4 : Epidemiology and Infection of Natural Animal Hosts

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This chapter presents the current knowledge available on classical and subclinical cases of natural Borna disease and cases of Borna-like disease in several animal species in different geographical regions. The clinical manifestations and pathological findings in naturally Borna disease virus (BDV)-infected horses and sheep are almost the same. The clinical and pathological manifestations in these animals are summarized and compared with those of other animals such as cattle, dogs, cats, and ostriches. Generally, the pathological findings after BDV infection in naturally infected horses and sheep are similar to those in experimentally infected animals such as rats. They are usually restricted to the central nervous system (CNS), spinal cord, and retina. Asymptomatic infection in horses seems to be more frequent than expected, based on the detection of antiviral antibodies in sera as well as viral nucleic acid in tissue samples. Although several groups have detected BDV nucleic acid in peripheral blood mononuclear cells (PBMCs) by nested RT-PCR, it is still not clear whether, during the course of infection in naturally BDV-infected animals, there is a period of viremia. Serum antibodies to BDV have been detected in cattle by Immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA).

Citation: Ikuta, Hagiwara K, Taniyama H, Nowotny N. 2002. Epidemiology and Infection of Natural Animal Hosts, p 87-123. In Carbone K (ed), Borna Disease Virus and Its Role in Neurobehavioral Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817909.ch4
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Figure 1.

Nonsuppurative encephalitis in the olfactory bulb from a horse (A) and the frontal lobe from a bovine naturally infected with BDV (B). The neurological lesions are characterized by perivascular cuffing and mononuclear cell infiltration. Hematoxylin and eosin stain was used. Magnifications, ×12 (A) and ×6 (B).

Citation: Ikuta, Hagiwara K, Taniyama H, Nowotny N. 2002. Epidemiology and Infection of Natural Animal Hosts, p 87-123. In Carbone K (ed), Borna Disease Virus and Its Role in Neurobehavioral Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817909.ch4
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1. Ashash, E.,, M. Malkinson,, R. Meir,, S. Perl,, and Y. Weisman. 1996. Causes of losses including a Borna disease paralytic syndrome affecting young ostriches of one breeding organization over a five-year period (1989-1993). Avian Dis. 40: 240 245.
2. Bahmani, M. K.,, I. Nowrouzian,, T. Nakaya,, Y. Nakamura,, K. Hagiwara,, H. Takahashi,, M. A. Rad,, and K. Ikuta. 1996. Varied prevalence of Borna disease virus infection in Arabic, thoroughbred and their cross-bred horses in Iran. Virus Res. 45: 1 13.
3. Becht, H.,, and J. A. Richt,. 1996. Borna disease, p. 235 244. In M. J. Studdert (ed.), Virus Infections of Equines. Elsevier Science Publishers BV, Amsterdam, The Netherlands.
4. Beck, A.,, and H. Frohöse. 1926. Die enzootische Encephalitis des Schafes. Vergleichende experimentelle Untersuchungen üer die seuchenhafte Gehirnrückenmarksentzundung der Pferde und Schafe. Schweiz. Arch. Tierheilkd. 54: 84 110.
5. Berg, A.-L.,, and M. Berg. 1998. A variant form of feline Borna disease. J. Comp. Pathol. 119: 323 331.
6. Berg, A.-L.,, R. Dorries,, and M. Berg. 1999. Borna disease virus infection in racing horses with behavioral and movement disorders. Arch. Virol. 144: 547 559.
7. Berg, A.-L.,, R. Reid-Smith,, M. Larsson,, and B. Bonnett. 1998. Case control study of feline Borna disease in Sweden. Vet. Rec. 142: 715 717.
8. Bilzer, T.,, A. Grabner,, and L. Stitz. 1996. Immunopathologie der Borna-Krankheit beim Pferd: klinische, virologische und neuropathologische Befunde. Tieraerztl. Prax. 24: 567 576.
9. Bilzer, T.,, O. Planz,, W. I. Lipkin,, and L. Stitz. 1995. Presence of CD4 + and CD8 + T cells and expression of MHC class I and MHC class II antigen in horses with Borna disease virus-induced encephalitis. Brain Pathol. 5: 223 230.
10. Bilzer, T.,, and L. Stitz. 1996. Immunopathogenesis of virus diseases affecting the central nervous system. Crit. Rev. Immunol. 16: 145 222.
11. Binz, T.,, J. Lebelt,, H. Niemann,, and K. Hagenau. 1994. Sequence analyses of the P gene of Borna disease virus in naturally infected horse, donkey and sheep. Virus Res. 34: 281 289.
12. Bode, L.,, R. Dürrwald,, P. Koeppel,, and H. Ludwig. 1994a. Neue Aspekte der equinen Borna- Virus-Infektion mit und ohne Krankheit. Prakt. Tierarzt 75: 1065 1068.
13. Bode, L.,, R. Dürrwald,, and H. Ludwig. 1994b. Borna virus infections in cattle associated with fatal neurological disease. Vet. Rec. 135: 283 284.
14. Bode, L.,, and H. Ludwig. 1997. Clinical similarities and close genetic relationship of human and animal Borna disease virus. Arch. Virol. 13(Suppl.): 167 182.
15. Borland, R.,, and N. McDonald. 1965. Feline encephalomyelitis. Br. Vet. J. 121: 479 483.
16. Boucher, J.-M.,, E. Barbillon,, and F. Cliquet. 1999. Borna disease: a possible emerging zoonosis. Vet. Res. 30: 549 557.
17. Caplazi, P.,, and F. Ehrensperger. 1998. Spontaneous Borna disease in sheep and horses: immunophenotyping of inflammatory cells and detection of MHC-I and MHC-II antigen expression in Borna encephalitis lesions. Vet. Immunol. Immunopathol. 61: 203 220.
18. Caplazi, P.,, K. Melzer,, R. Goetzmann,, A. Rohner-Cotti,, V. Bracher,, K. Zlinszky,, and F. Ehrensperger. 1999. Borna disease in Switzerland and in the principality of Liechtenstein. Schweiz. Arch. Tierheilkd. 141: 521 527.
19. Caplazi, P.,, A. Waldvogel,, L. Stitz,, U. Braun,, and F. Ehrensperger. 1994. Borna disease in naturally infected cattle. J. Comp. Pathol. 111: 65 72.
20. Danner, K. 1978. Bornasche Krankheit. Prakt. Tierarzt 59: 748 752.
21. Danner, K. 1982. Borna-Virus und Borna-Infektionen: vom Miasma zum Modell. Enke Copythek, Stuttgart, Germany.
22. Daubney, R.,, and E. A. Mahlau. 1967. Viral encephalomyelitis of equines and domestic ruminants in the Near East. I. Res. Vet. Sci. 8: 375 397.
23. Degiorgis, M.-P.,, A.-L. Berg,, C. Hård AfSegerstad,, T. Mörner,, M. Johansson,, and M. Berg. 2000. Borna disease in a free-ranging lynx ( Lynx lynx). J. Clin. Microbiol. 38: 3087 3091.
24. Deschl, U.,, L. Stitz,, S. Herzog,, K. Frese,, and R. Rott. 1990. Determination of immune cells and expression of major histocompatibility complex class II antigen in encephalitic lesions of experimental Borna disease. Acta Neuropathol. 81: 41 50.
25. Dürrwald, R. 1993. Die natürliche Borna-Virus-Infektion der Einhufer und Schafe. Untersuchungen zur Epidemiologie, zu neueren diagnostischen Methoden (ELISA, PCR) und zur Antikörperkinetik bel Pferden nach Vakzination mit Lebendimpfstoff. Inaugural dissertation. Freie Universität Berlin, Berlin, Germany.
26. Dürrwald, R.,, and H. Ludwig. 1997. Borna disease virus (BDV), a (zoonotic?) worldwide pathogen. A review of the history of the disease and the virus infection with comprehensive bibliography. J. Vet. Med. B 44: 147 184.
27. Ernst, W.,, and H. Hahn. 1927. Weitere Beiträge zur Borna’schen Krankheit der Pferde und zur Frage der Aetiologie des bösartgen Katarrhalfiebers der Rinder. Muench. Tieraerztl. Wochenschr. 78: 85 89.
28. Fechner, J., 1964. Impfung gegen die Bornasche Krankheit (Seuchenhafte Gehirn-Rückenmark- Entzündung), p. 208 214. In J. Fechner (ed.), Schutzimpfungen bei Haustieren. Hirzel, Leipzig, Germany.
29. Frankhouser, R. 1961. Sporadische Meningo-Encephalomyelitis beim Rind. Schweiz. Arch. Tierheilkd. 103: 225 235.
30. GonzalezDunia, D.,, C. Sauder,, and J. C. de la Torre. 1997. Borna disease virus and the brain. Brain Res. Bull. 44: 647 664.
31. Gosztonyi, G.,, and H. Ludwig. 1984. Borna disease of horse. An immunohistological and virological study of naturally infected animals. Acta Neuropathol. (Berlin) 64: 213 221.
32. Grabner, A.,, and A. Fischer. 1991. Symptomatology and diagnosis of Borna encephalitis of horses. A case analysis of the last 13 years. Tieraerztl. Prax. 19: 68 73.
33. Hagiwara, K.,, M. Asakawa,, L. Liao,, W. Jiang,, S. Yan,, J.-J. Chai,, Y. Oku,, K. Ikuta,, and M. Ito. 2001. Seroprevalence of Borna disease virus in domestic animals in Xinjiang, China. Vet. Microbiol. 80: 383 389.
34. Hagiwara, K.,, W. Kamitani,, S. Takamura,, H. Taniyama,, T. Nakaya,, H. Tanaka,, R. Kirisawa,, H. Iwai,, and K. Ikuta. 2000. Detection of Borna disease virus in a pregnant mare and her fetus. Vet. Microbiol. 72: 207 216.
35. Hagiwara, K.,, S. Kawamoto,, H. Takahashi,, Y. Nakamura,, T. Nakaya,, T. Hiramune,, C. Ishihara,, and K. Ikuta. 1997a. High prevalence of Borna disease virus infection in healthy sheep in Japan. Clin. Diagn. Lab. Immunol. 4: 339 344.
36. Hagiwara, K.,, N. Momiyama,, H. Taniyama,, T. Nakaya,, N. Tsunoda,, C. Ishihara,, and K. Ikuta. 1997b. Demonstration of Borna disease virus (BDV) in specific regions of the brain from horses positive for serum antibodies to BDV but negative for BDV RNA in the blood and internal organs. Med. Microbiol. Immunol. 186: 19 24.
37. Hagiwara, K.,, T. Nakaya,, Y. Nakamura,, S. Asahi,, H. Takahashi,, C. Ishihara,, and K. Ikuta. 1996. Borna disease virus RNA in peripheral blood mononuclear cells obtained from healthy dairy cattle. Med. Microbiol. Immunol. 185: 145 151.
38. Hagiwara, K.,, M. Okamoto,, W. Kamitani,, S. Takamura,, H. Taniyama,, N. Tsunoda,, H. Tanaka,, H. Iwai,, and K. Ikuta. 2002. Nosological study of Borna disease virus infection in race horses. Vet. Microbiol. 84: 367 374.
39. Hatalski, C. G.,, A. L. Lewis,, and W. I. Lipkin. 1997. Borna disease. Emerg. Infect. Dis. 3: 129 135.
40. Heinig, A., 1969. Die Bornasche Krankheit der Pferde und Schafe, p. 83 148. In H. Roehrer (ed.), Handbuch der Virusinfektionen bei Tieren , vol. 4. VEB Fischer Verlag, Jena, Germany.
41. Herden, C.,, S. Herzog,, T. Wehner,, C. Zink,, J. A. Richt,, and K. Frese. 1999. Comparison of different methods of diagnosing Borna disease in horses post mortem. Equine Infect. Dis. 8: 286 290.
42. Herzog, S.,, K. Frese,, J. A. Richt,, and R. Rott. 1994. Ein Beitrag zur Epizootiologie der Bornaschen Krankheit des Pferdes. Wien. Tieraerztl. Monschr. 81: 374 379.
43. Herzog, S.,, I. Pfeuffer,, K. Haberzettl,, H. Feldmann,, K. Frese,, K. Bechter,, and J. A. Richt. 1997. Molecular characterization of Borna disease virus from naturally infected animals and possible links to human disorders. Arch. Virol. 13(Suppl.): 183 190.
44. Hiepe, T. 1960. Die Bedeutung der Liquoruntersuchung für die Neurodiagnostik bei Pferd und Schaf. Zentbl. Vetmed. 7: 152 159.
45. Hoff, E. J.,, and M. Vandevelde. 1981. Non-suppurative encephalomyelitis in cats suggestive of a viral origin. Vet. Pathol. 18: 170 180.
46. Ihlenburg, H. 1962. Zur Therapie der Bornaschen Krankheit. Monatsh. Vetmed. 17: 151 156.
47. Jordan, I.,, and W. I. Lipkin. 2001. Borna disease virus. Rev. Med. Virol. 11: 37 57.
48. Kacza, J.,, T. W. Vahlenkamp,, H. Enbergs,, J. A. Richt,, A. Germer,, H. Kuhrt,, A. Reichenbach,, H. Müller,, C. Herden,, T. Stahl,, and J. Seeger. 2000. Neuron-glia interactions in the rat retina infected by Borna disease virus. Arch. Virol. 145: 127 147.
49. Kao, M.,, A. N. Hamir,, C. E. Rupprecht,, Z. F. Fu,, V. Shanker,, H. Koprowski,, and B. Dietzschold. 1993. Detection of antibodies against Borna disease virus in sera and cerebrospinal fluid of horses in the USA. Vet. Rec. 132: 241 244.
50. Katz, J. B.,, D. Alstad,, A. L. Jenny,, K. M. Carbone,, S. A. Rubin,, and R. W. Waltrip II. 1998. Clinical, serologic, and histopathologic characterization of experimental Borna disease in ponies. J. Vet. Diagn. Investig. 10: 338 343.
51. Khan, M. A.,, K. Yamaguchi,, H. Miyata,, A. Kazi,, T. Kamahora,, and S. Hino. 2000. Prevalence of anti-Borna disease virus antibody in horses and their caretakers in Bangladesh. Yonago Acta Med. 43: 59 67.
52. Korber, B. T.,, K. J. Kunstman,, B. K. Patterson,, M. Furtado,, M. M. McEvilly,, and R. Levy. 1994. Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences. J. Virol. 68: 7467 7481.
53. Krey, H. F.,, H. Ludwig,, and C. B. Boschek. 1979a. Multifocal retinopathy in Borna disease virus infected rabbits. Am. J. Ophthalmol. 87: 157 164.
54. Krey, H. F.,, H. Ludwig,, and R. Rott. 1979b. Spread of infectious virus along the optic nerve into the retina in Borna disease virus-infected rabbits. Arch. Virol. 61: 283 288.
55. Krey, H. F.,, L. Stitz,, and H. Ludwig. 1982. Virus-induced pigment epithelitis in rhesus monkeys. Clinical and histological findings. Ophthalmologica (Basel) 185: 205 213.
56. Kronevi, T.,, M. Nordström,, W. Moreno,, and P. O. Nilsson. 1974. Feline ataxia due to nonsuppurative meningoencephalomyelitis of unknown aetiology. Nord. Vet. Med. 26: 720 725.
57. Lange, H.,, S. Herzog,, W. Herbst,, and T. Schliesser. 1987. Seroepidemiologische Untersuchungen zur Bornaschen Krankheit (Ansteckende Gehirn-Rückenmarkentzündung) der Pferde. Tieraerztl. Umsch. 42: 938 946.
58. Lebelt, J.,, and K. Hagenau. 1996. Die Verteilung des Bornavirus in natürlich infizierten Tieren mit klinischer Erkrankung. Berl. Muench. Tieraerztl. Wochenschr. 109: 178 183.
59. Ludwig, H.,, L. Bode,, and G. Gosztonyi. 1988. Borna disease: a persistent virus infection of the central nervous system. Prog. Med. Virol. 35: 107 151.
60. Ludwig, H.,, K. Furuya,, L. Bode,, N. Klein,, and R. Dürrwald. 1993. Biology and neurobiology of Borna disease viruses (BDV), defined by antibodies, neutralizability and their pathogenic potential. Arch. Virol. 7(Suppl.): 111 133.
61. Ludwig, H.,, W. Kraft,, M. Kao,, G. Gosztony,, E. Dahme,, and H. Krey. 1985. Borna-Virus-Infektion (Borna-Krankheit) bei natürlich und experimentell infizierten Tieren: ihre Bedeutung für Forschung und Praxis. Tieraerztl. Prax. 13: 421 453.
62. Ludwig, H.,, and P. Thein. 1977. Demonstration of specific antibodies in the central nervous system of horses naturally infected with Borna disease virus. Med. Microbiol. Immunol. 163: 215 226.
63. Lundgren, A.-L. 1992. Feline non-suppurative meningoencephalomyelitis: a clinical and pathological study. J. Comp. Pathol. 107: 411 425.
64. Lundgren, A.-L.,, G. Czech,, L. Bode,, and H. Ludwig. 1993. Natural Borna disease in domestic animals other than horses and sheep. Zentbl. Vetmed. Reihe B 40: 298 303.
65. Lundgren, A.-L.,, A. Johannisson,, W. Zimmermann,, L. Bode,, B. Rozell,, A. Muluneh,, R. Lindberg,, and H. Ludwig. 1997. Neurological disease and encephalitis in cats experimentally infected with Borna disease virus. Acta Neuropathol. (Berlin) 93: 391 401.
66. Lundgren, A.-L.,, R. Lindberg,, H. Ludwig,, and G. Gosztony. 1995a. Immunoreactivity of the central nervous system in cats with a Borna disease-like meningoencephalomyelitis (staggering disease). Acta Neuropathol. (Berlin) 90: 184 193.
67. Lundgren, A.-L.,, and H. Ludwig. 1993. Clinically diseased cats with non-suppurative meningoencephalomyelitis have Borna disease virus-specific antibodies. Acta Vet. Scand. 34: 101 103.
68. Lundgren, A.-L.,, W. Zimmermann,, L. Bode,, G. Czech,, G. Gosztonyi,, R. Lindberg,, and H. Ludwig. 1995b. Staggering disease in cats: isolation and characterization of the feline Borna disease virus. J. Gen. Virol. 76: 2215 2222.
69. Malkinson, M.,, Y. Weisman,, E. Ashash,, L. Bode,, and H. Ludwig. 1993. Borna disease in ostriches. Vet. Rec. 133: 304.
70. Malkinson, M.,, Y. Weisman,, S. Perl,, and E. Ashash. 1995. A Borna-like disease of ostriches in Israel. Curr. Top. Microbiol. Immunol. 190: 31 38.
71. Martin, L.-A.,, and J. Hintermann. 1952. Sur l’existence, au Maroc, d’une maladie contagieuse du chat, non encore décrite: la myélite infectieuse. Bull. Acad. Vet. Fr. 25: 387 392.
72. Matthias, D. 1954. Der Nachweis von latent infizierten Pferden, Schafen und Rindern und deren Bedeutung als Virusreservoir bei der Bornaschen Krankheit. Arch. Exp. Vet. Med. 8: 506 511.
73. Mayr, A.,, and K. Danner. 1974. Persistent infections caused by Borna virus. Infection 2: 64 69.
74. Metzler, A., , Ehrensperger, F., , and R. Wyler. 1978. Natürliche Bornavirus-Infektion bei Kaninchen. Zentbl. Vetmed. Reihe B 25: 161 164.
75. Metzler, A.,, U. Frei,, and K. Danner. 1976. Virologically confirmed outbreak of Borna’s disease in a Swiss herd of sheep. Schweiz. Arch. Tierheilkd. 118: 483 492.
76. Metzler, A.,, H.-P. Minder,, X. Wegmann,, and W. Zindel. 1979. Die Borna’sche Krankheit, ein veterinärmedizinisches Problem von regionaler Bedeutung. Schweiz. Arch. Tierheilkd. 121: 207 213.
77. Möhlmann, H.,, and A. Maas. 1960. Wertigkeitsprüfung des Borna-Trockenimpfstoffes “Dessau” bei Pferden unter den Verhältnissen der Praxis. Arch. Exp. Vet. Med. 14: 1267 1280.
78. Monken, C. E.,, B. Wu,, and A. Srinivasan. 1995. High resolution analysis of HIV-1 quasispecies in the brain. AIDS 9: 345 349.
79. Morales, J. A.,, S. Herzog,, C. Kompter,, K. Frese,, and R. Rott. 1998. Axonal transport of Borna disease virus along olfactory pathways in spontaneously and experimentally infected rats. Med. Microbiol. Immunol. 177: 51 68.
80. Müller, L. F.,, and R. Fritzsch. 1955. Die Augenveränderungen bei der Bornaschen Krankheit. Wien. Tieraerztl. Monschr. 42: 866 871.
81. Nakamura, Y.,, S. Asahi,, T. Nakaya,, M. K. Bahmani,, S. Saito,, K. Yasui,, H. Mayama,, K. Hagiwara,, C. Ishihara,, and K. Ikuta. 1996. Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from domestic cats in Japan. J. Clin. Microbiol. 34: 188 191.
82. Nakamura, Y.,, M. Kishi,, T. Nakaya,, S. Asahi,, S. Tanaka,, H. Sentsui,, K. Ikeda,, and K. Ikuta. 1995. Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells from healthy horses in Japan. Vaccine 13: 1076 1079.
83. Nakamura, Y.,, M. Watanabe,, W. Kamitani,, H. Taniyama,, T. Nakaya,, Y. Nishimura,, H. Tsujimoto,, S. Machida,, and K. Ikuta. 1999. High prevalence of Borna disease virus in domestic cats with neurological disorders in Japan. Vet. Microbiol. 70: 153 169.
84. Narayan, O.,, S. Herzog,, K. Frese,, H. Scheefers,, and R. Rott. 1983. Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities. J. Infect. Dis. 148: 305 315.
85. Nicolau, S.,, and I. A. Galloway. 1928. Borna disease and enzootic encephalomyelitis of sheep and cattle. Spec. Rep. Ser. Med. Res. Council 121: 7 90.
86. Nishino, Y.,, M. Funaba,, R. Fukushima,, T. Mizutani,, T. Kimura,, R. Iizuka,, H. Hirami,, and M. Hara. 1999. Borna disease virus infection in domestic cats: evaluation by RNA and antibody detection. J. Vet. Med. Sci. 61: 1167 1170.
87. Nöske, K.,, T. Bilzer,, O. Planz,, and L. Stitz. 1998. Virus-specific CD4 + T cells eliminate Borna disease virus from the brain via induction of cytotoxic CD8 + T cells. J. Virol. 72: 4387 4395.
88. Nowotny, N.,, and J. Kolodziejek. 2000. Human bornaviruses and laboratory strains. Lancet 355: 1462 1463.
89. Nowotny, N.,, J. Kolodziejek,, C. O., Jehle,, A. Suchy,, P. Staeheli,, and M. Schwemmie. 2000. Isolation and characterization of a new subtype of Borna disease virus. J. Virol. 74: 5655 5658.
90. Nowotny, N.,, and H. Welssenböck. 1995. Description of feline nonsuppurative meningoencephalomyelitis (“staggering disease”) and studies of its etiology. J. Clin. Microbiol. 33: 1668 1669.
91. Okamoto, M.,, H. Furuoka,, K. Hagiwara,, W. Kamitani,, R. Kirisawa,, K. Ikuta,, and H. Taniyama. 2002a. Borna disease in a heifer in Japan. Vet. Rec. 150: 16 18.
92. Okamoto, M.,, Y. Kagawa,, W. Kamitani,, K. Hagiwara,, R. Kirisawa,, H. Iwai,, K. Ikuta,, and H. Taniyama. 2002b. Borna disease in a dog in Japan. J. Comp. Pathol. 126: 312 317.
93. Planz, O.,, and L. Stitz. 1999. Borna disease virus nucleoprotein (N) is a major target for CD8 +-T-cell-mediated immune response. J. Virol. 73: 1715 1718.
94. Reeves, N. A.,, C. R. Helps,, D. A. Gunn-Moore,, C. Blundell,, P. L. Finnermore,, G. R. Pearson,, and D. A. Harbour. 1998. Natural Borna disease virus infection in cats in the United Kingdom. Vet. Rec. 143: 523 526.
95. Richt, J. A.,, A. Grabner,, and S. Herzog. 2000. Borna disease in horses. Vet. Clin. N. Am. Equine Pract. 16: 579 595.
96. Richt, J. A.,, S. Herzog,, K. Haberzetl,, and R. Rott. 1993. Demonstration of Borna disease virus-specific RNA in secretions of naturally infected horses by the polymerase chain reaction. Med. Microbiol. Immunol. 182: 293 304.
97. Richt, J. A.,, S. Herzog,, A. Schmeel,, K. Frese,, and R. Rott. 1994. Current knowledge about Borna disease, p. 55 60. In H. Nakajima and W. Plowright (ed.), Equine Infectious Diseases, vol. VII. R & W Publications, Newmarket, United Kingdom.
98. Richt, J. A.,, I. Pfeuffer,, M. Christ,, K. Frese,, K. Bechter,, and S. Herzog. 1997. Borna disease virus infection in animals and humans. Emerg. Infect. Dis. 3: 343 352.
99. Richt, J. A.,, and R. Rott. 2001. Borna disease virus: a mystery as an emerging zoonotic pathogen. Vet. J. 161: 24 40.
100. Rott, R.,, and H. Becht. 1995. Natural and experimental Borna disease in animals. Borna disease. Curr. Top. Microbiol. Immunol. 190: 17 30.
101. Schmidt, J. 1912. Untersuchungen über das klinische Verhalten der seuchenhaften Gehirn- Rückenmarksentzündung (Bornaschen Krankheit) des Pferdes nebst Angaben über diesbezügliche therapeutische Versuche. Berl. Muench. Tieraerztl. Wochenschr. 28: 581 603.
102. Schmidt, J. 1952. Die Bornakrankheit des Pferdes. 55 Jahre Forschung und Lehre. Arch. Exp. Vet. Med. 6: 177 187.
103. Schneider, P. A.,, T. Briese,, W. Zimmermann,, H. Ludwig,, and W. I. Lipkin. 1994. Sequence conservation in field and experimental isolates of Borna disease virus. J. Virol. 68: 63 68.
104. Schüppel, K.-F.,, J. Kinne,, and M. Reinacher,. 1994. Bornavirus-Antigennachweis bei Alpakas (Lama pacos) sowie bei einen Faultier (Choloepus didactylus) und einem Zwergflusspferd (Choeropsis liberiensis), p. 189 194. In R. R. Hofmann, and R. Ippen (ed.), Verhandlungsbericht XXXVI Internationales Symposium über Erkrankungen von Zootieren.
105. Schüppel, K.-F.,, M. Reinacher,, J. Lebelt,, and D. Kulka,. 1995. Bornasche Krankheit bei Primaten, p. 115 120. In R. R. Hofmann, and R. Ippen (ed.), Verhandlungsbericht XXXVII Internationales Symposium über Erkrankungen von Zootieren.
106. Sierra-Honigmann, A. M.,, S. A. Rubin,, M. G. Estefanous,, R. H. Yolken,, and K. M. Carbone. 1993. Borna disease virus in peripheral blood mononuclear and bone marrow cells of neonatally and chronically infected rats. J. Neuroimmunol. 45: 31 36.
107. Staeheli, P.,, C. Sauder,, J. Hausmann,, F. Ehrensperger,, and M. Schwemmle. 2000. Epidemiology of Borna disease virus. J. Gen. Virol. 81: 2123 2135.
108. Stitz, L.,, T. Bilzer,, J. A. Richt,, and R. Rott. 1993. Pathogenesis of Borna disease. Arch. Virol. 7(Suppl.): 135 151.
109. Stitz, L.,, B. Dietzschold,, and K. M. Carbone. 1995. Immunopathogenesis of Borna disease. Curr. Top. Microbiol. Immunol. 190: 75 92.
110. Ström, B.,, B. Andrén,, and A.-L. Lundgren. 1992. Idiopathic non-suppurative meningoencephalomyelitis (staggering disease) in the Swedish cat: a study of 33 cases. Eur. J. Companion Anim. Pract. 3: 9 13.
111. Suchy, A.,, H. Weissenböck,, P. Caplazi,, S. Herzog,, and N. Nowotny. 2000. Equine Borna disease in Austria: evidence for a new endemic area of the natural disease. Equine Pract. 22: 26 27.
112. Suchy, A.,, H. Weissenböck,, R. Waller,, P. Schmidt,, and N. Nowotny. 1997. Nachweis der Bornaschen Krankheit bei einem Pferd in Österreich. Wien. Tieraerztl. Monschr. 84: 317 321.
113. Takahashi, H.,, T. Nakaya,, Y. Nakamura,, S. Asahi,, Y. Onishi,, K. Ikebuchi,, T. A. Takahashi,, T. Katoh,, S. Sekiguchi,, M. Takazawa,, H. Tanaka,, and K. Ikuta. 1997. Higher prevalence of Borna disease virus infection in blood donors living near thoroughbred horse farms. J. Med. Virol. 52: 330 335.
114. Taniyama, H.,, M. Okamoto,, K. Hirayama,, K. Hagiwara,, K. Kirisawa,, W. Kamitani,, and K. Ikuta. 2001. Equine Borna disease in Japan. Vet. Rec. 148: 480 482.
115. Theil, D.,, R. Fatzer,, I. Schiller,, P. Caplazi,, A. Zurbriggen,, and M. Vandevelde. 1998. Neuropathological and aetiological studies of sporadic non-suppurative meningoencephalomyelitis of cattle. Vet. Rec. 143: 244 249.
116. Tsujimura, K.,, T. Mizutani,, H. Kariwa,, K. Yoshimatsu,, M. Ogino,, Y. Morii,, H. Inagaki,, J. Arikawa,, and I. Takashima. 1999. A serosurvey of Borna disease virus infection in wild rats by a capture ELISA. J. Vet. Med. Sci. 61: 113 117.
117. Vahlenkamp, T. W.,, H. K. Enbergs,, and H. Müller. 2000. Experimental and natural borna disease virus infections: presence of viral RNA in cells of the peripheral blood. Vet. Microbiol. 76: 229 244.
118. Vandervelde, M.,, and K. G. Braund. 1979. Polioencephalomyelitis in cats. Vet. Pathol. 16: 420 427.
119. von Sind, J. B. 1767 and 1781. Der im Feld und auf der Reise geschwind heilende Pferdearzt, welcher einen gründlichen Unterricht von den gewöhnlichsten Krankheiten der Pferde im Feld und auf der Reise wie auch einen auserlesenen Vorrath der nützlichsten und durch die Erfahrung bewährtesten Heilungsmitteln eröffnet, 2nd and 3rd ed. Frankfurt, Germany.
120. Waelchli, R. O.,, F. Ehrensperger,, A. Metzler,, and C. Winder. 1985. Borna disease in a sheep. Vet. Rec. 117: 499 500.
121. Weissenböck, H.,, N. Nowotny,, P. Caplazi,, J. Kolodziejek,, and F. Ehrensperger. 1998a. Borna disease in a dog with lethal meningoencephalitis. J. Clin. Microbiol. 36: 2127 2130.
122. Weissenböck, H.,, N. Nowotny,, and J. Zöher. 1994. Feline meningoencephalomyelitis (“staggering disease”) in Österreich. Wien. Tieraerztl. Monschr. 81: 195 201.
123. Weissenböck, H.,, A. Suchy,, P. Caplazi,, S. Herzog,, and N. Nowotny. 1998b. Borna disease in Austrian horses. Vet. Rec. 143: 21 22.
124. Wörz, J. J. 1858. Die halb-acute Gehirn-Entzündung oder Kopf-Krankheit der Pferde. Ebner & Seubert, Stuttgart, Germany.
125. Yamaguchi, K.,, T. Sawada,, T. Naraki,, R. Igata-Yi,, H. Shiraki,, Y. Horii,, T. Ishii,, K. Ikeda,, N. Asou,, H. Okabe,, M. Mochizuki,, K. Takahashi,, S. Yamada,, K. Kubo,, S. Yashiki,, R. W. Waltrip II,, and K. M. Carbone. 1999. Detection of Borna disease virus-reactive antibodies from patients with psychiatric disorders and from horses by electrochemiluminescence immunoassay. Clin. Diagn. Lab. Immunol. 6: 696 700.
126. Zimmermann, W.,, R. Dürrwald,, and H. Ludwig. 1994. Detection of Borna disease virus RNA in naturally infected animals by a nested polymerase chain reaction. J. Virol. Methods 46: 133 143.
127. Zwick, W., 1939. Bornasche Krankheit und Enzephalomyelitis der Tiere, p. 254 354. In E. Gildenmeister, , E. Haagen, , and O. Waldmann (ed.), Handbuch der Viruskrankheiten, vol. 2. Fischer, Jena, Germany.
128. Zwick, W.,, O. Seifried,, and J. Witte. 1927. Experimentelle Untersuchungen über die seuchenhafte Gehim-und Rückenmarksentzündung der Pferde (Bornasche Krankheit). Z. Infektkrankh. Parasitare Krankh. Hyg. Haustiere 30: 42 136.
129. Zwick, W.,, and J. Witte. 1932. Zur Frage der Schutzimpfung und der Inkubationfrist bei der Bornaschen Krankheit. Schweiz. Arch. Tierheilkd. 64: 116 124.


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Table 1.

Clinical and pathological manifestations of Borna disease in several natural animal species

Citation: Ikuta, Hagiwara K, Taniyama H, Nowotny N. 2002. Epidemiology and Infection of Natural Animal Hosts, p 87-123. In Carbone K (ed), Borna Disease Virus and Its Role in Neurobehavioral Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817909.ch4
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Table 2.

Anti-BDV antibodies in naturally infected animals in different geographic areas

Citation: Ikuta, Hagiwara K, Taniyama H, Nowotny N. 2002. Epidemiology and Infection of Natural Animal Hosts, p 87-123. In Carbone K (ed), Borna Disease Virus and Its Role in Neurobehavioral Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817909.ch4
Generic image for table
Table 3.

BDV RNA or proteins in naturally infected animals in different geographic areas

Citation: Ikuta, Hagiwara K, Taniyama H, Nowotny N. 2002. Epidemiology and Infection of Natural Animal Hosts, p 87-123. In Carbone K (ed), Borna Disease Virus and Its Role in Neurobehavioral Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817909.ch4

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