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Category: Clinical Microbiology
Serodiagnosis of Rickettsial Infections, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555817435/9781555815271_Chap11_7-1.gif /docserver/preview/fulltext/10.1128/9781555817435/9781555815271_Chap11_7-2.gifAbstract:
Rickettsial diseases in humans result from infection with bacteria of the families Rickettsiaceae and Anaplasmataceae. The family Rickettsiaceae includes the genera Rickettsia and Orientia, both of which infect endothelial cells and thereby cause vasculitis. Rickettsia spp. share lipopolysaccharides and outer membrane protein B (OmpB); however, spotted fever group (SFG) rickettsiae also possess outer membrane protein A (OmpA), whereas typhus group (TG) rickettsiae do not. Since serologic cross-reactivity between groups is common but antibody titers are generally higher within the specific group, distinction between SFG and TG rickettsiae requires paired testing and is not always possible. The Anaplasmataceae family includes Ehrlichia chaffeensis, which infects monocytes and mononuclear phagocytes, and Anaplasma phagocytophilum (formerly Ehrlichia phagocytophila, Ehrlichia equi, and the HGA agent) and Ehrlichia ewingii, which infect granulocytes. Serologic cross-reactions occur often (3 to 30%) with Ehrlichia and Anaplasma, as they do with Rickettsia, and differentiation requires comparison of specific antibody titers.
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Manufacturers of rickettsial and Ehrlichial serodiagnostic kits and reagents a
a Check with each manufacturer regarding regional availability.
b Focus Diagnostics, 10703 Progress Way, Cypress, CA 90630-4717. Telephone: (714) 220-1900, (800) 445-0185. Fax: (714) 220-1683. URL: www.focusdx.com/focus/0-home/index.asp.
c PanBio, Limited—Australia, 116 Lutwyche Rd., Windsor, Brisbane 4030, Queensland, Australia. Telephone: 61 (0) 7 3363 7100. Fax: 61 (0) 7 3363 7199. E-mail: [email protected]. URL: http://www.panbio.com.
d SciMedx Corporation, 100 Ford Rd., Suite 100-08, Denville, NJ 07834. Telephone: (800) 221-5598 or (international) 1-973-625-8822. Fax: 1-973-625- 8796. E-mail: [email protected]. URL: http://www.scimedx.com/products/ifa_infectious.htm.
Manufacturers of rickettsial and Ehrlichial serodiagnostic kits and reagents a
a Check with each manufacturer regarding regional availability.
b Focus Diagnostics, 10703 Progress Way, Cypress, CA 90630-4717. Telephone: (714) 220-1900, (800) 445-0185. Fax: (714) 220-1683. URL: www.focusdx.com/focus/0-home/index.asp.
c PanBio, Limited—Australia, 116 Lutwyche Rd., Windsor, Brisbane 4030, Queensland, Australia. Telephone: 61 (0) 7 3363 7100. Fax: 61 (0) 7 3363 7199. E-mail: [email protected]. URL: http://www.panbio.com.
d SciMedx Corporation, 100 Ford Rd., Suite 100-08, Denville, NJ 07834. Telephone: (800) 221-5598 or (international) 1-973-625-8822. Fax: 1-973-625- 8796. E-mail: [email protected]. URL: http://www.scimedx.com/products/ifa_infectious.htm.
Sensitivity and specificity of serologic tests for confirmation of RMSF, murine typhus, HME, and HGA
Sensitivity and specificity of serologic tests for confirmation of RMSF, murine typhus, HME, and HGA
Selected conditions that may lead to false-positive serologic tests for rickettsial diseases
a ANA, antinuclear antibody.
b ANCA, antineutrophil cytoplasmic antibody.
Selected conditions that may lead to false-positive serologic tests for rickettsial diseases
a ANA, antinuclear antibody.
b ANCA, antineutrophil cytoplasmic antibody.