
Full text loading...
Category: Bacterial Pathogenesis
Tetracycline Resistance Due to Ribosomal Protection Proteins, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555817572/9781555813291_Chap02-1.gif /docserver/preview/fulltext/10.1128/9781555817572/9781555813291_Chap02-2.gifAbstract:
There have been 11 ribosomal protection genes identified which code for cytoplasmic proteins that protect the ribosomes from the action of tetracycline in vitro and in vivo and confer resistance to tetracycline, doxycycline, and minocycline to the host. The ribosomal protection proteins are thought to interact with the base of h34 protein, within the ribosome, causing an allosteric disruption of the primary tetracycline binding site(s). This releases the tetracycline molecules from the ribosome and allows the ribosome to return to its normal posttranslocational conformational state, which was altered by the binding of tetracycline. Glycylcyclines compete with tetracycline for ribosomal binding sites because they have either identical or overlapping sites on the ribosome and have the same mode of action as tetracycline. The differences in host range may be partially due to the type of element that each gene is associated with. This may be relevant because conjugative transposons, in general, have less host specificity than do plasmids and are able to be transferred to unrelated species and genera. The ribosomal protection genes are associated with plasmids, transposons, and conjugative transposons. Conjugative transfer appears to be influenced by the flanking sequences which correlate with the location of the Tn916-Tn1545 family inserted into the chromosome.
Full text loading...
G+C content of ribosomal protection genes
a Percentages are rounded off to the next whole number.
G+C content of ribosomal protection genes
a Percentages are rounded off to the next whole number.
Distribution of ribosomal protection genes
a Data from references 1 , 3 , 5 , 8 , 11 , 15 – 23 , 26 – 30 , 32 , 34 , 35 – 37 , 38 , 40 , 41 , 43 , 46 , 48 , 49 , 52 , 53 , 55 – 57 , 61 , 63 – 72 , 74 , 75 , 78 – 82 , 84 – 86 , 90 , 91 , 93 – 95 .
Distribution of ribosomal protection genes
a Data from references 1 , 3 , 5 , 8 , 11 , 15 – 23 , 26 – 30 , 32 , 34 , 35 – 37 , 38 , 40 , 41 , 43 , 46 , 48 , 49 , 52 , 53 , 55 – 57 , 61 , 63 – 72 , 74 , 75 , 78 – 82 , 84 – 86 , 90 , 91 , 93 – 95 .