Chapter 6 : Biofilms: Development, Architecture, and Resistance

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The use of indwelling devices in current therapeutic practice is associated with hospital-acquired bloodstream and deep tissue infections ( ). Transplantation medical procedures, immunosuppression, and prolonged intensive care unit stays have also increased the prevalence of nosocomial infections. Device-associated infections are commonly associated with the ability of bacteria and fungi to form biofilms, which are defined as communities of sessile organisms irreversibly associated with a surface, encased within a polysaccharide-rich extracellular matrix, and exhibiting enhanced resistance to antimicrobial drugs ( ). Forming a biofilm provides the microbes protection from host immunity, environmental stresses due to contaminants, and nutritional depletion or imbalances, while being dangerous to human health due to biofilms’ inherent robustness and elevated resistance.

Citation: Chandra J, Mukherjee P. 2015. Biofilms: Development, Architecture, and Resistance, p 115-134. In Ghannoum M, Parsek M, Whiteley M, Mukherjee P (ed), Microbial Biofilms, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.MB-0020-2015
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Generic image for table

Summary of -associated biofilm models

Citation: Chandra J, Mukherjee P. 2015. Biofilms: Development, Architecture, and Resistance, p 115-134. In Ghannoum M, Parsek M, Whiteley M, Mukherjee P (ed), Microbial Biofilms, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.MB-0020-2015
Generic image for table

Summary of -associated biofilm models

Citation: Chandra J, Mukherjee P. 2015. Biofilms: Development, Architecture, and Resistance, p 115-134. In Ghannoum M, Parsek M, Whiteley M, Mukherjee P (ed), Microbial Biofilms, Second Edition. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.MB-0020-2015

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