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Chapter 19 : The Clinical Importance of Animal-Related Resistance

Author: Kåre Mølbak1
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Affiliations: 1: Department of Epidemiology, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark
Content Type: Monograph
Publication Year: 2006

Category: Bacterial Pathogenesis

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Abstract:

This chapter reviews the clinical and public health consequences of antimicrobial drug resistance in bacteria transferred from food animals to humans. To address the clinical importance of animal-related antimicrobial drug resistance, one must review how resistant bacteria may be a cause of increased morbidity and mortality. The chapter discusses the significance of increased transmission as a result of the unrelated use of antimicrobial agents to which a pathogen is resistant. It further covers reduced efficacy of treatment and increased virulence from a public health perspective, i.e., by summarizing observational studies that address the clinical and public health consequences of animal-related resistance. The food chain contains an abundance of antimicrobial drug-resistant pathogens, including Salmonella and Campylobacter. There is growing evidence that this has significant public health consequences. Mitigation of antimicrobial resistance in food-borne bacteria such as Salmonella and Campylobacter will likely benefit human health.

Citation: Mølbak K. 2006. The Clinical Importance of Animal-Related Resistance, p 329-337. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch19
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Tables

The Clinical Importance of Animal-Related Resistance
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Citation: Mølbak K. 2006. The Clinical Importance of Animal-Related Resistance, p 329-337. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch19
/content/10.1128/9781555817534.chap19.tab19-1
Table 1.

Mechanisms by which human health may be affected by the emergence of animal-related antimicrobial drug resistance in food-borne bacteria

Generic image for table
Table 1.

Mechanisms by which human health may be affected by the emergence of animal-related antimicrobial drug resistance in food-borne bacteria

Citation: Mølbak K. 2006. The Clinical Importance of Animal-Related Resistance, p 329-337. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch19
/content/10.1128/9781555817534.chap19.tab19-2
Table 2.

Summary of selected epidemiological studies demonstrating that recent antimicrobial use is a risk factor for infection with drug-resistant salmonellae

Generic image for table
Table 2.

Summary of selected epidemiological studies demonstrating that recent antimicrobial use is a risk factor for infection with drug-resistant salmonellae

Citation: Mølbak K. 2006. The Clinical Importance of Animal-Related Resistance, p 329-337. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch19
/content/10.1128/9781555817534.chap19.tab19-3
Table 3.

Survival after infection with Salmonella serovar Typhimurium according to antimicrobial drug resistance

Generic image for table
Table 3.

Survival after infection with Salmonella serovar Typhimurium according to antimicrobial drug resistance

Citation: Mølbak K. 2006. The Clinical Importance of Animal-Related Resistance, p 329-337. In Aarestrup F (ed), Antimicrobial Resistance in Bacteria of Animal Origin. ASM Press, Washington, DC. doi: 10.1128/9781555817534.ch19

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