Chapter 129 : Antifungal Agents*

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Antifungal Agents*, Page 1 of 2

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This chapter reviews the four major families of antifungal drugs that are currently available for systemic administration: the allylamines (terbinafine), the azoles (ketoconazole, itraconazole, fluconazole, voriconazole, and posaconazole), the echinocandins (caspofungin, micafungin, and anidulafungin) and the polyenes (amphotericin B). The comparative activities of the major systemic antifungal agents against important groups of fungi are summarized. Discussion includes spectrum of activity, acquired resistance, pharmacokinetics, clinical use, drug interactions, and toxicity and adverse events. This chapter will also discuss the characteristics of the several other agents that can be used for the oral or parenteral treatment of superficial, subcutaneous, or systemic fungal infections. Novel agents that are currently in clinical trials are briefly reviewed.

Citation: Lockhart S, Warnock D. 2015. Antifungal Agents*, p 2223-2235. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch129
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Spectrum and extent of activity of commonly used systemic antifungal agents

Citation: Lockhart S, Warnock D. 2015. Antifungal Agents*, p 2223-2235. In Jorgensen J, Pfaller M, Carroll K, Funke G, Landry M, Richter S, Warnock D (ed), Manual of Clinical Microbiology, Eleventh Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817381.ch129

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