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Category: Applied and Industrial Microbiology; Food Microbiology
Comparative Genomics of Vibrio vulnificus: Biology and Applications, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555816902/9781555814571_Chap05-1.gif /docserver/preview/fulltext/10.1128/9781555816902/9781555814571_Chap05-2.gifAbstract:
Vibrio vulnificus, a gram-negative marine bacterium, has been recognized as an important pathogen of both humans and eels for decades. V. vulnificus infection is characterized by the rapid spread of this organism from intestine or skin into deeper tissue and even the bloodstream to result in septicemia and/or necrotic skin lesions. One of gene regions, region XII, was found to be associated with one of the two lineages of V. vulnificus divided based on the multilocus sequence typing (MLST) data of six housekeeping genes. The superintegron is unique to each Vibrio species, containing different kinds of gene cassettes. The functions of gene cassettes and open reading frames (ORFs) in superintegrons remain largely unknown. The publication of nucleotide sequences of two BT1 V. vulnificus genomes and the BT2 virulence plasmid has opened up opportunities for mining new virulence genes for mice and eels as well as developing new diagnostic methods. Moreover, the complete genome information can be applied to epidemiology study and food safety monitoring. Because of the high mortality rate of systemic infection with V. vulnificus, an effective vaccine against this organism is desired, particularly for individuals at high risk. Contaminated bivalve molluscan shellfish, including oysters, clams, and mussels, are major sources of per os infection by V. vulnificus. The vast information generated from the genomes of major representative Vibrio species has enabled comparative analysis and provided an opportunity to investigate the biology of this group of marine bacteria.
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Phenotypic and genetic traits that distinguish between the three V. vulnificus biotypes a
Sequenced Vibrio species genomes
Comparison between Vibrio vulnificus biotype 1 and biotype 2 genomes