unknown. The publication of nucleotide sequences of two BT1 genomes and the BT2 virulence plasmid has opened up opportunities for mining new virulence genes for mice and eels as well as developing new diagnostic methods. Moreover, the complete genome information can be applied to epidemiology study and food safety monitoring. Because of the high mortality rate of systemic infection with , an effective vaccine against this organism is desired, particularly for individuals at high risk. Contaminated bivalve molluscan shellfish, including oysters, clams, and mussels, are major sources of per os infection by . The vast information generated from the genomes of major representative species has enabled comparative analysis and provided an opportunity to investigate the biology of this group of marine bacteria.

Citation: Hor L, Shu H, Wu K, Tsai S. 2011. Comparative Genomics of : Biology and Applications, p 67-76. In Fratamico P, Liu Y, Kathariou S (ed), Genomes of Foodborne and Waterborne Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555816902.ch5

Key Concept Ranking

Type IV Pili
0.44448024
Multilocus Sequence Typing
0.43977436
Pulsed-Field Gel Electrophoresis
0.42065373
Vibrio vulnificus
0.41754204
0.44448024
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References

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Tables

Comparative Genomics of Vibrio vulnificus: Biology and Applications
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Citation: Hor L, Shu H, Wu K, Tsai S. 2011. Comparative Genomics of : Biology and Applications, p 67-76. In Fratamico P, Liu Y, Kathariou S (ed), Genomes of Foodborne and Waterborne Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555816902.ch5
/content/10.1128/9781555816902.ch05.ch05tab01
Table 1
Phenotypic and genetic traits that distinguish between the three biotypes
Generic image for table
Table 1

Phenotypic and genetic traits that distinguish between the three biotypes

Citation: Hor L, Shu H, Wu K, Tsai S. 2011. Comparative Genomics of : Biology and Applications, p 67-76. In Fratamico P, Liu Y, Kathariou S (ed), Genomes of Foodborne and Waterborne Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555816902.ch5
/content/10.1128/9781555816902.ch05.ch05tab02
Table 2
Sequenced species genomes
Generic image for table
Table 2

Sequenced species genomes

Citation: Hor L, Shu H, Wu K, Tsai S. 2011. Comparative Genomics of : Biology and Applications, p 67-76. In Fratamico P, Liu Y, Kathariou S (ed), Genomes of Foodborne and Waterborne Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555816902.ch5
/content/10.1128/9781555816902.ch05.ch05tab03
Table 3
Comparison between biotype 1 and biotype 2 genomes
Generic image for table
Table 3

Comparison between biotype 1 and biotype 2 genomes

Citation: Hor L, Shu H, Wu K, Tsai S. 2011. Comparative Genomics of : Biology and Applications, p 67-76. In Fratamico P, Liu Y, Kathariou S (ed), Genomes of Foodborne and Waterborne Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555816902.ch5

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