Chapter 16.12 : Q Fever—

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is the etiologic agent of Q fever. It is a pleomorphic coccobacillus that is gram negative, obligately intracellular, and 0.3 to 0.7 µm long. There is a spore-like form, the small cell variant, which is remarkably stable in extracellular environments. A large cell variant also exists that is the vegetative, metabolically active form. Mixtures of both forms are found in phagolysosomes. There is phase variation, similar to that in in which the lipopolysaccharide (LPS) varies chemically as either the virulent, phase I “smooth”-type LPS or the phase II “rough” LPS, associated with avirulent is phylogenetically related to and within the group of the c- subdivision. It is more distantly related to ( ).

Citation: Garcia L. 2010. Q Fever—, p 803-807. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch16.12
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Image of Figure 16.12-1
Figure 16.12-1

Fibroblast L929 line infected with . (Courtesy of Didier Raoult.)

Citation: Garcia L. 2010. Q Fever—, p 803-807. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch16.12
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Generic image for table
Table 16.12-1

Typical Q fever diagnostic titers with indirect immunofluorescence ( )

Fourfold rise in antibody titer between acute- and convalescent-phase samples is the strongest predictor of acute Q fever.

Citation: Garcia L. 2010. Q Fever—, p 803-807. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch16.12

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