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Chapter 12 : Antimicrobial Resistance in Staphylococci and Streptococci of Animal Origin

Authors: Frank M. Aarestrup1, Stefan Schwarz2
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Affiliations: 1: Danish Institute for Food and Veterinary Research, Bülowsvej 27, DK-1790 Copenhagen V, Denmark; 2: Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft, D-31535 Neustadt-Mariensee, Germany
Content Type: Monograph
Publication Year: 2006

Category: Bacterial Pathogenesis

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Abstract:

This chapter reviews the summarized data on susceptibility patterns and prevalence and epidemiology of resistance for the most clinically relevant staphylococcal and streptococcal pathogens in animals. The chapter focuses mainly on resistance in , , and . The first isolation of methicillin resistant (MRSA) from a veterinary specimen was reported from bovine mastitis in Belgium by Devriese et al. in 1972. The presence of other resistance genes and mechanisms has not been examined in streptococci of animal origin. Antimicrobial agents are most often used to control infections caused by these two groups of bacteria. The continuous monitoring of staphylococci and streptococci from animal infections is an essential prerequisite for early detection of new trends in the development of resistance to antimicrobials commonly used to control these infections. However, standardized procedures need to be made available for unambiguous species identification and for in vitro susceptibility testing, and such procedures also need to be applied by researchers in this field to make the results of susceptibility testing more comparable. More knowledge about the ability of certain subtypes to acquire resistance, together with the development of means to control such clones, could perhaps provide new means of controlling the increase in resistance.

Citation: Aarestrup F, Schwarz S. 2006. Antimicrobial Resistance in Staphylococci and Streptococci of Animal Origin, p 187-212. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch12
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Antimicrobial Resistance in Staphylococci and Streptococci of Animal Origin
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Citation: Aarestrup F, Schwarz S. 2006. Antimicrobial Resistance in Staphylococci and Streptococci of Animal Origin, p 187-212. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch12
/content/10.1128/9781555817534.chap12.fig12-1
Figure 1.

Trends in the occurrence of resistance to penicillin over time among isolates from bovine mastitis in Denmark. Adapted from references and .

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10.1128/9781555817534/fig12-1.gif
Image of Figure 1.
Figure 1.

Trends in the occurrence of resistance to penicillin over time among isolates from bovine mastitis in Denmark. Adapted from references and .

Citation: Aarestrup F, Schwarz S. 2006. Antimicrobial Resistance in Staphylococci and Streptococci of Animal Origin, p 187-212. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch12
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/content/10.1128/9781555817534.chap12.fig12-2
Figure 2.

Trends in the occurrence of resistance to penicillin over time among isolates from bovine mastitis in the United Kingdom. Adapted from references and .

10.1128/9781555817534/fig12-2_thmb.gif
10.1128/9781555817534/fig12-2.gif
Image of Figure 2.
Figure 2.

Trends in the occurrence of resistance to penicillin over time among isolates from bovine mastitis in the United Kingdom. Adapted from references and .

Citation: Aarestrup F, Schwarz S. 2006. Antimicrobial Resistance in Staphylococci and Streptococci of Animal Origin, p 187-212. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch12
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/content/10.1128/9781555817534.chap12.fig12-3
Figure 3.

Trends in the occurrence of resistance to macrolides over time among isolates from exudative epidermitis in pigs in Denmark. Adapted from references and .

10.1128/9781555817534/fig12-3_thmb.gif
10.1128/9781555817534/fig12-3.gif
Image of Figure 3.
Figure 3.

Trends in the occurrence of resistance to macrolides over time among isolates from exudative epidermitis in pigs in Denmark. Adapted from references and .

Citation: Aarestrup F, Schwarz S. 2006. Antimicrobial Resistance in Staphylococci and Streptococci of Animal Origin, p 187-212. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch12
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References

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1. Aarestrup, F. M. 2000. Occurrence, selection and spread of resistance to antimicrobial agents used for growth promotion for food animals in Denmark. APMIS 101: 1– 48.
2. Aarestrup, F. M. 2001. Comparative ribotyping of Staphylococcus intermedius isolated from members of the Canoidea gives possible evidence for host-specificity and co-evolution of bacteria and hosts. Int. J. Syst. Evol. Microbiol. 51: 1343– 1347.
3. Aarestrup, F. M.,, and L. B. Jensen. 2002. Trends in antimicrobial susceptibility in relation to antimicrobial usage and presence of resistance genes in Staphylococcus hyicus isolated from exudative epidermitis in pigs. Vet. Microbiol. 89: 83– 94.
4. Aarestrup, F. M.,, and N. E. Jensen. 1998. Development of penicillin resistance among Staphylococcus aureus isolated from bovine mastitis in Denmark and other countries. Microb. Drug Resist. 4: 247– 256.
5. Aarestrup, F. M.,, H. C. Wegener,, and V. T. Rosdahl. 1995. A comparative study of Staphylococcus aureus strains isolated from bovine subclinical mastitis during 1952-1956 and 1992. Acta Vet. Scand. 36: 237– 243.
6. Aarestrup, F. M.,, H. C. Wegener,, V. T. Rosdahl,, and N. E. Jensen. 1995. Staphylococcal and other bacterial species associated with intramammary infections in Danish dairy herds. Acta Vet. Scand. 36: 475– 487.
7. Aarestrup, F. M.,, S. E. Jorsal,, and N. E. Jensen. 1998. Serological characterization and antimicrobial susceptibility of Streptococcus suis isolates from diagnostic samples in Denmark during 1995 and 1996. Vet. Microbiol. 60: 59– 66.
8. Aarestrup, F. M.,, S. R. Rasmussen,, K. Artursson,, and N. E. Jensen. 1998. Trends in resistance to antimicrobial agents of Streptococcus suis isolates from Denmark and Sweden. Vet. Microbiol. 63: 71– 80.
9. Aarestrup, F. M.,, F. Bager,, N. E. Jensen,, M. Madsen,, A. Meyling,, and H. C. Wegener. 1998. Resistance to antimicrobial agents used for animal therapy in pathogenic-, zoonoticand indicator bacteria isolated from different food animals in Denmark: a baseline study for the Danish Integrated Antimicrobial Resistance Monitoring Programme (DANMAP). APMIS 106: 745– 770.
10. Aarestrup, F. M.,, H. D. Larsen,, N. H. Eriksen,, C. S. Elsberg,, and N. E. Jensen. 1999. Frequency of alpha- and betahaemolysin in Staphylococcus aureus of bovine and human origin. A comparison between pheno- and genotype and variation in phenotypic expression. APMIS 107: 425– 430.
11. Aarestrup, F. M.,, Y. Agersø,, J. C.Ø Christensen,, M. Madsen,, and L. B. Jensen. 2000. Antimicrobial susceptibility and presence of resistance genes in staphylococci from poultry. Vet. Microbiol. 74: 353– 364.
12. Almer, L. S.,, V. D. Shortridge,, A. M. Nilius,, J. M. Beyer,, N. B. Soni,, M. H. Bui,, G. G. Stone,, and R. K. Flamm. 2002. Antimicrobial susceptibility and molecular characterization of community-acquired methicillin-resistant Staphylococcus aureus. Diagn. Microbiol. Infect. Dis. 43: 225– 232.
13. Anonymous. ARBAO-II: Antibiotic resistance in bacteria of animal origin—II. A concerted action funded by the European Commission. [Online.] http://www.dfvf.dk/Default.asp?ID?9753/ext-link>.
14. Arends, J. P.,, and H. C. Zanen. 1988. Meningitis caused by Streptococcus suis in humans. Rev. Infect. Dis. 10: 131– 137.
15. Barber, M. 1947. Staphylococcal infection due to penicillinresistant strains. Br. Med. J. 2: 863– 865.
16. Barber, M.,, and J. E. M. Whitehead. 1949. Bacteriophage types in penicillin-resistant staphylococcal infection. Br. Med. J. 10: 565– 569.
17. Barcus, V. A.,, K. Ghanekar,, M. Yeo,, T. J. Coffey,, and C. G. Dowson. 1995. Genetics of high level penicillin resistance in clinical isolates of Streptococcus pneumoniae. FEMS Microbiol. Lett. 126: 299– 303.
18. Berghash, S. R.,, J. N. Davidson,, J. C. Armstrong,, and G. M. Dunny. 1983. Effects of antibiotic treatment of nonlactating dairy cows on antibiotic resistance patterns of bovine mastitis pathogens. Antimicrob. Agents Chemother. 24: 771– 776.
19. Betriu, C.,, E. Culebras,, I. Rodriguez-Avial,, M. Gomez,, B. A. Sanchez,, and J. J. Picazo. 2004. In vitro activities of tigecycline against erythromycin-resistant Streptococcus pyogenes and Streptococcus agalactiae: mechanisms of macrolide and tetracycline resistance. Antimicrob. Agents Chemother. 48: 323– 325.
20. Birgersson, A.,, P. Jonsson,, and O. Holmberg. 1992. Species identification and some characteristics of coagulase-negative staphylococci isolated from bovine udders. Vet. Microbiol. 31: 181– 189.
21. Bisharat, N.,, D. W. Crook,, J. Leigh,, R. M. Harding,, P. N. Ward,, T. J. Coffey,, M. C. Maiden,, T. Peto,, and N. Jones. 2004. Hyperinvasive neonatal group B streptococcus has arisen from a bovine ancestor. J. Clin. Microbiol. 42: 2161– 2167.
22. Bjorland, J.,, M. Sunde,, and S. Waage. 2001. Plasmid-borne smr gene causes resistance to quaternary ammonium compounds in bovine Staphylococcus aureus. J. Clin. Microbiol. 39: 3999– 4004.
23. Bjorland, J.,, T. Steinum,, M. Sunde,, S. Waage,, and E. Heir. 2003. Novel plasmid-borne gene qacJ mediates resistance to quaternary ammonium compounds in equine Staphylococcus aureus, Staphylococcus simulans, and Staphylococcus intermedius. Antimicrob. Agents Chemother. 47: 3046– 3052.
24. Boag, A.,, A. Loeffler,, and D. H. Lloyd. 2004. Methicillinresistant Staphylococcus aureus isolates from companion animals. Vet. Rec. 154: 411.
25. Boerlin, P.,, A. P. Burnens,, J. Frey,, P. Kuhnert,, and J. Nicolet. 2001. Molecular epidemiology and genetic linkage of macrolide and aminoglycoside resistance in Staphylococcus intermedius of canine origin. Vet. Microbiol. 79: 74– 79.
26. Bramley, A. J. 1978. The effect of subclinical Staphylococcus epidermidis infection of the lactating bovine udder on its susceptibility to infection with Streptococcus agalactiae or Escherichia coli. Br. Vet. J. 134: 146– 151.
27. Bramley, A. J. 1997. Environmental streptococci: summary and issues, p. 95– 103. In Proceedings of the Symposium on Udder Health Management for Environmental Streptococci. Ontario Veterinary College, Guelph, Ontario, Canada.
28. Brown, M. B.,, and M. C. Roberts. 1991. Tetracycline resistance determinants in streptococcal species isolated from the bovine mammary gland. Vet. Microbiol. 29: 173– 180.
29. Burriel, A. R. 1997. Resistance of coagulase-negative staphylococci isolated from sheep to various antimicrobial agents. Res. Vet. Sci. 63: 189– 190.
30. Cabral, K. G.,, C. Lammler,, M. Zschock,, H. Langoni,, M. E. de Sa,, C. Victoria,, and A. V. Da Silva. 2004. Pheno- and genotyping of Staphylococcus aureus, isolated from bovine milk samples from Sao Paulo State, Brazil. Can. J. Microbiol. 50: 901– 909.
31. Cain, D.,, F. Malouin,, M. Dargis,, J. Harel,, and M. Gottschalk. 1995. Alterations in penicillin-binding proteins in strains of Streptococcus suis possessing moderate and high levels of resistance to penicillin. FEMS Microbiol. Lett. 130: 121– 127.
32. Cantin, M.,, J. Harel,, R. Higgins,, and M. Gottschalk. 1992. Antimicrobial resistance patterns and plasmid profiles of Streptococcus suis isolates. J. Vet. Diagn. Investig. 4: 170– 174.
33. Cardoso, M.,, and S. Schwarz. 1992. Characterization of the chloramphenicol acetyltransferase variants encoded by the plasmids pSCS6 and pSCS7 from Staphylococcus aureus. J. Gen. Microbiol. 138: 275– 281.
34. Cefai, C.,, S. Ashurst,, and C. Owens. 1994. Human carriage of methicillin-resistant Staphylococcus aureus linked with pet dog. Lancet 344: 539– 540.
35. Chambers, H. F. 1997. Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications. Clin. Microbiol. Rev. 10: 781– 791.
36. Chambers, H. F. 2001. The changing epidemiology of Staphylococcus aureus? Emerg. Infect. Dis. 7: 178– 182.
37. Chung, W. O.,, C. Werckenthin,, S. Schwarz,, and M. C. Roberts. 1999. Host range of the erm(F) rRNA methylase gene in bacteria of human and animal origin. J. Antimicrob. Chemother. 43: 5– 14.
38. Clewell, D. B.,, S. E. Flannagan,, and D. D. Jaworski. 1995. Unconstrained bacterial promiscuity: the Tn 916-Tn 1545 family of conjugative transposons. Trends Microbiol. 3: 229– 236.
39. Coffey, T. J.,, C. G. Dowson,, M. Daniels,, and B. G. Spratt. 1993. Horizontal spread of an altered penicillin-binding protein 2B gene between Streptococcus pneumoniae and Streptococcus oralis. FEMS Microbiol. Lett. 110: 335– 339.
40. Coffey, T. J.,, M. Daniels,, L. K. McDougal,, C. G. Dowson,, F. C. Tenover,, and B. G. Spratt. 1995. Genetic analysis of clinical isolates of Streptococcus pneumoniae with high-level resistance to expanded-spectrum cephalosporins. Antimicrob. Agents Chemother. 39: 1306– 1313.
41. Cox, H. U.,, J. D. Hoskins,, A. F. Roy,, S. S. Newman,, and D. G. Luther. 1984. Antimicrobial susceptibility of coagulasepositive staphylococci isolated from Louisiana dogs. Am. J. Vet. Res. 45: 2039– 2042.
42. Culebras, E.,, I. Rodriguez-Avial,, C. Betriu,, M. Redondo,, and J. J. Picazo. 2002. Macrolide and tetracycline resistance and molecular relationships of clinical strains of Streptococcus agalactiae. Antimicrob. Agents Chemother. 46: 1574– 1576.
43.Reference deleted.
44. Davidson, T. J.,, I. R. Dohoo,, A. W. Donald,, H. Hariharan,, and K. Collins. 1992. A cohort study of coagulase-negative staphylococcal mastitis in selected dairy herds in Prince Edward island. Can. J. Vet. Res. 56: 275– 280.
45. DeBoer, L. R.,, D. M. Slaughter,, R. D. Applegate,, R. J. Sobieski,, and S. S. Crupper. 2001. Antimicrobial susceptibility of staphylococci isolated from the faeces of wild turkeys ( Meleagris gallopavo). Lett. Appl. Microbiol. 33: 382– 386.
45a.. de Leener, E.,, A. Martel,, A. Decostere,, and F. Haesebrouck. 2004. Distribution of the erm (B) gene, tetracycline resistance genes, and Tn 1545-like transposons in macrolide- and lincosamide-resistant enterococci from pigs and humans. Microb. Drug Resist. 10: 341– 345.
45b.. de Mouy, D.,, J. D. Cavallo,, R. Leclercq,, R. Fabre; AFICORPI-BIO Network. Association de Formation Continue en Pathologie Infectieuse des Biologistes. 2001. Antibiotic susceptibility and mechanisms of erythromycin resistance in clinical isolates of Streptococcus agalactiae: French multicenter study. Antimicrob. Agents Chemother. 45: 2400– 2402.
46. Devriese, L. A. 1977. Antibiotic susceptibility of Staphylococcus hyicus isolated from exudative epidermitis cases in Belgium. Vlaams Diergeeneskd. Tijdschr. 46: 143– 144.
47. Devriese, L. A. 1991. Streptococcal ecovars associated with different animal species: epidemiological significance of serogroups and biotypes. J. Appl. Bacteriol. 71: 478– 483.
48. Devriese, L. A.,, and J. Hommez. 1975. Epidemiology of methicillin-resistant Staphylococcus aureus in dairy herds. Res. Vet. Sci. 19: 23– 27.
49. Devriese, L. A.,, and F. Haesebrouck. 1992. Streptococcus suis infections in horses and cats. Vet. Rec. 130: 380.
50. Devriese, L. A.,, L. R. Van Damme,, and L. Fameree. 1972. Methicillin (cloxacillin)-resistant Staphylococcus aureus strains isolated from bovine mastitis cases. Zentbl. Veterinärmed. B 19: 598– 605.
51. Devriese, L. A.,, D. Nzuambe,, and C. Godard. 1985. Identification and characteristics of staphylococci isolated from lesions and normal skin of horses. Vet. Microbiol. 10: 269– 277.
52. Devriese, L. A.,, B. Sustronck,, T. Maenhout,, and F. Haesebrouck. 1990. Streptococcus suis meningitis in a horse. Vet. Rec. 127: 68.
53. Devriese, L. A.,, M. Desmidt,, S. Roels,, J. Hoorens,, and F. Haesebrouck. 1993. Streptococcus suis infection in fallow deer. Vet. Rec. 132: 283.
54. Devriese, L. A.,, M. Baele,, M. Vaneechoutte,, A. Martel,, and F. Haesebrouck. 2002. Identification and antimicrobial susceptibility of Staphylococcus chromogenes isolates from intramammary infections of dairy cows. Vet. Microbiol. 87: 175– 182.
55. Diekema, D. J.,, M. A. Pfaller,, F. J. Schmitz,, J. Smayevsky,, J. Bell,, R. N. Jones,, M. Beach, and the SENTRY Participants Group. 2001. Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997-1999. Clin. Infect. Dis. 32: 114– 132.
56. Diernhofer, K. 1932. Aesculinbouillon als Hilfmittel für die Differenzierung von Euter-und Milchstreptokokken bei Masseuntersuchungen. Milchwirtsch. Forsch. 368– 374.
57. Dowson, C. G.,, A. Hutchison,, J. A. Brannigan,, R. C. George,, D. Hansman,, J. Linares,, A. Tomasz,, J. M. Smith,, and B. G. Spratt. 1989. Horizontal transfer of penicillinbinding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Proc. Natl. Acad. Sci. USA 86: 8842– 8846.
58. Dowson, C. G.,, T. J. Coffey,, C. Kell,, and R. A. Whiley. 1993. Evolution of penicillin resistance in Streptococcus pneumoniae; the role of Streptococcus mitis in the formation of a low affinity PBP2b in S. pneumoniae. Mol. Microbiol. 9: 635– 643.
59. Duarte, R. S.,, O. P. Miranda,, B. C. Bellei,, M. A. Brito,, and L. M. Teixeira. 2004. Phenotypic and molecular characteristics of Streptococcus agalactiae isolates recovered from milk of dairy cows in Brazil. J. Clin. Microbiol. 42: 4214– 4222.
60. Duarte, R. S.,, B. C. Bellei,, O. P. Miranda,, M. A. Brito,, and L. M. Teixeira. 2005. Distribution of antimicrobial resistance and virulence-related genes among Brazilian group B streptococci recovered from bovine and human sources. Antimicrob. Agents Chemother. 49: 97– 103.
61. Dufour, P.,, Y. Gillet,, M. Bes,, G. Lina,, F. Vandenesch,, D. Floret,, J. Etienne,, and H. Richet. 2002. Community-acquired methicillin-resistant Staphylococcus aureus infections in France: emergence of a single clone that produces Panton-Valentine leukocidin. Clin. Infect. Dis. 35: 819– 824.
62. Duquette, R. A.,, and T. J. Nuttall. 2004. Methicillin-resistant Staphylococcus aureus in dogs and cats: an emerging problem? J. Small Anim. Pract. 45: 591– 597.
63.Reference deleted.
64. Eady, E. A.,, and J. H. Cove. 2003. Staphylococcal resistance revisited: community-acquired methicillin resistant Staphylococcus aureus—an emerging problem for the management of skin and soft tissue infections. Curr. Opin. Infect. Dis. 16: 103– 124.
65. Eady, E. A.,, J. I. Ross,, J. L. Tipper,, C. E. Walters,, J. H. Cove,, and W. C. Noble. 1993. Distribution of genes encoding erythromycin ribosomal methylases and an erythromycin efflux pump in epidemiologically distinct groups of staphylococci. J. Antimicrob. Chemother. 31: 211– 217.
66. Enright, M. C. 2003. The evolution of a resistant pathogen— the case of MRSA. Curr. Opin. Pharmacol. 3: 474– 479.
67. Erskine, R. J.,, R. D. Walker,, C. A. Bolin,, P. C. Bartlett,, and D. G. White. 2002. Trends in antibacterial susceptibility of mastitis pathogens during a seven-year period. J. Dairy Sci. 85: 1111– 1118.
68. Evans, A. C. 1916. The bacteria of freshly drawn milk from normal udders. J. Infect. Dis. 18: 437– 476.
69. Farrell, D. J.,, and S. G. Jenkins. 2004. Distribution across the USA of macrolide resistance and macrolide resistance mechanisms among Streptococcus pneumoniae isolates collected from patients with respiratory tract infections: PROTEKT US 2001-2002. J. Antimicrob. Chemother. 54: 17– 22.
70. Farrow, J. A. E.,, and M. D. Collins. 1984. Taxonomic studies on streptococci of serological groups, C, G and L and possible related taxa. Syst. Appl. Microbiol. 5: 483– 493.
71.Reference deleted.
72. Fleming, A. 1929. On the antibacterial action of cultures of a penicillum, with special reference to their use in the isolation of B. influenzae. Br. J. Exp. Pathol. 10: 226– 236.
73. Fluit, A. C.,, J. Verhoef,, F. J. Schmitz; European SENTRY Participants. 2001. Frequency of isolation and antimicrobial resistance of gram-negative and gram-positive bacteria from patients in intensive care units of 25 European university hospitals participating in the European arm of the SENTRY Antimicrobial Surveillance Program 1997-1998. Eur. J. Clin. Microbiol. Infect. Dis. 20: 617– 625.
74. Francis, J. S.,, M. C. Doherty,, U. Lopatin,, C. P. Johnston,, G. Sinha,, T. Ross,, M. Cai,, N. N. Hansel,, T. Perl,, J. R. Ticehurst,, K. Carroll,, D. L. Thomas,, E. Nuermberger,, and J. G. Bartlett. 2005. Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes. Clin. Infect. Dis. 40: 100– 107.
75. Frank, L. A.,, S. A. Kania,, K. A. Hnilica,, R. P. Wilkes,, and D.A. Bemis. 2003. Isolation of Staphylococcus schleiferi from dogs with pyoderma. J. Am. Vet. Med. Assoc. 222: 451– 454.
76. Fraser-Moodie, W. 1971. Struggle against infection. Proc. R. Soc. Med. 64: 87– 94.
77. Garvie, E. I.,, J. A. E. Farrow,, and A. J. Bramley. 1983. Streptococcus dysgalactiae (Diernhofer) nom. rev. Int. J. Syst. Bacteriol. 33: 404– 405.
78. Gentilini, E.,, G. Denamiel,, P. Llorente,, S. Godaly,, M. Rebuelto,, and O. DeGregorio. 2000. Antimicrobial susceptibility of Staphylococcus aureus isolated from bovine mastitis in Argentina. J. Dairy Sci. 83: 1224– 1227.
79. Gentilini, E.,, G. Denamiel,, A. Betancor,, M. Rebuelto,, M. Rodriguez Fermepin,, and R. A. De Torrest. 2002. Antimicrobial susceptibility of coagulase-negative staphylococci isolated from bovine mastitis in Argentina. J. Dairy Sci. 85: 1913– 1917.
80. Giovanetti, E.,, A. Brenciani,, R. Lupidi,, M. C. Roberts,, and P. E. Varaldo. 2003. Presence of the tet(O) gene in erythromycinand tetracycline-resistant strains of Streptococcus pyogenes and linkage with either the mef(A) or the erm(A) gene. Antimicrob. Agents Chemother. 47: 2844– 2849.
81. Gortel, K.,, K. L. Campbell,, I. Kakoma,, T. Whittem,, D. J. Schaeffer,, and R. M. Weisiger. 1999. Methicillin resistance among staphylococci isolated from dogs. Am. J. Vet. Res. 60: 1526– 1530.
82. Gottschalk, M.,, R. Higgins,, M. Jacques,, K. R. Mittal,, and J. Henrichsen. 1989. Description of 14 new capsular types of Streptococcus suis. J. Clin. Microbiol. 27: 2633– 2635.
83. Gottschalk, M.,, R. Higgins,, M. Jacques,, M. Beaudoin,, and J. Henrichsen. 1991. Characterization of six new capsular types (23 through 28) of Streptococcus suis. J. Clin. Microbiol. 29: 2590– 2594.
84. Guérin-Faublee, V.,, F. Tardy,, C. Bouveron,, and G. Carret. 2002. Antimicrobial susceptibility of Streptococcus species isolated from clinical mastitis in dairy cows. Int. J. Antimicrob. Agents 19: 219– 226.
85. Hajek, V. 1976. Staphylococcus intermedius, a new species isolated from animals. Int. J. Syst. Bacteriol. 26: 401– 408.
86. Hajek, V.,, and E. Marsalek. 1971. The differentiation of pathogenic staphylococci and a suggestion for their taxonomic classification. Zentbl. Bakteriol. Orig. A 217: 176– 182.
87. Hakenbeck, R.,, M. Tarpay,, and A. Tomasz. 1980. Multiple changes of penicillin-binding proteins in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 17: 364– 371.
88. Hakenbeck, R.,, H. Ellerbrok,, T. Briese,, S. Handwerger,, and A. Tomasz. 1986. Penicillin-binding proteins of penicillinsusceptible and -resistant pneumococci: immunological relatedness of altered proteins and changes in peptides carrying the beta-lactam binding site. Antimicrob. Agents Chemother. 30: 553– 558.
89. Hariharan, H.,, J. Bryenton,, J. St. Onge,, N. McNair,, and J. R. Long. 1989. Antimicrobial drug susceptibility of Streptococcus suis type 2. Ir. Vet. J. 42: 113– 114.
90. Hartmann, F. A.,, S. S. Trostle,, and A. A. Klohnen. 1997. Isolation of methicillin-resistant Staphylococcus aureus from a postoperative wound infection in a horse. J. Am. Vet. Med. Assoc. 211: 590– 592.
91. Hazarika, R. A.,, P. N. Mahanta,, G. N. Dutta,, and L. A. Devriese. 1991. Cutaneous infection associated with Staphylococcus hyicus in cattle. Res. Vet. Sci. 50: 374– 375.
91a.. Heuer, O. E.,, and P. B. Larsen (ed.). 2004. DANMAP 2003— Use of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Bacteria from Food Animals, Foods and Humans in Denmark. Danish Integrated Antimicrobial Resistance Monitoring and Research Programme, Copenhagen, Denmark.
92. Higgins, R.,, and M. Gottschalk,. 1999. Streptococcal diseases,, p. 563– 578. In B. Straw,, S. D’Allaire,, W. L. Mengeling,, and D. J. Taylor (ed.), Diseases of Swine. Iowa State University Press, Ames.
93. Higgins, R.,, and M. Gottschalk. 2001. Distribution of Streptococcus suis capsular types in 2000. Can. Vet. J. 42: 223.
94. Higgins, R.,, M. Gottschalk,, M. Boudreau,, A. Lebrun,, and J. Henrichsen. 1995. Description of six new capsular types (29-34) of Streptococcus suis. J. Vet. Diagn. Investig. 7: 405– 406.
95. Hogan, J. S.,, K. L. Smith,, D. A. Todhunter,, and P. S. Schoenberger. 1987. Rate of environmental mastitis in quarters infected with Corynebacterium bovis and Staphylococcus species. J. Dairy Sci. 71: 2520– 2525.
96. Holm, B. R.,, U. Petersson,, A. Morner,, K. Bergstrom,, A. Franklin,, and C. Greko. 2002. Antimicrobial resistance in staphylococci from canine pyoderma: a prospective study of first-time and recurrent cases in Sweden. Vet. Rec. 151: 600– 605.
97. Hommez, J.,, J. Wullepit,, P. Cassimon,, F. Castryck,, K. Ceyssens,, and L. A. Devriese. 1988. Streptococcus suis and other streptococcal species as a cause of extramammary infection in ruminants. Vet. Rec. 123: 626– 627.
98. Hommez, J.,, L. A. Devriese,, F. Castryck,, and C. Miry. 1991. β-hemolytic streptococci from pigs: bacteriological diagnosis. J. Vet. Med. B 38: 441– 444.
99. Honkanen-Buzalski, T.,, V. Myllys,, and S. Pyörälä. 1994. Bovine clinical mastitis due to coagulase-negative staphylococci and their susceptibility to antimicrobials. J. Vet. Med. B 41: 344– 350.
100. Jensen, L. B.,, N. Frimodt-Møller,, and F. M. Aarestrup. 1999. Presence of erm classes in Gram-positive bacteria of animal and human origin. FEMS Microbiol. Lett. 170: 151– 158.
101. Jensen, N. E. 1982. Experimental bovine group-B streptococcal mastitis induced by strains of human and bovine origin. Nord. Vetmed. 34: 441– 450.
102. Jensen, N. E.,, and F. M. Aarestrup. 1996. Epidemiological aspects of group B streptococci of bovine and human origin. Epidemiol. Infect. 117: 417– 422.
103. Kania, S. A.,, N. L. Williamson,, L. A. Frank,, R. P. Wilkes,, R. D. Jones,, and D. A. Bemis. 2004. Methicillin resistance of staphylococci isolated from the skin of dogs with pyoderma. Am. J. Vet. Res. 65: 1265– 1268.
104. Kapur, V.,, W. M. Sisco,, R. S. Greer,, T. S. Whittam,, and J. M. Musser. 1995. Molecular population genetic analysis of Staphylococcus aureus recovered from cows. J. Clin. Microbiol. 33: 376– 380.
105. Kaszanyitzky, E. J.,, Z. Egyed,, S. Janosi,, J. Keseru,, Z. Gal,, I. Szabo,, Z. Veres,, and P. Somogyi. 2004. Staphylococci isolated from animals and food with phenotypically reduced susceptibility to beta-lactamase-resistant beta-lactam antibiotics. Acta Vet. Hung. 52: 7– 17.
106. Kataoka, Y.,, C. Sugimoto,, M. Nakazawa,, T. Morozumi,, and M. Kashiwazaki. 1993. The epidemiological studies of Streptococcus suis infections in Japan from 1987 to 1991. J. Vet. Med. Sci. 55: 623– 626.
107. Kataoka, Y.,, T. Yoshida,, and T. Sawada. 2000. A 10-year survey of antimicrobial susceptibility of Streptococcus suis isolates from swine in Japan. J. Vet. Med. Sci. 62: 1053– 1057.
108. Kawano, J.,, A. Shimizu,, Y. Saitoh,, M. Yagi,, T. Saito,, and R. Okamoto. 1996. Isolation of methicillin-resistant coagulasenegative staphylococci from chickens. J. Clin. Microbiol. 34: 2072– 2077.
109. Kehrenberg, C.,, and S. Schwarz. 2004. fexA, a novel Staphylococcus lentus gene encoding resistance to florfenicol and chloramphenicol. Antimicrob. Agents Chemother. 48: 615– 618.
110. Kehrenberg, C.,, K. K. Ojo,, and S. Schwarz. 2004. Nucleotide sequence and organisation of the multiresistance plasmid pSCFS1 from Staphylococcus sciuri. J. Antimicrob. Chemother. 54: 936– 939.
111. Kehrenberg, C.,, J. Mumme,, J. Wallmann,, J. Verspohl,, R. Tegeler,, T. Kühn,, and S. Schwarz. 2004. Monitoring of florfenicol susceptibility among bovine and porcine respiratory tract pathogens collected in Germany during the years 2002 and 2003. J. Antimicrob. Chemother. 54: 572– 574.
112. Keymer, I. F.,, S. E. Heath,, and J. G. Wood. 1983. Streptococcus suis type II infection in a raccoon dog ( Nyctereutes procyonoides) family Canidae. Vet. Rec. 113: 624.
113. Khan, S. A.,, M. S. Nawaz,, A. A. Khan,, R. S. Steele,, and C. E. Cerniglia. 2000. Characterization of erythromycinresistant methylase genes from multiple antibiotic resistant Staphylococcus spp. isolated from milk samples of lactating cows. Am. J. Vet. Res. 61: 1128– 1132.
114. Kirby, W. M. M. 1944. Extraction of a highly potent penicillin inactivator from penicillin resistant staphylococci. Science 99: 452– 453.
115. Kloos, W. E. 1980. Natural populations of the genus Staphylococcus. Annu. Rev. Microbiol. 34: 559– 592.
116. Kloos, W. E.,, and T. L. Bannerman. 1994. Update on clinical significance of coagulase-negative staphylococci. Clin. Microbiol. Rev. 7: 117– 140.
117. Kloos, W. E.,, and T. L. Bannerman,. 1999. Staphylococcus and Micrococcus, p. 264– 282. In P. R. Murray et al. (ed.), Manual of Clinical Microbiology, 7th ed. ASM Press, Washington D.C.
118. Kloos, W. E.,, and K. H. Schleifer. 1976. Characterization of Staphylococcus sciuri sp. nov. and its subspecies. Int. J. Syst. Bacteriol. 26: 22– 37.
119. Kloos, W. E.,, D. N. Ballard,, J. A. Webster,, R. J. Hubner,, A. Tomasz,, I. Couto,, G. L. Sloan,, H. P. Dehart,, F. Fiedler,, K. Schubert,, H. de Lencastre,, I. S. Sanches,, H. E. Heath,, P. A. Leblanc,, and A. Ljungh. 1997. Ribotype delineation and description of Staphylococcus sciuri subspecies and their potential as reservoirs of methicillin resistance and staphylolytic enzyme genes. Int. J. Syst. Bacteriol. 47: 313– 323.
120. Kloos, W. E.,, C. G. George,, J. S. Olgiate,, L. Van Pelt,, M. L. McKinnon,, B. L. Zimmer,, E. Muller,, M. P. Weinstein,, and S. Mirrett. 1998. Staphylococcus hominis subsp. novobiosepticus subsp. nov., a novel trehalose- and N-acetyl-dglucosamine- negative, novobiocin- and multiple-antibioticresistant subspecies isolated from human blood cultures. Int. J. Syst. Bacteriol. 48: 799– 812.
121. Lambert, L. H.,, T. Cox,, K. Mitchell,, R. A. Rossello-Mora,, C. Del Cueto,, D. E. Dodge,, P. Orkand,, and R. J. Cano. 1998. Staphylococcus succinus sp. nov., isolated from Dominican amber. Int. J. Syst. Bacteriol. 48: 511– 518.
122. Lancefield, R. C. 1933. A serological differentiation of human and other groups of hemolytic streptococci. J. Exp. Med. 57: 571– 595.
123. Lange, C. C.,, M. Cardoso,, D. Senczek,, and S. Schwarz. 1999. Molecular subtyping of Staphylococcus aureus from cases of bovine mastitis in Brazil. Vet. Microbiol. 67: 127– 141.
124. Lange, C. C.,, C. Werckenthin,, and S. Schwarz. 2003. Molecular analysis of the plasmid-borne aacA/aphD resistance gene region of coagulase-negative staphylococci from chickens. J. Antimicrob. Chemother. 51: 1397– 1401.
125. Lee, J. H. 2003. Methicillin (oxacillin)-resistant Staphylococcus aureus strains isolated from major food animals and their potential transmission to humans. Appl. Environ. Microbiol. 69: 6489– 6494.
126.Reference deleted.
127. Leigh, J. A. 1999. Streptococcus uberis: a permanent barrier to the control of bovine mastitis? Vet. J. 157: 225– 238.
128. Lilenbaum, W.,, E. L. Nunes,, and M. A. Azeredo. 1998. Prevalence and antimicrobial susceptibility of staphylococci isolated from the skin surface of clinically normal cats. Lett. Appl. Microbiol. 27: 224– 228.
129. Lilenbaum, W.,, A. L. Esteves,, and G. N. Souza. 1999. Prevalence and antimicrobial susceptibility of staphylococci isolated from saliva of clinically normal cats. Lett. Appl. Microbiol. 28: 448– 452.
130. Lilenbaum, W.,, M. Veras,, E. Blum,, and G. N. Souza. 2000. Antimicrobial susceptibility of staphylococci isolated from otitis externa in dogs. Lett. Appl. Microbiol. 31: 42– 45.
131. Lina, G.,, Y. Piemont,, F. Godail-Gamot,, M. Bes,, M. O. Peter,, V. Gauduchon,, F. Vandenesch,, and J. Etienne. 1999. Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia. Clin. Infect. Dis. 29: 1128– 1132.
132. Lloyd, D. H.,, A. I. Lamport,, and C. Feeney. 1996. Sensitivity to antibiotics amongst cutaneous and mucosal isolates of canine pathogenic staphylococci in the UK, 1980-96. Vet. Dermatol. 7: 171– 175.
133. Loeza-Lara, P. D.,, M. Soto-Huipe,, V. M. Baizabal-Aguirre,, A. Ochoa-Zarzosa,, J. J. Valdez-Alarcon,, H. Cano-Camacho,, and J. E. Lopez-Meza. 2004. pBMSa1, a plasmid from a dairy cow isolate of Staphylococcus aureus, encodes a lincomycin resistance determinant and replicates by the rollingcircle mechanism. Plasmid 52: 48– 56.
134. Lüthje, P.,, G. Luhofer,, M. Zschöck,, P. Krabisch,, and S. Schwarz. 2004. Susceptibility of coagulase-negative staphylococci from cases of bovine subclinical mastitis to pirlimycin and other antimicrobial agents. Int. J. Med. Microbiol. 294: 222.
135. MacFarlane, G. 1984. Alexander Fleming: the Man and the Myth. Harvard University Press, Cambridge, Mass.
136. Manian, F. A. 2003. Asymptomatic nasal carriage of mupirocin-resistant, methicillin-resistant Staphylococcus aureus (MRSA) in a pet dog associated with MRSA infection in household contacts. Clin. Infect. Dis. 36: e26– e28.
137. Marie, J.,, H. Morvan,, F. Berthelot-Herault,, P. Sanders,, I. Kempf,, A. V. Gautier-Bouchardon,, E. Jouy,, and M. Kobisch. 2002. Antimicrobial susceptibility of Streptococcus suis isolated from swine in France and from humans in different countries between 1996 and 2000. J. Antimicrob. Chemother. 50: 201– 209.
138. Martel, A.,, M. Baele,, L. A. Devriese,, H. Goossens,, H. J. Wisselink,, A. Decostere,, and F. Haesebrouck. 2001. Prevalence and mechanism of resistance against macrolides and lincosamides in Streptococcus suis isolates. Vet. Microbiol. 83: 287– 297.
139. Martinez, G.,, J. Harel,, R. Higgins,, S. Lacouture,, D. Daignault,, and M. Gottschalk. 2000. Characterization of Streptococcus agalactiae isolates of bovine and human origin by randomly amplified polymorphic DNA analysis. J. Clin. Microbiol. 38: 71– 78.
140. Mdegela, R. H.,, L. J. Kusiluka,, A. M. Kapaga,, E. D. Karimuribo,, F. M. Turuka,, A. Bundala,, F. Kivaria,, B. Kabula,, A. Manjurano,, T. Loken,, and D. M. Kambarage. 2004. Prevalence and determinants of mastitis and milkborne zoonoses in smallholder dairy farming sector in Kibaha and Morogoro districts in Eastern Tanzania. J. Vet. Med. B 51: 123– 128.
141. Medleau, L.,, R. E. Long,, J. Brown,, and W. H. Miller. 1986. Frequency and antimicrobial susceptibility of Staphylococcus species isolated from canine pyodermas. Am. J. Vet. Res. 47: 229– 231.
142. Mendonca-Souza, C. R.,, M. da G.Carvalho,, R. R. Barros,, C. A. Dias,, J. L. Sampaio,, A. C. Castro,, R. R. Facklam,, and L. M. Teixeira. 2004. Occurrence and characteristics of erythromycin-resistant Streptococcus pneumoniae strains isolated in three major Brazilian states. Microb. Drug Resist. 10: 313– 320.
143. Montanari, M. P.,, I. Cochetti,, M. Mingoia,, and P. E. Varaldo. 2003. Phenotypic and molecular characterization of tetracycline- and erythromycin-resistant strains of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 47: 2236– 2241.
144.Reference deleted.
145. Munckhof, W. J.,, S. L. Kleinschmidt,, and J. D. Turnidge. 2004. Resistance development in community-acquired strains of methicillin-resistant Staphylococcus aureus: an in vitro study. Int. J. Antimicrob. Agents 24: 605– 608.
146. Musser, J. M.,, S. J. Mattingly,, R. Quentin,, A. Goudeau,, and R. K. Selander. 1989. Identification of a high-virulence clone of type III Streptococcus agalactiae (group B Streptococcus) causing invasive neonatal disease. Proc. Natl. Acad. Sci. USA 86: 4731– 4735.
146a.. Myllyniemi, A.-L.,, V. Gindonis,, S. Nykäsenoja,, and J. Koppinen. 2004. FINRES-Vet 2002-2003, Finnish Veterinary Antimicrobial Resistance Monitoring and Consumption of Antimicrobial Agents. National Veterinary and Food Research Institute, Helsinki, Finland.>
147. Naimi, T. S.,, K. H. LeDell,, K. Como-Sabetti,, S. M. Borchardt,, D. J. Boxrud,, J. Etienne,, S. K. Johnson,, F. Vandenesch,, S. Fridkin,, C. O’Boyle,, R. N. Danila,, and R. Lynfield. 2003. Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. JAMA 290: 2976– 2984.
148. National Committee for Clinical Laboratory Standards. 2002. Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria isolated from animals. Approved standard, 2nd ed. NCCLS document M31-A2. National Committee for Clinical Laboratory Standards, Wayne, Pa.
148a.. National Veterinary Institute. 2003. SVARM 2002: Swedish Veterinary Antimicrobial Resistance Monitoring. National Veterinary Institute, Uppsala, Sweden.
149. Nawaz, M. S.,, A. A. Khan,, S. A. Khan,, D. D. Paine,, J. V. Pothuluri,, and C. E. Cerniglia. 1999. Biochemical and molecular characterization of erythromycin resistant avian Staphylococcus spp. isolated from chickens. Poult. Sci. 78: 1191– 1197.
150. Nawaz, M. S.,, S. A. Khan,, A. A. Khan,, F. M. Khambaty,, and C. E. Cerniglia. 2000. Comparative molecular analysis of erythromycin-resistance determinants in staphylococcal isolates of poultry and human origin. Mol. Cell. Probes 14: 311– 319.
151. Noble, W. C.,, and R. P. Allaker. 1992. Staphylococci on the skin of pigs: isolates from two farms with different antibiotic policies. Vet. Rec. 130: 466– 468.
152. Nomoto, R.,, L. I. Munasinghe,, D.-H. Jin,, Y. Shimahara,, H. Yasuda,, A. Nakamura,, N. Misawa,, T. Itami,, and T. Yoshida. 2004. Lancefield group C Streptococcus dysgalactiae infection responsible for fish mortalities in Japan. J. Fish Dis. 27: 679– 686.
153. NORM and NORM-VET. 2003. NORM/NORM-VET 2002: Consumption of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway. NORM, Tromsø, Norway, and NORM-VET, Oslo, Norway.
154. North, E. A.,, and R. Christie. 1946. Acquired resistance of staphylococci to the action of penicillin. Med. J. Aust. 1: 176– 179.
155. Oughton, M.,, H. Dick,, B. M. Willey,, A. McGeer,,and D. E. Low. 2001. Methicillin-resistant Staphylococcus aureus (MRSA) as a cause of infections in domestic animals: evidence for a new humanotic disease? Can. Bacterial Surveill. Network News. April: 1– 2.
156. Ozaki, K.,, T. Yamagami,, K. Nomura,, M. Haritani,, Y. Tsutsumi,, and I. Narama. 2003. Abscess-forming inflammatory granulation tissue with Gram-positive cocci and prominent eosinophil infiltration in cats: possible infection of methicillin-resistant Staphylococcus. Vet. Pathol. 40: 283– 287.
157. Pak, S. I.,, H. R. Han,, and A. Shimizu. 1999. Characterization of methicillin-resistant Staphylococcus aureus isolated from dogs in Korea. J. Vet. Med. Sci. 61: 1013– 1018.
158. Pellerin, J. L.,, P. Bourdeau,, H. Sebbag,, and J. M. Person. 1998. Epidemiosurveillance of antimicrobial compound resistance of Staphylococcus intermedius clinical isolates from canine pyodermas. Comp. Immunol. Microbiol. Infect. Dis. 21: 115– 133.
159. Perch, B.,, K. B. Pedersen,, and J. Henrichsen. 1983. Serology of capsulated streptococci pathogenic for pigs: six new serotypes of Streptococcus suis. J. Clin. Microbiol. 17: 993– 996.
160. Petersen, A. D.,, R. D. Walker,, M. M. Bowman,, H. C. Schott II,, and E. J. Rosser, Jr. 2002. Frequency of isolation and antimicrobial susceptibility patterns of Staphylococcus intermedius and Pseudomonas aeruginosa isolates from canine skin and ear samples over a 6-year period (1992-1997). J. Am. Anim. Hosp. Assoc. 38: 407– 413.
161. Phillips, W. E., Jr.,, and B. J. Williams. 1984. Antimicrobial susceptibility patterns of canine Staphylococcus intermedius isolates from veterinary clinical specimens. Am. J. Vet. Res. 45: 2376– 2379.
162. Phuektes, P.,, P. D. Mansell,, R. S. Dyson,, N. D. Hooper,, J. S. Dick,, and G. F. Brown. 2001. Molecular epidemiology of Streptococcus uberis isolates from dairy cows with mastitis. J. Clin. Microbiol. 39: 1460– 1466.
163. Piriz, S.,, J. Valle,, E. M. Mateos,, R. delaFuente,, D. Cid,, J. A. Ruiz- Santaquiteria,, and S. Vadillo. 1996. In vitro activity of fifteen antimicrobial agents against methicillin-resistant and methicillin-susceptible Staphylococcus intermedius. J. Vet. Pharmacol. Ther. 19: 118– 123.
164. Pitkälä, A.,, M. Haveri,, S. Pyorala,, V. Myllys,, and T. Honkanen-Buzalski. 2004. Bovine mastitis in Finland 2001—prevalence, distribution of bacteria, and antimicrobial resistance. J. Dairy Sci. 87: 2433– 2441.
165. Place, R. B.,, D. Hiestand,, S. Burri,, and M. Teuber. 2002. Staphylococcus succinus subsp. casei subsp. nov., a dominant isolate from a surface ripened cheese. Syst. Appl. Microbiol. 25: 353– 359.
166. Place, R. B.,, D. Hiestand,, H. R. Gallmann,, and M. Teuber. 2003. Staphylococcus equorum subsp. linens, subsp. nov., a starter culture component for surface ripened semi-hard cheeses. Syst. Appl. Microbiol. 26: 30– 37.
167. Poyart, C.,, L. Jardy,, G. Quesne,, P. Berche,, and P. Trieu- Cuot. 2003. Genetic basis of antibiotic resistance in Streptococcus agalactiae strains isolated in a French hospital. Antimicrob. Agents Chemother. 47: 794– 797.
168. Priebe, S.,, and S. Schwarz. 2003. In vitro activities of florfenicol against bovine and porcine respiratory tract pathogens. Antimicrob. Agents Chemother. 47: 2703– 2705.
169. Prieto, C.,, J. Pena,, P. Suarez,, M. Imaz,, and J. M. Castro. 1993. Isolation and distribution of Streptococcus suis capsular types from diseased pigs in Spain. Zentbl. Veterinärmed B 40: 544– 548.
170. Probst, A. J.,, C. Hertel,, L. Richter,, L. Wassill,, W. Ludwig,, and W. P. Hammes. 1998. Staphylococcus condimenti sp. nov., from soy sauce mash, and Staphylococcus carnosus (Schleifer and Fischer 1982) subsp. utilis subsp. nov. Int. J. Syst. Bacteriol. 48: 651– 658.
171. Rajala-Schultz, P. J.,, K. L. Smith,, J. S. Hogan,, and B. C. Love. 2004. Antimicrobial susceptibility of mastitis pathogens from first lactation and older cows. Vet. Microbiol. 102: 33– 42.
172. Rasmussen, S. R.,, F. M. Aarestrup,, N. E. Jensen,, and S. E. Jorsal. 1999. Associations of Streptococcus suis serotype 2 ribotype profiles with clinical disease and antimicrobial resistance. J. Clin. Microbiol. 37: 404– 408.
173. Rather, P. N.,, A. P. Davis,, and B. J. Wilkinson. 1986. Slime production by bovine milk Staphylococcus aureus and identification of coagulase-negative staphylococcal isolates. J. Clin. Microbiol. 23: 858– 862.
174. Reinert, R. R.,, C. Franken,, M. van derLinden,, R. Lutticken,, M. Cil,, and A. Al-Lahham. 2004. Molecular characterisation of macrolide resistance mechanisms of Streptococcus pneumoniae and Streptococcus pyogenes isolated in Germany, 2002-2003. Int. J. Antimicrob. Agents 24: 43– 47.
175. Renneberg, J.,, and V. T. Rosdahl. 1992. Epidemiological studies of penicillin resistance in Danish Staphylococcus aureus strains in the period 1977-1990. Scand. J. Infect. Dis. 24: 401– 409.
176. Rich, M.,, and L. Roberts. 2004. Methicillin-resistant Staphylococcus aureus isolates from companion animals. Vet. Rec. 154: 310.
177. Roberts, M. C.,, and M. B. Brown. 1994. Macrolidelincosamide resistance determinants in streptococcal species isolated from the bovine mammary gland. Vet. Microbiol. 40: 253– 261.
178. Rosenbach, F. J., 1884. Mikroorganismen bei den Wundinfektionskrankheiten des Menschen. J. F. Bergmann, Wiesbaden, Germany.
179. Rossitto, P. V.,, L. Ruiz,, Y. Kikuchi,, K. Glenn,, K. Luiz,, J. L. Watts,, and J. S. Cullor. 2002. Antibiotic susceptibility patterns for environmental streptococci isolated from bovine mastitis in central California dairies. J. Dairy Sci. 85: 132– 138.
180. Rouch, D. A.,, M. E. Byrne,, Y. C. Kong,, and R. A. Skurray. 1987. The aacA-aphD gentamicin and kanamycin resistance determinant of Tn 4001 from Staphylococcus aureus: expression and nucleotide sequence analysis. J. Gen. Microbiol. 133: 3039– 3052.
181. Rowland, S. J.,, and K. G. H. Dyke. 1989. Characterization of the staphylococcal β-lactamase transposon Tn 552. EMBO J. 8: 2761– 2773.
182. Sachdé, F.,, S. Schwarz,, C. Werckenthin,, and C. Lämmler. 1997. Tetracycline and minocycline resistance in Streptococcus suis. Med. Sci. Res. 25: 11– 13.
183. Sandford, E. E.,, and A. M. E. Tilker. 1989. Streptococcus suis antimicrobial susceptibility. Can. Vet. J. 30: 679– 680.
184. Santos Sanches, I.,, R. Mato,, H. de Lencastre,,and A. Tomasz; CEM/NET Collaborators and the International Collaborators. 2000. Patterns of multidrug resistance among methicillin-resistant hospital isolates of coagulase-positive and coagulase-negative staphylococci collected in the international multicenter study RESIST in 1997 and 1998. Microb. Drug Resist. 6: 199– 211.
185. Schalm, O. W.,, E. J. Carroll,, and N. C. Jain. 1971. Bovine Mastitis. Lea and Febiger, Philadelphia, Pa.
186. Schleifer, K. H.,, and R. Kilpper-Balz. 1984. Transfer of Streptococcus faecalis and Streptococcus faecium to the genus Enterococcus nom. rev. as Enterococcus faecalis comb. nov. and Enterococcus faecium comb. nov. Int. J. Syst. Bacteriol. 34: 31– 34.
187. Schleifer, K. H.,, J. Kraus,, C. Dvorak,, R. Kilpper-Balz,, M. D. Collins,, and W. Fischer. 1985. Transfer of Streptococcus lactis and related streptococci to the genus Lactococcus gen. nov. Syst. Appl. Microbiol. 6: 183– 195.
188. Schwarz, S. 1994. Emerging chloramphenicol resistance in Staphylococcus lentus from mink following chloramphenicol treatment: characterisation of the resistance genes. Vet. Microbiol. 41: 51– 61.
189. Schwarz, S.,, and H. Blobel. 1989 Plasmids and resistance to antimicrobial agents and heavy metals in Staphylococcus hyicus from pigs and cattle. Zentbl. Veterinärmed. B 36: 669– 673.
190. Schwarz, S.,, and H. Blobel. 1990. A new streptomycinresistance plasmid from Staphylococcus hyicus and its structural relationship to other staphylococcal resistance plasmids. J. Med. Microbiol. 32: 201– 205.
191. Schwarz, S.,, and Z. Wang. 1993. Tetracycline resistance in Staphylococcus intermedius. Lett. Appl. Microbiol. 17: 88– 91.
192. Schwarz, S.,, and W. C. Noble. 1994. Tetracycline resistance genes in staphylococci from the skin of pigs. J. Appl. Bacteriol. 76: 320– 326.
193. Schwarz, S.,, and W.C. Noble. 1994. Structure and putative origin of a plasmid from Staphylococcus hyicus that mediates chloramphenicol and streptomycin resistance. Lett. Appl. Microbiol. 18: 281– 284.
194. Schwarz, S.,, and S. Grölz-Krug. 1991. A chloramphenicolstreptomycin- resistance plasmid from a clinical strain of Staphylococcus sciuri and its structural relationship to other staphylococcal plasmids. FEMS Microbiol. Lett. 66: 319– 322.
195. Schwarz, S.,, M. Cardoso,, and H. Blobel. 1989. Plasmidmediated chloramphenicol resistance in Staphylococcus hyicus. J. Gen. Microbiol. 135: 3329– 3336.
196. Schwarz, S.,, H. C. Wegener,, and H. Blobel. 1990. Plasmidencoded resistance to macrolides and lincosamides in Staphylococcus hyicus. J. Appl. Bacteriol. 69: 845– 849.
197. Schwarz, S.,, I. W. Wibawan,, and C. Lammler. 1994. Distribution of genes conferring combined resistance to tetracycline and minocycline among group B streptococcal isolates from humans and various animals. Zentbl. Bakteriol. 281: 526– 533.
198. Schwarz, S.,, P. D. Gregory,, C. Werckenthin,, S. Curnock,, and K. G. H. Dyke. 1996. A novel plasmid from Staphylococcus epidermidis specifying resistance to kanamycin, neomycin and tetracycline. J. Med. Microbiol. 45: 57– 63.
199. Schwarz, S.,, M. C. Roberts,, C. Werckenthin,, Y. Pang,, and C. Lange. 1998. Tetracycline resistance in Staphylococcus spp. from domestic animals. Vet. Microbiol. 63: 217– 227.
200. Schwarz, S.,, C. Werckenthin,, and C. Kehrenberg. 2000. Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri. Antimicrob. Agents Chemother. 44: 2530– 2533.
201. Schwarz, S.,, C. Kehrenberg,, and K. K. Ojo. 2002. Staphylococcus sciuri gene erm(33), encoding inducible resistance to macrolides, lincosamides, and streptogramin B antibiotics, is a product of recombination between erm(C) and erm(A). Antimicrob. Agents Chemother. 46: 3621– 3623.
202. Seguin, J. C.,, R. D. Walker,, J. P. Caron,, W. E. Kloos,, C. G. George,, R. J. Hollis,, R. N. Jones,, and M. A. Pfaller. 1999. Methicillin-resistant Staphylococcus aureus outbreak in a veterinary teaching hospital: potential human-to-animal transmission. J. Clin. Microbiol. 37: 1459– 1463.
203. Seol, B.,, Z. Kelneric,, D. Hajsig,, J. Madic,, and T. Naglic. 1996. Susceptibility to antimicrobial agents of Streptococcus suis capsular type 2 strains isolated from pigs. Zentbl. Bakteriol. 283: 328– 331.
204. Seral, C.,, F. J. Castillo,, M. C. Rubio-Calvo,, A. Fenoll,, C. Garcia,, and R. Gomez-Lus. 2001. Distribution of resistance genes tet(M), aph3'-III, catpC194 and the integrase gene of Tn 1545 in clinical Streptococcus pneumoniae harbouring erm(B) and mef(A) genes in Spain. J. Antimicrob. Chemother. 47: 863– 866.
205. Shaw, K. J.,, P. N. Rather,, R. S. Hare,, and G. H. Miller. 1993. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol. Rev. 57: 138– 163.
206. Sherman, J. M. 1937. The streptococci. Bacteriol. Rev. 1: 3– 97.
207. Shimizu, A.,, J. Kawano,, C. Yamamoto,, O. Kakutani,, T. Anzai,, and M. Kamada. 1997. Genetic analysis of equine methicillin-resistant Staphylococcus aureus by pulsed-field gel electrophoresis. J. Vet. Med. Sci. 59: 935– 937.
208. Shimizu, A.,, Y. Wakita,, S. Nagase,, M. Okabe,, T. Koji,, T. Hayashi,, N. Nagase,, A. Sasaki,, J. Kawano,, K. Yamashita,, and M. Takagi. 2001. Antimicrobial susceptibility of Staphylococcus intermedius isolated from healthy and diseased dogs. J. Vet. Med. Sci. 63: 357– 360.
209. Sihvonen, L.,, D. N. Kurl,, and J. Henrichsen. 1988. Streptococcus suis isolated from pigs in Finland. Acta Vet. Scand. 29: 9– 13.
210. Skov, R.,, T. J. Williams,, L. Pallesen,, V. T. Rosdahl,, and F. Espersen. 1995. Beta-lactamase production and genetic location in Staphylococcus aureus: introduction of a betalactamase plasmid in strains of phage group II. J. Hosp. Infect. 30: 111– 124.
211. Slaughter, D. M.,, T. G. Patton,, G. Sievert,, R. J. Sobieski,, and S. S. Crupper. 2001. Antibiotic resistance in coagulase- negative staphylococci isolated from Cope’s gray treefrogs ( Hyla chrysoscelis). FEMS Microbiol. Lett. 205: 265– 270.
212. Soedarmanto, I.,, S. Schwarz,, B. Liebisch,, and C. Lämmler. 1995. Tetracycline resistance determinants among streptococci of serological groups G and L. Vet. Microbiol. 45: 331– 337.
213. Spergser, J.,, M. Wieser,, M. Taubel,, R. A. Rossello-Mora,, R. Rosengarten,, and H. J. Busse. 2003. Staphylococcus nepalensis sp. nov., isolated from goats of the Himalayan region. Int. J. Syst. Evol. Microbiol. 53: 2007– 2011.
214. Stemper, M. E.,, S. K. Shukla,, and K. D. Reed. 2004. Emergence and spread of community-associated methicillinresistant Staphylococcus aureus in rural Wisconsin, 1989 to 1999. J. Clin. Microbiol. 42: 5673– 5680.
215. Stuart, J. G.,, E. J. Zimmerer,, and R. L. Maddux. 1992. Conjugation of antibiotic resistance in Streptococcus suis. Vet. Microbiol. 30: 213– 222.
216.Reference deleted.
217. Tarradas, C.,, I. Luque,, D. de Andres,, Y. E. Abdel-Aziz Shahein,, P. Pons,, F. Gonzalez,, C. Borge,, and A. Perea. 2001. Epidemiological relationship of human and swine Streptococcus suis isolates. J. Vet. Med. B 48: 347– 355.
218. Tate, C. R.,, W. C. Mitchell,, and R. G. Miller. 1993. Staphylococcus hyicus associated with turkey stifle joint osteomyelitis. Avian Dis. 37: 905– 907.
219. Teale, C. J.,, S. Cobb,, P. K. Martin,, and G. Watkins. 2002. VLA Antimicrobial Sensitivity Report— 2002. DEFRA, London, United Kingdom.
220. Teranishi, H.,, A. Shimizu,, J. Kawano,, and S. Kimura. 1987. Antibiotic resistance of Staphylococcus hyicus subsp. hyicus strains isolated from pigs, cattle and chickens. Nippon Juigaku Zasshi 49: 427– 432.
221. Tian, Y.,, F. M. Aarestrup,, and C. P. Lu. 2004. Characterization of Streptococcus suis serotype 7 isolates from diseased pigs in Denmark. Vet. Microbiol. 103: 55– 62.
222. Tiemei, Z.,, F. Xiangqun,, and L. Youning. 2004. Resistance phenotypes and genotypes of erythromycin-resistant Streptococcus pneumoniae isolates in Beijing and Shenyang, China. Antimicrob. Agents Chemother. 48: 4040– 4041.
223. Tiemersma, E. W.,, S. L. Bronzwaer,, O. Lyytikainen,, J. E. Degener,, P. Schrijnemakers,, N. Bruinsma,, J. Monen,, W. Witte,, and H. Grundman. 2004. Methicillin-resistant Staphylococcus aureus in Europe, 1999-2002. Emerg. Infect. Dis. 10: 1627– 1634.
224. Timms, L. L.,, and L. H. Schultz. 1987. Dynamics and significance of coagulase-negative staphylococcal intramammary infections. J. Dairy Sci. 70: 2648– 2657.
225. Todhunter, D. A.,, L. L. Cantwell,, K. L. Smith,, K. H. Hoblet,, and J. S. Hogan. 1993. Characteristics of coagulase-negative staphylococci isolated from bovine intramammary infections. Vet. Microbiol. 34: 373– 380.
226. Tomlin, J.,, M. J. Pead,, D. H. Lloyd,, S. Howell,, F. Hartmann,, H. A. Jackson,, and P. Muir. 1999. Methicillinresistant Staphylococcus aureus infections in 11 dogs. Vet. Rec. 144: 60– 64.
227. Trostle, S. S.,, C. L. Peavey,, D. S. King,, and F. A. Hartmann. 2001. Treatment of methicillin-resistant Staphylococcus epidermidis infection following repair of an ulnar fracture and humeroradial joint luxation in a horse. J. Am. Vet. Med. Assoc. 218: 554– 559.
228. Vancraeynest, D.,, K. Hermans,, A. Martel,, M. Vaneechoutte,, L. A. Devriese,, and F. Haesebrouck. 2004. Antimicrobial resistance and resistance genes in Staphylococcus aureus strains from rabbits. Vet. Microbiol. 101: 245– 251.
229. Vandamme, P.,, B. Pot,, E. Falsen,, K. Kersters,, and L. A. Devriese. 1996. Taxonomic study of Lancefield streptococcal groups C, G, and L ( Streptococcus dysgalactiae) and proposal of S. dysgalactiae subsp. equisimilis subsp. nov. Int. J. Syst. Bacteriol. 46: 774– 781.
229a.. van Duijkeren, E.,, A. T. Box,, M. E. Heck,, W. J. Wannet,, and A. C. Fluit. 2004. Methicillin-resistant staphylococci isolated from animals. Vet. Microbiol. 103: 91– 97.
230. Vela, A. I.,, J. Goyache,, C. Tarradas,, I. Luque,, A. Mateos,, M. A. Moreno,, C. Borge,, J. A. Perea,, L. Dominguez,, and J. F. Fernandez-Garayzabal. 2003. Analysis of genetic diversity of Streptococcus suis clinical isolates from pigs in Spain by pulsed-field gel electrophoresis. J. Clin. Microbiol. 41: 2498– 2502.
231. Vela, A. I.,, M. A. Moreno,, J. A. Cebolla,, S. Gonzalez,, M. V. Latre,, L. Dominguez,, and J. F. Fernandez-Garayzabal. 2005. Antimicrobial susceptibility of clinical strains of Streptococcus suis isolated from pigs in Spain. Vet. Microbiol. 105: 143– 147.
232. Vernozy-Rozand, C.,, C. Mazuy,, H. Meugnier,, M. Bes,, Y. Lasne,, F. Fiedler,, J. Etienne,, and J. Freney. 2000. Staphylococcus fleurettii sp. nov., isolated from goat’s milk cheeses. Int. J. Syst. Evol. Microbiol. 50: 1521– 1527.
233. Vesterholm-Nielsen, M.,, M. Ø. Larsen, J. E. Olsen, and F. M. Aarestrup. 1999. Occurrence of the blaZ gene in penicillin resistant Staphylococcus aureus isolated from bovine mastitis in Denmark. Acta Vet. Scand. 40: 279– 286.
234. Vieira, V. V.,, L. M. Teixeira,, V. Zahner,, H. Momen,, R. R. Facklam,, A. G. Steigerwalt,, D. J. Benner,, and A. C. D. Castro. 1998. Genetic relationship among the different phenotypes of Streptococcus dysgalactiae strains. Int. J. Syst. Bacteriol. 48: 1231– 1243.
235. Vilaichone, R. K.,, W. Vilaichone,, P. Nunthapisud,, and H. Wilde. 2002. Streptococcus suis infection in Thailand. J. Med. Assoc. Thail. 85: 109– 117.
236. Vintov, J.,, F. M. Aarestrup,, C. E. Zinn,, and J. E. Olsen. 2003. Association between phage types and antimicrobial resistance among bovine Staphylococcus aureus from 10 countries. Vet. Microbiol. 95: 133– 147.
237. Vintov, J.,, F. M. Aarestrup,, C. E. Zinn,, and J. E. Olsen. 2003. Phage types and antimicrobial resistance among Danish bovine Staphylococcus aureus isolates since the 1950s. Vet. Microbiol. 97: 63– 72.
238. Waage, S.,, J. Bjorland,, D. A. Caugant,, H. Oppegaard,, T. Tollersrud,, T. Mørk,, and F. M. Aarestrup. 2002. Spread of Staphylococcus aureus resistant to penicillin and tetracycline within and between dairy herds. Epidemiol. Infect. 129: 193– 202.
239. Wallmann, J.,, H. Kaspar,, and R. Kroker. 2004. Data on the prevalence of antimicrobial susceptibility of veterinary pathogens from cattle and pigs: national antibiotic resistance monitoring 2002/2003 of the BVL. Berl. Münch. Tierärztl. Wochenschr. 117: 480– 492.
240. Wannet, W.,, M. Heck,, G. Pluister,, E. Spalburg,, M. Van Santen,, X. Huijsdans,, E. Tiemersma,, and A. J. de Neeling. 2004. Panton-Valentine leukocidin positive MRSA in 2003: the Dutch situation. Euro Surveill. 9.
241. Wasteson, Y.,, S. Hoie,, and M. C. Roberts. 1994. Characterization of antibiotic resistance in Streptococcus suis. Vet. Microbiol. 41: 41– 49.
242. Watts, J. L.,, and W. E. Owens. 1989. Prevalence of staphylococcal species in four dairy herds. Res. Vet. Sci. 46: 1– 4.
243. Weese, J. S.,, M. Archambault,, B. M. Willey,, H. Dick,, P. Hearn,, B. N. Kreiswirth,, B. Said-Salim,, A. McGeer,, Y. Likhoshvay,, J. F. Prescott,, and D. E. Low. 2005. Methicillin-resistant Staphylococcus aureus in horses and horse personnel, 2000-2002. Emerg. Infect. Dis. 11: 430– 435.
244. Werckenthin, C.,, M. Cardoso,, J.-L. Martel,, and S. Schwarz. 2001. Antimicrobial resistance in staphylococci from animals with particular reference to bovine Staphylococcus aureus, porcine Staphylococcus hyicus, and canine Staphylococcus intermedius. Vet. Res. 32: 341– 362.
245. Werckenthin, C.,, S. Schwarz,, and K. G. H. Dyke. 1996. Macrolide-lincosamide-streptogramin B resistance in Staphylococcus lentus results from the integration of part of a transposon into a small plasmid. Antimicrob. Agents Chemother. 40: 2224– 2225.
246. Werckenthin, C.,, S. Schwarz,, and M. C. Roberts. 1996. Integration of pT181-like tetracycline resistance plasmids into large staphylococcal plasmids involves IS 257. Antimicrob. Agents Chemother. 40: 2542– 2544.
247. Werckenthin, C.,, and S. Schwarz. 2000. Molecular analysis of the translational attenuator of a constitutively expressed erm(A) gene from Staphylococcus intermedius. J. Antimicrob. Chemother. 46: 785– 788.
248. Werckenthin, C.,, S. Schwarz,, and H. Westh. 1999. Structural alterations in the translational attenuator of constitutively expressed ermC genes. Antimicrob. Agents Chemother. 43: 1681– 1685.
249. Westh, H.,, C. S. Zinn,, V. T. Rosdahl, and the SARISA Study Group. 2004. An international multicenter study of antimicrobial consumption and resistance in Staphylococcus aureus isolates from 15 hospitals in 14 countries. Microb. Drug Resist. 10: 169– 176.
250. Williams, A. M.,, and M. D. Collins. 1990. Molecular taxonomic studies on Streptococcus uberis type I and II. Description of Streptococcus parauberis sp. nov. J. Appl. Bacteriol. 68: 485– 490.
251. Wilson, C. D. 1961. The treatment of staphylococcal mastitis. Vet. Rec. 73: 1019– 1024.
252. Wissing, A.,, J. Nicolet,, and P. Boerlin. 2001. The current antimicrobial resistance situation in Swiss veterinary medicine. Schweiz. Arch. Tierheilkd. 143: 503– 510.
253. Witte, W. 2004. Glycopeptide resistant Staphylococcus. J. Vet. Med. B 51: 370– 373.
254. Witte, W.,, C. Braulke,, C. Cuny,, B. Strommenger,, G. Werner,, D. Heuck,, U. Jappe,, C. Wendt,, H. J. Linde,, and D. Harmsen. 2005. Emergence of methicillin-resistant Staphylococcus aureus with Panton-Valentine leukocidin genes in central Europe. Eur. J. Clin. Microbiol. Infect. Dis. 24: 1– 5.
255. Yamane, A.,, H. Nakano,, Y. Asahi,, K. Ubukata,, and M. Konno. 1996. Directly repeated insertion of 9-nucleotide sequence detected in penicillin-binding protein 2B gene of penicillin-resistant Streptococcus pneumoniae. Antimicrob. Agents Chemother. 40: 1257– 1259.
256. Yasuda, R.,, J. Kawano,, H. Onda,, M. Takagi,, A. Shimizu,, and T. Anzai. 2000. Methicillin-resistant coagulase-negative staphylococci isolated from healthy horses in Japan. Am. J. Vet. Res. 61: 1451– 1455.
257. Yasuda, R.,, J. Kawano,, E. Matsuo,, T. Masuda,, A. Shimizu,, T. Anzai,, and S. Hashikura. 2002</