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Category: Clinical Microbiology
Pathogenic and Opportunistic Free-Living Amebae, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555817381/9781555817381.ch139-1.gif /docserver/preview/fulltext/10.1128/9781555817381/9781555817381.ch139-2.gifAbstract:
Pathogenic and opportunistic free-living amebae, such as Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia pedata, cause devastating central nervous system and disseminated infections in humans, leading to death. A brief review of the types of infections caused, clinical characteristics, pathologic manifestations, morphologic and molecular diagnoses, treatment, and prevention, if any, are discussed.
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N. fowleri. ( 1 ) Trophozoite, phase contrast (note the uroid and filaments at the arrow); ( 2 ) trophozoite, trichrome stain; ( 3 ) biflagellate, phase contrast; ( 4 ) smooth-walled cyst, phase contrast (note the pore at the arrow). All magnifications, approximately ×835. doi:10.1128/9781555817381.ch139.f1-4
N. fowleri. ( 1 ) Trophozoite, phase contrast (note the uroid and filaments at the arrow); ( 2 ) trophozoite, trichrome stain; ( 3 ) biflagellate, phase contrast; ( 4 ) smooth-walled cyst, phase contrast (note the pore at the arrow). All magnifications, approximately ×835. doi:10.1128/9781555817381.ch139.f1-4
A. castellanii. ( 5 ) Trophozoite, phase contrast (note the acanthopodia at the arrow); ( 6 ) double-walled cyst, phase contrast. Both magnifications, approximately ×835. doi:10.1128/9781555817381.ch139.f5-6
A. castellanii. ( 5 ) Trophozoite, phase contrast (note the acanthopodia at the arrow); ( 6 ) double-walled cyst, phase contrast. Both magnifications, approximately ×835. doi:10.1128/9781555817381.ch139.f5-6
B. mandrillaris. ( 7 ) Trophozoite, phase contrast; ( 8 ) cyst, phase contrast. Both magnifications, approximately ×1,140. doi:10.1128/9781555817381.ch139.f7-8
B. mandrillaris. ( 7 ) Trophozoite, phase contrast; ( 8 ) cyst, phase contrast. Both magnifications, approximately ×1,140. doi:10.1128/9781555817381.ch139.f7-8
Large numbers of N. fowleri trophozoites (arrows) in a section of CNS tissue, showing extensive necrosis and destruction of brain tissue. Magnification, approximately ×564. doi:10.1128/9781555817381.ch139.f9
Large numbers of N. fowleri trophozoites (arrows) in a section of CNS tissue, showing extensive necrosis and destruction of brain tissue. Magnification, approximately ×564. doi:10.1128/9781555817381.ch139.f9
A. culbertsoni trophozoites (arrows) and a cyst (arrowhead) around a blood vessel in a section of CNS tissue from a GAE patient. Magnification, approximately ×489. doi:10.1128/9781555817381.ch139.f10
A. culbertsoni trophozoites (arrows) and a cyst (arrowhead) around a blood vessel in a section of CNS tissue from a GAE patient. Magnification, approximately ×489. doi:10.1128/9781555817381.ch139.f10
B. mandrillaris trophozoites and a cyst (arrowhead) in a brain section from a GAE patient. Note the double (small arrow) and triple (large arrow) nucleolar elements within the nuclei of the trophozoites. Magnification, approximately ×413. doi:10.1128/9781555817381.ch139.f11
B. mandrillaris trophozoites and a cyst (arrowhead) in a brain section from a GAE patient. Note the double (small arrow) and triple (large arrow) nucleolar elements within the nuclei of the trophozoites. Magnification, approximately ×413. doi:10.1128/9781555817381.ch139.f11
Immunofluorescence localization of B. mandrillaris in a brain section from a GAE patient. Note the fluorescent amebae (arrows) around blood vessels. Magnification, approximately ×188. doi:10.1128/9781555817381.ch139.f12
Immunofluorescence localization of B. mandrillaris in a brain section from a GAE patient. Note the fluorescent amebae (arrows) around blood vessels. Magnification, approximately ×188. doi:10.1128/9781555817381.ch139.f12