Chapter 16.7 : Plague—

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is the causative agent of plague, an acute febrile infectious disease with a high fatality rate ( ). Plague may present in three forms: bubonic, pneumonic, and septicemic ( ). Bubonic plague is characterized by sepsis that is accompanied by the sudden onset of fever, chills, weakness, headache, and the formation of buboes and swelling of regional lymph nodes of the groin, axilla, or neck. Septicemic plague is basically the same as bubonic plague but without the swelling of the lymph nodes. Pneumonic plague, the most deadly form of the disease and the form that can spread rapidly among susceptible individuals, presents as fever and lymphadenopathy with cough, chest pain, and often hemoptysis. Secondary pneumonia from hematogenous spread of the organisms can occur, or the organism can occasionally be passed by aerosols from human to human as primary pneumonic plague.

Citation: Garcia L. 2010. Plague—, p 774-778. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch16.7
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Figure 16.7-1

sentinel-level laboratory flowchart. LRN, Laboratory Response Network.

Citation: Garcia L. 2010. Plague—, p 774-778. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch16.7
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1. Baltazard, M. D.,, H. S Davis,, R. Devignat,, G. Girard,, M. A. Gohar,, L. Kartman,, K. F. Meyer,, M. T. Parker,, T. Pollitzer,, F. M. Prince,, S. F. Quan,, and P. Wagle. 1956. Recommended laboratory methods for the diagnosis of plague. Bull. W. H. O. 14: 457 509.
2. Butler, T., 1983. Plague and other Yersinia infections, p. 163 188. In W. B. Greenough III, and T. C. Merigan (ed.), Current Topics in Infectious Disease. Plenum Medical Book Company, New York, NY.
3. Cavanaugh, D. C.,, P. J. Deoras,, D. H. Hunter,, J. D. Marshall,, D. V. Quy,, J. H. Rust,, S. Purnaveja,, and P. E. Winter. 1970. Some observations on the necessity for serological testing of rodent sera for Pasteurella pestis antibody in a plague control program. Bull. W. H. O. 42: 451 459.
4. Cavanaugh, D. C.,, M. K. Fortier,, D. M. Robinson,, J. E. Williams,, and J. H. Rust. 1979. Application of the ELISA technique to the problems in the serologic diagnosis of plague. Bull. Pan Am. Health Org. 13: 399 402.
5. Chen, T. H.,, and K. F. Meyer. 1966. An evaluation of Pasteurella pestis fraction-1-specific antibody for the confirmation of plague infections. Bull. W. H. O. 34: 911 918.
6. Forbes, B. A.,, D. F. Sahm,, and A. S. Weissfeld (ed.). 1998. Bailey and Scott’s Diagnostic Microbiology, 10th ed., p. 509 526. Mosby, St. Louis, MO.
7. Gilchrist, M. J. R.,, W. P. McKinney,, J. M. Miller,, and A. S. Weissfeld. 2000. Cumitech 33, Laboratory Safety, Management, and Diagnosis of Biological Agents Associated with Bioterrorism. Coordinating ed., J. W. Snyder. ASM Press, Washington, DC.
8. Hudson, B. W.,, K. Wolff,, and T. Butler. 1980. The use of solid-phase-radioimmunoassay techniques for serodiagnosis of human plague infection. Bull. Pan Am. Health Org. 14: 244 250.
9. Koneman, E. W.,, S. D. Allen,, W. M. Janda,, P. C. Schreckenberger,, and W. C. Winn, J r. (ed.). 1997. Color Atlas and Textbook of Diagnostic Microbiology, 5th ed., p. 171 252. Lippincott, Philadelphia, PA.
10. McDonough, K. A.,, T. G. Schwan,, R. E. Thomas,, and S. Falkow. 1988. Identification of Yersinia pestis-specific DNA probe with potential for use in plague surveillance. J. Clin. Microbiol. 26: 2515 2519.
11. Norkina, O. V.,, A. N. Kulichenko,, A. L. Gintsberg,, I. V. Tuchkov,, Y. A. Popov,, M. U. Aksenor,, and I. G. Drosdov. 1994. Development of a diagnostic test for Yersinia pestis by the polymerase chain reaction. J. Appl. Bacteriol. 76: 240 245.
12. Nunes, P. M.,, and I. Suassuna. 1978. Bacteriophage specificity in the identification of Yersinia pestis as compared with other Enterobacteriaceae. Rev. Bras. Pesqui Med. Biol. 11: 359 363.
13. Perry, R. D.,, and J. D. Fetherston. 1997. Yersinia pestis—etiologic agent of plague. Clin. Microbiol. Rev. 10: 35 66.
14. Sharp, S. E., 2008. The genus Yersinia, p. 603 608. In E. Goldman, and L. H. Green (ed.), Practical Handbook of Microbiology, 2nd ed. CRC Press, Boca Raton, FL.
15. Suzuki, S.,, H. Sakakibara,, and S. Horta. 1977. Latex agglutination tests for measurements of antiplague antibodies. J. Clin. Microbiol. 6: 332 336.
16. Titball, R. W.,, and S. E. Leary. 1998. Plague. Br. Med. Bull. 54: 625 633.
17. Wilmoth, B. A.,, M. C. Chu,, and T. J. Quan. 1996. Identification of Yersinia pestis by BBL Crystal Enteric Nonfermenter identification system. J. Clin. Microbiol. 43: 2829 2830.
18. Centers for Disease Control and Prevention. 2000. Biological and chemical terrorism: strategic plan for preparedness and response. MMWR Morb. Mortal. Wkly. Rep. 49( RR-4): 114.
19. Klietmann, W. F.,, and K. L. Ruoff. 2001. Bioterrorism: implications for the clinical microbiologist. Clin. Microbiol. Rev. 14: 364 381.


Generic image for table
Table 16.7-1

Key biochemical reactions for

Citation: Garcia L. 2010. Plague—, p 774-778. In Clinical Microbiology Procedures Handbook, 3rd Edition. ASM Press, Washington, DC. doi: 10.1128/9781555817435.ch16.7

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