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Category: Microbial Genetics and Molecular Biology; Genomics and Bioinformatics
Genome Plasticity in Candida albicans, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555817213/9781555817084_Chap18-1.gif /docserver/preview/fulltext/10.1128/9781555817213/9781555817084_Chap18-2.gifAbstract:
This chapter describes the different mechanisms of genome plasticity in Candida albicans and their impact on phenotypic plasticity, with an emphasis on recent advances in antifungal drug resistance. The average divergence between C. albicans genetic groups is approximately 2 million years. As a consequence, the recombination and genetic exchanges are most likely due to ancient mating events in C. albicans and not due to recent mating events. The requirement of sex to repair DNA damage may be moot in a diploid because sequences on homologous chromosomes can be used as templates to repair DNA breaks by an effective homologous recombination mechanism. The chapter gives a brief overview of some of the hypotheses that may particularly apply to C. albicans. A source of genome plasticity associated with recombination at MRS loci is chromosome translocation. The possibility exists that recombinations at the MRS can alter its structure and affect filamentation. In conclusion, the development of resistance to fluconazole can involve mutations at TAC1 and ERG11, as well as several genome plasticity events leading to loss of eterozygosity (LOH) and aneuploidy that affect these two genes as well as additional genes on chromosome 5.
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The proportion of C. albicans MTL-homozygous strains increases in older collections a
The proportion of C. albicans MTL-homozygous strains increases in older collections a