Chapter 17 : Antimicrobial Resistance in Nontyphoidal Salmonellae

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Epidemiologic data of a study of a multistate outbreak of food-borne salmonellosis due to resistant serovar Newport carrying a common ampicillin and tetracycline resistance plasmid, strongly associated hamburger meat originating from a single farm in South Dakota. Similarly, an outbreak study reported by a group used antimicrobial resistance and plasmid profiling to trace chloramphenicol-resistant serovar Newport from the incriminated hamburger meat back through the abattoir and to the dairy farm from which the meat was derived. As with many bacterial pathogens, antimicrobial resistance in nontyphoidal spp. is an international problem. Resistance associated with integrons has been studied extensively and is common in many multiple-drug resistance (MDR) serovars. An outbreak of quinolone-resistant DT104 in Denmark, originating in swine, resulted in 11 hospitalizations and the death of 2 patients due to therapeutic failure. The majority of AmpC β-lactamases belong to the CMY gene family, whose sequence similarity suggests an origin in . Food is an important vehicle for the national and international transmission of antimicrobial-resistant bacteria and antimicrobial resistance genes from food animals to humans. As food is distributed worldwide, attempts to control the spread of antimicrobial resistance must be approached internationally, in order to reduce or eliminate contamination by antimicrobial-resistant at the primary production site.

Citation: McDermott P. 2006. Antimicrobial Resistance in Nontyphoidal Salmonellae, p 293-314. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch17
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Figure 1.

Proportion of serovar Typhimurium isolates displaying DT104-like antimicrobial resistance in the United States. Adapted from references 45 and 95.

Citation: McDermott P. 2006. Antimicrobial Resistance in Nontyphoidal Salmonellae, p 293-314. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch17
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Image of Figure 2.
Figure 2.

Changes in phage types of multidrug-resistant serovar Typhimurium in England and Wales. Reprinted from reference 17a with permission from E. J. Threlfall.

Citation: McDermott P. 2006. Antimicrobial Resistance in Nontyphoidal Salmonellae, p 293-314. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch17
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1. Aarestrup, F. M.,, H. Hasman,, I. Olsen,, and G. Sorensen. 2004. International spread of bla CMY-2-mediated cephalosporin resistance in a multiresistant Salmonella enterica serovar Heidelberg isolate stemming from the importation of a boar by Denmark from Canada. Antimicrob. Agents Chemother. 48: 1916 1917.
2. Aarestrup, F. M.,, M. Lertworapreecha,, M. C. Evans,, A. Bangtrakulnonth,, T. Chalermchaikit,, R. S. Hendriksen,, and H. C. Wegener. 2003. Antimicrobial susceptibility and occurrence of resistance genes among Salmonella enterica serovar Weltevreden from different countries. J. Antimicrob. Chemother. 52: 715 718.
3. Aarestrup, F. M.,, C. Wiuff,, K. Molbak,, and E. J. Threlfall. 2003. Is it time to change fluoroquinolone breakpoints for Salmonella spp.? Antimicrob. Agents Chemother. 47: 827 829.
4. Adak, G. K.,, S. M. Long,, and S. J. O’Brien. 2002. Trends in indigenous foodborne disease and deaths, England and Wales: 1992 to 2000. Gut 51: 832 841.
5. Agarwal, K. C.,, R. K. Garg,, B. R. Panhotra,, A. D. Verma,, A. Ayyagari,, and J. Mahanta. 1980. Drug resistance in Salmonellae isolated at Chandigarh (India) during 1972-1978. Antonie Leeuwenhoek 46: 383 390.
6. Ait Melloul, A.,, L. Hassani,, and L. Rafouk. 2001. Salmonella contamination of vegetables irrigated with untreated wastewater. World J. Microbiol. Biotechnol. 17: 207 209.
7. Alekshun, M. N.,, and S. B. Levy. 1999. The mar regulon: multiple resistance to antibiotics and other toxic chemicals. Trends Microbiol. 7: 410 413.
8. Allen, K. J.,, and C. Poppe. 2002. Occurrence and characterization of resistance to extended-spectrum cephalosporins mediated by β-lactamase CMY-2 in Salmonella isolated from food-producing animals in Canada. Can. J. Vet. Res. 66: 137 144.
9. Allen, K. J.,, and C. Poppe. 2002. Phenotypic and genotypic characterization of food animal isolates of Salmonella with reduced sensitivity to ciprofloxacin. Microb. Drug Resist. 8: 375 383.
10. Alvseike, O.,, T. Leegaard,, P. Aavitsland,, and J. Lassen. 2002. Trend of multiple drug resistant Salmonella Typhimurium in Norway. Eur. Surveill. 7: 5 7.
11. Anderson, E. S.,, and M. J. Lewis. 1965. Drug resistance and its transfer in Salmonella typhimurium. Nature 206: 579 583.
12. Angulo, F. J.,, K. R. Johnson,, R. V. Tauxe,, and M. L. Cohen. 2000. Origins and consequences of antimicrobial-resistant nontyphoidal Salmonella: implications for the use of fluoroquinolones in food animals. Microb. Drug Resist. 6: 77 83.
13. Angulo, F. J.,, V. N. Nargund,, and T. C. Chiller. 2004. Evidence of an association between use of anti-microbial agents in food animals and anti-microbial resistance among bacteria isolated from humans and the human health consequences of such resistance. J. Vet. Med. B 51: 374 379.
14.Reference deleted.
15.Anonymous. 2000. Salmonella infections, p. 501506. In L. K. Pickering (ed.), Red Book: Report of the Committee on Infectious Diseases. American Academy of Pediatrics, Committee on Infectious Diseases, Elk Grove Village, Ill.
16.Anonymous. 2002. Outbreak of multidrug-resistant Salmonella Newport—United States, January-April 2002. JAMA 288: 951 953.
17.Anonymous. 2003. Salmonellosis in Japan as of June 2003. Infect. Agents Surveill. Rep. 24: 179 180.
17a.. Anonymous. 2003. Annual Report 2002. Division of Gastrointestinal Infections, Central Public Health Laboratory, Health Protection Agency, London, United Kingdom. [Online.] http://www.hpa.org.uk/srmd/div_dgi/dgi_annual_re port_02.pdf.
18.Anonymous. 2004. Annual Report on Zoonoses in Denmark 2003. Ministry of Agriculture, Food and Fisheries, Copenhagen, Denmark.
19. Antunes, P.,, J. Machado,, J. C. Sousa,, and L. Peixe. 2004. Dissemination amongst humans and food products of animal origin of a Salmonella typhimurium clone expressing an integron-borne OXA-30 β-lactamase. J. Antimicrob. Chemother. 54: 429 434.
20. Arcangioli, M. A.,, S. Leroy-Setrin,, J. L. Martel,, and E. Chaslus- Dancla. 1999. A new chloramphenicol and florfenicol resistance gene flanked by two integron structures in Salmonella typhimurium DT104. FEMS Microbiol. Lett. 174: 327 332.
21. Armand-Lefevre, L.,, V. Leflon-Guibout,, J. Bredin,, F. Barguellil,, A. Amor,, J. M. Pages,, and M. H. Nicolas-Chanoine. 2003. Imipenem resistance in Salmonella enterica serovar Wien related to porin loss and CMY-4 β-lactamase production. Antimicrob. Agents Chemother. 47: 1165 1168.
22. Baggesen, D. L.,, and F. M. Aarestrup. 1998. Characterisation of recently emerged multiple antibiotic-resistant Salmonella enterica serovar Typhimurium DT104 and other multiresistant phage types from Danish pig herds. Vet. Rec. 143: 95 97.
23. Baggesen, D. L.,, D. Sandvang,, and F. M. Aarestrup. 2000. Characterization of Salmonella enterica serovar Typhimurium DT104 isolated from Denmark and comparison with isolates from Europe and the United States. J. Clin. Microbiol. 38: 1581 1586.
24. Bangtrakulnonth, A.,, S. Pornreongwong,, C. Pulsrikarn,, P. Sawanpanyalert,, R. S. Hendriksen,, D. M. Lo Fo Wong,, and F. M. Aarestrup. 2004. Salmonella serovars from humans and other sources in Thailand, 1993-2002. Emerg. Infect. Dis. 10: 131 136.
25. Barnass, S.,, M. O’Mahony,, P. N. Sockett,, J. Garner,, J. Franklin,, and S. Tabaqchali. 1989. The tangible cost implications of a hospital outbreak of multiply-resistant Salmonella. Epidemiol. Infect. 103: 227 234.
26. Barza, M. 2002. Potential mechanisms of increased disease in humans from antimicrobial resistance in food animals. Clin. Infect. Dis. 34(Suppl. 3): S123 S125.
27. Ben Hassen, A.,, G. Fournier,, A. Kechrid,, C. Fendri,, S. Ben Redjeb,, and A. Philippon. 1990. Enzymatic resistance to cefotaxime in 56 strains of Klebsiella spp., Escherichia coli and Salmonella spp. at a Tunisian hospital (1984-1988). Pathol. Biol. (Paris) 38: 464 469. (In French.)
28. Bezanson, G. S.,, R. Khakhria,, and E. Bollegraaf. 1983. Nosocomial outbreak caused by antibiotic-resistant strain of Salmonella typhimurium acquired from dairy cattle. Can. Med. Assoc. J. 128: 426 427.
29. Boonmar, S.,, A. Bangtrakulnonth,, S. Pornrunangwong,, N. Marnrim,, K. Kaneko,, and M. Ogawa. 1998. Predominant serovars of Salmonella in humans and foods from Thailand. J. Vet. Med. Sci. 60: 877 880.
30. Boyd, D.,, G. A. Peters,, A. Cloeckaert,, K. S. Boumedine,, E. Chaslus-Dancla,, H. Imberechts,, and M. R. Mulvey. 2001. Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona. J. Bacteriol. 183: 5725 5732.
31. Bradford, P. A. 2001. Extended-spectrum β-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. Clin. Microbiol. Rev. 14: 933 951.
32. Breuil, J.,, A. Brisabois,, I. Casin,, L. Armand-Lefevre,, S. Fremy,, and E. Collatz. 2000. Antibiotic resistance in salmonellae isolated from humans and animals in France: comparative data from 1994 and 1997. J. Antimicrob. Chemother. 46: 965 971.
33. Briggs, C. E.,, and P. M. Fratamico. 1999. Molecular characterization of an antibiotic resistance gene cluster of Salmonella typhimurium DT104. Antimicrob. Agents Chemother. 43: 846 849.
34. Brisabois, A.,, I. Cazin,, J. Breuil,, and E. Collatz. 1997. Surveillance of antibiotic resistance in Salmonella. Eur. Surveill. 2: 19 20.
35. Buchwald, D. S.,, and M. J. Blaser. 1984. A review of human salmonellosis: II. Duration of excretion following infection with nontyphi Salmonella. Rev. Infect. Dis. 6: 345 356.
36. Burkhardt, J. E.,, J. N. Walterspiel,, and U. B. Schaad. 1997. Quinolone arthropathy in animals versus children. Clin. Infect. Dis. 25: 1196 1204.
37. Burt, C. R.,, J. C. Proudfoot,, M. Roberts,, and R. H. Horowitz. 1990. Fatal myocarditis secondary to Salmonella septicemia in a young adult. J. Emerg. Med. 8: 295 297.
38. Bush, K.,, G. A. Jacoby,, and A. A. Medeiros. 1995. A functional classification scheme for β-lactamases and its correlation with molecular structure. Antimicrob. Agents Chemother. 39: 1211 1233.
39. Carattoli, A.,, L. Villa,, C. Pezzella,, E. Bordi,, and P. Visca. 2001. Expanding drug resistance through integron acquisition by IncFI plasmids of Salmonella enterica Typhimurium. Emerg. Infect. Dis. 7: 444 447.
40. Cardinale, E.,, P. Colbachini,, J. D. Perrier-Gros-Claude,, A. Gassama,, and A. Aidara-Kane. 2001. Dual emergence in food and humans of a novel multiresistant serotype of Salmonella in Senegal: Salmonella enterica subsp. enterica serotype 35:c:1,2. J. Clin. Microbiol. 39: 2373 2374.
41. Carter, P. J.,, L. L. English,, B. Cook,, T. Proescholdt,, and D. G. White. 2002. Prevalence and antimicrobial susceptibility profiles of Salmonella and Campylobacter isolated from retail meats, abstr. P-84. Abstr. 102nd Gen. Meet. Am. Soc. Microbiol. American Society for Microbiology, Washington, D.C.
42. Casin, I.,, J. Breuil,, A. Brisabois,, F. Moury,, F. Grimont,, and E. Collatz. 1999. Multidrug-resistant human and animal Salmonella typhimurium isolates in France belong predominantly to a DT104 clone with the chromosome- and integron-encoded β-lactamase PSE-1. J. Infect. Dis. 179: 1173 1182.
43. Casin, I.,, J. Breuil,, J. P. Darchis,, C. Guelpa,, and E. Collatz. 2003. Fluoroquinolone resistance linked to GyrA, GyrB, and ParC mutations in Salmonella enterica Typhimurium isolates in humans. Emerg. Infect. Dis. 9: 1455 1457.
44. Centers for Disease Control and Prevention. 2001. Salmonella Surveillance: Annual Summary, 2000. Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Ga.
45. Centers for Disease Control and Prevention. 2004. National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS): 2002 Annual Report. Centers for Disease Control and Prevention, U.S.Departmentof Health and Human Services, Atlanta, Ga.
46. Centers for Disease Control and Prevention. 004. Preliminary Food Net data on the incidence of infection with pathogens transmitted commonly through food—selected sites,United States,2003. Morb. Mortal. Wkly. Rep. 53: 338343.
47. Chen, S.,, S. Zhao,, D. G. White,, C. M. Schroeder,, R. Lu,, H. Yang,, P. F. McDermott,, S. Ayers,, and J. Meng. 2004. Characterization of multiple-antimicrobial-resistant Salmonella serovars isolated from retail meats. Appl. Environ. Microbiol. 70: 1 7.
48. Chiappini, E.,, L. Galli,, P. Pecile,, A. Vierucci,, and M. de Martino. 2002. Results of a 5-year prospective surveillance study of antibiotic resistance among Salmonella enterica isolates and ceftriaxone therapy among children hospitalized for acute diarrhea. Clin. Ther. 24: 1585 1594.
49. Chiu, C. H.,, T. Y. Lin,, and J. T. Ou. 1999. Predictors for extraintestinal infection of non-typhoidal Salmonella in patients without AIDS. Int. J. Clin. Pract. 53: 161 164.
50. Chiu, C. H.,, T. Y. Lin,, and J. T. Ou. 1999. Prevalence of the virulence plasmids of nontyphoid Salmonella in the serovars isolated from humans and their association with bacteremia. Microbiol. Immunol. 43: 899 903.
51. Chiu, C. H.,, T. L. Wu,, L. H. Su,, C. Chu,, J. H. Chia,, A. J. Kuo,, M. S. Chien,, and T. Y. Lin. 2002. The emergence in Taiwan of fluoroquinolone resistance in Salmonella enterica serotype Choleraesuis. N. Engl. J. Med. 346: 413 419.
52. Chiu, S.,, C. H. Chiu,, and T. Y. Lin. 2004. Salmonella enterica serotype Choleraesuis infection in a medical center in northern Taiwan. J. Microbiol. Immunol. Infect. 37: 99 102.
53. Choi, M.,, T. T. Yoshikawa,, J. Bridge,, A. Schlaifer,, D. Osterweil,, D. Reid,, and D. C. Norman. 1990. Salmonella outbreak in a nursing home. J. Am. Geriatr. Soc. 38: 531 534.
54. Chu, C.,, C. H. Chiu,, W. Y. Wu,, C. H. Chu,, T. P. Liu,, and J. T. Ou. 2001. Large drug resistance virulence plasmids of clinical isolates of Salmonella enterica serovar Choleraesuis. Antimicrob. Agents Chemother. 45: 2299 2303.
55. CIPARS. 2004. Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS), Annual Report, 2002. [Online.] http://www.phac-aspc.gc.ca/cipars-picra/pdf/cipars-picra-2002_e.pdf.
56. Clinical and Laboratory Standards Institute. 2004. Performance standards for antimicrobial susceptibility testing. CLSI document M100-S14, 14th informational supplement. Clinical and Laboratory Standards Institute, Wayne, Pa.
57. Cohen, S. P.,, L. M. McMurry,, and S. B. Levy. 1988. marA locus causes decreased expression of OmpF porin in multipleantibiotic- resistant (Mar) mutants of Escherichia coli. J. Bacteriol. 170: 5416 5422.
58. Coldham, N. G.,, and M. J. Woodward. 2004. Characterization of the Salmonella typhimurium proteome by semi-automated two dimensional HPLC-mass spectrometry: detection of proteins implicated in multiple antibiotic resistance. J. Proteome Res. 3: 595 603.
59. Crook, P. D.,, J. F. Aguilera,, E. J. Threlfall,, S. J. O’Brien,, G. Sigmundsdottir,, D. Wilson,, I. S. Fisher,, A. Ammon,, H. Briem,, J. M. Cowden,, M. E. Locking,, H. Tschape,, W. van Pelt,, L. R. Ward,, and M. A. Widdowson. 2003. A European outbreak of Salmonella enterica serotype Typhimurium definitive phage type 204b in 2000. Clin. Microbiol. Infect. 9: 839 845.
60. Cruchaga, S.,, A. Echeita,, A. Aladuena,, J. Garcia-Pena,, N. Frias,, and M. A. Usera. 2001. Antimicrobial resistance in salmonellae from humans, food and animals in Spain in 1998. J. Antimicrob. Chemother. 47: 315 321.
61. Daly, M.,, J. Buckley,, E. Power,, and S. Fanning. 2004. Evidence for a chromosomally located third integron in Salmonella enterica serovar Typhimurium DT104b. Antimicrob. Agents Chemother. 48: 1350 1352.
62. Daly, M.,, J. Buckley,, E. Power,, C. O’Hare,, M. Cormican,, B. Cryan,, P. G. Wall,, and S. Fanning. 2000. Molecular characterization of Irish Salmonella enterica serotype Typhimurium: detection of class I integrons and assessment of genetic relationships by DNA amplification fingerprinting. Appl. Environ. Microbiol. 66: 614 619.
63. Daly, M.,, and S. Fanning,. 2004. Integron analysis and genetic mapping of antimicrobial resistance genes in Salmonella enterica serotype Typhimurium. p. 15 32. In J. F. T. Spencer, and A. L. Ragout de Spencer (ed.), Public Health Microbiology: Methods and Protocols. Humana Press, Inc., Totowa, N.J.
64. DANMAP. 2004. DANMAP 2003—Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark. [Online.] http://www.dfvf.dk/Files/Filer/Zoonosecentret/Publikationer/ Danmap/Danmap_2003.pdf.
65. Darwin, K. H.,, and V. L. Miller. 1999. Molecular basis of the interaction of Salmonella with the intestinal mucosa. Clin. Microbiol. Rev. 12: 405 428.
66. Das, S.,, S. Gupta,, and Mukesh. 2002. Serotypic and antibiotic susceptibility pattern of Salmonella species isolated from cases of gastroenteritis at Infectious Diseases Hospital (IDH), Delhi from 1997-2000. J. Commun. Dis. 34: 237 244.
67. Davis, M. A.,, D. D. Hancock,, and T. E. Besser. 2002. Multiresistant clones of Salmonella enterica: the importance of dissemination. J. Lab. Clin. Med. 140: 135 141.
68. Davis, M. A.,, D. D. Hancock,, T. E. Besser,, D. H. Rice,, J. M. Gay,, C. Gay,, L. Gearhart,, and R. Digiacomo. 1999. Changes in antimicrobial resistance among Salmonella enterica serovar Typhimurium isolates from humans and cattle in the Northwestern United States, 1982-1997. Emerg. Infect. Dis. 5: 802 806.
69. Demczuk, W.,, R. Ahmed,, D. Woodward,, C. Clark,, and F. Rodgers. 2000. Laboratory Surveillance for Enteric Pathogens in Canada, 2000 Annual Summary. The Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada.
70. Department for Environment, Food and Rural Affairs. 2004. Salmonella in Livestock Production in Great Britain in 2003,p. 17. Veterinary Laboratories Agency, Addlestone, Surrey, United Kingdom.
71. Di Conza, J.,, J. A. Ayala,, P. Power,, M. Mollerach,, and G. Gutkind. 2002. Novel class 1 integron (InS21) carrying bla CTX-M-2 in Salmonella enterica serovar Infantis. Antimicrob. Agents Chemother. 46: 2257 2261.
72. Dolman, C. E.,, and R. J. Wolfe. 2003. Suppressing the Diseases of Animals and Man: Theobald Smith, Microbiologist. Harvard University Press, Boston, Mass.
73. Doublet, B.,, P. Butaye,, H. Imberechts,, D. Boyd,, M. R. Mulvey,, E. Chaslus-Dancla,, and A. Cloeckaert. 2004. Salmonella genomic island 1 multidrug resistance gene clusters in Salmonella enterica serovar Agona isolated in Belgium in 1992 to 2002. Antimicrob. Agents Chemother. 48: 2510 2517.
74. Doublet, B.,, R. Lailler,, D. Meunier,, A. Brisabois,, D. Boyd,, M. R. Mulvey,, E. Chaslus-Dancla,, and A. Cloeckaert. 2003. Variant Salmonella genomic island 1 antibiotic resistance gene cluster in Salmonella enterica serovar Albany. Emerg. Infect. Dis. 9: 585 591.
75. Doublet, B.,, F. X. Weill,, L. Fabre,, E. Chaslus-Dancla,, and A. Cloeckaert. 2004. Variant Salmonella genomic island 1 antibiotic resistance gene cluster containing a novel 3′- N-aminoglycoside acetyltransferase gene cassette, aac(3)- Id, in Salmonella enterica serovar Newport. Antimicrob. Agents Chemother. 48: 3806 3812.
76. Drlica, K.,, and M. Malik. 2003. Fluoroquinolones: action and resistance. Curr. Top. Med. Chem. 3: 249 282.
77. Dunne, E. F.,, P. D. Fey,, P. Kludt,, R. Reporter,, F. Mostashari,, P. Shillam,, J. Wicklund,, C. Miller,, B. Holland,, K. Stamey,, T. J. Barrett,, J. K. Rasheed,, F. C. Tenover,, E. M. Ribot,, and F. J. Angulo. 2000. Emergence of domestically acquired ceftriaxone-resistant Salmonella infections associated with AmpC beta-lactamase. JAMA 284: 3151 3156.
78. Eaves, D. J.,, L. Randall,, D. T. Gray,, A. Buckley,, M. J. Woodward,, A. P. White,, and L. J. Piddock. 2004. Prevalence of mutations within the quinolone resistance-determining region of gyrA, gyrB, parC, and parE and association with antibiotic resistance in quinolone-resistant Salmonella enterica. Antimicrob. Agents Chemother. 48: 4012 4015.
79. Ebel, E.,, and W. Schlosser. 2000. Estimating the annual fraction of eggs contaminated with Salmonella enteritidis in the United States. Int. J. Food Microbiol. 61: 51 62.
80. Ebner, P.,, K. Garner,, and A. Mathew. 2004. Class 1 integrons in various Salmonella enterica serovars isolated from animals and identification of genomic island SGI1 in Salmonella enterica var. Meleagridis. J. Antimicrob. Chemother. 53: 1004 1009.
81. Edelstein, M.,, M. Pimkin,, T. Dmitrachenko,, V. Semenov,, N. Kozlova,, D. Gladin,, A. Baraniak,, and L. Stratchounski. 2004. Multiple outbreaks of nosocomial salmonellosis in Russia and Belarus caused by a single clone of Salmonella enterica serovar Typhimurium producing an extended-spectrum β-lactamase. Antimicrob. Agents Chemother. 48: 2808 2815.
82. Esaki, H.,, A. Morioka,, K. Ishihara,, A. Kojima,, S. Shiroki,, Y. Tamura,, and T. Takahashi. 2004. Antimicrobial susceptibility of Salmonella isolated from cattle, swine and poultry (2001-2002): report from the Japanese Veterinary Antimicrobial Resistance Monitoring Program. J. Antimicrob. Chemother. 53: 266 270.
83. Espié, E.,, and F. X. Weill. 2003. Outbreak of multidrug resistant Salmonella Newport due to the consumption of horsemeat in France. Eur. Surveill. 7: 2.
84. Faldynova, M.,, M. Pravcova,, F. Sisak,, H. Havlickova,, I. Kolackova,, A. Cizek,, R. Karpiskova,, and I. Rychlik. 2003. Evolution of antibiotic resistance in Salmonella enterica serovar Typhimurium strains isolated in the Czech Republic between 1984 and 2002. Antimicrob. Agents Chemother. 47: 2002 2005.
85. Farhoudi-Moghaddam, A. A.,, M. Katouli,, A. Jafari,, M. A. Bahavar,, M. Parsi,, and F. Malekzadeh. 1990. Antimicrobial drug resistance and resistance factor transfer among clinical isolates of salmonellae in Iran. Scand. J. Infect. Dis. 22: 197 203.
86. Fey, P. D.,, T. J. Safranek,, M. E. Rupp,, E. F. Dunne,, E. Ribot,, P. C. Iwen,, P. A. Bradford,, F. J. Angulo,, and S. H. Hinrichs. 2000. Ceftriaxone-resistant salmonella infection acquired by a child from cattle. N. Engl. J. Med. 342: 1242 1249.
87. Fisher, I. 2004. Enter-net Quarterly Salmonella Report: Jul.-Sept. 2004. [Online.] http://www.hpa.org.uk/hpa/inter/ enter-net_reports.htm. Health Protection Agency, London, United Kingdom.
88. Fisher, I. S. 2004. International trends in salmonella serotypes 1998-2003—a surveillance report from the Enter-net international surveillance network. Eur. Surveill. 9: 9 10.
89. Franklin, A.,, J. Acar,, F. Anthony,, R. Gupta,, T. Nicholls,, Y. Tamura,, S. Thompson,, E. J. Threlfall,, D. Vose,, M. van Vuuren,, D. G. White,, H. C. Wegener,, and M. L. Costarrica. 2001. Antimicrobial resistance: harmonisation of national antimicrobial resistance monitoring and surveillance programmes in animals and in animal-derived food. Rev. Sci. Tech. 20: 859 870.
90. Galanis, E.,, F. L., D. M. Wong, M. Patrick, and H. C. Wegener. 2004. Characterizing the worldwide distribution of Salmonella serotypes: the role of WHO Global Salm-Surv, abstr. 78, p. 177. Abstr. Int. Conf. Emerg. Infect. Dis., Atlanta, Ga.
91. Gassama-Sow, A.,, A. Aidara-Kane,, N. Raked,, F. Denis,, and M. C. Ploy. 2004. Integrons in Salmonella Keurmassar, Senegal. Emerg. Infect. Dis. 10: 1339 1341.
92. Gebreyes, W. A.,, P. R. Davies,, P. K. Turkson,, W. E. Morrow,, J. A. Funk,, C. Altier,, and S. Thakur. 2004. Characterization of antimicrobial-resistant phenotypes and genotypes among Salmonella enterica recovered from pigs on farms, from transport trucks, and from pigs after slaughter. J. Food Prot. 67: 698 705.
93. Gensberg, K.,, Y. F. Jin,, and L. J. Piddock. 1995. A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimurium. FEMS Microbiol. Lett. 132: 57 60.
94. Giraud, E.,, A. Cloeckaert,, D. Kerboeuf,, and E. Chaslus-Dancla. 2000. Evidence for active efflux as the primary mechanism of resistance to ciprofloxacin in Salmonella enterica serovar Typhimurium. Antimicrob. Agents Chemother. 44: 1223 1228.
95. Glynn, M. K.,, C. Bopp,, W. Dewitt,, P. Dabney,, M. Mokhtar,, and F. J. Angulo. 1998. Emergence of multidrug-resistant Salmonella enterica serotype Typhimurium DT104 infections in the United States. N. Engl. J. Med. 338: 1333 1338.
96. Glynn, M. K.,, V. Reddy,, L. Hutwagner,, T. Rabatsky-Ehr,, B. Shiferaw,, D. J. Vugia,, S. Segler,, J. Bender,, T. J. Barrett,, and F. J. Angulo. 2004. Prior antimicrobial agent use increases the risk of sporadic infections with multidrug-resistant Salmonella enterica serotype Typhimurium: a FoodNet case-control study, 1996-1997. Clin. Infect. Dis. 38(Suppl. 3): S227 S236.
97. Gomez, T. M.,, Y. Motarjemi,, S. Miyagawa,, F. K. Kaferstein,, and K. Stohr. 1997. Foodborne salmonellosis. World Health Stat. Q. 50: 81 89.
98. Gorman, R.,, and C. C. Adley. 2004. Characterization of Salmonella enterica serotype Typhimurium isolates from human, food, and animal sources in the Republic of Ireland. J. Clin. Microbiol. 42: 2314 2316.
99. Grant, R. B.,, and L. Di Mambro. 1977. Antimicrobial resistance and resistance plasmids in Salmonella from Ontario, Canada. Can. J. Microbiol. 23: 1266 1273.
100. Guerra, B.,, S. Soto,, S. Cal,, and M. C. Mendoza. 2000. Antimicrobial resistance and spread of class 1 integrons among Salmonella serotypes. Antimicrob. Agents Chemother. 44: 2166 2169.
101. Guerra, B.,, S. Soto,, R. Helmuth,, and M. C. Mendoza. 2002. Characterization of a self-transferable plasmid from Salmonella enterica serotype Typhimurium clinical isolates carrying two integron-borne gene cassettes together with virulence and drug resistance genes. Antimicrob. Agents Chemother. 46: 2977 2981.
102. Guerra, B.,, S. M. Soto,, J. M. Argüelles,, and M. C. Mendoza. 2001. Multidrug resistance is mediated by large plasmids carrying a class 1 integron in the emergent Salmonella enterica serotype [4,5,12:i:-]. Antimicrob. Agents Chemother. 45: 1305 1308.
103. Gupta, A.,, J. Fontana,, C. Crowe,, B. Bolstorff,, A. Stout,, S. Van Duyne,, M. P. Hoekstra,, J. M. Whichard,, T. J. Barrett,, and F. J. Angulo. 2003. Emergence of multidrugresistant Salmonella enterica serotype Newport infections resistant to expanded-spectrum cephalosporins in the United States. J. Infect. Dis. 188: 1707 1716.
104. Hakanen, A.,, P. Kotilainen,, P. Huovinen,, H. Helenius,, and A. Siitonen. 2001. Reduced fluoroquinolone susceptibility in Salmonella enterica serotypes in travelers returning from Southeast Asia. Emerg. Infect. Dis. 7: 996 1003.
104a.. Hall, R.M. 1997. Mobile gene cassettes and integrons: moving antibiotic resistance genes in gram-negative bacteria. Ciba Found. Symp. 207: 192 202.
105. Hansen, H.,, and P. Heisig. 2003. Topoisomerase IV mutations in quinolone-resistant salmonellae selected in vitro. Microb. Drug Resist. 9: 25 32.
106. Hanson, N. D.,, E. S. Moland,, A. Hossain,, S. A. Neville,, I. B. Gosbell,, and K. S. Thomson. 2002. Unusual Salmonella enterica serotype Typhimurium isolate producing CMY-7, SHV-9 and OXA-30 β-lactamases. J. Antimicrob. Chemother. 49: 1011 1014.
107. Harada, K.,, M. Kameda,, M. Suzuki,, and S. Mitsuhashi. 1963. Drug resistance of enteric bacterial II. Tranduction of transmissible drug-resistance (R) factors with phage epsilon. J. Bacteriol. 86: 1332 1338.
108. Hastings, L.,, A. Burnens,, B. de Jong,, L. Ward,, I. Fisher,, J. Stuart,, C. Bartlett,, and B. Rowe. 1996. Salm-Net facilitates collaborative investigation of an outbreak of Salmonella tosamanga infection in Europe. Commun. Dis. Rep. CDR Rev. 6: R100 R102.
109. Hawkey, P. M. 2003. Mechanisms of quinolone action and microbial response. J. Antimicrob. Chemother. 51 (Suppl. 1): 29 35.
110. Heisig, P. 1993. High-level fluoroquinolone resistance in a Salmonella typhimurium isolate due to alterations in both gyrA and gyrB genes. J. Antimicrob. Chemother. 32: 367 377.
111. Helms, M.,, J. Simonsen,, and K. Molbak. 2004. Quinolone resistance is associated with increased risk of invasive illness or death during infection with Salmonella serotype Typhimurium. J. Infect. Dis. 190: 1652 1654.
112. Helms, M.,, P. Vastrup,, P. Gerner-Smidt,, and K. Molbak. 2002. Excess mortality associated with antimicrobial drug-resistant Salmonella typhimurium. Emerg. Infect. Dis. 8: 490 495.
113. Herikstad, H.,, Y. Motarjemi,, and R. V. Tauxe. 2002. Salmonella surveillance: a global survey of public health serotyping. Epidemiol. Infect. 129: 1 8.
114. Hernandez, T.,, C. Rodriguez-Alvarez,, M. P. Arevalo,, A. Torres,, A. Sierra,, and A. Arias. 2002. Antimicrobial-resistant Salmonella enterica serovars isolated from chickens in Spain. J. Chemother. 14: 346 350.
115. Hohmann, E. L. 2001. Nontyphoidal salmonellosis. Clin. Infect. Dis. 32: 263 269.
116. Holmberg, S. D.,, S. L. Solomon,, and P. A. Blake. 1987. Health and economic impacts of antimicrobial resistance. Rev. Infect. Dis. 9: 1065 1078.
117. Holmberg, S. D.,, J. G. Wells,, and M. L. Cohen. 1984. Animal-to-man transmission of antimicrobial-resistant Salmonella: investigations of U.S. outbreaks, 1971-1983. Science 225: 833 835.
118. Hornish, R. E.,, and S. F. Kotarski. 2002. Cephalosporins in veterinary medicine—ceftiofur use in food animals. Curr. Top. Med. Chem. 2: 717 731.
119. Howard, A. J.,, T. D. Joseph,, L. L. Bloodworth,, J. A. Frost,, H. Chart,, and B. Rowe. 1990. The emergence of ciprofloxacin resistance in Salmonella typhimurium. J. Antimicrob. Chemother. 26: 296 298.
120. Hsueh, P. R.,, L. J. Teng,, S. P. Tseng,, C. F. Chang,, J. H. Wan,, J. J. Yan,, C. M. Lee,, Y. C. Chuang,, W. K. Huang,, D. Yang,, J. M. Shyr,, K. W. Yu,, L. S. Wang,, J. J. Lu,, W. C. Ko,, J. J. Wu,, F. Y. Chang,, Y. C. Yang,, Y. J. Lau,, Y. C. Liu,, C. Y. Liu,, S. W. Ho,, and K. T. Luh. 2004. Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan. Emerg. Infect. Dis. 10: 60 68.
121. Hudson, C. R.,, C. Quist,, M. D. Lee,, K. Keyes,, S. V. Dodson,, C. Morales,, S. Sanchez,, D. G. White,, and J. J. Maurer. 2000. Genetic relatedness of Salmonella isolates from nondomestic birds in Southeastern United States. J. Clin. Microbiol. 38: 1860 1865.
122. Hutchison, M. L.,, L. D. Walters,, S. M. Avery,, B. A. Synge,, and A. Moore. 2004. Levels of zoonotic agents in British livestock manures. Lett. Appl. Microbiol. 39: 207 214.
123. Irwin, R. J.,, C. Poppe,, S. Messier,, G. G. Finley,, and J. Oggel. 1994. A national survey to estimate the prevalence of Salmonella species among Canadian registered commercial turkey flocks. Can. J. Vet. Res. 58: 263 267.
124. Izumiya, H.,, N. Nojiri,, Y. Hashiwata,, K. Tamura,, J. Terajima,, and H. Watanabe. 2003. Salmonella enterica serovar Enteritidis, Japan. Emerg. Infect. Dis. 9: 1650 1651.
125. Jorgensen, F.,, R. Bailey,, S. Williams,, P. Henderson,, D. R. Wareing,, F. J. Bolton,, J. A. Frost,, L. Ward,, and T. J. Humphrey. 2002. Prevalence and numbers of Salmonella and Campylobacter spp. on raw, whole chickens in relation to sampling methods. Int. J. Food Microbiol. 76: 151 164.
126. Kam, K. M. 1996. Serotype epidemiology and patterns of antibiotic susceptibilities of salmonellae isolated in Hong Kong 1983-93. Chin. Med. J. (Engl. Ed.) 109: 276 281.
127. Kariuki, S.,, G. Revathi,, N. Kariuki,, J. Muyodi,, J. Mwituria,, A. Munyalo,, D. Kagendo,, L. Murungi,, and C. A. Hart. 2005. Increasing prevalence of multidrug-resistant non-typhoidal salmonellae, Kenya, 1994-2003. Int. J. Antimicrob. Agents 25: 38 43.
128. Kaszanyitzky, E. J.,, A. Tarpai,, S. Janosi,, M. Papp,, J. Skare,, and G. Semjen. 2002. Development of an antibiotic resistance monitoring system in Hungary. Acta Vet. Hung. 50: 189 197.
129. Kennedy, M.,, R. Villar,, D. J. Vugia,, T. Rabatsky-Ehr,, M. M. Farley,, M. Pass,, K. Smith,, P. Smith,, P. R. Cieslak,, B. Imhoff,, and P. M. Griffin. 2004. Hospitalizations and deaths due to Salmonella infections, FoodNet, 1996-1999. Clin. Infect. Dis. 38(Suppl. 3): S142 S148.
130. Kiessling, C. R.,, J. H. Cutting,, M. Loftis,, W. M. Kiessling,, A. R. Datta,, and J. N. Sofos. 2002. Antimicrobial resistance of food-related Salmonella isolates, 1999-2000. J. Food Prot. 65: 603 608.
131. Killalea, D.,, L. R. Ward,, D. Roberts,, J. de Louvois,, F. Sufi,, J. M. Stuart,, P. G. Wall,, M. Susman,, M. Schwieger,, P. J. Sanderson,, I. S. Fisher,, P. S. Mead,, O. N. Gill,, C. L. Bartlett,, and B. Rowe. 1996. International epidemiological and microbiological study of outbreak of Salmonella agona infection from a ready to eat savoury snack—I: England and Wales and the United States. Br. Med. J. 313: 1105 1107.
132. Kim, J. Y.,, Y. J. Park,, S. O. Lee,, W. Song,, S. H. Jeong,, Y. A. Yoo,, and K. Y. Lee. 2004. Case report: bacteremia due to Salmonella enterica serotype Montevideo producing plasmid-mediated AmpC beta-lactamase (DHA-1). Ann. Clin. Lab Sci. 34: 214 217.
133. Koutsolioutsou, A.,, E. A. Martins,, D. G. White,, S. B. Levy,, and B. Demple. 2001. A soxRS-constitutive mutation contributing to antibiotic resistance in a clinical isolate of Salmonella enterica (serovar Typhimurium). Antimicrob. Agents Chemother. 45: 38 43.
134. Kruger, T.,, D. Szabo,, K. H. Keddy,, K. Deeley,, J. W. Marsh,, A. M. Hujer,, R. A. Bonomo,, and D. L. Paterson. 2004. Infections with nontyphoidal Salmonella species producing TEM- 63 or a novel TEM enzyme, TEM-131, in South Africa. Antimicrob. Agents Chemother. 48: 4263 4270.
135. Layton, M. C.,, S. G. Calliste,, T. M. Gomez,, C. Patton,, and S. Brooks. 1997. A mixed foodborne outbreak with Salmonella heidelberg and Campylobacter jejuni in a nursing home. Infect. Control Hosp. Epidemiol. 18: 115 121.
136. Lee, K.,, D. Yong,, J. H. Yum,, H. H. Kim,, and Y. Chong. 2003. Diversity of TEM-52 extended-spectrum beta-lactamaseproducing non-typhoidal Salmonella isolates in Korea. J. Antimicrob. Chemother. 52: 493 496.
137. Lee, L. A.,, N. D. Puhr,, E. K. Maloney,, N. H. Bean,, and R. V. Tauxe. 1994. Increase in antimicrobial-resistant Salmonella infections in the United States, 1989-1990. J. Infect. Dis. 170: 128 134.
138. Liebana, E.,, M. Batchelor,, F. A. Clifton-Hadley,, R. H. Davies,, K. L. Hopkins,, and E. J. Threlfall. 2004. First report of Salmonella isolates with the DHA-1 AmpC β-lactamase in the United Kingdom. Antimicrob. Agents Chemother. 48: 4492.
139. Liebana, E.,, M. Batchelor,, C. Torres,, L. Brinas,, L. A. Lagos,, B. Abdalhamid,, N. D. Hanson,, and J. Martinez-Urtaza. 2004. Pediatric infection due to multiresistant Salmonella enterica serotype Infantis in Honduras. J. Clin. Microbiol. 42: 4885 4888.
140. Liebana, E.,, M. Gibbs,, C. Clouting,, L. Barker,, F. A. Clifton- Hadley,, E. Pleydell,, B. Abdalhamid,, N. D. Hanson,, L. Martin,, C. Poppe,, and R. H. Davies. 2004. Characterization of β-lactamases responsible for resistance to extended-spectrum cephalosporins in Escherichia coli and Salmonella enterica strains from food-producing animals in the United Kingdom. Microb. Drug Resist. 10: 1 9.
141. Ling, J. M.,, E. W. Chan,, A. W. Lam,, and A. F. Cheng. 2003. Mutations in topoisomerase genes of fluoroquinolone-resistant salmonellae in Hong Kong. Antimicrob. Agents Chemother. 47: 3567 3573.
142. Lyons, R. W.,, C. L. Samples,, H. N. DeSilva,, K. A. Ross,, E. M. Julian,, and P. J. Checko. 1980. An epidemic of resistant Salmonella in a nursery. Animal-to-human spread. JAMA 243: 546 547.
143. Makanera, A.,, G. Arlet,, V. Gautier,, and M. Manai. 2003. Molecular epidemiology and characterization of plasmid-encoded β-lactamases produced by Tunisian clinical isolates of Salmonella enterica serotype Mbandaka resistant to broad-spectrum cephalosporins. J. Clin. Microbiol. 41: 2940 2945.
144. Mammina, C.,, L. Cannova,, S. Massa,, E. Goffredo,, and A. Nastasi. 2002. Drug resistances in salmonella isolates from animal foods, Italy 1998-2000. Epidemiol. Infect. 129: 155 161.
145. Marimon, J. M.,, M. Gomariz,, C. Zigorraga,, G. Cilla,, and E. Perez-Trallero. 2004. Increasing prevalence of quinolone resistance in human nontyphoid Salmonella enterica isolates obtained in Spain from 1981 to 2003. Antimicrob. Agents Chemother. 48: 3789 3793.
146. Martin, L. J.,, M. Fyfe,, K. Dore,, J. A. Buxton,, F. Pollari,, B. Henry,, D. Middleton,, R. Ahmed,, F. Jamieson,, B. Ciebin,, S. A. McEwen,, and J. B. Wilson. 2004. Increased burden of illness associated with antimicrobial-resistant Salmonella enterica serotype Typhimurium infections. J. Infect. Dis. 189: 377 384.
147. Maxwell, A.,, and S. E. Critchlow,. 1998. Mode of action, p. 119 166. In J. Kuhlman,, A. Dalhoff,, and H. J. Zeiler (ed.), Quinolone Antibacterials. Springer-Verlag, Berlin, Germany.
148. Mayrhofer, S.,, P. Paulsen,, F. J. Smulders,, and F. Hilbert. 2004. Antimicrobial resistance profile of five major foodborne pathogens isolated from beef, pork and poultry. Int. J. Food Microbiol. 97: 23 29.
149. McDermott, P. F.,, S. Zhao,, D. D. Wagner,, S. Simjee,, R. D. Walker,, and D. G. White. 2002. The food safety perspective of antibiotic resistance. Anim. Biotechnol. 13: 71 84.
150. Mead, P. S.,, L. Slutsker,, V. Dietz,, L. F. McCaig,, J. S. Bresee,, C. Shapiro,, P. M. Griffin,, and R. V. Tauxe. 1999. Foodrelated illness and death in the United States. Emerg. Infect. Dis. 5: 607 625.
151. Mendoza-Medellin, A.,, E. Curiel-Quesada,, and R. Camacho- Carranza. 2004. Escherichia coli R-factors unstable in Salmonella typhi are deleted before being segregated in this host. Plasmid 51: 75 86.
152. Meunier, D.,, D. Boyd,, M. R. Mulvey,, S. Baucheron,, C. Mammina,, A. Nastasi,, E. Chaslus-Dancla,, and A. Cloeckaert. 2002. Salmonella enterica serotype Typhimurium DT 104 antibiotic resistance genomic island I in serotype paratyphi B. Emerg. Infect. Dis. 8: 430 433.
153. Miriagou, V.,, P. T. Tassios,, N. J. Legakis,, and L. S. Tzouvelekis. 2004. Expanded-spectrum cephalosporin resistance in non-typhoid Salmonella. Int. J. Antimicrob. Agents 23: 547 555.
154. Molbak, K. 2004. Spread of resistant bacteria and resistance genes from animals to humans—the public health consequences. J. Vet. Med. B Infect. Dis. Vet. Public Health 51: 364 369.
155. Molbak, K.,, D. L. Baggesen,, F. M. Aarestrup,, J. M. Ebbesen,, J. Engberg,, K. Frydendahl,, P. Gerner-Smidt,, A. M. Petersen,, and H. C. Wegener. 1999. An outbreak of multidrugresistant, quinolone-resistant Salmonella enterica serotype typhimurium DT104. N. Engl. J. Med. 341: 1420 1425.
156. Moubareck, C.,, F. Doucet-Populaire,, M. Hamze,, Z. Daoud,, and F. X. Weill. 2005. First extended-spectrum-β-lactamase (CTX-M-15)-producing Salmonella enterica serotype Typhimurium isolate identified in Lebanon. Antimicrob. Agents Chemother. 49: 864 865.
157. Mulvey, M. R.,, D. A. Boyd,, L. Baker,, O. Mykytczuk,, E. M. Reis,, M. D. Asensi,, D. P. Rodrigues,, and L. K. Ng. 2004. Characterization of a Salmonella enterica serovar Agona strain harbouring a class 1 integron containing novel OXA-type beta-lactamase ( bla OXA-53) and 6′- N-aminoglycoside acetyltransferase genes [ aac(6′)-I30]. J. Antimicrob. Chemother. 54: 354 359.
158. Nakaya, H.,, A. Yasuhara,, K. Yoshimura,, Y. Oshihoi,, H. Izumiya,, and H. Watanabe. 2003. Life-threatening infantile diarrhea from fluoroquinolone-resistant Salmonella enterica Typhimurium with mutations in both gyrA and parC. Emerg. Infect. Dis. 9: 255 257.
159. Nastasi, A.,, and C. Mammina. 2001. Presence of class I integrons in multidrug-resistant, low-prevalence Salmonella serotypes, Italy. Emerg. Infect. Dis. 7: 455 458.
160. Nastasi, A.,, C. Mammina,, and L. Cannova. 2000. Antimicrobial resistance in Salmonella enteritidis, southern Italy, 1990-1998. Emerg. Infect. Dis. 6: 401 403.
160a.. National Committee for Clinical Laboratory Standards. 2003. Performance Standards for Antimicrobial Susceptibility Testing; Thirteenth Informational Supplement. NCCLS document M100-S13. National Committee for Clinical Laboratory Standards, Wayne, Pa.
160b.. National Veterinary Institute. 2001. SVARM 2000: Swedish Veterinary Antimicrobial Resistance Monitoring. National Veterinary Institute, Uppsala, Sweden.
161. Nel, H.,, M. van Vuuren,, and G. E. Swan. 2004. Towards the establishment and standardization of a veterinary antimicrobial resistance surveillance and monitoring programme in South Africa. Onderstepoort J. Vet. Res. 71: 239 246.
162. Neu, H. C.,, C. E. Cherubin,, E. D. Longo,, B. Flouton,, and J. Winter. 1975. Antimicrobial resistance and R-factor transfer among isolates of Salmonella in the northeastern United States: a comparison of human and animal isolates. J. Infect. Dis. 132: 617 622.
163. Oethinger, M.,, W. V. Kern,, A. S. Jellen-Ritter,, L. M. McMurry,, and S. B. Levy. 2000. Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump. Antimicrob. Agents Chemother. 44: 10 13.
164. Okusu, H.,, D. Ma,, and H. Nikaido. 1996. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J. Bacteriol. 178: 306 308.
165. Olsen, S. J.,, E. E. DeBess,, T. E. McGivern,, N. Marano,, T. Eby,, S. Mauvais,, V. K. Balan,, G. Zirnstein,, P. R. Cieslak,, and F. J. Angulo. 2001. A nosocomial outbreak of fluoroquinolone-resistant salmonella infection. N. Engl. J. Med. 344: 1572 1579.
166. Orman, B. E.,, S. A. Pineiro,, S. Arduino,, M. Galas,, R. Melano,, M. I. Caffer,, D. O. Sordelli,, and D. Centron. 2002. Evolution of multiresistance in nontyphoid Salmonella serovars from 1984 to 1998 in Argentina. Antimicrob. Agents Chemother. 46: 3963 3970.
167. Orrett, F. A.,, and S. M. Shurland. 2001. Susceptibility patterns and serotypes of non-typhoidal Salmonella in Trinidad. Saudi Med. J. 22: 852 855.
168. Oundo, J. O.,, S. Kariuki,, J. K. Maghenda,, and B. S. Lowe. 2000. Antibiotic susceptibility and genotypes of non-typhi Salmonella isolates from children in Kilifi on the Kenya coast. Trans. R. Soc. Trop. Med. Hyg. 94: 212 215.
169. Pang, T.,, Z. A. Bhutta,, B. B. Finlay,, and M. Altwegg. 1995. Typhoid fever and other salmonellosis: a continuing challenge. Trends Microbiol. 3: 253 255.
170. Panhotra, B. R.,, A. K. Saxena,, and A. M. Al-Ghamdi. 2004. Emerging nalidixic acid and ciprofloxacin resistance in nontyphoidal Salmonella isolated from patients having acute diarrhoeal disease. Ann. Saudi Med. 24: 270 272.
171. Paszti, J.,, V. G. Laszlo,, I. Gado,, H. Milch,, K. Krisztalovics,, M. Kiraly,, J. Orban,, and V. Koppany. 2001. The spread and antibiotic resistance of Salmonella enterica serotype Typhimurium DT104 in Hungary. Acta Microbiol. Immunol. Hung. 48: 95 105.
172. Patrick, M. E.,, P. M. Adcock,, T. M. Gomez,, S. F. Altekruse,, B. H. Holland,, R. V. Tauxe,, and D. L. Swerdlow. 2004. Salmonella Enteritidis infections, United States, 1985-1999. Emerg. Infect. Dis. 10: 1 7.
173. Pavia, A. T.,, L. D. Shipman,, J. G. Wells,, N. D. Puhr,, J. D. Smith,, T. W. McKinley,, and R. V. Tauxe. 1990. Epidemiologic evidence that prior antimicrobial exposure decreases resistance to infection by antimicrobial-sensitive Salmonella. J. Infect. Dis. 161: 255 260.
174. Pegues, D. A.,, M. E. Ohl,, and S. I. Miller,. 2002. Salmonella, including Salmonella typhi, p. 669 697. In M. J. Blaser,, P. D. Smith,, J. I. Ravdin,, H. B. Greenberg,, and R. L. Guerrant (ed.), Infections of the Gastrointestinal Tract. Lippincott Williams & Wilkins, Philadelphia, Pa.
175. Petersen, A.,, F. M. Aarestrup,, F. J. Angulo,, S. Wong,, K. Stohr,, and H. C. Wegener. 2002. WHO Global Salm-Surv External Quality Assurance System (EQAS): an important step toward improving the quality of Salmonella serotyping and antimicrobial susceptibility testing worldwide. Microb. Drug Resist. 8: 345 353.
176. Piddock, L. J.,, D. G. White,, K. Gensberg,, L. Pumbwe,, and D. J. Griggs. 2000. Evidence for an efflux pump mediating multiple antibiotic resistance in Salmonella enterica serovar Typhimurium. Antimicrob. Agents Chemother. 44: 3118 3121.
177. Poole, K. 2004. Efflux-mediated multiresistance in Gramnegative bacteria. Clin. Microbiol. Infect. 10: 12 26.
178. Popoff, M. Y.,, J. Bockemuhl,, and L. L. Gheesling. 2004. Supplement 2002 (no. 46) to the Kauffmann-White scheme. Res. Microbiol. 155: 568 570.
179. Poppe, C.,, M. Ayroud,, G. Ollis,, M. Chirino-Trejo,, N. Smart,, S. Quessy,, and P. Michel. 2001. Trends in antimicrobial resistance of Salmonella isolated from animals, foods of animal origin, and the environment of animal production in Canada, 1994-1997. Microb. Drug Resist. 7: 197 212.
180. Poppe, C.,, R. J. Irwin,, S. Messier,, G. G. Finley,, and J. Oggel. 1991. The prevalence of Salmonella enteritidis and other Salmonella sp. among Canadian registered commercial chicken broiler flocks. Epidemiol. Infect. 107: 201 211.
181. Poppe, C.,, K. Ziebell,, L. Martin,, and K. Allen. 2002. Diversity in antimicrobial resistance and other characteristics among Salmonella typhimurium DT104 isolates. Microb. Drug Resist. 8: 107 122.
182. Prats, G.,, B. Mirelis,, T. Llovet,, C. Munoz,, E. Miro,, and F. Navarro. 2000. Antibiotic resistance trends in enteropathogenic bacteria isolated in 1985-1987 and 1995-1998 in Barcelona. Antimicrob. Agents Chemother. 44: 1140 1145.
183. Quigley, J. D.,, J. J. Drewry,, L. M. Murray,, and S. J. Ivey. 1997. Body weight gain, feed efficiency, and fecal scores of dairy calves in response to galactosyl-lactose or antibiotics in milk replacers. J. Dairy Sci. 80: 1751 1754.
184. Rabatsky-Ehr, T.,, J. Whichard,, S. Rossiter,, B. Holland,, K. Stamey,, M. L. Headrick,, T. J. Barrett,, and F. J. Angulo. 2004. Multidrug-resistant strains of Salmonella enterica Typhimurium, United States, 1997-1998. Emerg. Infect. Dis. 10: 795 801.
185. Rabsch, W.,, H. Tschape,, and A. J. Baumler. 2001. Nontyphoidal salmonellosis: emerging problems. Microbes Infect. 3: 237 247.
186. Rahman, M.,, H. Islam,, D. Ahmed,, and R. B. Sack. 2001. Emergence of multidrug-resistant Salmonella Gloucester and Salmonella typhimurium in Bangladesh. J. Health Popul. Nutr. 19: 191 198.
187. Randall, L. P.,, S. W. Cooles,, M. K. Osborn,, L. J. Piddock,, and M. J. Woodward. 2004. Antibiotic resistance genes, integrons and multiple antibiotic resistance in thirty-five serotypes of Salmonella enterica isolated from humans and animals in the UK. J. Antimicrob. Chemother. 53: 208 216.
188. Rankin, S. C.,, H. Aceto,, J. Cassidy,, J. Holt,, S. Young,, B. Love,, D. Tewari,, D. S. Munro,, and C. E. Benson. 2002. Molecular characterization of cephalosporin-resistant Salmonella enterica serotype Newport isolates from animals in Pennsylvania. J. Clin. Microbiol. 40: 4679 4684.
189. Rhimi-Mahjoubi, F.,, M. Bernier,, G. Arlet,, Z. B. Jemaa,, P. Jouve,, A. Hammami,, and A. Philippon. 2002. Identification of plasmid-encoded cephalosporinase ACC-1 among various enterobacteria ( Klebsiella pneumoniae, Proteus mirabilis, Salmonella) isolated from a Tunisian hospital (Sfax 997-2000). Pathol. Biol. (Paris) 50: 7 11. (In French.)
190. Ribot, E. M.,, R. K. Wierzba,, F. J. Angulo,, and T. J. Barrett. 2002. Salmonella enterica serotype Typhimurium DT104 isolated from humans, United States, 1985, 1990, and 1995. Emerg. Infect. Dis. 8: 387 391.
191. Rigney, C. P.,, B. P. Salamone,, N. Anandaraman,, B. E. Rose,, R. L. Umholtz,, K. E. Ferris,, D. R. Parham,, and W. James. 2004. Salmonella serotypes in selected classes of food animal carcasses and raw ground products, January 1998 through December 2000. J. Am. Vet. Med. Assoc. 224: 524 530.
192. Rodrigue, D. C.,, R. V. Tauxe,, and B. Rowe. 1990. International increase in Salmonella Enteritidis: a new pandemic? Epidemiol. Infect. 105: 21 27.
193. Rossi, M. S.,, M. Tokumoto,, E. Couto,, A. Di Bella,, M. Alstchuler,, N. Gomez,, F. Dujovney,, L. Galanternik,, M. Woloj,, N. Hardie,, J. Stelling,, M. Schlipak,, and T. O’Brien. 1995. Survey of the levels of antimicrobial resistance in Argentina: WHONET program—1991 to 1994. Int. J. Antimicrob. Agents 6: 103 110.
194. Rowe-Magnus, D. A.,, and D. Mazel. 2001. Integrons: natural tools for bacterial genome evolution. Curr. Opin. Microbiol. 4: 565 569.
195. Ryder, R. W.,, P. A. Blake,, A. C. Murlin,, G. P. Carter,, R. A. Pollard,, M. H. Merson,, S. D. Allen,, and D. J. Brenner. 1980. Increase in antibiotic resistance among isolates of Salmonella in the United States, 1967-1975. J. Infect. Dis. 142: 485 491.
196. Schmieger, H.,, and P. Schicklmaier. 1999. Transduction of multiple drug resistance of Salmonella enterica serovar typhimurium DT104. FEMS Microbiol. Lett. 170: 251 256.
197. Schroeter, A.,, B. Hoog,, and R. Helmuth. 2004. Resistance of Salmonella isolates in Germany. J. Vet. Med. B Infect. Dis. Vet. Public Health 51: 389 392.
198. Snoeyenbos, G. H.,, C. F. Smyser,, and H. Van Roekel. 1969. Salmonella infections of the ovary and peritoneum of chickens. Avian Dis. 13: 668 670.
199. Spika, J. S.,, S. H. Waterman,, G. W. Hoo,, M. E. St. Louis, R. E. Pacer, S. M. James, M. L. Bissett, L. W. Mayer, J. Y. Chiu, B. Hall, et al. 1987. Chloramphenicol-resistant Salmonella newport traced through hamburger to dairy farms. A major persisting source of human salmonellosis in California. N. Engl. J. Med. 316: 565 570.
200. Stephen, J. M.,, M. A. Toleman,, T. R. Walsh,, and R. N. Jones. 2003. Salmonella bloodstream infections: report from the SENTRY Antimicrobial Surveillance Program (1997-2001). Int. J. Antimicrob. Agents 22: 395 405.
201.St. Louis, M. E., D. L. Morse, M. E. Potter, T. M. DeMelfi, J. J. Guzewich, R. V. Tauxe, and P. A. Blake. 1988. The emergence of grade A eggs as a major source of Salmonella Enteritidis infections. New implications for the control of salmonellosis. JAMA 259: 21032107.
202. Summers, A. O. 2002. Generally overlooked fundamentals of bacterial genetics and ecology. Clin. Infect. Dis. 34(Suppl. 3): S85 S92.
203.Reference deleted.
204. Szych, J.,, A. Cieslik,, J. Paciorek,, and S. Kaluzewski. 2001. Antibiotic resistance in Salmonella enterica subsp. enterica strains isolated in Poland from 1998 to 1999. Int. J. Antimicrob. Agents 18: 37 42.
205. Tassios, P. T.,, M. Gazouli,, E. Tzelepi,, H. Milch,, N. Kozlova,, S. Sidorenko,, N. J. Legakis,, and L. S. Tzouvelekis. 1999. Spread of a Salmonella typhimurium clone resistant to expanded-spectrum cephalosporins in three European countries. J. Clin. Microbiol. 37: 3774 3777.
206. Tassios, P. T.,, A. Markogiannakis,, A. C. Vatopoulos,, E. Katsanikou,, E. N. Velonakis,, J. Kourea-Kremastinou,, and N. J. Legakis. 1997. Molecular epidemiology of antibiotic resistance of Salmonella enteritidis during a 7-year period in Greece. J. Clin. Microbiol. 35: 1316 1321.
207. Thomson, K. S.,, and M. E. Smith. 2000. Version 2000: the new β-lactamases of Gram-negative bacteria at the dawn of the new millennium. Microbes. Infect. 2: 1225 1235.
208. Thong, K. L.,, Y. L. Goh,, S. Radu,, S. Noorzaleha,, R. Yasin,, Y. T. Koh,, V. K. Lim,, G. Rusul,, and S. D. Puthucheary. 2002. Genetic diversity of clinical and environmental strains of Salmonella enterica serotype Weltevreden isolated in Malaysia. J. Clin. Microbiol. 40: 2498 2503.
209. Threlfall, E. J. 2000. Epidemic Salmonella typhimurium DT 104—a truly international multiresistant clone. J. Antimicrob. Chemother. 46: 7 10.
210. Threlfall, E. J.,, I. S. Fisher,, C. Berghold,, P. Gerner-Smidt,, H. Tschape,, M. Cormican,, I. Luzzi,, F. Schnieder,, W. Wannet,, J. Machado,, and G. Edwards. 2003. Antimicrobial drug resistance in isolates of Salmonella enterica from cases of salmonellosis in humans in Europe in 2000: results of international multi-centre surveillance. Eur. Surveill. 8: 41 45.
211. Threlfall, E. J.,, J. A. Frost,, L. R. Ward,, and B. Rowe. 1994. Epidemic in cattle and humans of Salmonella typhimurium DT 104 with chromosomally integrated multiple drug resistance. Vet. Rec. 134: 577.
212. Threlfall, E. J.,, M. L. Hall,, and B. Rowe. 1992. Salmonella bacteraemia in England and Wales, 1981-1990. J. Clin. Pathol. 45: 34 36.
213. Threlfall, E. J.,, B. Rowe,, and L. R. Ward. 1993. A comparison of multiple drug resistance in salmonellas from humans and food animals in England and Wales, 1981 and 1990. Epidemiol. Infect. 111: 189 197.
214. Threlfall, E. J.,, L. R. Ward,, J. A. Frost,, and G. A. Willshaw. 2000. The emergence and spread of antibiotic resistance in food-borne bacteria. Int. J. Food Microbiol. 62: 1 5.
215. Threlfall, E. J.,, L. R. Ward,, M. D. Hampton,, A. M. Ridley,, B. Rowe,, D. Roberts,, R. J. Gilbert,, P. Van Someren,, P. G. Wall,, and P. Grimont. 1998. Molecular fingerprinting defines a strain of Salmonella enterica serotype Anatum responsible for an international outbreak associated with formula-dried milk. Epidemiol. Infect. 121: 289 293.
216. Threlfall, E. J.,, L. R. Ward,, J. A. Skinner,, and A. Graham. 2000. Antimicrobial drug resistance in non-typhoidal salmonellas from humans in England and Wales in 1999: decrease in multiple resistance in Salmonella enterica serotypes Typhimurium, Virchow, and Hadar. Microb. Drug Resist. 6: 319 325.
217. Threlfall, E. J.,, L. R. Ward,, J. A. Skinner,, and B. Rowe. 1997. Increase in multiple antibiotic resistance in nontyphoidal salmonellas from humans in England and Wales: a comparison of data for 1994 and 1996. Microb. Drug Resist. 3: 263 266.
218. Tibbetts, R. J.,, T. L. Lin,, and C. C. Wu. 2003. Phenotypic evidence for inducible multiple antimicrobial resistance in Salmonella choleraesuis. FEMS Microbiol. Lett. 218: 333 338.
219. Tjaniadi, P.,, M. Lesmana,, D. Subekti,, N. Machpud,, S. Komalarini,, W. Santoso,, C. H. Simanjuntak,, N. Punjabi,, J. R. Campbell,, W. K. Alexander,, H. J. Beecham III,, A. L. Corwin,, and B. A. Oyofo. 2003. Antimicrobial resistance of bacterial pathogens associated with diarrheal patients in Indonesia. Am. J. Trop. Med. Hyg. 68: 666 670.
220. Tosini, F.,, P. Visca,, I. Luzzi,, A. M. Dionisi,, C. Pezzella,, A. Petrucca,, and A. Carattoli. 1998. Class 1 integron-borne multiple-antibiotic resistance carried by IncFI and IncL/M plasmids in Salmonella enterica serotype Typhimurium. Antimicrob. Agents Chemother. 42: 3053 3058.
221. Tzouvelekis, L. S.,, V. Lukova,, P. T. Tassios,, A. C. Fluit,, R. N. Jones,, and N. J. Legakis. 2003. Resistance to β-lactams among blood isolates of Salmonella spp. in European hospitals: results from the SENTRY Antimicrobial Surveillance Program 1997-98. Clin. Microbiol. Infect. 9: 149 152.
222. Van Looveren, M.,, M. L. Chasseur-Libotte,, C. Godard,, C. Lammens,, M. Wijdooghe,, L. Peeters,, and H. Goossens. 2001. Antimicrobial susceptibility of nontyphoidal Salmonella isolated from humans in Belgium. Acta Clin. Belg. 56: 180 186.
223. Varma, J. K.,, K. Molbak,, T. J. Barrett,, J. L. Beebe,, T. F. Jones,, T. Rabatsky-Ehr,, K. E. Smith,, D. J. Vugia,, H. G. Chang,, and F. J. Angulo. 2005. Antimicrobial-resistant nontyphoidal Salmonella is associated with excess bloodstream infections and hospitalizations. J. Infect. Dis. 191: 554 561.
224. Verdet, C.,, G. Arlet,, G. Barnaud,, P. H. Lagrange,, and A. Philippon. 2000. A novel integron in Salmonella enterica serovar Enteritidis, carrying the blaDHA-1 gene and its regulator gene ampR, originated from Morganella morganii. Antimicrob. Agents Chemother. 44: 222 225.
225. Voetsch, A. C.,, T. J. Van Gilder,, F. J. Angulo,, M. M. Farley,, S. Shallow,, R. Marcus,, P. R. Cieslak,, V. C. Deneen,, and R. V. Tauxe. 2004. FoodNet estimate of the burden of illness caused by nontyphoidal Salmonella infections in the United States. Clin. Infect. Dis. 38(Suppl. 3): S127 S134.
226. Wang, M.,, L. Ran,, Z. Wang,, and Z. Li. 2004. Study on national active monitoring for food borne pathogens and antimicrobial resistance in China 2001. Wei Sheng Yan Jiu 33: 49 54. (In Chinese.)
227. Wegener, H. C.,, T. Hald,, W. D. Lo Fo,, M. Madsen,, H. Korsgaard,, F. Bager,, P. Gerner-Smidt,, and K. Molbak. 2003. Salmonella control programs in Denmark. Emerg. Infect. Dis. 9: 774 780.
228. White, D. G.,, A. Datta,, P. McDermott,, S. Friedman,, S. Qaiyumi,, S. Ayers,, L. English,, S. McDermott,, D. D. Wagner,, and S. Zhao. 2003. Antimicrobial susceptibility and genetic relatedness of Salmonella serovars isolated from animalderived dog treats in the USA. J. Antimicrob. Chemother. 52: 860 863.
229. White, D. G.,, S. Zhao,, R. Sudler,, S. Ayers,, S. Friedman,, S. Chen,, P. F. McDermott,, S. McDermott,, D. D. Wagner,, and J. Meng. 2001. The isolation of antibiotic-resistant salmonella from retail ground meats. N. Engl. J. Med. 345: 1147 1154.
230. Wilmshurst, P.,, and H. Sutcliffe. 1995. Splenic abscess due to Salmonella heidelberg. Clin. Infect. Dis. 21: 1065.
231. Wilson, I. G. 2004. Antimicrobial resistance of Salmonella in raw retail chickens, imported chicken portions, and human clinical specimens. J. Food Prot. 67: 1220 1225.
232. Winokur, P. L.,, A. Brueggemann,, D. L. DeSalvo,, L. Hoffmann,, M. D. Apley,, E. K. Uhlenhopp,, M. A. Pfaller,, and G. V. Doern. 2000. Animal and human multidrug-resistant, cephalosporin-resistant Salmonella isolates expressing a plasmid-mediated CMY-2 AmpC β-lactamase. Antimicrob. Agents Chemother. 44: 2777 2783.
233. Winokur, P. L.,, R. Canton,, J. M. Casellas,, and N. Legakis. 2001. Variations in the prevalence of strains expressing an extended-spectrum β-lactamase phenotype and characterization of isolates from Europe, the Americas, and the Western Pacific region. Clin. Infect. Dis. 32(Suppl. 2): S94 S103.
234. Winokur, P. L.,, D. L. Vonstein,, L. J. Hoffman,, E. K. Uhlenhopp,, and G. V. Doern. 2001. Evidence for transfer of CMY-2 AmpC β-lactamase plasmids between Escherichia coli and Salmonella isolates from food animals and humans. Antimicrob. Agents Chemother. 45: 2716 2722.
235. World Health Organization. 1992. Surveillance Programme for Control of Food borne Infections and Intoxication in Europe. Fifth Report 1985-1989. Robert von Istertag Institute, FAO/WHO Collaborating Centre, Berlin, Germany.
236. World Health Organization. 2001. WHO Global Principles for the Containment of Antimicrobial Resistance in Animals Intended for Food. Report of a WHO Consultation with the Participation of the Food and Agriculture Organization of the United Nations and the Office InternationaldesEpizooties, Geneva, Switzerland5-9June2000. World Health Organization, Geneva, Switzerland.
237. World Health Organization. 2002. Monitoring Antimicrobial Usage in Food Animals for the Protection of Human Health. Report of a WHO Consultation, Oslo, Norway 10-13 September 2001. World Health Organization, Geneva, Switzerland.
238. World Health Organization. 2004. Global Salm Surv(GSS).[Online.]http://www.who.int/salmsurv/en/.000
239. Wybot, I.,, C. Wildemauwe,, C. Godard,, S. Bertrand,, and J. M. Collard. 2004. Antimicrobial drug resistance in nontyphoid human Salmonella in Belgium: trends for the period 2000-2002. Acta Clin. Belg. 59: 152 160.
240. Yang, S. 1998. FoodNet and Enter-net: emerging surveillance programs for foodborne diseases. Emerg. Infect. Dis. 4: 457 458.
241. Yang, Y. J.,, C. C. Liu,, S. M. Wang,, J. J. Wu,, A. H. Huang,, and C. P. Cheng. 1998. High rates of antimicrobial resistance among clinical isolates of nontyphoidal Salmonella in Taiwan. Eur. J. Clin. Microbiol. Infect. Dis. 17: 880 883.
242. Yasin, R. M.,, M. M. Jegathesan,, and C. C. Tiew. 1996. Salmonella serotypes isolated in Malaysia over the ten-year period 1983-1992. Asia Pac. J. Public Health 9: 1 5.