Impact of the Toxoplasma gondii Genome Project

Benjamin M. Rosenthal

doi:10.1128/9781555816902.ch22

Chapter 22 : Impact of the Toxoplasma gondii Genome Project

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Affiliations: 1: Animal Parasite Disease Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705

Content Type: Monograph

Publication Year: 2011

Category: Applied and Industrial Microbiology; Food Microbiology

Book DOI: 10.1128/9781555816902

Chapter DOI: 10.1128/9781555816902.ch22

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Abstract:

This chapter provides an assessment of the extent to which the Toxoplasma gondii genome has fulfilled its promise. It describes the available genomic resources, and provides an overview of those aspects of toxoplasmosis research that have grown most as a consequence of genomic resources. To provide an estimate and description of the "attributable fraction" of progress owed to genomic biology, most of this chapter reviews the hundred (or so) papers that acknowledge several key developments in Toxoplasma gondii genomics. The chapter discusses some additional perspectives intended to expand upon and supplement the documented record of developments made possible by genomic biology, including a discussion of literature that may only indirectly establish that causal link. Finally, the chapter considers the impact that genomics has made on our understanding of T. gondii toxoplasmosis, and broader issues in eukaryotic Microbiology. Recombinant vaccine candidates for N. caninum have been identified by searching T. gondii genomic and expressed sequence tags (ESTs) databases. A genomewide survey of SNP polymorphism provided a means to more fully substantiate and explain earlier observations, that most isolates of T. gondii studied to date can be classified as members of one of three multilocus types, and that only a few ancestors could have contributed all of the diversity represented among them. In the case of T. gondii, the genomic data have encouraged the engagement of a creative and inquisitive cadre of research scientists.

Citation: Rosenthal B. 2011. Impact of the Toxoplasma gondii Genome Project, p 309-320. In Fratamico P, Liu Y, Kathariou S (ed), Genomes of Foodborne and Waterborne Pathogens. ASM Press, Washington, DC. doi: 10.1128/9781555816902.ch22

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