Antibodies for Infectious Diseases

Editors: James E. Crowe1, Diana Boraschi2, Rino Rappuoli3
Affiliations: 1: Vanderbilt University Medical Center, Nashville, Tennessee; 2: National Research Council, Napoli, Italy; 3: Novartis Vaccines, Siena, Italy
Content Type: Monograph
Format: Electronic
Publication Year: 2015

Category: Clinical Microbiology

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The connection between antibodies and infectious diseases has spawned entire related fields of study. presents perspectives from leading research scientists and summarizes the amazing progress in this area into a single definitive source.

Providing a broad survey of the most important aspects of the field of antibodies for infectious diseases, this book

  • presents general features pertaining to structure, function, isotype, and the role of complement in antibody function
  • examines the role of antibodies in antimicrobial immunity with specific targets
  • details new methods for expression of monoclonal antibodies, in plants or by transfer of antibody genes for in vivo expression in treated subjects

is a comprehensive reference for researchers, pharmaceutical developers, and health care professionals on the status of the development of antibody-based therapies for treating infectious diseases. It is also useful as supplemental reading for upper level life sciences students.

is an immunologist and board-certified pediatric infectious diseases specialist. Dr. Crowe is the Ann Scott Carell Chair and Professor of Pediatrics, Pathology, Microbiology and Immunology, and Director of the Vanderbilt Vaccine Center. He is an Elected Member of the Institute of Medicine and a Fellow of the American Association for the Advancement of Science, the American Academy of Microbiology, and the American Society for Clinical Investigation. Dr. Crowe’s laboratory has a broad portfolio of work in the area of viral immunology and cell biology focused on discovery of the genetic and structural determinants of neutralization of viruses by human antibodies and immune mechanisms important to development of new vaccines.

is the Research Director at the CNR Institute of Protein Biochemistry. She is actively involved in high education activities, in particular in Africa. Dr. Boraschi’s studies focus on the role of macrophages and IL-1 cytokines in the innate/inflammatory response against infections and tumors and their possible involvement in chronic inflammatory and autoimmune pathologies.

is the Global Head of Research and Development at Novartis Vaccines. Dr. Rappuoli has worked on several molecules that became part of, or are near to becoming, licensed vaccines. He is an elected member of the U.S. National Academy of Sciences and of the European Molecular Biology Organization.

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