Chapter 1 : Principles and Approaches

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This chapter introduces definitions and general concepts underlying an emerging discipline in epidemiology applied to infectious diseases. Molecular epidemiology of infectious diseases integrates practices and principles of molecular biology with those of epidemiology. The chapter presents an overview of the types of epidemiologic problems that can be addressed by molecular strain-typing techniques after the techniques have been validated. It discusses in detail the general approaches to evaluating and validating new strain-typing techniques, as they apply to epidemiology. The general concepts introduced in the chapter were derived from empirical examinations of specific epidemiologic problems that could not be readily solved by conventional epidemiologic methods. While these concepts mostly focus on the methodological and practical aspects of molecular epidemiology, it is evident that these concepts help to challenge old notions and reveal new paradigms concerning the epidemiology of infectious diseases in general.

Citation: Riley L. 2004. Principles and Approaches, p 1-28. In Molecular Epidemiology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817688.ch1
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Figure 1.1

Steps that should be considered in validating a new molecular strain-typing test for application to epidemiology.

Citation: Riley L. 2004. Principles and Approaches, p 1-28. In Molecular Epidemiology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817688.ch1
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Generic image for table
Table 1.1

Applications of molecular strain-typing methods to epidemiologic problems

Citation: Riley L. 2004. Principles and Approaches, p 1-28. In Molecular Epidemiology of Infectious Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817688.ch1

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