Chapter 110 : Antiviral Agents

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The use of antiviral agents for the treatment of viral diseases has rapidly increased over the past 2 decades. In this chapter, antiviral therapy for the most common, clinically relevant viral infections is reviewed. The chapter is organized by virus type and covers human immunodeficiency virus types 1 and 2 (HIV-1, HIV-2), hepatitis viruses B and C (HBV and HCV), influenza A and B viruses, and the human herpesviruses with a focus on herpes simplex virus, varicella-zoster virus, and human cytomegalovirus. For each virus, an overview of available therapies is provided, followed by an in-depth description of individual antiviral agents. This description includes information on the agent’s chemical structure, mechanism of action, bioavailability, adverse effects, and significant drug interactions. In addition, current treatment guideline recommendations are incorporated when available. References for these guidelines allow for access to future updates to recommended drug therapies. This chapter strives to provide readers with an up-to-date overview of antiviral therapy. Newly approved agents as well as promising agents in the late stages of clinical trials have been included. Specific new additions to this edition include the antiretroviral agent dolutegravir and newly approved directly acting antiviral agents for hepatitis C virus.

Citation: Hodowanec A, Thompson K, Lurain N. 2015. Antiviral Agents, p 1869-1893. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch110
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Antiviral agents for HIV therapy

Citation: Hodowanec A, Thompson K, Lurain N. 2015. Antiviral Agents, p 1869-1893. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch110
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Antiviral agents for HCV therapy

Citation: Hodowanec A, Thompson K, Lurain N. 2015. Antiviral Agents, p 1869-1893. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch110
Generic image for table

Antiviral agents for HBV therapy

Citation: Hodowanec A, Thompson K, Lurain N. 2015. Antiviral Agents, p 1869-1893. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch110
Generic image for table

Antiviral agents for herpesviruses

Citation: Hodowanec A, Thompson K, Lurain N. 2015. Antiviral Agents, p 1869-1893. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch110
Generic image for table

Antiviral agents for influenza virus

Citation: Hodowanec A, Thompson K, Lurain N. 2015. Antiviral Agents, p 1869-1893. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch110

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