Intracellular Pathogens II:

Editors: Guy H. Palmer1, Abdu F. Azad2
Affiliations: 1: Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA; 2: Department of Microbiology and Immunology, School of Medicine, University of Maryland—Baltimore,Baltimore, MD
Content Type: Monograph
Format: Electronic, Hardcover
Publication Year: 2012

Category: Bacterial Pathogenesis

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

A current review of basic research on biology and pathogenesis in one comprehensive volume. The text details the scientific knowledge about how these obligate intracellular bacteria invade, survive and replicate inside eukaryotic cells. It also describes the spectrum of disease caused by an infection and the role of vectors in tramsmission, and discusses protective and pathologic immune responses and establishment of persisten infection. In addition, the text describes the latest developments including genomics and progress in vaccine development.

The title serves as a significant research book for scientists, physicians, medical students, public health professionals, epidemiologists, biocomputational scientists and government policy makers.

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image of Intracellular Pathogens II: <span class="jp-italic">Rickettsiales</span>

The Quarterly Review of Biology

09 September 2014

 The order Rickettsiales comprises an enormous diversity of bacteria that live and grow inside eukaryotic cells, including a number of important human pathogens that are vectored by blood-feeding arthropods, including ticks, lice, fleas, and mites. Within the family Rickettsiaceae, human pathogens include typhus group Rickettsia (e.g., R. prowazekii and R. typhi, the causal agents of epidemic typhus and murine typhus), spotted fever Rickettsia (e.g.,  R. rickettsii, the causal agent of Rocky Mountain spotted fever), and Orientia tsutsugamushi, the causal agent of scrub typhus. Within the family Anaplasmataceae, human pathogens include Ehrlichia chaffeensis and Anaplasma phagocytophilum, causal agents of human ehrlichiosis. As the lineage that gave rise to mitochondria is also closely allied with this order, the study of Rickettsiales may yield important insights into basic functions and evolution of the eukaryotic cell.

This book focuses on human pathogenic Rickettsiales and will be especially useful for microbiologists, immunologists, physicians, epidemiologists, and public health workers, as well as medical students and graduate students in microbiology and immunology. There are 14 chapters, all by different authors. The bulk of the volume focuses on how these pathogens invade mammalian cells, how they establish intracellular infections, and on innate and adaptive immune responses. This consists of paired chapters, alternating in focus between Rickettsiaceae and Anaplasmataceae, as pathogens from these two families exhibit major differences with important immunological consequences, with the former quickly escaping the host cell vacuole and the latter persisting within it. Also, the cell walls of pathogens in the Anaplasmataceae appear to lack lipopolysaccharides and peptidoglycan. Two chapters will be especially useful for physicians and public health workers—one on clinical aspects of infection, including diagnosis and treatment, and one on public health and epidemiology, primarily in the U.S. but touching on other parts of the world as well.

This book is timely as it discusses a number of important recent developments in the field. These include the fact that the incidence of infections has increased significantly. Also, a number of strains have only recently been shown to cause disease. Environmental surveys have uncovered a great diversity of novel strains in a wide range of eukaryotes. Genome sequencing has transformed the field, guiding searches for novel virulence factors and potential vaccine candidates. Rickettsia genomes are models in the study of reductive genome evolution. The recent discovery of plasmids in Rickettsia has also opened up new possibilities for genetic transformation.

The volume specifically avoids treatment of Wolbachia, a widespread vertically transmitted symbiont of terrestrial arthropods. There is little discussion of nonpathogenic Rickettsiales, except for an interesting chapter on phylogeny and diversity, including poorly studied lineages that infect protists. Other topics that receive less attention are effects of infection and immune responses in the arthropod vector, and the biology of infection in native nonhuman hosts.

The book is nicely produced with clear, useful figures and tables. In summary, this is an excellent reference and survey of human-pathogenic Rickettsiales.

The Quarterly Review of Biology

Volume 89, Number 3, Pages 271-272

Reviewer: Steve Perlman, Biology, University of Victoria, Victoria, British Columbia, Canada

Review Date: September 2014

Microbiology Today

30 May 2013

This book reviews the recent advances in rickettsiology (Anaplasma, Ehrlichia, Neorickettsia, Orientia and Rickettsia) over recent years and as such provides a wealth of relevant, state-of-the-art thinking on these microbes. Rather than giving a complete review of the subject, this book presents new data, methods and current thinking regarding this group of fascinating micro- organisms. The book provides, by way of introduction, chapters on the clinical challenges, public health issues and comparative genomics before a series of chapters focused upon the pathogenesis of the group. This is rounded off with a thought-provoking chapter on perspectives for future directions of rickettsial research mediated through genetic manipulation. These have been written by active researchers in the field and thus give valuable insights into the recent findings that have changed our understanding of the Rickettsiales, thus providing a hugely valuable resource to other researchers in the field. By way of criticism, the book presents a very American view (particularly evident during the introductory chapters), and would benefit from a more global perspective, though this might also reflect funding support in this area. Furthermore, chapters are written as isolated units and are prone to contain some duplication when read back-to-back.

This book provides a wonderful resource to those young researchers coming into the field of rickettsiology and would also be valuable to clinical or veterinary researchers, but perhaps not quite so accessible to the non-specialist. The price is high and might be prohibitive to those who might be considering personal copies of this book.

Society for General Microbiology: Microbiology Today

Reviewer: Sally Cutler, University of East London

Review Date: February 2013

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