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Category: Microbial Genetics and Molecular Biology; Clinical Microbiology
Pathoadaptive Mutations in Uropathogenic Escherichia coli, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555817404/9781555817398_Chap15-1.gif /docserver/preview/fulltext/10.1128/9781555817404/9781555817398_Chap15-2.gifAbstract:
Adaptive evolution of bacterial pathogens happens through the action of positive selection on random genetic changes, affecting their frequency within the compartment they infect (e.g., the urinary tract) or during the transmission to new hosts. The evolution of virulence, in general, results in the ability of the microorganism to cause clinically manifested damage of the host, i.e., diseases like cystitis or pyelonephritis. This, in turn, reflects the microbial fitness during the infection – the ability to survive and reproduce during the infection itself, at the level and in a mode to induce the tissue damage. Driving forces and mechanisms behind the evolution of microbial virulence can be understood from the perspective of bacterial ecology and by comparative analysis of the microorganisms that are able or unable to cause the infection.
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Eco-Evo categories of E. coli. UPEC = uropathogenic E. coli, EHEC = enterohemorrhagic E. coli, EPEC = enteropathogenic E. coli.
Eco-Evo categories of E. coli. UPEC = uropathogenic E. coli, EHEC = enterohemorrhagic E. coli, EPEC = enteropathogenic E. coli.
UPEC ecology.
UPEC ecology.
Different genetic mechanisms of evolution of virulence exemplified by an adaptive increase in bacterial adhesiveness. Green surface = gastrointestinal mucosa; Gray surface = urothelium.
Different genetic mechanisms of evolution of virulence exemplified by an adaptive increase in bacterial adhesiveness. Green surface = gastrointestinal mucosa; Gray surface = urothelium.
Type 1 fimbriae of E. coli and functional variability of the FimH adhesin.
Type 1 fimbriae of E. coli and functional variability of the FimH adhesin.
Shear-dependent (A) and conformational (B) properties of FimH adhesin.
Shear-dependent (A) and conformational (B) properties of FimH adhesin.
Strategies of detection of patho-adapted gene variants (red).
Strategies of detection of patho-adapted gene variants (red).
Pathoadaptive genes inactivation in long-term bladder colonization trial (premature stop-codons; frame-shift mutations, deletions)
Pathoadaptive genes inactivation in long-term bladder colonization trial (premature stop-codons; frame-shift mutations, deletions)
Pathoadaptive gene variations found by genome-wide screening
Pathoadaptive gene variations found by genome-wide screening