Chapter 26 : Mucosal Candidiasis

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Mucosal candidiasis is extremely common and vastly more common than invasive, systemic candidiasis, although the latter receives far more attention due to the accompanying mortality. Although considerable progress has been made in the understanding of pathogenesis of mucosal candidiasis, considerable deficits in our knowledge persist, accompanied by dynamic changes in microbiology of the responsible species and antifungal drug susceptibility, including drug resistance. Mucosal candidiasis involving the oral, gastrointestinal, and vaginal mucosae represents the commonest forms of superficial candidiasis and contrasts significantly with systemic and visceral candidiasis and disease. Although involving widely different anatomical sites with profoundly divergent physiological influences, the forms of mucosal candidiasis at the various sites have much in common with regard to pathophysiology, diagnostic principles, clinical manifestations, and therapy. Oral candidiasis (OC) is a commonly encountered condition in clinical practice, almost invariably associated with underlying disease or risk factors. Esophageal candidiasis (EC) is seen less commonly than OC, though usually in more immuno-compromised patients. The hormonal dependence of vulvovaginal candidiasis (VVC) is illustrated by the facts that is seldom isolated from premenarchial girls and the prevalence of vaginitis is lower after menopause, except in women taking hormone replacement therapy. In spite of progress in understanding the pathogenesis of mucosal candidiasis, there continues to be significant defects in one's knowledge of normal mucosal host defense mechanisms, both innate and acquired, effective in preventing symptomatic mucosal candidiasis.

Citation: Revankar S, Sobel J. 2012. Mucosal Candidiasis, p 419-427. In Calderone R, Clancy C (ed), and Candidiasis, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817176.ch26
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Pathogenesis of RVVC. IUD, intrauterine device. doi:10.1128/9781555817176.ch26.f1

Citation: Revankar S, Sobel J. 2012. Mucosal Candidiasis, p 419-427. In Calderone R, Clancy C (ed), and Candidiasis, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817176.ch26
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Recommendations for prevention and treatment of mucosal candidiasis

Citation: Revankar S, Sobel J. 2012. Mucosal Candidiasis, p 419-427. In Calderone R, Clancy C (ed), and Candidiasis, Second Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817176.ch26

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