Borrelia: a Diverse and Ubiquitous Genus of Tick-Borne Pathogens

Alan G. Barbour

doi:10.1128/9781555816988.ch10

10 : Borrelia: a Diverse and Ubiquitous Genus of Tick-Borne Pathogens

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Affiliations: 1: Departments of Medicine and of Microbiology and Molecular Genetics, University of California, Irvine, CA 92697-4025

Content Type: Monograph

Publication Year: 2001

Category: Clinical Microbiology

Book DOI: 10.1128/9781555816988

Chapter DOI: 10.1128/9781555816988.ch10

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Abstract:

Although the new species associated with Lyme disease were more closely related to previously known Borrelia species than they were to treponemes, leptospires, or other spirochetes, the new species were clearly distinct from the relapsing fever species on the basis of DNA relatedness. As investigators in North America, Europe, and Asia gathered more samples from ticks and animals in the field, isolates that could not be classified as Borrelia burgdorferi, Borrelia afzelii, or Borrelia garinii were noted. The report of isolates of B. burgdorferi from Ixodes scapularis in Texas is in doubt, because similar organisms were allegedly also recovered from fleas and ticks that are incompetent as vectors. One of the isolates of B. burgdorferi from a study of I. scapularis ticks, was also highly similar to a commonly used laboratory strain of B. burgdorferi, and a study of five Texas isolates of B. burgdorferi demonstrated that the isolates were noninfectious for mice, a characteristic of serially cultivated isolates. The study of the outbreak at the summer camp in North Carolina found that 97% of 588 ticks collected from vegetation were A. americanum, 2% were Dermacentor variabilis, and only 2 (0.3%) were I. scapularis. Although it is more distant from members of the Lyme disease group than from those of the relapsing fever group, the species of the third major group are transmitted by hard ticks-prostriate ticks in the cases of B. miyamotoi and the new Borrelia sp. and metastriate ticks in the cases of B. theileri and B. lonestari.

Citation: Barbour A. 2001. Borrelia: a Diverse and Ubiquitous Genus of Tick-Borne Pathogens, p 153-174. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 5. ASM Press, Washington, DC. doi: 10.1128/9781555816988.ch10

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Borrelia: a Diverse and Ubiquitous Genus of Tick-Borne Pathogens

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Figure 1

Unrooted neighbor-joining phylogenetic tree of selected Borrelia species. 16S rRNA sequences corresponding to base positions 56 to 1345 of the B. burgdorferi 16S rRNA gene (GenBank accession number M88329) were aligned and analyzed by using the ClustalX program package. Selected other Borrelia species included in the analysis (with accession numbers given in parentheses) are B. bissettii (AJ224141), B. andersonii (L46701), B. afzelii (X85189), B. garinii (AJ009749), B. turdi (D67024), B. tanukii (D67023), B. japonica (U42299), B. valaisiana (X98232), B. lusitaniae (X98229), B. miyamotoi (D45192), B. lonestari (U23211), B. theileri (U38375), B. anserina (U42284), B. coriaceae (U42286), B. persica (U42297), B. crocidurae (U42302), B. recurrentis (U42300), B. turicatae (U42299), B. hennsii (U42292), and Borrelia spp. from a patient in Spain (U28502), a dog from Florida (L37837), and an owl from Washington State (AFI16903). The outgroup is the spirochete Treponema pallidum (M88726). Three major groupings are demarcated, and the types of ticks that are the usual vectors of members of each are indicated. B. recurrentis is the only known Borrelia species transmitted by an insect instead of a tick.

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Figure 1

References

/content/book/10.1128/9781555816988.chap10

1. Anda, P.,, W. Sanchez-Yebra,, M. del Mar Vitutia,, E. Perez Pastrana,, I. Rodriguez,, N. S. Miller,, P. B. Backenson,, and J. L. Benach. 1996. A new Borrelia species isolated from patients with relapsing fever in Spain. Lancet 348: 162– 165.

2. Anderson, J. F.,, S. W. Barthold,, and L. A. Magnarelli. 1990. Infectious but nonpathogenic isolate of Borrelia burgdorferi. J. Clin. Microbiol. 28: 2693– 2699.

3. Anderson, J. F.,, L. A. Magnarelli,, R. B. LeFebvre,, T. G. Andreadis,, J. B. McAninch,, G. C. Perng,, and R. C. Johnson. 1989. Antigenically variable Borrelia burgdoiferi isolated from cottontail rabbits and Ixodes dentatus in rural and urban areas. J. Clin. Microbiol. 27: 13– 20.

4. Armstrong, P. M.,, S. M. Rich,, R. D. Smith,, D. L. Hartl,, A. Spielman,, and S. R. Telford III. 1996. A new borreiia infecting Lone Star ticks. Lancet 347: 67– 68.

5. Baranton, G.,, N. Marti Ras,, and D. Postic. 1998. Molecular epidemiology of the aetiological agents of Lyme borreliosis. Wien. Klin. Wochenschr. 110: 850– 855.

6. Barbour, A. G., 2000. Borrelia infections: relapsing fever and Lyme disease, p. 57– 70. In M. W. Cunningham, and R. S. Fujinami (ed.), Effects of Microbes on the Immune System. Lippincott Williams& Wilkins, Philadelphia, Pa.

7. Barbour, A. G. 1996. Does Lyme disease occur in the South?: a survey of emerging tick-borne infections in the region. Am. J. Med. Sci. 311: 34– 40.

8. Barbour, A. G. 1987. lmrnunobiology of relapsing fever. Contrib. Microbiol. Immunol. 8: 125– 137.

9. Barbour, A. G. 1984. Isolation and cultivation of Lyme disease spirochetes. Yale J. BioI. Med. 57: 521– 525.

10. Barbour, A. G. 1988. Plasmid analysis of Borrelia burgdorferi, the Lyme disease agent. J. Clin. Microbiol. 26: 475– 478.

11. Barbour, A. G.,, and D. Fish. 1993. The biological and social phenomenon of Lyme disease. Science 260: 1610– 1616.

12. Barbour, A. G.,, and S. F. Hayes. 1986. Biology of Borrelia species. Microbial. Rev. 50: 381– 400.

13. Barbour, A. G.,, R. A. Heiland,, and T. R. Howe. 1985. Heterogeneity of major proteins in Lyme disease borreliae: a molecular analysis of North American and European isolates. J. Infect. Dis. 152: 478– 484.

14. Barbour, A. G.,, G. O. Maupin,, G. J. Teltow,, C. J. Carter,, and J. Piesman. 1996. Identification of an un cultivable Borrelia species in the hard tick Amblyomma americanum: possible agent of a Lyme disease-like illness. J. Infect. Dis. 173: 403– 409.

15. Barbour, A. G.,, O. Peter,, A. Aschleimann,, and W. Burgdorfer. 1983. Isolation of a cultivable spirochete from Ixodes ricinus ticks of Switzerland. Curro Microbiol. 8: 123– 126.

16. Bissett, M. L.,, and W. Hill. 1987. Characterization of Borrelia burgdorferi strains isolated from Ixodes pacificus ticks in California. J. Clin. Microbiol. 25: 2296– 2301.

17. Breitner-Ruddock, S.,, R. Wurzner,, J. Schulze,, and V. Brade. 1997. Heterogeneity in the complement- dependent bacteriolysis within the species of Borrelia burgdorferi. Med. Microbiol. Immunol. (Berlin) 185: 253– 260.

18. Breitschwerdt, E. B.,, W. L. Nicholson,, A. R. Kiehl,, C. Steers,, D. J. Meuten,, and J. F. Levine. 1994. Natural infections with Borrelia spirochetes in two dogs from Florida. J. Clin. Microbiol. 32: 352– 357.

19. Burgdorfer, W.,, A. G. Barbour,, S. F. Hayes,, J. L. Benach,, E. Grunwaldt,, and J. P. Davis. 1982. Lyme disease-a tick-borne spirochetosis? Science 216: 1317– 1319.

20. Burgdorfer, W.,, R. S. Lane,, A. G. Barbour,, R. A. Gresbrink,, and J. R. Anderson. 1985. The western black-legged tick, Ixodes pacificus: a vector of Borrelia burgdorferi. Am. 1. Trop. Med. Hyg. 34: 925– 930.

21. Burkot, T. R.,, B. S. Schneider,, N. J. Pieniazek,, C. M. Happ,, J. S. Rutherford,, S. B. Slemenda,, E. Hoffmeister,, G. O. Maupin,, and N. S. Zeidner. 2000. Babesia microti and Borrelia bissettii transmission by Ixodes spinipalpis ticks among prairie voles, Microtus ochrogaster, in Colorado. Parasitology 121: 595– 599.

22. Campbell, G. L.,, W. S. Paul,, M. E. Schriefer,, R. B. Craven,, K. E. Robbins,, and D. T. Dennis. 1995. Epidemiologic and diagnostic studies of patients with suspected early Lyme disease, Missouri, 1990-1993. J. Infect. Dis. 172: 470– 480.

23.Centers for Disease Control. 1989. Tickborne diseases-Georgia. Morb. Mortal. Wkly. Rep. 39: 397– 399.

24. Cutler, S. J.,, D. Fekade,, K. Hussein,, K. A. Knox,, A. Melka,, K. Cann,, A. R. Emilianus,, D. A. Warrell,, and D. J. Wright. 1994. Successful in-vitro cultivation of Borrelia recurrentis. Lancet 343: 242.

25. De Michelis, S.,, H. S. Sewell,, M. Collares-Pereira,, M. Santos-Reis,, L. M. Schouls,, V. Benes,, E. C. Holmes,, and K. Kurtenbach. 2000. Genetic diversity of Borrelia burgdorferi sensu lato in ticks from mainland Portugal. J. Clin. Microbiol. 38: 2128– 2133.

26. Feir, D.,, C. R. Santanello,, B. W. Li,, C. S. Xie,, E. Masters,, R. Marconi,, and G. Wei!. 1994. Evidence supporting the presence of Borrelia burgdorferi in Missouri. Am. J. Trop. Med. Hyg. 51: 475– 482.

27. Felz, M. W.,, F. W. Chandler, Jr.,, J. H. Oliver, Jr.,, D. W. Rahn,, and M. E. Schriefer. 1999. Solitary erythema migrans in Georgia and South Carolina. Arch. Dermatol. 135: 1317– 1326.

28. Fukunaga, M.,, A. Hamase,, K. Okada,, H. Inoue,, Y. Tsuruta,, K. Miyamoto,, and M. Nakao. 1996. Characterization of spirochetes isolated from ticks ( Ixodes tanuki, Ixodes turdus, and Ixodes columnae) and comparison of the sequences with those of Borrelia burgdorferi sensu lato strains. Appl. Environ. Microbiol. 62: 2338– 2344.

29. Fukunaga, M.,, A. Hamase,, K. Okada,, and M. Nakao. 1996. Borrelia tanukii sp. nov. and Borrelia turdae sp. nov. found from ixodid ticks in Japan: rapid species identification by 16S rRNA genetargeted PCR analysis. Microbiol. Immunol. 40: 877– 881.

30.. Fukunaga, M.,, Y. Takahashi,, Y. Tsuruta,, O. Matsushita,, D. Ralph,, M. McClelland,, and M. Nakao. 1995. Genetic and phenotypic analysis of Borrelia miyamotoi sp. nov., isolated from the ixodid tick Ixodes persulcatus, the vector for Lyme disease in Japan. Int. J. Syst. Bacterial. 45: 804– 810.

31. Hamase, A.,, Y. Takahashi,, K. Nohgi,, and M. Fukunaga. 1996, Homology of variable major protein genes between Borrelia herrnsii and Borrelia miyamotoi. FEMS Microbial. Lett. 140: 131– 137.

32. Hendson, M.,, and R. S. Lane. 2000. Genetic characteristics of Borrelia coriaceae isolates from the soft tick Ornithodoros coriaceus (Acari: Argasidae). J. Clin. Microbiol. 38: 2678– 2682.

33.. Humair, P. F.,, D. Postic,, R. Wallich,, and L. Gem. 1998 , An avian reservoir (Turdus merula) of the Lyme borreliosis spirochetes. Zentbl. Bakteriol, 287: 521– 538.

34. Isogai, E.,, H. Isogai,, K. Kimura,, S. Hayashi,, T. Kubota,, T. Nishikawa,, A. Nakane,, and N. Fujii. 1996. Cytokines in the serum and brain in mice infected with distinct species of Lyme disease Borrelia. Microb. Pathog. 21: 413– 419.

35. James, A. M.,, D. Liveris,, G. P. Wormser,, I. Schwartz,, M. A. Montecalvo,, and B. J. Johnson. 2001. Borrelia lonestari infection after a bite by an Amblyomma americanum tick. J. Infect. Dis. 183: 1810– 1814.

36. Kaneda, K.,, T. Masuzawa,, M. M. Simon,, E. Isogai,, H. Isogai,, K. Yasugami,, T. Suzuki,, Y. Suzuki,, and Y. Yanagihara. 1998. Infectivity and arthritis induction of Borrelia japonica on SCID mice and immune competent mice: possible role of galactosylceramide binding activity on initiation of infection. Microbiol. Immunol. 42: 171– 175.

37. Kawabata, H.,, T. Masuzawa,, and Y. Yanagihara. 1993. Genomic analysis of Borrelia japonica sp. nov. isolated from Ixodes ovatus in Japan. Microbiol. Immunol. 37: 843– 848.

38. Keirans, J. E.,, H. J. Hutcheson,, L. A. Durden,, and J. S. Klompen. 1996. Ixodes (Ixodes) scapularis (Acari:Ixodidae): redescription of all active stages, distribution, hosts, geographical variation, and medical and veterinary importance. J. Med. Entomol. 33: 297– 318.

39. Kirkland, K. B.,, T. B. Klimko,, R. A. Meriwether,, M. Schriefer,, M. Levin,, J. Levine,, W. R. Mac Kenzie,, and D. T. Dennis. 1997. Erythema migrans-like rash illness at a camp in North Carolina: a new tick-borne disease? Arch. Intern. Med. 157: 2635– 2641.

40. Kolbert, C. P.,, D. S. Podzorski,, D. A. Mathiesen,, A. T. Wortman,, A. Gazumyan,, I. Schwartz,, and D. H. Persing. 1995. Two geographically distinct isolates of Borrelia burgdorferi from the United States share a common unique ancestor. Res. Microbial. 146: 415– 424.

41. Kuo, M. M.,, R. S. Lane,, and P. C. GicIas. 2000. A comparative study of mammalian and reptilian alternative pathway of complement-mediated killing of the Lyme disease spirochete (Borrelia burgdorferi). J. Parasitol. 86: 1223– 1228.

42. Kurtenbach, K.,, M. Peacey,, S. G. Rijpkema,, A. N. Hoodless,, P. A. Nuttall,, and S. E. Randolph. 1998. Differential transmission of the genospecies of Borrelia burgdorferi sensu lato by game birds and small rodents in England. Appl. Environ. Microbiol. 64: 1169– 1174.

43. Kurtenbach, K.,, H. S. Sewell,, N. H. Ogden,, S. E. Randolph,, and P. A. Nuttall. 1998. Serum complement sensitivity as a key factor in Lyme disease ecology. Infect. Immun. 66: 1248– 1251.

44. Lane, R. S. 1990. Susceptibility of the western fence lizard (Sceloporus occidentalis) to the Lyme borreliosis spirochete (Borrelia burgdorferi). Am. J. Trop. Med. Hyg. 42: 75– 82.

45. Lane, R. S.,, W. Burgdorfer,, S. F. Hayes,, and A. G. Barbour. 1985. Isolation of a spirochete from the soft tick, Ornithodoros coriaccus: a possible agent of epizootic bovine abortion. Science 230: 85– 87.

46. Lane, R. S.,, and S. A. Manweiler. 1988. Borrelia coriaceae in its tick vector, Ornithodoros coriaceus (Acari: Argasidae), wilh emphasis on transstadial and lransovarial infection. J. Med. Entomol. 25: 172– 177.

47. Lane, R. S.,, and G. B. Quistad. 1998. Borreliacidal factor in the blood of the western fence lizard (Sceloporus occidentalis). J. Parasitol. 84: 29– 34.

48. Lash, A.,, S. Granter,, E. J. Masters,, and P. H. Duray. 1998. Erythema migrans (EM) in Missouri compared to EM in the northeastern U.S. Modern Pathol. 11: 145.

49. Le Fleche, A.,, D. Postic,, K. Girardet,, O. Peter,, and G. Baranton. 1997. Characterization of Borrelia lusitaniae sp. nov. by 16S ribosomal DNA sequence analysis. Int. J. Syst. Bacteriol. 47: 921– 925.

50. Levine, J. F.,, C. S. Apperson,, and W. L. Nicholson. 1989. The occurrence of spirochetes in ixodid ticks in North Carolina. J. Entomol. Sci. 24: 594– 602.

51. Levine, J. F.,, C. S. Apperson,, R. A. Spiegel,, W. L. Nicholson,, and C. J. Staes. 1991. Indigenous cases of Lyme disease diagnosed in North Carolina. South. Med. J. 84.

52. Luckhart, S.,, G. R. Mullen,, L. A. Durden,, and J. C. Wright. 1992. Borrelia sp. in ticks recovered from white-tailed deer in Alabama. J. Wildl. Dis. 28: 449– 452.

53. Luckhart, S.,, G. R. Mullen,, and J. C. Wright. 1991. Etiologic agent of Lyme disease, Borrelia burgdorferi, detected in ticks (Acari: Ixodidae) collected at a focus in Alabama. J. Med. Entomol. 28: 652– 657.

54. Masters, E. J. 1990. Case histories in Missouri: Lyme disease in the southcentral United States. Mo. Acad. Sci. Occas. Pap. no. 8 88: 5– 8.

55. Masters, E. J.,, and H. D. Donnell. 1995. Lyme and/ or Lyme-like disease in Missouri. Mo. Med. 92: 346– 353.

56. Masters, E. J.,, S. Granter,, P. Duray,, and P. Cordes. 1998. Physician-diagnosed erythema migrans and erythema migrans-like rashes following Lone Star tick biles. Arch. DermatoZ. 134: 955– 960.

57. Masuzawa, T.,, T. Fukui,, M. Miyake,, H. B. Oh,, M. K. Cho,, W. H. Chang,, Y. Imai,, and Y. Yanagihara. 1999. Determination of members of a Borrelia afzelii-related group isolated from Ixodes nipponensis in Korea as Borrelia valaisiana. Int. J. Syst. Bacteriol. 49: 1409– 1415.

58. Masuzawa, T.,, T. Kurita,, H. Kawabata,, K. Muramatsu,, K. Uchikawa,, and Y. Yanagihara. 1994. Infectivity and early antibody response to Borrelia burgdorferi sensu lato isolated in Japan in outbred mice. Microbiol. Immunol. 38: 621– 627.

59. Masuzawa, T.,, H. Suzuki,, H. Kawabata,, F. Ishiguro,, N. Takada,, and Y. Yanagihara. 1996. Characterization of Borrelia spp. isolated from the tick, Ixodes tanuki and small rodents in Japan. J. Wildl. Dis. 32: 565– 571.

60. Masuzawa, T.,, Y. Yanagihara,, and H. Fujita. 1996. A case of Lyme borreliosis which was suspected to be caused by Borrelia japonica infection in Shizuoka, Japan. Kansenshogaku Zasshi 70: 264– 267. (In Japanese.)

61. Mather, T. N.,, and M. E. Mather. 1990. Intrinsic competence of three ixodid ticks (Acari) as vectors of the Lyme disease spirochete. J. Med. Entomol. 27: 646– 650.

62. Mathiesen, D. A.,, J. H. Oliver, Jr.,, C. P. Kolbert,, E. D. Tullson,, B. J. Johnson,, G. L. Campbell,, P. D. Mitchell,, K. D. Reed,, S. R. Telford III,, J. F. Anderson,, R. S. Lane,, and D. H. Persing. 1997. Genetic heterogeneity of Borrelia burgdorferi in the United States. J. Infect. Dis. 175: 98– 107.

63. Maupin, G.0., , K. L. Gage,, J. Piesman,, J. Montenieri,, S. L. Sviat,, L. VanderZanden,, C. M. Happ,, M. Dolan,, and B. J. Johnson. 1994. Discovery of an enzootic cycle of Borrelia burgdorferi in Neotoma mexicana and Ixodes spinipalpis from northern Colorado, an area where Lyme disease is nonendemic. J. Infect. Dis. 170: 636– 643.

64. Melski, J. W. 1999. Language, logic, and Lyme disease. Arch. Dermatol. 135: 1398– 1400.

65. Nakao, M.,, K. Miyamoto,, and M. Fukunaga. 1994. Borrelia japonica in nature: genotypic identification of spirochetes isolated from Japanese small mammals. Microbiol. Immunol. 38: 805– 808.

66. Norris, D. E.,, B. J. Johnson,, J. Piesman,, G. O. Maupin,, J. L. Clark,, and W. C. T. Black. 1999. Population genetics and phylogenetic analysis of Colorado Borrelia burgdorferi. Am. J. Trop. Med .Hyg. 60: 699– 707.

67. Oliver, J. H., Jr. 1996. Lyme borreliosis in the southern United States: a review. J. Parasitol. 82: 926– 935.

68. Oliver, J. H., Jr.,, F. W. Chandler, Jr.,, A. M. James,, L. O. Huey,, G. N. Vogel,, and F. H. Sanders, Jr. 1996. Unusual strain of Borrelia burgdorferi isolated from Ixodes dentatus in central Georgia. J. Parasitol. 82: 936– 940.

69. Oliver, J. H. Jr.,, F. W. Chandler, Jr.,, A. M. James,, F. H. Sanders, Jr.,, H. J. Hutcheson,, L. O. Huey,, B. S. McGuire,, and R. S. Lane. 1995. Natural occurrence and characterization of the Lyme disease spirochete, Borrelia burgdorferi, in cotton rats (Sigmodon hispidus) from Georgia and Florida. J. Parasitol. 81: 30– 36.

70. Oliver, J. H., Jr.,, F. W. Chandler, Jr.,, M. P. Luttrell,, A. M. James,, D. E. Stallknecht,, B. S. McGuire,, H. J. Hutcheson,, G. A. Cummins,, and R. S. Lane. 1993. Isolation and transmission of the Lyme disease spirochete from the southeastern United States. Proc. Natl. Acad. Sci. USA 90: 7371– 7375.

71. Oliver, J. H., Jr.,, K. L. Clark,, F. W. Chandler, Jr.,, L. Tao,, A. M. James,, C. W. Banks,, L. O. Huey,, A. R. Banks,, D. C. Williams,, and L. A. Durden. 2000. Isolation, cultivation, and characterization of Borrelia burgdoiferi from rodents and ticks in the Charleston area of South Carolina. J. Clin. Microbiol. 38: 120– 124.

72. Oliver, J. H., Jr.,, T. M. Kollars, Jr.,, F. W. Chandler, Jr.,, A. M. James,, E. J. Masters,, R. S. Lane,, and L. O. Huey. 1998. First isolation and cultivation of Borrelia burgdorferi sensu lato from Missouri. J. Clin. Microbiol. 36: 1– 5.

73. Oliver, J. H., Jr.,, L. A. Magnarelli,, H. J. Hutcheson,, and J. F. Anderson. 1999. Ticks and antibodies to Borrelia burgdorferi from mammals at Cape Hatteras, NC and Assateague Island, MD and VA. J. Med. Entomol. 36: 578– 587.

74. Olsen, B.,, T. G. Jaenson,, L. Noppa,, J. Bunikis,, and S. Bergstrom. 1993. A Lyme borreliosis cycle in seabirds and Ixodes uriae ticks. Nature 362: 340– 342.

75. Ouellette, J.,, C. S. Apperson,, P. Howard,, T. L. Evans,, and J. F. Levine. 1997. Tick-raccoon associations and the potential for Lyme disease spirochete transmission in the coastal plain of North Carolina. J. Wildl. Dis. 33: 28– 39.

76. Park, H. K.,, B. E. Jones,, and A. G. Barbour. 1986. Erythema chronicum migrans of Lyme disease: diagnosis by monoclonal antibodies. J. Am. Acad. Dermatol. 15: 406– 410.

77. Peavey, C. A.,, and R. S. Lane. 1996. Comparison of infectivities of six tick-derived isolates of Borrelia burgdorferi for rodents and ticks. J. Clin. Microbiol. 34: 71– 75.

78. Pennington, P. M.,, C. D. Allred,, C. S. West,, R. Alvarez,, and A. G. Barbour. 1997. Arthritis severity and spirochete burden are detennined by serotype in the Borrelia turicatae-mouse model of Lyme disease. Infect. Immun. 65: 285– 292.

79.Péter, 0., A. G. Bretz, and D. Bee. 1995. Occurrence of different genospecies of Borrelia burgdorferi sensu lato in ixodid ticks of Valais, Switzerland. Eur. J. Epidemiol. 11: 463– 467.

80. Picken, R. N.,, Y. Cheng,, F. Strle,, and M. M. Picken. 1996. Patient isolates of Borrelia burgdorferi sensu lato with genotypic and phenotypic similarities of strain 25015. J. Infect. Dis. 174: 1112– 1115.

81. Picken, R. N.,, and M. M. Picken. 2000. Molecular characterization of Borrelia spp. isolates from greater metropolitan Chicago reveals the presence of Borrelia bissettii. Preliminary report. J. Mol. Microbiol. Biotechnol. 2: 505– 507.

82. Piesman, J.,, K. L. Clark,, M. C. Dolan,, C. M. Happ,, and T. R. Burkot. 1999. Geographic survey of vector ticks (Ixodes scapularis and Ixodes pacificus) for infection with the Lyme disease spirochete, Borrelia burgdorferi. J. Vector Ecol. 24: 91– 98.

83. Piesman, J.,, and C. M. Happ. 1997. Ability of the Lyme disease spirochete Borrelia burgdorferi to infect rodents and three species of human-biting ticks (blacklegged tick, American dog tick, lone star tick) (Acari:Ixodidae). J. Med. Entomol. 34: 451– 456.

84. Piesman, J.,, and R. J. Sinsky. 1988. Ability of Ixodes scapularis, Dennacentor variabilis, and Amblyomma americanum (Acari: Ixodidae) to acquire, maintain, and transmit Lyme disease spirochetes (Borrelia burgdorferi). J. Med. Entomol. 25: 336– 339.

85. Postic, D.,, M. V. Assous,, P. A. Grimont,, and G. Baranton. 1994. Diversity of Borrelia burgdorferi sensu lato evidenced by restriction fragment length polymorphism of rrf (5S)-rrl (23S) intergenic spacer amplicons. Int. J. Syst. Bacteriol. 44: 743– 752.

86. Postic, D.,, J. Belfaiza,, E. Isogai,, I. Saint Girons,, P. A. Grimont,, and G. Baranton. 1993. A new genomic species in Borrelia burgdorferi sensu lato isolated from Japanese ticks. Res. Microbio/. 144: 467– 473.

87. Postic, D.,, N. M. Ras,, R. S. Lane,, M. Hendson,, and G. Baranton. 1998. Expanded diversity among Californian borrelia isolates and description of Borrelia bissettii sp. nov. (fonnedy Borrelia group DNI27). J. Clin. Microbiol. 36: 3497– 3504.

88. Postic, D.,, N. M. Ras,, R. S. Lane,, P. Humair,, M. M. Wittenbrink,, and G. Baranton. 1999. Common ancestry of Borrelia burgdorferi sensu lato strains from North America and Europe. J. Clin. Microbiol. 37: 3010– 3012.

89. Rawlings, J. A.,, and G. J. Teltow. 1994. Prevalence of Borrelia (Spirochaetaceae) spirochetes in Texas ticks. J. Med. Entomol. 31: 297– 301.

90. Rich, S. M.,, P. M. Armstrong,, R. D. Smith,, and S. R. Telford III. 2001. Lone star tick-infecting borreliae are most closely related to the agent of bovine borreliosis. J. Clin. Microbiol. 39: 494– 497.

91. Rijpkema, S. G.,, D. J. Tazelaar,, and M. Molkenboer. 1997. Detection of Borrelia afzelii, Borrelia burgdorferi sensu stricto, Borrelia garinii, and group VS116 by PCR in skin biopsies of patients with erythema migrans and acrodennatitis chronic a atrophicans. Clin. Microbiol. Infect. 3: 109– 116.

92. Ryder, J. W.,, R. R. Pinger,, and T. Glancy. 1992. Inability of Ixodes cookei and Amblyomma americanum nymphs (Acari: Ixodidae) to transmit Borrelia burgdorferi. J. Med. Entomol. 29: 525– 530.

93. Schulze, T. L.,, G. S. Bowen,, E. M. Bosler,, M. F. Lakat,, W. E. Parkin,, R. Altman,, B. G. Ormiston,, and J. K. Shisler. 1984. Amblyomma americanum: a potential vector of Lyme disease in New Jersey. Science 224: 601– 603.

94. Schwan, T. G.,, M. E. Schrumpf,, R. H. Karstens,, J. R. Clover,, J. Wong,, M. Daugherty,, M. Struthers,, and P. A. Rosa. 1993. Distribution and molecular analysis of Lyme disease spirochetes, Borrelia burgdorferi, isolated from ticks throughout California. J. Clin. Microbiol. 31: 3096– 3108.

95. Scoles, G. A.,, M. Papero,, L. Beati,, and D. Fish. 2001. A relapsing fever group spirochete transmitted by Ixodes scapularis ticks. Vector Borne Zoonotic Dis. 1: 21– 34.

96. Semtner, P. J.,, and J. A. Hair. 1973. The ecology and behavior of the lone star tick (Acarina: Ixodidae). V. Abundance and seasonal distribution in different habitat types. J. Med. Entomol. 31: 618– 628.

97. Shanbaky, N. M.,, and N. Helmy. 2000. First record of natural infection with Borrelia in ornithodoros (Ornithodoros) savignyi. Reservoir potential and specificity of the tick to Borrelia. 1. Egypt. Soc. Parasitol. 30: 765– 780.

98. Spielman, A.,, R. J. Pollack,, A. E. Kiszewski,, and S. R. Telford, 3rd. 2001. Issues in public health entomology. Vector Borne Zoonotic Dis. 1: 3– 20.

99. Steere, A. C.,, V. K. Sikand,, F. Meurice,, D. L. Parenti,, E. Fikrig,, R. T. Schoen,, J. Nowakowski,, C. H. Schmid,, S. Laukamp,, C. Buscarino,, and D. S. Krause. 1998. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. N. Engl. J. Med. 339: 209– 215.

100. Strle, F.,, R. N. Picken,, Y. Cheng,, J. Cimperman,, V. Maraspin,, S. Lotric-Furlan,, E. RuzicSabljic,, and M. M. Picken. 1997. Clinical findings for patients with Lyme borreliosis caused by Borrelia burgdorferi sensu lato with genotypic and phenotypic similarities to strain 25015. Clin. Infect. Dis. 25: 273– 280.

101. Talleklint-Eisen, L.,, and R. S. Lane. 1999. Variation in the density of questing Ixodes pacificus (Acari:Ixodidae) nymphs infected with Borrelia burgdorferi at different spatial scales in California. J. Parasitol. 85: 824– 831.

102. Telford, S. R. III,, and A. Spielman. 1989. Enzootic transmission of the agent of Lyme disease in rabbits. Am. J. Trop. Med. Hyg. 41: 482– 490.

103. Teltow, G. J.,, P. V. Fournier,, and J. A. Rawlings. 1991. Isolation of Borrelia burgdorferi from arthropods collected in Texas. Am. J. Trop. Med. Hyg. 44: 469– 474.

104. Thomas, N. J.,, J. Bunikis,, A. G. Barbour,, and M. J. Wolcott. Fatal spirochetosis due to a relapsing fever-like Borrelia sp. in a Northern Spotted Owl. J. Wildl. Dis., in press.

105. van Dam, A. P.,, A. Oei,, R. Jaspars,, C. Fijen,, B. Wilske,, L. Spanjaard,, and J. Dankert. 1997. Complement-mediated serum sensitivity among spirochetes that cause Lyme disease. Infect. Immun. 65: 1228– 1236.

106. Wang, G.,, A. P. van Dam,, and J. Dankert. 1999. Phenotypic and genetic characterization of a novel Borrelia burgdorferi sensu lato isolate from a patient with Lyme borreliosis. J. Clin. Microbioi. 37: 3025– 3028.

107. Wang, G.,, A. P. van Dam,, A. Le Fleche,, D. Postic,, O. Peter,, G. Baranton,, R. de Boer,, L. Spanjaard,, and J. Dankert. 1997. Genetic and phenotypic analysis of Borrelia valaisiana sp. nov. (Borrelia genomic groups VS116 and MI9). Int. J. Syst. Bacteriol. 47: 926– 932.

108. Wang, G.,, A. P. van Dam,, I. Schwartz,, and J. Dankert. 1999. Molecular typing of Borrelia burgdorferi sensu lato: taxonomic, epidemiological, and clinical implications. Clin. Microbiol. Rev. 12: 633– 653.

109. Zingg, B. C.,, R. N. Brown,, R. S. Lane,, and R. B. LeFebvre. 1993. Genetic diversity among Borrelia burgdorferi isolates from wood rats and kangaroo rats in California. J. Clin. Microbiol. 31: 3109– 3114.

110. Zingg, B. C.,, and R. B. LeFebvre. 1994. Polymerase chain reaction for detection of Borrelia coriaceae, putative agent of epizootic bovine abortion. Am. J. Vet. Res. 55: 1509– 1515.

Tables

Borrelia: a Diverse and Ubiquitous Genus of Tick-Borne Pathogens

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Table 1

New Borrelia species associated with hard ticks

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10.1128/9781555816988/tab10-1.gif

Table 1

New Borrelia species associated with hard ticks