5 Systemic Viral Diseases and Encephalitis

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Encephalitis may appear in the context of systemic viral illness or viral infection of another organ system. Consideration of the diagnostic features of the non-central nervous system (CNS) portion of the disease will facilitate an etiologic diagnosis. Bacterial diseases such as Rocky Mountain fever and meningococcal disease are also associated with CNS disease and skin manifestations. Aseptic meningitis and stroke have also been reported in connection with parvovirus B-19. The virus is a demonstrated cause, albeit rare, of aseptic meningitis. Viral diagnostic studies rely on immunoglobulin M (IgM) and IgG antibody capture enzyme-linked immunosorbent assay (ELISA) or immunofluorescent antibody determinations and cerebrospinal fluid (CSF) PCR. Exanthem subitum, roseola, and sixth disease are synonyms for a brief illness of infants and children characterized by the appearance of a rash following lysis of fever. Human herpesvirus 6 (HHV-6) is classified as a beta herpesvirus, and its genetic structure resembles those of HHV-7 and cytomegalovirus (CMV). HHV-7, the herpesvirus bearing the greatest similarity to HHV-6, is another ubiquitous virus; antibody is usually acquired by the age of 3 years. Like HHV-6, it is tropic for CD4 lymphocytes, and it too may cause encephalopathic disease, but details of this remain sketchy. Prior to widespread vaccination, mumps was one of the most common causes of aseptic meningitis. Acute and subacute diffuse encephalopathic signs were reported, including somnolence, confusion, stupor, dysarthria, dysphagia, and incontinence.

Citation: Booss J, Esiri M. 2003. 5 Systemic Viral Diseases and Encephalitis, p 61-80. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch5
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1. Afzal, M. A.,, J. Buchanan,, J. A. Dias,, M. Cordiero,, M. L. Bentley,, C. A. Shorrock,, and P. D. Minor. 1997. RT-PCR based diagnosis and molecular characterization of mumps viruses derived from clinical specimens collected during the 1996 mumps outbreak in Portugal. J. Med. Virol. 52: 349 353.
2. Agut, H.,, H. Collandre,, J.-T. Aubin,, D. Guetard,, V. Favier,, D. Ingrand,, L. Montagnier,, and J.-M. Huraux. 1989. In vitro sensitivity of human herpesvirus-6 to antiviral drugs. Res. Virol. 140: 219 228.
3. Ahtiluoto, S.,, L. Mannonen,, A. Paetau,, A. Vaheri,, M. Koskiniemi,, P. Rautiainen,, and M. Muttilainen. 2000. In situ hybridization detection of human herpesvirus 6 in brain tissue from fatal encephalitis. Pediatrics 105: 431 433.
4. Albright, A. V.,, E. Lavi,, J. B. Black,, S. Goldberg,, M. J. O'Connor,, and F. Gonzalez-Scarano. 1998. The effect of human herpesvirus-6 (HHV-6) on cultured human neural cells: oligodendrocytes and microglia. J. Neurovirol. 4: 486 494.
5. Alter, M. J.,, D. Druszon-Moran,, O. V. Nainan,, G. M. McQuillan,, F. Gao,, L. A. Moyer,, R. A. Kaslow,, and H. S. Margolis. 1999. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N. Engl. J. Med. 341: 556 562.
6. Ambler, M.,, J. Stoll,, A. Tzamaloukas,, and M. M. Albala. 1971. Focal encephalomyelitis in infectious mononucleosis. Ann. Intern. Med. 75: 579 583.
7. Anderson, D. A., 2000. Waterborne hepatitis, p. 295 305. In S. Specter,, R. L. Hodinka,, and S. A. Young (ed.), Clinical Virology Manual, 3rd ed. ASM Press, Washington, D.C.
8. Anderson, M. J.,, S. E Jones,, S. P. Fisher-Hoch,, E. Lewis,, S. M. Hall,, C. L. R. Bartlett,, B. J. Cohen,, R. R. Mortimer,, and M. S. Pereira. 1983. Human parvovirus, the cause of erethema infectiosum (Fifth Disease). Lancet i: 1378.
9. Ascherio, A.,, K. L. Munger,, E. X Lennette,, D. Spiegelman,, M. A. Hernan,, M. J. Olek,, S. E. Hankinson,, and D. J. Hunter. 2001. Epstein-Barr virus antibodies and risk of multiple sclerosis. A prospective study. JAMA 286: 3083 3088.
10. Azimi, R. H.,, H. G. Cramblett,, and R. E. Haynes. 1969. Mumps meningoencephalitis in children. JAMA 207: 509 512.
11. Bakshi, N.,, J. Lawson,, R. Hanson,, C. Ames,, and H. V. Vinters. 1996. Fatal mumps meningoencephalitis in a child with severe combined immunodeficiency after bone marrow transplantation. J. Child Neurol 11: 159 162.
12. Balfour, H. H., Jr., G. M. Schiff, and J. E. Bloom. 1970. Encephalitis associated with erythema infectiosum. Pediatrics 77: 133 136.
13. Bang, H. O.,, and J. Bang. 1943. Involvement of the central nervous system in mumps. Acta Med. Scand. 63: 487 505.
14. Barah, E.,, P. J. Vallely,, M. L. Chiswick,, G. M. Cleator,, and J. R. Kerr. 2001. Association of human parvovirus B-19 infection with acute meningoencephalitis. Lancet 358: 729 730.
15. Barraza, E. M.,, S. L. Ludwig,, J. C. Gaydos,, and E. Brundage. 1999. Reemergence of adenovirus type 4 acute respiratory disease in military trainees: report of an outbreak during a lapse in vaccination. J. Infect. Dis. 179: 1531 1533.
16. Bech, E.,, J. Lycke,, P. Gadeberg,, M. J. Hansen,, C. Malmestrom,, O. Anderson,, T. Christensen,, S. Eckholm,, S. Haahr,, P. Hoolsberg,, T. Bergstrom,, B. Svennerholm,, and J. Jakobsen. 2002. A randomized double blind, placebo-controlled MRI study of anti-herpes virus therapy in MS. Neurology 58: 31 36.
17. Bendinelli, M.,, M. Pistello,, E. Maggi,, and M. Vatteroni,. 2000. Blood-borne hepatitis viruses: hepatitis B, C, D and G viruses and XT virus, p. 306 337. In S. Specter,, R. L. Hodinka,, and S. A. Young (ed.), Clinical Virology Manual, 3rd ed. ASM Press, Washington, D.C.
18. Bergin, J. D. 1960. Fatal encephalopathy in glandular fever. J. Neurol. Neurosurg. Psychiatr. 23: 69 73.
19. Bernstein, T. C.,, and H. G. Wolff. 1950. Involvement of the nervous system in infectious mononucleosis. Ann. Intern. Med. 335: 1120 1138.
20. Bistrian, B.,, C. A. Phillips,, and I. S. Kaye. 1972. Fatal mumps meningoencephalitis. Isolation of virus pre-mortem and postmortem. JAMA 222: 478 479.
21. Bolay, H.,, F. Soylemezoglu,, G. Nurlu,, S. Tuncer,, and K. Varli. 1996. PCR detected hepatitis C virus genome in brain of a case with progressive encephalomyelitis with rigidity. Clin. Neurol. Neurosurg. 98: 305 308.
22. Bosi, A.,, M. Zazzi,, A. Amantini,, M. Cellerini,, A. M. Vannucchi,, A. De Milito,, S. Guidi,, R. Saccardi,, L. Lombardini,, D. Laszlo,, and P. Rossi Ferrini. 1998. Fatal herpesvirus 6 encephalitis after unrelated bone marrow transplant. Bone Marrow Transplant 22: 285 288.
23. Bossolasco, S.,, R. Marenzi,, H. Dahl,, L. Vago,, M. R. Terreni,, F. Broccolo,, A. Lazzarin,, A. Linde,, and P. Cinque. 1999. Human herpesvirus 6 in cerebrospinal fluid of patients infected with HIV: frequency and clinical significance. J. Neurol. Neurosurg. Psychiat. 67: 789 792.
24. Braun, D. K.,, G. Dominguez,, and P. E. Pellett. 1997. Human herpesvirus 6. Clin. Microbiol. Rev. 10: 521 567.
25. Bromberg, K.,, D. N. Newhall,, and G. Pater. 1982. Hepatitis A and meningoencephalitis. JAMA 247: 815.
26. Brooks, B. R. 1977. Viral hepatitis type B presenting with seizure. JAMA 237: 472 473.
27. Brown, K. E., 2000. Parvoviridae parvovirus B-19, p. 1685 1693. In J. E. Bennett, and R. Dolin (ed.), Principles and Practice of Infectious Diseases, 5th ed. Churchill Livingstone, Philadelphia, Pa.
28. Campadelli-Fiume, G.,, P. Mirandola,, and I. Menotti. 1999. Human herpesvirus-6: an emerging pathogen. Emerg. Infect. Dis. 5: 353 366.
29. Carrigan, D. R.,, D. Harrington,, and K. K. Knox. 1996. Subacute leukoencephalitis caused by CNS infection with human herpesvirus-6 manifesting as acute multiple sclerosis. Neurobgy 47: 145 148.
30. Carter, R. L.,, and H. G. Penman. 1969. Infectious Mononucleosis. Blackwell Scientific Publications, Oxford, United Kingdom.
31. Caruso, J. M.,, G. A. Tung,, G. G. Gascon,, J. Rogg,, L. Davis,, and W. D. Brown. 2000. Persistent preceding focal neurologic deficits in children with chronic Epstein-Barr virus infections. J. Child. Neurol. 15: 791 796.
32. Caserta, M. T.,, and C. B. Hall,. 1997. Human herpesvirus-6, p. 129 138. In W. M. Scheld,, R. J. Whitley,, and D. T. Durack (ed.), Infections of the Central Nervous System, 2nd ed. Lippincott, Raven, Philadelphia, Pa.
33. Caserta, M. T.,, C. B. Hall,, K. Schnabel,, K. Mclntyre,, C. Long,, M. Costanzo,, S. Dewhurts,, R. Insel,, and L. G. Epstein. 1994. Neuroinvasion and persistence of human herpesvirus 6 in children. J. Infect. Dis. 170: 1586 1589.
34. Center for Disease Control. 1978. Mumps—United States. Morb. Mortal. Wkly Rep. 27: 379381.
35. Centers for Disease Control and Prevention. 2001. Two fatal cases of adenovirus-related illness in previously healthy young adults—Illinois, 2000. Morb. Mortal. Wkly. Rep. 50: 553555.
36. Challoner, P. B.,, K. T. Smith,, J. D. Parker,, D. L. MacLeod,, S. N. Coulter,, T. M. Rose,, E. R. Shultz,, L. Benneti,, R. L. Garber,, M. Chang,, P. A. Schad,, P. A. Steward,, R. C. Nowinski,, J. P. Brown,, and G. C. Burmer. 1995. Plaque-associated expression of human herpesvirus-6 in multiple sclerosis. Proc. Natl. Acad. Sci. USA 92: 7440 7444.
37. Chou, S. M.,, R. Roos,, R. Burrell,, L. Gutmann,, and J. B. Harley. 1973. Subacute focal adenovirus encephalitis. J. Neuropath. Exp. Neurol. 32: 34 50.
38. Cohen, H. A.,, A. Ashkenazi,, M. Nussinovitch,, J. Amia,, J. Hart,, and M. Frydman. 1992. Mumps-associated acute cerebellar ataxia. Am. J. Dis. Child. 146: 930 931.
39. Cohen, J. 1. 2000. Epstein-Barr virus infection. N. Engl. J. Med. 343: 481 492.
40. Cole, P. D.,, J. Stiles,, E. Boulad,, T. N. Small,, R. J. O'Reilly,, D. George,, P. Szaboles,, T. E. Kiehn,, and N. A. Kernan. 1998. Successful treatment of human herpesvirus 6 encephalitis in a bone marrow transplant recipient. Clin. Infect. Dis. 27: 653 654.
41. Colville, A.,, and S. Pugh. 1992. Mumps meningitis and measles, mumps, and rubella vaccine. Lancet 340: 768.
42. Cooperman, S. M. 1977. "Alice in Wonderland" syndrome as a presenting symptom of infectious mononucleosis in children. Clin. Pediatr. 16: 143 146.
43. Cossart, Y. E.,, A. M. Field,, B. Cant,, and D. Widdows. 1975. Parvovirus-like particles in human sera. Lancet i: 72 73.
44. Daibata, M.,, N. Hatakeyama,, M. Kamioka,, Y. Nemoto,, M. Hiroi,, I. Miyoshi,, and H. Taguchi. 2001. Detection of human herpesvirus 6 and JC virus in progressive multifocal leukoen-cephalopathy. Am. J. Hematol. 67: 200 205.
45. Davis, L. E.,, L. E. Brown,, B. H. Robertson,, B. Khanna,, and L. B. Polish. 1993. Hepatitis A post-viral encephalitis. Acta Neurol.Scand. 87: 67 69.
46. DeSimone, P. A.,, and D. Snyder. 1978. Hypoglossal nerve palsy in infectious mononucleosis. Neurology 28: 844 847.
47. DiBisceglie, A. M.,, and B. R. Bacon. 1999. The unmet challenges of hepatitis C. Sci. Am. October: 80 85.
48. Dolgopol, V. B.,, and G. S. Husson. 1949. Infectious mononucleosis with neurologic complications: report of fatal cases. Arch. Intern. Med. 83: 179 196.
49. Donovan, W. D.,, and R. D. Zimmerman. 1996. MRI findings of severe Epstein-Barr virus encephalomyelitis. J. Comput. Assist.Tomogr. 20: 1027 1029.
50. Drobyski, W. R.,, K. K. Knox,, D. Majewski,, and D. R. Carrigan. 1994. Brief report: fatal encephalitis due to variant B human herpes-6 infection in bone marrow transplant recipient. N. Engl.J. Med. 330: 1356 1360.
51. Dudding, B. A.,, S. C. Wagner,, A. Zellerj,, J. T. Gmelich,, G. R. French,, and F. H. Top, Jr. 1972. Fatal pneumonia associated with adenovirus type 7 in three military trainees. N. Engl. J. Med. 286: 1289 1292.
52. Duffy, J.,, M. D. Lidsky,, J. T. Sharp,, J. S. Davis,, D. A. Person,, E. B. Hollinger,, and K.-W. Min. 1976. Polyarthritis, polyarteritis, and hepatitis B. Medicine 55: 19 37.
53. Faden, H.,, G. W. Gary, Jr.,, and M. Korman. 1990. Numbness and tingling of fingers associated with parvovirus B-19 infection. J. Infect. Dis. 161: 354 355.
54. Feldman, H. A., 1982. Mumps, p. 419 440. In A. S. Evans (ed.), Viral Infections of Humans, Epidemiology and Control, 2nd ed. Plenum Press, New York, N.Y.
55. Ford, F. R. 1966. Mumps meningoencephalitis, p. 391 397. In Diseases of the Nervous System in Infancy, Childhood and Adolescence, 5th ed. Thomas, Springfield, III.
56. Frieden, I. J.,, and S. D. Resnick. 1991. Childhood exanthems, old and new. Pediatr. Clin. N. Am. 38: 859 887.
57. Friedland, R.,, and M. D. Yahr. 1977. Meningoencephalopathy secondary to infectious mononucleosis. Unusual presentation with stupor and chorea. Arch. Neurol. 34: 186 188.
58. Friedlander, W. J. 1956. Neurologic signs and symptoms as prodrome to virus hepatitis. Neurology 6: 574 578.
59. Gabrielson, M. O.,, C. Joseph,, and G. D. Hsiung. 1966. Encephalitis associated with adenovirus type 7 occurring in a family outbreak. J. Pediatr. 68: 142 144.
60. Gautier-Smith, P. C. 1965. Neurological complications of glandular fever (Infectious Mononucleosis). Brain 88: 323 334.
61. Glikmann, G. A.,, M. Pedersen,, and C.-H. Mordhorst. 1986. Detection of specific immunoglobulin M to mumps virus in serum and cerebrospinal fluid samples from patients with acute mumps infection, using an antibody-capture enzyme immunoassay. Acta Pathol. Microbiol. Immunol. Scand. Sect. C 94: 145 156.
62. Gnann, J. W., Jr., 1997. Meningitis and encephalitis caused by mumps virus, p. 169 180. In M. W. Scheld,, R. J. Whitley,, and D. T. Durrack (ed.), Infections of the Central Nervous System, 2nd ed. Lippincott-Raven, Philadelphia, Pa.
63. Grose, C.,, W. Henle,, G. Henle,, and P. M. Feorino. 1975. Primary Epstein-Barr virus infections in acute neurological diseases. N. Engl. J. Med. 292: 392 395.
64. Grose, C., 1983. Neurologic complications of infectious mononucleosis, p. 49 68. In D. Schlossberg (ed.), Infectious Mononucleosis, 2nd ed. Springer-Verlag, New York, N.Y.
65. Hall, C. B.,, and E. A. Horner. 1977. Encephalopathy with erythema infectiosum. Am. J. Dis. Child. 131: 65 67.
66. Hall, C. B.,, C. E. Long,, K. C. Schnabel,, M. T. Caserta,, K. M. Mclntyre,, M. A. Costanzo,, A. Knott,, S. Dewhurst,, R. A. Insel,, and L. G. Epstein. 1994. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N. Engl. J. Med. 331: 432 438.
67. Hammond, G. W.,, B. K. MacDougall,, E. Plummer,, and L. H. Seka. 1982. Encephalitis during the prodromal stage of acute hepatitis A. Can. Med. Assoc. J. 126: 269 270.
68. Heckmann, J. G.,, C. Kayser,, D. Heuss,, B. Manger,, H. E. Blum,, and B. Nenndorfer. 1999. Neurological manifestations of chronic hepatitis C. J. Neurol. 246: 486 491.
69. Heegard, E. D.,, and K. E. Brown. 2002. Human parvovirus B19. Clin. Microbiol. Rev. 15: 485 505.
70. Herndon, R. M.,, R. T. Johnson,, L. E. Davis,, and L. R. Descalzi. 1974. Ependymitis in mumps virus meningitis. Electron microscopical studies of cerebrospinal fluid. Arch. Neurol. 30: 475 479.
71. Hochberg, E. H.,, J. R. Lehrich,, E. P. Richardson,, P. M. Feorino,, and K. E. Astrom. 1976. Mononucleosis-associated subacute sclerosing panencephalitis. Acta Neuropathol. (Berlin) 34: 33 40.
72. Hochberg, E. H.,, G. Miller,, R. T. Schooley,, M. S. Hirsch,, P. Feorino,, and W. Henle. 1983. Central-nervous-system lymphoma related to Epstein-Barr virus. N. Engl. J. Med. 309: 745 748.
73. Hongou, K.,, T. Konishi,, S. Yagi,, K. Araki,, and T. Miyawaki. 1998. Rotavirus encephalitis mimicking afebrile benign convulsions in infants. Pediatr. Neurol. 18: 354 357.
74. Ito, M.,, T. Go,, T. Okundo,, and H. Mikawa. 1991. Chronic mumps virus encephalitis. Pediatr. Neurol. 7: 467 470.
75. Ito, M.,, J. V. Baker,, D. J. Mock,, A. D. Goodman,, B. M. Blumberg,, D. A. Shrier,, and J. M. Powers. 2000. Human herpesvirus 6-meningoencephalitis in an HIV patient with progressive multifocal leukoencephalopathy. Acta Neuropathol. (Berlin) 100: 337 341.
76. Jackson, G. G.,, and R. L. Muldoon. 1973. Viruses causing common respiratory infection in man. IV Reoviruses and Adenoviruses. J. Infect. Dis. 128: 811 866.
77. Johnstone, J. A.,, C. A. C. Ross,, and M. Dunn. 1972. Meningitis and encephalitis associated with mumps infection. A ten year survey. Arch. Dis. Child. 47: 647 651.
78. Kamei, A.,, S. Ichinohe,, R. Onuma,, S. Hiraga,, and T. Fujiwara. 1997. Acute disseminated demyelination due to primary human herpesvirus-6 infection. Eur. J. Pediatr. 156: 709 712.
79. Katsafanas, G. C.,, E. C. Schirmer,, L. S. Wyatt,, and N. Frenkel. 1996. In vitro activation of human herpesviruses 6 and 7 from latency. Proc. Natl Acad. Sci. USA 93: 9788 9792.
80. Keidan, I.,, I. Shif,, G. Keren,, and J. H. Passwell. 1992. Rotavirus encephalopathy: evidence of central nervous system involvement during rotavirus infection. Pediatr. Infect. Dis. J. 11: 773 774.
81. Kelsey, D. S. 1978. Adenovirus meningoencephalitis. Pediatrics 61: 291 293.
82. Kelsey, D. S.,, and W. T. McLean. 1979. Adenoviral meningoencephalitis in a patient with lead toxicity. Arch. Neurol. 36: 384 385.
83. Knox, K. K.,, and D. R. Carrigan. 1995. Active human herpesvirus (HHV-6) infection of the central nervous system in patients with AIDS. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 9: 69 73.
84. Knox, K. K.,, D. P. Harrington,, and D. R. Carrigan. 1995. Fulminant human herpesvirus six encephalitis in a human immunodeficiency virus-infected infant. J. Med. Virol. 45: 288 292.
85. Knox, K. K.,, J. H. Brewer,, J. M. Henry,, D. J. Harrington,, and D. R. Carrigan. 2000. Human herpesvirus-6 and multiple sclerosis: systemic active infections in patients with early disease. Clin. Infect. Dis. 31: 894 903.
86. Kondo, K.,, T. Kondo,, T. Okuno,, M. Takahashi,, and K. Yamanishi. 1991. Latent human herpesvirus 6 infection of human monocytes/macrophages. J. Gen. Virol. 72: 1401 1408.
87. Krugman, S.,, and R. Ward. 1968. Mumps (epidemic parotitis), p. 184 198. In Infectious Diseases of Children. C. V. Mosby Co., St. Louis, Mo.
88. Kuo, Y. X.,, N.-O. Chiu,, E. Y. Shen,, C.-S. Ho,, and M. C. Wu. 1998. Cerebral perfusion in children with Alice in Wonderland syndrome. Pediatr. Neurol. 19: 105 108.
89. Lahat, E.,, M. Berkovitch,, J. Barr,, G. Paret,, and A. Barzilai. 1999. Abnormal visual evoked potentials in children with "Alice in Wonderland"syndrome due to infectious mononucleosis. Child. Neurol. 14: 732 735.
90. Landry, M. L.,, and G. D. Hsiung. 1988. Adenovirus-associated meningoencephalitis in a healthy adult. Ann. Neurol 23: 627 628.
91. Lanzinger-Rossnagel, G.,, and B. Kommerell. 1980. EEG changes in acute viral hepatitis. Electroenceph. Clin. Neurophysiol. 50: 96 101.
92. Lauer, G. M.,, and B. D. Walker. 2001. Hepatitis C virus infection. N. Engl. J.Med. 345: 41 52.
93. Lelong, M.,, P. Lepine,, E. Alison,, P. Le-Tan-Vinh Satge,, and C. Chany. 1956. La pneumonie A virus du group A.P.C. chez de nourrison isolement du virus: les lisions anatomohistologiques. Arch. Fr. Pediatr. 13: 1092 1096.
94. Lennette, E. H.,, G. E. Caplan,, and R. L. Magoffin. 1960. Mumps virus infection simulating paralytic poliomyelitis. A report of 11 cases. Pediatrics 25: 788 797.
95. Leppik, I. E.,, V. Ramani,, R. J. Sawchuk,, and R. J. Gumnit. 1979. Increased clearance of phenytoin during infectious mononucleosis. N. Engl. J. Med. 300: 481 482.
96. Levitt, L. P.,, T. A. Rich,, S. W. Kinde,, A. L. Lewis,, E. H. Gates,, and J. O. Bond. 1970. Central nervous system mumps. A review of 64 cases. Neurology 20: 829 834.
97. Lippman, C. W. 1952. Certain hallucinations peculiar to migraine. J. New. Ment. Dis. 116: 346 351.
98. Ljungman, P.,, F. Z. Wang,, D. A. Clark,, V. C. Emery,, M. Remberger,, O. Ringden,, and A. Linde. 2000. High levels of human herpesvirus 6 DNA in peripheral blood leucocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients. Br. J. Haematol. 111: 774 781.
99. Lockwood, A. H., 1995. Hepatic encephalopathy and other neurological disorders associated with gastrointestinal disease, p. 247 266. In M. J. Aminoff (ed.), Neurology and General Medicine. Churchill Livingstone, New York, N.Y.
100. Lord, A.,, N. P. Sutton,, and J. A. N. Corsellis. 1975. Recovery of adenovirus type 7 from human brain cell cultures. J. Neurol. Neurosurg. Psychiatr. 38: 710 712.
101. Love, S.,, and C. A. Wiley,. 2002. Viral infections, p. 1 106. In D. I. Graham, and P. L. Lantos (ed.), Greenfield's Neuropathology. Arnold, London, United Kingdom.
102. Lundgren, O.,, A. T. Peregrin,, K. Persson,, S. Kordasti,, I. Uhnoo,, and L. Svensson. 2000. Role of the enteric nervous system in the fluid and electrolyte secretion of rotavirus diarrhea. Science 287: 491 495.
103. Luppi, M.,, P. Barozzi,, A. Maiorana,, R. Marasca,, and G. Torelli. 1994. Human herpes 6 infection in normal human brain tissue. J. Infect. Dis. 169: 943 944.
104. Lycke, J.,, B. Svennerholm,, E. Hjeimquist,, L. Frisen,, G. Badr,, M. Andersson,, A. Vahlne,, and O. L. Andereson. 1966. Acyclovir treatment of relapsing-remitting multiple sclerosis. A randomized placebo-controlled, double-blind study. J. Neurol. 243: 214 224.
105. MacKenzie, I. R. A.,, D. R. Carrigan,, and C. A. Wiley. 1995. Chronic myelopathy associated with human herpesvirus-6. Neurology 45: 2015 2017.
106. Maggi, E.,, M. Giorgi,, C. Fornai,, A. Morrica,, M. L. Vatteroni,, M. Pistello,, G. Sieiliano,, A. Nuecorini,, and M. Bendinelli. 1999. Detection and quasispecies analysis of hepatitis C virus in the cerebrospinal fluid of infected patients. J. Neurovirol. 5: 319 323.
107. Majid, A.,, S. L. Galetta,, C. J. Sweeney,, C. Robinson,, R. Mahalingam,, J. Smith,, B. Forgham,, and D. H. Gilden. 2002. Epstein-Barr virus myeloradiculitis and encephalomyeloradi-culitis. Brain 125: 159 165.
108. Malnick, S. D. H.,, Y. Abend,, E. Evron,, and Z. M. Sthoeger. 1997. HCV hepatitis associated with anticardiolipin antibody and a cerebrovascular event. Response to interferon therapy. J. Clin. Gastroenterol. 24: 40 42.
109. Matson, D. O.,, M. L. O'Ryan,, X. Jiang,, and D. K. Mitchell,. 2000. Rotavirus, enteric adenoviruses, calciviruses, astro-viruses, and other viruses causing gastroenteritis, p. 270 275. In S. Specter,, R. L. Hodinka,, and S. A. Young (ed.), Clinical Virology Manual, 3rd ed. ASM Press, Washington, D.C.
110. McCullers, J. A.,, E. D. Lakeman,, and R. J. Whitley. 1995. Human herpesvirus 6 is associated with focal encephalitis. Clin. Infect. Dis. 21: 571 576.
111. McDonald, J. C.,, D. L. Moore,, and P. Quennec. 1989. Clinical and epidemiologic features of mumps meningoencephalitis and possible vaccine-related disease. Pediatr. Infect. Dis. J. 8: 751 755.
112. Melbye, M.,, P. Ebbesen,, N. Jacobsen,, and C. H. Mordhorst. 1983. Simultaneous primary infections with Epstein-Barr virus and measles virus in fatal acute encephalitis. Br. Med. J. 286: 521 522.
113. Merelli, E.,, R. Bedin,, P. Sola,, M. Gentilini,, P. Pietrosemoii,, M. Meacci,, and M. Portolani. 1997. Encephalomyeloradicu-lopathy associated with Epstein-Barr virus: primary infection or reactivation? Acta Neurol. Scand. 96: 416 420.
114. Michalak, T. 1978. Immune complexes of hepatitis B surface antigen in the pathogenesis of periarteritis nodosa. Am. J. Pathol. 90: 619 628 and following figures.
115. Mookerjee, B. P.,, and G. Vogelsang. 1997. Human herpesvirus-6 encephalitis after bone marrow transplantation: successful treatment with ganciclovir. Bone Marrow Transplant. 20: 905 906.
116. Morgenlander, J. C. 1996. A syndrome of concurrent central and peripheral nervous system involvement due to Epstein-Barr virus infection. Muscle Nerve 19: 1037 1039.
117. Morsica, G.,, M. T. Bernardi,, R. Novati,, C. U. Foppa,, A. Castagna,, and A. Lazzarin. 1997. Detection of hepatitis C virus genomic sequences in the cerebrospinal fluid of HIV infected patients. J. Med. Virol. 53: 252 254.
118. Naides, S. J., 2000. Parvoviruses, p. 487 500. In S. Specter,, R. L. Hodinka,, and S. A. Young (ed.), Ctinical Virology Manual, 3rd ed. ASM Press, Washington, D.C.
119. Nalesnik, M. A., 1999. Epstein-Barr virus, p. 385 407. In E. H. Lennette, and T. E. Smith (ed.), Laboratory Diagnosis of Viral Infections, 3rd ed. Marcel Dekker, New York, N.Y.
120. Novoa, L. J.,, R. M. Nagra,, T. Nakawatase,, T. Edwards-Lee,, W. W. Tourtellotte,, and M. E. Cornford. 1997. Fulminant demyelinating encephalomyelitis associated with productive HHV-6 infection in an immunocompetent adult. J. Med. Virol. 52: 301 308.
121. Nussinovich, M.,, N. Brand,, M. Frydman,, and I. Varsano. 1992. Transverse myelitis following mumps in children. Acta Paediatr. 81: 183 184.
122. Origgi, L.,, M. Vanoli,, A. Carbone,, M. Grasso,, and R. Scorza. 1998. Central nervous system involvement with HCV-related cryoglobulinemia. Am. J. Med. Sci. 315: 208 210.
123. Osamura, T.,, R. Mizuta,, H. Yoshioka,, and S. Fushiki. 1993. Isolation of adenovirus type 11 from the brain of a neonate with pneumonia and encephalitis. Eur. J. Pediatr. 152: 496 499.
124. Pang, X.'L.,, J. Joensuu,, and T. Vesikar. 1996. Detection of Rotavirus RNA in cerebrospinal fluid in a case of Rotavirus gastroenteritis with febrile seizures. Pedriatr. Infect. Dis. J. 15: 543 545.
125. Paskavitz, J. R.,, C. A. Anderson,, C. H. Filley,, B. K. Kleinschmidt'DeMasters,, and K. L. Tyler. 1995. Acute arcuate fiber demyelinating encephalopathy following Epstein-Barr virus infection. Ann. Neurol. 38: 127 131.
126. Petty, G. W.,, J. Duffy,, and J. Huston III. 1996. Cerebral ischemia in patients with hepatitis C virus infection and mixed cryoglobulinemia. Mayo Clin. Proc. 71: 671 678.
127. Poggio, G. P.,, C. Rodriguez,, D. Cisterna,, M. C. Freire,, and J. Cello. 2000. Nested PCR for rapid detection of mumps virus in cerebrospinal fluid from patients with neurological disease. J. Clin. Microbiol. 38: 274 278.
128. Poppe, M.,, W. Bruck,, G. Hahn,, B. Weissbrick,, G. Heubner,, H. H. Goebel,, and H. Todt. 2001. A fulminant course in a case of diffuse myelinoclastic encephalitis—a case report. Neuropediatrics 32: 41 44.
129. Radkowski, M.,, J. Wilkenson,, M. Nowicki,, D. Adair,, H. Vargas,, C. Ingui,, J. Rakela,, and T. Laskus. 2002. Search for hepatitis C virus negative strand RNA sequences and analysis of viral sequences in the central nervous system: evidence of replication. J. Virol. 76: 600 608.
130. Rantala, H.,, M. Uhari,, and H. Tuokko. 1990. Viral infections and recurrences of febrile convulsions. J. Pediatr. 116: 195 199.
131. Rezza, G.,, M. Dorrucci,, M. Andreoni,, C. Arpino,, A. DeLuca,, P. Monini,, E. Nicastri,, M. B. Alliegro,, P. Pezzoti,, and B. Ensoli for the Italian HIV-Seroconversion Study. 1999. Does HHV-8 have a protective role on the development of HIV encephalopathy? Neurology 53: 2032 2036.
132. Ricker, W.,, A. Blumberg,, C. H. Peters,, and A. Widerman. 1947. The association of the Guillain-Barre syndrome with infectious mononucleosis, with a report of two fatal cases. Blood 2: 217 226.
133. Ringelstein, E. B.,, H. Sobczak,, B. Pfeifer,, and W. Hacke. 1984. [Polyradiculomeningo-encephalitis caused by Epstein-Barr virus infection—description of a case with fatal outcome]. Fortschr. Neurol. Psychiatr. 52: 73 82.
134. Roos, R.,, S. M. Chou,, N. G. Rogers,, M. Basnight,, and D. C. Gaidusek. 1972. Isolation of an adenovirus 32 strain from human brain in a case of subacute encephalitis. Proc. Soc. Exp. Biol. Med. 139: 636 640.
135. Rosenberg, R. N.,, E. A. Neuwelt,, J. Kirkpatrick,, and P. Kohler. 1976. Encephalopathy associated with cryoprecipitable Australia antigen. Ann. Neurol. 1: 298 300.
136. Ross, J. P.,, and J. I. Cohen,. 1997. Epstein-Barr virus, p. 117 127. In W. M. Scheld,, R. J. Whitley,, and D. T. Durack (ed.), Infections of the Central Nervous System, 2nd ed. Lippincott-Raven, Philadelphia, Pa.
137. Roulet'Perez, E.,, P. Maeder,, J. Cotting,, A. C. Eskenazy-Cottier,, and T. Deonna. 1993. Acute fatal parainfectious cerebellar swelling in two children. A rare or an overlooked situation? Neuropediatrics 24: 346 351.
138. Ruuskanen, O.,, O. Meurman,, and G. Akusjarvi,. 1997. Adenoviruses, p. 525 547. In D. D. Richman,, R. J. Whitley,, and F. G. Hyden (ed.), Clinical Virology. Churchill Livingstone, New York, N.Y.
139. Sacconi, S.,, L. Salviati,, and E. Merelli. 2001. Acute disseminated encephalomyelitis associated with hepatitis C virus infection. Arch. Neurol. 58: 1679 1681.
140. Salahuddin, S. Z.,, D. V. Ablashi,, P. D. Markham,, S. F. Josephs,, S. Sturzenegger,, M. Kaplan,, G. Halligan,, P. Biberfeld,, E. Wong-Staal,, G. Kramarsky,, and R. C. Gallo. 1986. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234: 596 601.
141. Salmi, T. T.,, P. Arstila,, and A. Koivikko. 1978. Central nervous system involvement in patients with rotavirus gastroenteritis. Scand.J. Infect. Dis. 10: 29 31.
142. Schellinger, P. D.,, C. Sommer,, F. Leithauser,, S. Schwab,, B. StorclvHagenlocher,, W. Hacke,, and M. Kiessling. 1999. Epstein-Barr virus meningoencephalitis with a lymphoma-like response in an immunocompetent host. Ann. Neurol. 45: 659 662.
143. Schiff, J. A.,, A. Schaeferj,, and E. Robinson. 1982. Epstein-Barr virus in cerebrospinal fluid during infectious mononucleosis encephalitis. Yale J. Biol. Med. 55: 59 63.
144. Schnell, R. G.,, P. J. Dyck,, E. J. W. Bowie,, D. W. Klass,, and H. F. Taswell. 1966. Infectious mononucleosis: neurologic and EEG findings. Medicine 45: 51 63.
145. Schwarz, G. A.,, D. C. Yang,, and E. L. Noone. 1964. Meningoen-cephalomyelitis with epidemic parotitis. Arch. Neurol. 11: 453 462.
146. Sergent, J. S.,, M. D. Lockshin,, C. L. Christian,, and D. J. Gocke. 1976. Vasculitis with hepatitis B antigenemia. Long-term observations in nine patients. Medicine 55: 1 18.
147. Sharief, M. K.,, and E. J. Thompson. 1990. A sensitive ELISA system for the rapid detection of virus specific IgM antibodies in the cerebrospinal fluid. J. Immunol. Methods 130: 19 24.
148. Sharma, K. R.,, S. Sriram,, T. Fries,, H. J. Bevan,, and W. G. Bradley. 1993. Lumbosacral radiculoplexopathy as a manifestation of Epstein-Barr virus infection. Neurology 43: 2550 2554.
149. Shian, W. J.,, and C. S. Chi. 1996. Epstein-Barr virus encephalitis and encephalomyelitis: MR findings. Pediatr. Radiol. 26: 690 693.
150. Shoji, H.,, T. Kusuhara,, Y. Honda,, K. Kojima,, T. Abe,, and M. Watanabe. 1992. Relapsing acute disseminated encephalomyelitis associated with chronic Epstein-Barr virus infection: MRI findings. Neuroradiology 34: 340 342.
151. Silverstein, A.,, G. Steinberg,, and M. Nathanson. 1972. Nervous system involvement in infectious mononucleosis. The heralding and/or major manifestation. Arch. Neurol. 26: 353 358.
152. Simila, S.,, R. Jouppila,, A. Salmi,, and R. Pohionen. 1970. En-cephalomeningitis in children associated with an adenovirus Type 7 epidemic. Acta Pediatr. Scand. 59: 310 316.
153. Skaff, P. T.,, and D. M. Labiner. 2001. Status epilepticus due to human parvovirus B-19 in an immunocompetent adult. Neurology 57: 1336 1337.
154. Staud, R.,, R. A. Davidson,, and L. C. Corman. 1995. Brachial plexitis in a patient with acute parvovirus B-19 infection. Br. J. Rheumat. 34: 480 481.
155. Suga, S.,, T. Yoshikawa,, Y. Asano,, T. Kozawa,, T. Nakashima,, I. Kobayashi,, T. Yazaki,, M. Yamamoto,, Y. Kajita,, T. Ozaki,, Y. Nishimura,, T. Yamanaka,, A. Yamada,, and J. Imanishi. 1993. Clinical and virological analyses of 21 infants with ex-anthem subitum (roseola infantum) and central nervous system complications. Ann. Neurol. 33: 597 603.
156. Suga, S.,, K. Suzuki,, M. Ihira,, T. Yoshikawa,, Y. Kajita,, T. Ozaki,, K. Iida,, Y. Saito,, and Y. Asano. 2000. Clinical characteristics of febrile convulsions during primary HHV-6 infection. Arch. Dis. Child. 82: 62 66.
157. Sugita, K.,, M. Ando,, K. Minamitani,, H. Miyamoto,, and H. Niimi. 1991. Magnetic resonance imaging in a case of mumps post infectious encephalitis with asymptomatic optic neuritis. Eur.J. Pediatr. 150: 773 775.
158. Sutton, R. N. P.,, H. J. M. Pullen,, P. Blackledge,, E. H. Brown,, L. Sinclair,, and P. N. Swift. 1976. Adenovirus Type 7; 1971-4. Lancet ii: 987 991.
159. Sworn, M. J.,, and H. Urich. 1972. Acute encephalitis in infectious mononucleosis. J. Pathol. 100: 201 205.
160. Tabak, E.,, A. Mert,, R. Ozturk,, V. Koksal,, I. Akbas,, and Y. Aktuglu. 1999. Prolonged fever caused by parvovirus B-19-induced meningitis: case report and review. Clin. Infect. Dis. 29: 446 447.
161. Tabor, E. 1987. Guillain-Barre syndrome and other neurologic syndromes in hepatitis A, B, and non-A, non-B. J. Med. Virol. 21: 207 216.
162. Taylor, F. B.,, and W. E. Toreson. 1963. Primary mumps meningoencephalitis. Arch. Intern. Med. 112: 216 221.
163. Tembl, J. I.,, J. M. Ferrer,, M. T. Sevilla,, A. Lago,, F. Mayordomo,, and J. J. Vilchez. 1999. Neurologic complications associated with hepatitis C virus infection. J. Clin. Gastroenterol. 24: 40 42.
164. Tiacci, E.,, M. Luppi,, P. Barozzi,, G. Gurdo,, A. Tabilio,, S. Ballanti,, G. Torelli,, and E. Aversa. 2000. Fatal herpesvirus-6 encephalitis in a recipient of a T-cell-depleted peripheral blood stem cell transplant from a 3-loci mismatched related donor. Haematologica 85: 94 97.
165. Timmons, G. D.,, and K. P. Johnson. 1970. Aqueductal stenosis and hydrocephalus after mumps encephalitis. N. Engl. J. Med. 283: 1505 1507.
166. Tolly, T. L.,, R. G. Wells,, and J. R. Sty. 1989. MR features of fleeting CNS lesions associated with Epstein-Barr virus infection. J. Comput. Assist. Tomogr. 20: 1027 1029.
167. Tselis, A. Epstein-Barr virus and the nervous system. In A. Nath and J. Berger (ed.), Clinical Neurovirology. Marcel Dekker, New York, N.Y., in press.
168. Tselis, A.,, R. Duman,, G. A. Storch,, and R. P. Lisak. 1997. Epstein-Barr virus encephalomyelitis diagnosed by polymerase chain reaction: detection of genome in the CSF. Neurology 48: 1351 1355.
169. Uesugi, H.,, H. Shimizu,, T. Maehara,, N. Arai,, and H. Nakayama. 2000. Presence of human herpesvirus 6 and herpes simplex virus detected by polymerase chain reaction in surgical tissue from temporal lobe epileptic patients. Psychiatry Clin. Neurosci. 54: 589 593.
170. Ushijima, H.,, K. Bosu,, T. Abe,, and T. Shinozaki. 1986. Suspected Rotavirus encephalitis. Arch. Dis. Child. 61: 692 694.
171. Vandvik, B.,, E. Norrby,, J. Steen-Johnsen,, and K. Stensvold. 1978. Mumps meningitis: prolonged pleocytosis and occurrence of mumps virus-specific oligoclonal IgG in the cerebrospinal fluid. Eur. Neurol. 17: 13 22.
172. Verma, A.,, and B. Brozman. 2002. Opsoclonus-myoclonus syndrome following Epstein Barr virus infection. Neurology 58: 1131 1132.
173. Wagner, M.,, J. Muller-Berghaus,, R. Schroeder,, S. Sollberg,, J. Luka,, N. Leyssens,, B. Schneider,, and G. R. Krueger. 1997. Human herpesvirus-6 (HHV-6)-associated necrotizing encephalitis in Griscelli's syndrome. J. Med. Virol. 53: 306 312.
174. Wainwright, M. S.,, P. L. Martin,, R. P. Morse,, M. Lacaze,, J. M. Provenzale,, R. E. Cdeman,, M. A. Morgan,, C. Hulette,, J. Kurtzberg,, C. Bushneil,, L. Epstein,, and D. V. Lewis. 2001. Human herpes 6 limbic encephalitis after stem cell transplantation. Ann. Neurol. 50: 612 619.
175. Walsh, F. C.,, C. M. Poser,, and S. Carter. 1954. Infectious mononucleosis encephalitis. Pediatrics 13: 536 543.
176. Wang, J.,, K. Huff,, R. McMasters,, and M. E. Cornford. 1999. Sudden unexpected death associated with HHV-6 in an adolescent with tuberous sclerosis. Pediatr. Neurol. 21: 488 491.
177. Watanabe, T.,, M. Satoh,, and Y. Oda. 1994. Human parvovirus B-19 encephalopathy. Arch. Dis. Child. 70: 71.
178. Weinberg, A.,, S. Li,, M. Palmer,, and K. L. Tyler. 2002. Quantitative PCR in Epstein-Barr virus infections of the central nervous system. Ann. Neurol. 52: 543 548.
179. West, T. E.,, C. J. Papsian,, B. H. Park,, and S. W. Parker. 1985. Adenovirus type 2 encephalitis and concurrent Epstein-Barr virus infection in an adult man. Arch. Neurol. 42: 815 817.
180. Wierenga, K. J. J.,, B. E. Serjeant,, and G. R. Serjeant. 2001. Cerebrovascular complications and parvovirus infection in homozygous sickle cell disease. J. Pediatr. 139: 438 442.
181. World Health Organization. 2001. Mumps virus vaccines. WHO position paper. Wkly. Epidemiol. Rec. 76: 346355.
182. Xie, J.,, Y. Cai,, and L. E. Davis. 1998. Guillain-Barre syndrome and Hepatitis A: lack of association during a major epidemic. Ann. Neurol. 24: 697 698.
183. Yahr, M. D.,, and A. T. Frontera. 1975. Acute autonomic neuropathy. Its occurrence in infectious mononucleosis. Arch. Neurol. 32: 132 133.
184. Yamadera, S.,, K. Yamashita,, M. Akatsuka,, N. Kato,, and S. Inouye. 1998. Trend of adenovirus type 7 infection, an emerging disease in Japan. Jpn. J. Med. Sci. Biol. 51: 43 51.
185. Yamanishi, K.,, T. Okuno,, K. Shiraki,, M. Takahashi,, T. Kondo,, Y. Asano,, and T. Kurata. 1988. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet 1: 1065 1067.
186. Yoshida, A.,, T. Kawamitu,, R. Tanaka,, M. Okumura,, S. Yamakura,, Y. Takasaki,, H. Hiramatsu,, T. Momoi,, M. Lizuka,, and S. Nakagomi. 1995. Rotavirus encephalitis: detection of the virus genomic RNA in the cerebrospinal fluid of a child. Pediatr. Infect. Dis. J. 14: 914 916.
187. Yoto, Y.,, T. Kudoh,, K. Haseyama,, and H. Tsutsumi. 2001. Human parvovirus B-19 and meningoencephalitis. Lancet 358: 2168.
188. Zagardo, M. T.,, C. B. Shanholtz,, G. H. Zoarski,, and M. I. Rothman. 1998. Rhombencephalitis caused by adenovirus: MR imaging appearance. Am J. Neuroradiol. 19: 1901 1903.


Generic image for table

Representative viral exanthems and encephalitis/encephalopathy

Citation: Booss J, Esiri M. 2003. 5 Systemic Viral Diseases and Encephalitis, p 61-80. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch5
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Neurological disorders attributed to HHV-6

Citation: Booss J, Esiri M. 2003. 5 Systemic Viral Diseases and Encephalitis, p 61-80. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch5
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Presence of parotitis in mumps encephalitis at time of CNS complications a

Citation: Booss J, Esiri M. 2003. 5 Systemic Viral Diseases and Encephalitis, p 61-80. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch5
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Neurological complications and associations with EBV a

Citation: Booss J, Esiri M. 2003. 5 Systemic Viral Diseases and Encephalitis, p 61-80. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch5
Generic image for table

Comparison of hepatitis viruses a

Citation: Booss J, Esiri M. 2003. 5 Systemic Viral Diseases and Encephalitis, p 61-80. In Viral Encephalitis in Humans. ASM Press, Washington, DC. doi: 10.1128/9781555817831.ch5

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