Chapter 9 : Reservoirs of Extraintestinal Pathogenic

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The existence of important infection-causing ExPEC lineages (i.e., genetically closely related clones or clonal groups) has been recognized for the past 40 years. However, identification and detailed characterization of specific lineages has only recently been advanced, owing to the development of new methods for bacterial genotyping. Since ExPEC can colonize and persist in the human intestinal tract without detriment to the host, the operational definition of ExPEC is critical for defining the chain of ExPEC transmission from non-human reservoir to human intestinal colonization to active infection.

Citation: Manges A, Johnson J. 2017. Reservoirs of Extraintestinal Pathogenic , p 161-177. In Mulvey M, Klumpp D, Stapleton A (ed), Urinary Tract Infections: Molecular Pathogenesis and Clinical Management, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.UTI-0006-2012
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Figure 1

The tree, which is drawn to scale, was inferred using the Neighbor-Joining method, based on concatenated DNA sequences from the seven MLST loci. was used to root the tree, but for simplicity has been excluded. All positions containing gaps and missing data were eliminated. There were a total of 3423 positions in the final dataset.

Citation: Manges A, Johnson J. 2017. Reservoirs of Extraintestinal Pathogenic , p 161-177. In Mulvey M, Klumpp D, Stapleton A (ed), Urinary Tract Infections: Molecular Pathogenesis and Clinical Management, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.UTI-0006-2012
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