Antimicrobial Resistance in Members of the FamilyPasteurellaceae

Corinna Kehrenberg; Stefan; Robert D. Walker; Ching Ching Wu

doi:10.1128/9781555817534.ch11

Chapter 11 : Antimicrobial Resistance in Members of the FamilyPasteurellaceae

Authors: Corinna Kehrenberg¹, Stefan ², Robert D. Walker³, Ching Ching Wu⁴

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Affiliations: 1: Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft, D-31535 Neustadt-Mariensee, Germany; 2: Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft, D-31535 Neustadt-Mariensee, Germany; 3: Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708; 4: Animal Disease Diagnostic Laboratory, Department of Veterinary Pathobiology, Purdue University School of Veterinary Medicine, West Lafayette, IN 47907-2065

Content Type: Monograph

Publication Year: 2006

Category: Bacterial Pathogenesis

Book DOI: 10.1128/9781555817534

Chapter DOI: 10.1128/9781555817534.ch11

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Abstract:

This chapter focuses mainly on the genera Pasteurella, Mannheimia, Actinobacillus, Haemophilus, and Histophilus, for which sufficient data on antimicrobial susceptibility and the detection of resistance genes are currently available. A study in Germany, investigating the susceptibility of bovine isolates of P. multocida and M. haemolytica collected in 1999 to spectinomycin and comparator agents, showed that none of the 302 isolates tested were resistant to florfenicol, cefquinome, or ceftiofur, and only 6.5% of the P. multocida and 1.4% of the M. haemolytica isolates were classified as resistant to spectinomycin. The chapter provides an overview of the current knowledge of resistance genes and resistance mediating mutations so far detected in bacteria of the genera Pasteurella, Mannheimia, Actinobacillus, and Haemophilus. Molecular analysis of isolates of Pasteurella, Mannheimia and Actinobacillus revealed that antimicrobial resistance genes were associated with plasmids in many cases. The examples given in the chapter illustrate that Pasteurella, Mannheimia, Actinobacillus, and Haemophilus have obviously acquired a number of resistance genes from other gram-negative or maybe even gram-positive bacteria. Knowledge of the location and colocation of the resistance genes on mobile genetic elements as well as the conditions for their coselection and persistence will be valuable for veterinarians and will assist them in selecting the most efficacious antimicrobial agents for the control of isolates of the family Pasteurellaceae.

Citation: Kehrenberg C, Stefan, Walker R, Wu C. 2006. Antimicrobial Resistance in Members of the FamilyPasteurellaceae, p 167-186. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch11

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Mobile Genetic Elements: 0.5898564
Outer Membrane Proteins: 0.47186574
Gram-Negative Bacteria: 0.46010306
Gram-Positive Bacteria: 0.45024964
16s rRNA Sequencing: 0.44632477

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Antimicrobial Resistance in Members of the FamilyPasteurellaceae

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/content/10.1128/9781555817534.chap11.fig11-1

Figure 1.

Structure and organization of selected resistance plasmids from members of the family Pasteurellaceae (Table 3). The genes are shown as arrows with the arrowhead indicating the direction of transcription. A distance scale in kilobases is given below each map. The following genes are involved in antimicrobial resistance: tetR-tet(H) (tetracycline resistance), sul2 (sulfonamide resistance), strA and strB (streptomycin resistance), catA3 (chloramphenicol resistance), aphA1 (kanamycin and neomycin resistance), and blaRob-1 (β-lactam resistance). rep, repA″, repB″, and repC″ are involved in plasmid replication, and mobA, mobB, mobC, mobA″, mobB″, and mobC″ are involved in mobilization functions. The prefix Δ indicates a truncated, functionally inactive gene. The boxes in the map of pPMT1 indicate the insertion sequences IS1596 and IS1597, with the arrows within these boxes marking the transposase genes. Restriction endonuclease cleavage sites are abbreviated as follows: C, ClaI; E, EcoRI; Ev, EcoRV; Hp, HpaI; P, PstI; S, SacI.

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10.1128/9781555817534/fig11-1.gif

Figure 1.

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Tables

Antimicrobial Resistance in Members of the FamilyPasteurellaceae

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Table 1.

In vitro susceptibility data for P. multocida isolates from different animal sources

Table 1.

In vitro susceptibility data for P. multocida isolates from different animal sources

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Table 2.

Antimicrobial resistance genes identified in Pasteurella, Mannheimia, Actinobacillus, and Haemophilus

Table 2.

Antimicrobial resistance genes identified in Pasteurella, Mannheimia, Actinobacillus, and Haemophilus

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Table 3.

Resistance plasmids identified in Pasteurella, Mannheimia, Actinobacillus, and Haemophilus

Table 3.

Resistance plasmids identified in Pasteurella, Mannheimia, Actinobacillus, and Haemophilus