Human Metapneumovirus

Jennifer E. Schuster; John V. Williams

doi:10.1128/microbiolspec.AID-0020-2014

Chapter 14 : Human Metapneumovirus

Authors: Jennifer E. Schuster¹, John V. Williams²

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Affiliations: 1: Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO 64108-4619; 2: Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232-2581; 3: Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232-2581

Content Type: Monograph

Publication Year: 2015

Category: Clinical Microbiology

Book DOI: 10.1128/9781555817411

Chapter DOI: 10.1128/microbiolspec.AID-0020-2014

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Human Metapneumovirus, Page 1 of 2

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Abstract:

Human metapneumovirus (HMPV), a paramyxovirus first discovered in 2001, is a significant cause of respiratory tract disease in children and adults ( 1 ). Humoral immunity plays an important role in HMPV infection, and the study of HMPV antibodies provides important clinical information including the seroprevalence of HMPV, age of primary infection, serological cross-protection between HMPV subgroups, evaluation of vaccine immunogenicity, and strategies for prophylaxis and therapy using monoclonal antibodies (mAbs).

Citation: Schuster J, Williams J. 2015. Human Metapneumovirus, p 237-247. In Crowe J, Boraschi D, Rappuoli R (ed), Antibodies for Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.AID-0020-2014

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Human Metapneumovirus

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Figure 1

Maximum clade credibility tree of HMPV and avian metapneumovirus (AMPV) F nucleotide diversity. Phylogenetic analysis of 85 full-length HMPV F nucleotide sequences from Canada (CAN), Japan (JPS or JPY), Tennessee (TN), or the Netherlands (NL) and 16 AMPV F sequences. The first two digits of the HMPV sequence names indicate the year of the isolate. The names of the AMPV sequences indicate geographic origin (US, United States; UK, United Kingdom; MN, Minnesota) and year. The posterior probability of divergence is indicated at each node. Scale bar represents time in years. Reprinted from reference 13 with permission of the publisher http://creativecommons.org/licenses/by/2.0/legalcode.

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Figure 1

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Figure 2

Schematic of HMPV and RSV F protein domain structures and relative location of MARM mutation sites. Indicated are the N terminus (N), signal peptide (SP), fusion peptide (FP), heptad repeat 1 (HR1), heptad repeat 2 (HR2), transmembrane domain (TM), and C terminus (C), as well as the F1 and F2 segments of the F protein. The amino acid positions that border domains (predicted) or cleavage sites and C termini (known) are indicated. Also depicted are the relative positions of the HMPV epitope group MARM mutations and corresponding MARM mutation sites on the RSV F protein. Reprinted with permission from Ulbrandt ND, Ji H, Patel NK, Barnes AS, Wilson S, Kiener PA, Suzich J, McCarthy MP. 2008. J Gen Virol 89:3113–3118. Copyright 2008 Society for General Microbiology. Permission conveyed through Copyright Clearance Center, Inc.

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