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Chapter 22 : Picornavirus Genetics: an Overview

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Abstract:

This chapter overviews the mechanisms underlying the stability and especially the variability of the picornavirus phenotype and genotype. It also talks about the principles of genetic analysis of viral functions and of manipulations with the viral genome. The pathogenic potential of picornaviruses may vary in two respects: (i) viral variants may be more or less virulent, in the sense that different doses of a virus are required to inflict similar clinical signs (at the extreme, even the highest possible dose may fail to produce any signs); and (ii) the variants may cause different clinical patterns. The picornavirus RNA polymerase, like analogous enzymes of other RNA viruses, lacks the ability to remove the erroneously incorporated nucleotide (the proofreading activity), characteristic of many DNA polymerases. Viral RNA rearrangements of any kind (recombination, deletions, insertions) may contribute to genome plasticity and evolution. There are two general approaches to linking specific phenotypic traits to specific genes or their parts: (i) identification of mutations associated with a distinct phenotype, and (ii) observation of phenotypic effects of engineered mutations in specific genes. The current understanding of the mechanisms of picornavirus genome variability and stability is rather superficial and limited.

Citation: Agol V. 2002. Picornavirus Genetics: an Overview, p 269-284. In Semler B, Wimmer E (ed), Molecular Biology of Picornavirus. ASM Press, Washington, DC. doi: 10.1128/9781555817916.ch22

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FIGURE 1

Two modes of recombination between RNA genomes. In the replicative mode, the synthesis of a nascent strand is started on one parental RNA molecule and is completed on another, due to template switching. Alternatively, fragments of different parental RNA molecules may be covalently joined in a nonreplicative reaction.

Citation: Agol V. 2002. Picornavirus Genetics: an Overview, p 269-284. In Semler B, Wimmer E (ed), Molecular Biology of Picornavirus. ASM Press, Washington, DC. doi: 10.1128/9781555817916.ch22
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Image of FIGURE 2
FIGURE 2

A model showing how heteroduplex formation may facilitate finding the proper anchoring site upon precise replicative recombination. Two homologous RNA molecules may form a heteroduplex through interaction between identical secondary structure elements. As a result, the to-be parting and anchoring sites on these molecules are brought in close proximity.

Citation: Agol V. 2002. Picornavirus Genetics: an Overview, p 269-284. In Semler B, Wimmer E (ed), Molecular Biology of Picornavirus. ASM Press, Washington, DC. doi: 10.1128/9781555817916.ch22
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References

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1. Adam, M. A.,, N. Ramesh,, A. D. Miller,, and W. R. Osborne. 1991. Internal initiation of translation in retroviral vectors carrying Picornavirus 5' nontranslated regions. J. Virol. 65: 4985 4990.
2. Agol, V. I. 1997. Recombination and other genomic rearrangements in picornaviruses. Semin. Virol. 8: 1 9.
3. Agol, V. I.,, G. A. Belov,, E. A. Cherkasova,, E. V. Gavrilin,, M. S. Kolesnikova,, L. I. Romanova,, and E. A. Tolskaya. 2001. Some problems of molecular biology of poliovirus infection relevant to pathogenesis and viral spread. Dev. Biol. (Basel) 105: 43 50.
4. Agol, V. I.,, V. P. Grachev,, S. G. Drozdov,, M. S. Kolesnikova,, V. G. Kozlov,, N. M. Ralph,, L. I. Romanova,, E. A. Tolskaya,, A. V. Tyufanov,, and E. G. Viktorova. 1984. Construction and properties of intertypic poliovirus recombinants: first approximation mapping of the major determinants of neurovirulence. Virology 136: 41 55.
5. Agol, V. I.,, A. V. Paul,, and E. Wimmer. 1999. Paradoxes of the replication of picornaviral genomes. Virus Res. 62: 129 147.
6. Agol, V. I.,, and G. A. Shirman. 1964. Interaction of guanidine-sensitive and guanidine-dependent variants of poliovirus in mixedly infected cells. Biochem. Biophys. Res. Commun. 17: 28 33.
7. Agut, H.,, K. M. Kean,, O. Fichot,, J. Morasco,, J. B. Flanegan,, and M. Girard. 1989. A point mutation in the poliovirus polymerase gene determines a complementable temperature-sensitive defect of RNA replication. Virology 168: 302 311.
8. Ahmad, A. L.,, A. B. Dowsett,, and D. A. Tyrrell. 1987. Studies of rhinovirus Resistant to an antiviral chalcone. Antiviral Res. 8: 27 39.
9. Almond, J. W.,, D. Stone,, K. Burke,, M. A. Skinner,, A. J. Macadam,, D. Wood,, M. Ferguson,, and P. D. Minor. 1993. Approaches to the construction of new candidate poliovirus type 3 vaccine strains. Dev. Biol. Stand. 78: 161 169.
10. Andino, R.,, G. E. Rieckhof,, D. Trono,, and D. Baltimore. 1990. Substitutions in the protease (3Cpro) gene of poliovirus can suppress a mutation in the 5? noncoding region. J. Virol. 64: 607 612.
11. Andino, R.,, D. Silvera,, S. D. Suggett,, P. L. Achacoso,, C. J. Miller,, D. Baltimore,, and M. B. Feinberg. 1994. Engineering poliovirus as a vaccine vector for the expression of diverse antigens. Science 265: 1448 1451.
12. Armstrong, C. 1939. Successful transfer of the Lansing strain of poliomyelitis virus from the cotton rat to the white mouse. Public Health Rep. 54: 2302 2305.
13. Arnold, J. J.,, and C. E. Cameron. 1999. Poliovirus RNA-dependent RNA polymerase (3Dpol) is sufficient for template switching in vitro. J. Biol. Chem. 274: 2706 2716.
14. Baltera, R. E., Jr.,, and D. R. Tershak. 1989. Guanidine-resistant mutants of poliovirus have distinct mutations in peptide 2C. J. Virol. 63: 4441 4444.
15. Baranowski, E.,, C. M. Ruiz-Jarabo,, N. Sevilla,, D. An-dreu,, E. Beck,, and E. Domingo. 2000. Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif: flexibility in aphthovirus receptor usage. J. Virol. 74: 1641 1647.
16. Barclay, W.,, Q. Li,, G. Hutchison,, D. Moon,, A. Richardson,, N. Percy,, J. W. Almond,, and D. J. Evans. 1998. Encapsidation studies of poliovirus subgenomic replicons. J. Gen. Virol. 79: 1725 1734.
17. Bell, Y. C.,, B. L. Semler,, and E. Ehrenfeld. 1999. Requirements for RNA replication of a poliovirus replicon by coxsackievirus B3 RNA polymerase. J. Virol. 73: 9413 9421.
18. Beneduce, E.,, G. Pisani,, M. Divizia,, A. Pana,, and G. Morace. 1995. Complete nucleotide sequence of a cytopathic hepatitis A virus strain isolated in Italy. Virus Res. 36: 299 309.
19. Bergstrom, C. T.,, P. McElhany,, and L. A. Real. 1999. Transmission bottlenecks as determinants of virulence in rapidly evolving pathogens. Proc. Natl. Acad. Sci. USA 96: 5095 5100.
20. Bernstein, H. D.,, P. Sarnow,, and D. Baltimore. 1986. Genetic complementation among poliovirus mutants derived from an infectious cDNA clone. J. Virol. 60: 1040 1049.
21. Bernstein, H. D.,, N. Sonenberg,, and D. Baltimore. 1985. Poliovirus mutant that does not selectively inhibit host cell protein synthesis. Mol. Cell. Biol. 5: 2913 2923.
22. Bodian, D.,, L. M. Morgan,, and H. A. Howe. 1949. Differentiation of types of poliomyelitis virus. III. The grouping of fourteen strains into three basic immunological types. Am. J. Hyg. 49: 234 245.
23. Boeyé, U.,, D. Kobasa,, S. Onodera,, G. D. Parks,, A. C. Palmenberg,, and D. G. Scraba. 1991. Characterization of mengo virus neutralization epitopes. Virology 181: 1 13.
24. Boeye, A. 1959. Induction of mutation in poliovirus by nitrous acid. Virology 9: 691 700.
25. Bolwell, C.,, B. E. Clarke,, N. R. Parry,, E. J. Ouldridge,, F. Brown,, and D. J. Rowlands. 1989. Epitope mapping of foot-and-mouth disease virus with neutralizing monoclonal antibodies. J. Gen. Virol. 70: 59 68.
26. Bradley, D. W.,, C. A. Schable,, K. A. McCaustland,, E. H. Cook,, B. L. Murphy,, H. A. Fields,, J. W. Ebert,, C. Wheeler,, and J. E. Maynard. 1984. Hepatitis A virus: growth characteristics of in vivo and in vitro propagated wild and attenuated virus strains. J. Med. Virol. 14: 373 386.
27. Brooksby, J. B. 1958. The virus of foot-and-mouth disease. Adv. Virus Res. 5: 1 37.
28. Bunch, T.,, E. Rieder,, and P. Mason. 1994. Sequence of the S fragment of foot-and-mouth disease virus type A12. Virus Genes 8: 173 175.
29. Burke, K. L.,, D. J. Evans,, O. Jenkins,, J. Meredith,, E. D. D'Souza,, and J. W. Almond. 1989. A cassette vector for the construction of antigen chimaeras of poliovirus. J. Gen. Virol. 70: 2475 2479.
30. Burnet, F. M.,, and J. Macnamara. 1931. Immunological differences between strains of poliomyelitis virus. Br. J. Exp. Pathol. 12: 57 61 (quoted in reference 73).
31. Cammack, N.,, A. Phillips,, G. Dunn,, V. Patel,, and P. D. Minor. 1988. Intertypic genomic rearrangements of poliovirus strains in vaccinees. Virology 167: 507 514.
32. Cao, X.,, and E. Wimmer. 1995. Intragenomic complementation of a 3AB mutant in dicistronic polioviruses. Virology 209: 315 326.
33. Cao, X. M.,, I. E. Bergmann,, and E. Beck. 1991. Comparison of the 5' and 3' untranslated genomic regions of virulent and attenuated foot-and-mouth disease viruses (strains Ol Campos and C3 Resende). J. Gen. Virol. 72: 2821 2825.
34. Chapman, N. M.,, A. Ragland,, J. S. Leser,, K. Hofling,, S. Willian,, B. L. Semler,, and S. Tracy. 2000. A group B coxsackievirus/poliovirus 5' nontranslated region chimera can act as an attenuated vaccine strain in mice. J. Virol. 74: 4047 4056.
35. Chapman, N. M.,, A. I. Ramsingh,, and S. Tracy. 1997. Genetics of coxsackievirus virulence. Curr. Top. Microbiol. 223: 227 258.
36. Charini, W. A.,, C. C. Burns,, E. Ehrenfeld,, and B. L. Semler. 1991. trans rescue of a mutant poliovirus RNA polymerase function. J. Virol. 65: 2655 2665.
37. Charini, W. A.,, S. Todd,, G. A. Gutman,, and B. L. Semler. 1994. Transduction of a human RNA sequence by poliovirus. J. Virol. 68: 6547 6552.
38. Charpentier, N.,, M. Davila,, E. Domingo,, and C. Escarmis. 1996. Long-term, large-population passage of aphthovirus can generate and amplify defective noninterfering particles deleted in the leader protease gene. Virology 223: 10 18.
38a. Cherkasova, E. A.,, E. A. Korotkova,, M. L. Yakovenko,, O. E. Ivanova,, T. P. Eremeeva,, K. M. Chumakov,, and V. I. Agol. 2002. Long-term circulation of vaccine-derived poliovirus that causes paralytic disease. J. Virol. 76: 6791 6799.
39. Chetverin, A. B. 1999. The puzzle of RNA recombination. FEBS Lett. 460: 1 5.
40.> Chetverin, A. B.,, H. V. Chetverina,, A. A. Demidenko,, and V. I. Ugarov. 1997. Nonhomologous RNA recombination in a cell-free system: evidence for a transesterification mechanism guided by secondary structure. Cell 88: 503 513.
41. Cole, C. N.,, and D. Baltimore. 1973. Defective interfering particles of poliovirus. II. Nature of the defect. J. Mol. Biol. 76: 325 343.
42. Cole, C. N.,, D. Smoler,, E. Wimmer,, and D. Baltimore. 1971. Defective interfering particles of poliovirus. I. Isolation and physical properties. J. Virol. 7: 478 485.
43. Colston, E. M.,, and V. R. Racaniello. 1995. Poliovirus variants selected on mutant receptor-expressing cells identify capsid residues that expand receptor recognition. J. Virol. 69: 4823 4829.
44. Colter, J. S.,, H. H. Bird,, A. W. Mover,, and R. A. Brown. 1957. Infectivity of ribonucleic acid isolated from virus infected tissues. Virology 4: 522 532.
45. Cooper, P. D. 1968. A genetic map of poliovirus temperature-sensitive mutants. Virology 35: 584 596.
46. Cooper, P. D. 1977. Genetics of picornaviruses. Comp. Virol. 9: 133 207.
47. Cords, C. E.,, and J. J. Holland. 1964. Interference between enteroviruses and conditions affecting its reversal. Virology 22: 226 234.
48. Cords, C. E.,, and J. J. Holland. 1964. Replication of poliovirus RNA induced by heterologous virus. Proc. Natl. Acad. Sci. USA 51: 1080 1082.
49. Couderc, T.,, J. Hogle,, H. Le Blay,, F. Horaud,, and B. Blondel. 1993. Molecular characterization of mouse-virulent poliovirus type I Mahoney mutants: involvement of residues of polypeptides VP1 and VP2 located on the inner surface of the capsid protein shell. J. Virol. 67: 3808 3817.
49a. Crotty, S.,, C. E. Cameron,, and R. Andino. 2001. RNA virus error catastrophe: direct molecular test by using ribavirin. Proc. Natl. Acad. Sci. USA 98: 6895 6900.
50. Crowell, R. L.,, and B. J. Landau. 1983. Receptors in the initiation of Picornavirus infection. Comp. Virol. 18: 1 43.
51. Curran, J.,, and D. Kolakofsky. 1999. Replication of paramyxoviruses. Adv. Virus Res. 54: 403 422.
52. Day, S. P.,, P. Murphy,, E. A. Brown,, and S. M. Lemon. 1992. Mutations within the 5' nontranslated region of hepatitis A virus RNA which enhance replication in BS-C-l cells. J. Virol. 66: 6533 6540.
53. de la Torre, J. C.,, C. Giachetti,, B. L. Semler,, and J. J. Holland. 1992. High frequency of single-base transitions and extreme frequency of precise multiple-base reversion mutations in poliovirus. Proc. Natl. Acad. Sci. USA 89: 2531 2535.
54. de la Torre, J. C.,, E. Wimmer,, and J. J. Holland. 1990. Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus. J. Virol. 64: 664 671.
55. Dewalt, P. G.,, M. A. Lawson,, R. J. Colonno,, and B. L. Semler. 1989. Chimeric Picornavirus polyproteins demonstrate a common 3C proteinase substrate specificity. J. Virol. 63: 3444 3452.
56. Diez, J.,, M. Hofner,, E. Domingo,, and A. I. Donaldson. 1990. Foot-and-mouth disease virus strains isolated from persistantly infected cell cultures are attenuated for mice and cattle. Virus Res. 18: 3 7.
57. Diez, J.,, M. G. Mateu,, and E. Domingo. 1989. Selection of antigenic variants of foot-and-mouth disease virus in the absence of antibodies, as revealed by an in situ assay. J. Gen. Virol. 70: 3281 3289.
58. Dildine, S. L.,, and B. L. Semler. 1989. The deletion of 41 proximal nucleotides reverts a poliovirus mutant containing a temperature-sensitive lesion in the 5'noncoding region of genomic RNA. J. Virol. 63: 847 862.
59. Domingo, E.,, M. Davila,, and J. Ortin. 1980. Nucleotide sequence heterogeneity of the RNA from a natural population of foot-and-mouth-disease virus. Gene 11: 333 346.
60. Domingo, E.,, C. Escarmis,, L. Menéndez-Arias,, and J. J. Holland,. 1999. Viral quasi-species and fitness variations, p. 141 161. In E. Domingo,, R. G. Webster,, and J. J. Holland (ed.), Origin and Evolution of Viruses. Academic Press, San Diego, Calif.
61. Domingo, E.,, and J. J. Holland. 1997. RNA virus mutations and fitness for survival. Annu. Rev. Microbiol. 51: 151 178.
62. Domingo, E.,, E. Martinez-Salas,, F. Sobrino,, J. C. de la Torre,, A. Portela, J. Ortin,, C. Lopez-Galindez,, P. Perez-Brena,, N. Villanueva,, R. Najera,, S. VandePol,, D. Steinhauer,, N. De Polo,, and J. J. Holland. 1985. The quasi-species (extremely heterogeneous) nature of viral RNA genome populations: biological relevance—a review. Gene 40: 1 8.
63. Dove, A., W, and V. R. Racaniello. 1997. Cold-adapted poliovirus mutants bypass a postentry replication block. J. Virol. 71: 4728 4735.
64. Drake, J. W.,, and J. J. Holland. 1999. Mutation rates among RNA viruses. Proc. Natl. Acad. Sci. USA 96: 13910 13913.
65. Duarte, E.,, D. Clarke,, A. Moya,, E. Domingo,, and J. Holland. 1992. Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet. Proc. Natl. Acad. Sci. USA 89: 6015 6019.
66. Dubes, G. R.,, and M. Chapin. 1956. Cold-adapted genetic variants of polioviruses. Science 124: 586 588.
67. Duggal, R.,, and E. Wimmer. 1999. Genetic recombination of poliovirus in vitro and in vivo: temperature-dependent alteration of crossover sites. Virology 258: 30 41.
68. Duke, G. M.,, J. E. Osorio,, and A. C. Palmenberg. 1990. Attenuation of mengo virus through genetic engineering of the 5' noncoding poly(C) tract. Nature 343: 474 476.
69. Dulbecco, R.,, and M. Vogt. 1954 Plaque formation and isolation of pure lines with polioviruses. J. Exp. Med. 99: 167 182.
70. Dulbecco, R.,, and M. Vogt. 1958. Studies on the induction of mutations in poliovirus by proflavine. Virology 5: 236 243.
71. Dunn, J. J.,, N. M. Chapman,, S. Tracy,, and J. R. Romero. 2000. Genomic determinants of cardiovirulence in coxsackievirus B3 clinical isolates: localization to the 5? nontranslated region. J. Virol. 74: 4787 4794.
72. Egger, D.,, N. Teterina,, E. Ehrenfeld,, and K. Bienz. 2000. Formation of the poliovirus replication complex requires coupled viral translation, vesicle production, and viral RNA synthesis. J. Virol. 74: 6570 6580.
73. Eggers, H. J. 1999. Milestones in early poliomyelitis research (1840 to 1949). J. Virol. 73: 4533 4535.
74. Eggers, H. J.,, and B. Rosenwirth. 1988. Isolation and characterization of an arildone-resistant poliovirus 2 mutant with an altered capsid protein VP1. Antiviral Res. 9: 23 35.
75. Eggers, H. J.,, and I. Tamm. 1962. On the mechanism of selective inhibition of enterovirus multiplication by 2-( α-hydroxybenzyl)-benzimidazole. Virology 18: 426 438.
76. Elena, S. F.,, F. Gonzalez-Candelas,, and A. Moya. 1992. Does the VP1 gene of foot-and-mouth disease virus behave as a molecular clock? J. Mol. Evol. 35: 223 229.
77. Emerson, S. U.,, Y. K. Huang,, C. McRill,, M. Lewis,, and R. H. Purcell. 1992. Mutations in both the 2B and 2C genes of hepatitis A virus are involved in adaption to growth in cell culture. J. Virol. 66: 650 654.
78. Emini, E. A.,, B. A. Jameson,, A. J. Lewis,, G. R. Larsen,, and E. Wimmer. 1982. Poliovirus neutralization epitopes: analysis and localization with neutralizing monoclonal antibodies. J. Virol. 43: 997 1005.
79. Emini, E. A.,, J. Leibowitz,, D. C. Diamond,, J. Bonin,, and E. Wimmer. 1984. Recombinants of Mahoney and Sabin strain poliovirus type 1: analysis of in vitro phe-notypic markers and evidence that resistance to guanidine maps in the nonstructural proteins. Virology 137: 74 85.
80. Enders, J. F.,, T. H. Weiler,, and F. C. Robbins. 1949. Cultivation of the Lansing strain of poliomyelitis virus in cultures of various human embryonic tissues. Science 109: 85 87.
81. Escarmis, C.,, M. Davila,, N. Charpentier,, A. Bracho,, A. Moya,, and E. Domingo. 1996. Genetic lesions associated with Muller's ratchet in an RNA virus. J. Mol. Biol. 264: 255 267.
82. Escarmis, C.,, M. Davila,, and E. Domingo. 1999. Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller's ratchet. J. Mol. Biol. 285: 495 505.
83. Escarmis, C.,, J. Dopazo,, M. Davila,, E. L. Palma,, and E. Domingo. 1995. Large deletions in the 5?-untranslated region of foot-and-mouth disease virus of serotype C. Virus Res. 35: 155 167.
84. Escarmis, C.,, M. Toja,, M. Medina,, and E. Domingo. 1992. Modifications of the 5? untranslated region of foot-and-mouth disease virus after prolonged persistence in cell culture. Virus Res. 26: 113 125.
85. Gavrilin, G. V.,, E. A. Cherkasova,, G. Yu,, Lipskaya,, O. M. Kew,, and V. I. Agol. 2000. Evolution of circulating wild poliovirus and of vaccine-derived poliovirus in an immunodeficient patient: a unifying model. J. Virol. 74: 7381 7390.
86. Genschik, P.,, E. Billy,, M. Swianiewicz,, and W. Filipowicz. 1997. The human RNA 3?-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea. EMBO J. 16: 2955 2967.
87. Georgescu, M. M.,, F. Delpeyroux,, M. Tardy-Panit,, J. Balanant,, M. Combiescu,, A. A. Combiescu,, S. Guillot,, and R. Crainic. 1994. High diversity of poliovirus strains isolated from the central nervous system from patients with vaccine-associated paralytic poliomyelitis. J. Virol. 68: 8089 8101.
88. Ghendon, Y. Z. 1972. Conditional-lethal mutants of animal viruses. Prog. Med. Virol. 14: 68 90.
89. Giachetti, C.,, S. S. Hwang,, and B. L. Semler. 1992. cis-acting lesions targeted to the hydrophobic domain of a poliovirus membrane protein involved in RNA replication. J. Virol. 66: 6045 6057.
90. Gmyl, A. P.,, E. V. Belousov,, S. V. Maslova,, E. V. Khitrina,, A. B. Chetverin, and V. I. Agol. 1999. Nonreplicative RNA recombination in poliovirus. J. Virol. 73: 8958 8965.
91. Gmyl, A. P.,, E. V. Pilipenko,, S. V. Maslova,, G. A. Belov, and V. I. Agol. 1993. Functional and genetic plasticities of the poliovirus genome: quasi-infectious RNAs modified in the 5'-untranslated region yield a variety of pseudorevertants. J. Virol. 67: 6309 6316.
92. Gojobori, T.,, E. N. Moriyama,, and M. Kimura. 1990. Molecular clock of viral evolution, and the neutral theory. Proc. Natl. Acad. Sci. USA 87: 10015 10018.
93. Goodfellow, I.,, Y. Chaudhry,, A. Richardson,, J. Meredith,, J. W. Almond,, W. Barclay,, and D. J. Evans. 2000. Identification of a cis-acting replication element within the poliovirus coding region. J. Virol. 74: 4590 4600.
94. Graff, J.,, C. Kasang,, A. Normann,, M. Pfisterer-Hunt,, S. M. Feinstone,, and B. Flehmig. 1994. Mutational events in consecutive passages of hepatitis A virus strain GBM during cell culture adaptation. Virology 204: 60 68.
95. Graff, J.,, A. Normann,, and B. Flehmig. 1997. Influence of the 5' noncoding region of hepatitis A virus strain GBM on its growth in different cell lines. J. Gen. Virol. 78: 1841 1849.
96. Gromeier, M.,, L. Alexander,, and E. Wimmer. 1996. Internal ribosomal entry site substitution eliminates neurovirulence in inter-generic poliovirus recombinants. Proc. Natl. Acad. Sci. USA 93: 2370 2375.
97. Gromeier, M.,, B. Bossert,, M. Arita,, A. Nomoto,, and E. Wimmer. 1999. Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence. J. Virol. 73: 958 964.
98. Gromeier, M.,, E. Wimmer,, and A. E. Gorbalenya,. 1999. Genetics, pathogenesis and evolution of picornaviruses, p. 287 343. In E. Domingo,, R. G. Webster,, and J. J. Holland (ed.), Origin and Evolution of Viruses. Academic Press, San Diego, Calif.
99. Guillot, S.,, V. Caro,, N. Cuervo,, E. Korotkova,, M. Combiescu,, A. Persu,, A. Aubert-Combiescu,, F. Delpeyroux,, and R. Crainic. 2000. Natural genetic exchanges between vaccine and wild poliovirus strains in humans. J. Virol. 74: 8434 8443.
100. Hadfield, A. T.,, M. A. Oliveira,, K. H. Kim,, I. Minor,, M. J. Kremer,, B. A. Heinz,, D. Shepard,, D. C. Pevear,, R. R. Rueckert,, and M. G. Rossmann. 1995. Structural studies on human rhinovirus 14 drug-resistant compensation mutants. J. Mol. Biol. 253: 61 73.
101. Hagino-Yamagishi, K.,, and A. Nomoto. 1989. In vitro construction of poliovirus defective interfering particles. J. Virol. 63: 5386 5392.
102. Harris, T. J.,, and F. Brown. 1977. Biochemical analysis of a virulent and an avirulent strain of foot-and-mouth disease virus. J. Gen. Virol. 34: 87 105.
103. Heinz, B. A.,, R. R. Rueckert,, D. A. Shepard,, F. J. Dutko,, M. A. McKinlay,, M. Fancher, M. G. Rossmann,, J. Badger,, and T. J. Smith. 1989. Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound. J. Virol. 63: 2476 2485.
104. Hirst, G. K. 1962. Genetic recombination with Newcastle disease virus, polioviruses and influenza. Cold Spring Harbor Symp. Quant. Biol. 27: 303 308.
105. Holland, J. J.,, E. Domingo,, J. C. de la Torre,, and D. A. Steinhauer. 1990. Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis. J. Virol. 64: 3960 3962.
106. Hughes, P. J.,, C. North,, P. D. Minor,, and G. Stanway. 1989. The complete nucleotide sequence of coxsackievirus A21. J. Gen. Virol. 70: 2943 2952.
107. Huovilainen, A.,, T. Hovi,, L. Kinnunen,, K. Takkinen,, M. Ferguson,, and P. Minor. 1987. Evolution of poliovirus during an outbreak: sequential type 3 poliovirus isolates from several persons show shifts of neutralization determinants. J. Gen. Virol. 68: 1373 1378.
108. Huovilainen, A.,, L. Kinnunen,, M. Ferguson,, and T. Hovi. 1988. Antigenic variation among 173 strains of type 3 poliovirus isolated in Finland during the 1984 to 1985 outbreak. J. Gen. Virol. 69: 1941 1848.
109. Iizuka, N.,, M. Kohara,, K. Hagino-Yamagishi,, S. Abe,, T. Komatsu,, K. Tago,, M. Arita,, and A. Nomoto. 1989. Construction of less neurovirulent polioviruses by introducing deletions into the 5? noncoding sequence of the genome. J. Virol. 63: 5354 5363.
110. Ishiko, H.,, N. Takeda,, K. Miyamura,, N. Kato,, M. Tanimura,, K. H. Lin,, M. Yin-Murphy,, J. S. Tam,, G. F. Mu,, and S. Yamazaki. 1992. Phylogenetic analysis of a coxsackievirus A24 variant: the most recent worldwide pandemic was caused by progenies of a virus prevalent around 1981. Virology 187: 748 759.
111. Jackson, T.,, D. Sheppard,, M. Denyer,, W. Blakemore,, and A. M. King. 2000. The epithelial integrin alphavbetao is a receptor for foot-and-mouth disease virus. J. Virol. 74: 4949 4956.
112. Jakob, J.,, and R. P. Roos. 1996. Molecular determinants of Theiler's murine encephalomyelitis-induced disease. J. Neurovirol. 2: 70 77.
113. Jarvis, T. C.,, and K. Kirkegaard. 1991. The polymerase in its labyrinth: mechanisms and implications of RNA recombination. Trends Genet. 7: 186 191.
114. Jarvis, T. C.,, and K. Kirkegaard. 1992. Poliovirus RNA recombination: mechanistic studies in the absence of selection. EMBO J. 11: 3135 3145.
115. Jia, Q.,, S. Ohka,, K. Iwasaki,, K. Tohyama,, and A. Nomoto. 1999. Isolation and molecular characterization of a poliovirus type 1 mutant that replicates in the spinal cords of mice. J. Virol. 73: 6041 6047.
116. Johnson, K. L.,, and P. Sarnow. 1991. Three poliovirus 2B mutants exhibit noncomplementable defects in viral RNA amplification and display dosage-dependent dominance over wild-type poliovirus. J. Virol. 65: 4341 4349.
117. Johnson, V. H.,, and B. L. Semler. 1988. Defined recombinants of poliovirus and coxsackievirus: sequence-specific deletions and functional substitutions in the 5'-noncoding regions of viral RNAs. Virology 162: 47 57.
118. Kaplan, G.,, and V. R. Racaniello. 1988. Construction and characterization of poliovirus subgenomic replicons. J. Virol. 62: 1687 1696.
119. Karron, R. A.,, R. Daemer,, J. Ticehurst,, E. D'Hondt,, H. Popper,, K. Mihalik,, J. Philips,, S. Feinstone,, and R. H. Purcell. 1988. Studies of prototype live hepatitis A virus vaccines in primate models. J. Infect. Dis. 157: 338 345.
119a. Kew, O.,, V. Morris-Glasgow,, M. Landaverde,, C. Burns,, J. Shaw,, Z. Garib,, J. Andre,, E. Blackman,, C. J. Freeman,, J. Jorba,, R. Sutter,, G. Tambinia,, L. Venczel,, C. Perdreira,, F. Laender,, H. Shimizu,, T. Yoneyama,, T. Miyamura,, H. van der Avoort,, M. S. Oberste,, D. Kilpatrick,, S. Cochi,, M. Pallansch,, and C. de Quadros. 2002. Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus. Science 296: 356 359.
120. Kew, O. M.,, M. N. Mulders,, G. Y. Lipskaya,, E. E. da Silva,, and M. A. Pallansch. 1995. Molecular epidemiology of poliovirus. Semin. Virol. 6: 401 414.
121. Kimura, M. 1983. The Neutral Theory of Molecular Evolution. Cambridge University Press, Cambridge, United Kingdom.
122. King, A. M. 1988. Preferred sites of recombination in poliovirus RNA: an analysis of 40 intertypic cross-over sequences. Nucleic Acids Res. 16: 11705 11723.
123. King, A. M.,, D. McCahon,, W. R. Slade,, and J. W. Newman. 1982. Recombination in RNA. Cell 29: 921 928.
124. Kinnunen, L.,, A. Huovilainen,, T. Poyry,, and T. Hovi. 1990. Rapid molecular evolution of wild type 3 poliovirus during infection in individual hosts. J. Gen. Virol. 71: 317 324.
125. Kirkegaard, K.,, and D. Baltimore. 1986. The mechanism of RNA recombination in poliovirus. Cell 47: 433 443.
126. Kitamura, N.,, B. L. Semler,, P. G. Rothberg,, G. R. Larsen,, C. J. Adler,, A. J. Dorner,, E. A. Emini,, R. Hanecak,, J. J. Lee,, S. Werf,, C. W. Anderson,, and E. Wimmer. 1981. Primary structure, gene organization and polypeptide expression of poliovirus RNA. Nature 291: 547 553.
127. Koch, F.,, and G. Koch. 1985. The Molecuhr Biology of Poliovirus. Springer-Verlag, Vienna, Austria.
128. Kohara, M.,, T. Omata,, A. Kameda,, B. L. Semler,, H. Itoh, E. Wimmer,, and A. Nomoto. 1985. In vitro phenotypic markers of a poliovirus recombinant constructed from infectious cDNA clones of the neurovirulent Ma-honey strain and the attenuated Sabin 1 strain. J. Virol. 53: 786 792.
129. Koprowski, H.,, G. A. Jarvis,, and T. W. Norton. 1952. Immune responses in human volunteers upon oral administration of a rodent-adapted strain of poliomyelitis virus. Am. J. Hyg. 55: 108 126.
130. Krebs, O.,, and O. Marquardt. 1992. Identification and characterization of foot-and-mouth disease virus O1 Burgwedel/1987 as an intertypic recombinant. J. Gen. Virol. 73: 613 619.
131. Kuge, S.,, N. Kawamura,, and A. Nomoto. 1989. Strong inclination toward transition mutation in nucleotide substitutions by poliovirus replicase. J. Mol. Biol. 207: 175 182.
132. Kuge, S.,, N. Kawamura,, and A. Nomoto. 1989. Genetic variation occurring on the genome of an in vitro insertion mutant of poliovirus type 1. J. Virol. 63: 1069 1075.
133. Kuge, S.,, and A. Nomoto. 1987. Construction of viable deletion and insertion mutants of the Sabin strain of type 1 poliovirus: function of the 5' noncoding sequence in viral replication. J. Virol. 61: 1478 1487.
137. 134Kuge, S.,, I. Saito,, and A. Nomoto. 1986. Primary structure of poliovirus defective-interfering particle genomes and possible generation mechanisms of the particles. J. Mol. Biol. 192: 473 487.
135. Lafontaine, D.,, D. Beaudry,, P. Marquis,, and J. P. Perreault. 1995. Intra- and intermolecular nonenzymatic ligations occur within transcripts derived from the peach latent mosaic viroid. Virology 212: 705 709.
136. La Monica, N.,, C. Meriam,, and V. R. Racaniello. 1986. Mapping of sequences required for mouse neurovirulence of poliovirus type 2 Lansing. J. Virol. 57: 515 525.
137. Ledinko, N. 1963. Genetic recombination with poliovirus type 1. Studies of crosses between a normal horse serum-resistant mutant and several guanidine-resistant mutants of the same strain. Virology 20: 107 119.
138. Ledinko, N.,, and G. K. Hirst. 1961. Mixed infection of HeLa cells with polioviruses types 1 and 2. Virology 14: 107 119.
139. Li, C. P.,, and K. Habel. 1951. Adaptation of Leon strain of poliomyelitis virus to mice. Proc. Soc. Exp. Biol. Med. 78: 233 238.
140. Li, C. P.,, and M. Schaeffer. 1953. Adaptation of type 1 poliomyelitis virus to mice. Proc. Soc. Exp. Biol. Med. 82: 477 481.
141. Li, J. P.,, and D. Baltimore. 1988. Isolation of poliovirus 2C mutants defective in viral RNA synthesis. J. Virol. 62: 4016 4021.
142. Li, J. P.,, and D. Baltimore. 1990. An intragenic revertant of a poliovirus 2C mutant has an uncoating defect. J. Virol. 64: 1102 1107.
143. Lipskaya, G. Y.,, E. A. Chervonskaya,, G. I. Belova,, S. V. Maslova,, T. N. Kutateladze,, S. G. Drozdov,, M. Mulders,, M. A. Pallansch,, O. M. Kew,, and V. I. Agol. 1995. Geographical genotypes (geotypes) of poliovirus case isolates from the former Soviet Union: relatedness to other known poliovirus genotypes. J. Gen. Virol. 76: 1687 1699.
144. Lipskaya, G. Y.,, A. R. Muzychenko,, O. K. Kutitova,, S. V. Maslova,, M. Equestre, S. G. Drozdov,, R. R. Perez Bercoff,, and V. I. Agol. 1991. Frequent isolation of intertypic poliovirus recombinants with serotype 2 specificity from vaccine-associated polio cases. J. Med. Virol. 35: 290 296.
145. Lipton, H. L.,, and M. L. Jelachich. 1997. Molecular pathogenesis of Theiler's murine encephalomyelitis virus-induced demyelinating disease in mice. Intervirology 40: 143 152.
146. Loddo, B.,, W. Ferrari,, A. Spaneda,, and G. Brotzu. 1962. In vitro guanidine-resistance and guanidine-dependence of poliovirus. Experientia 18: 518 519.
147. Lu, H. H.,, X. Li,, A. Cuconati,, and E. Wimmer. 1995. Analysis of Picornavirus 2A(pro) proteins: separation of proteinase from translation and replication functions. J. Virol. 69: 7445 7452.
148. Lwoff, A. Factors influencing evolution of viral disease at the cellular level and in the organism. Bacteriol. Rev. 23: 109 124.
149. Mandl, S.,, L. J. Sigal,, K. L. Rock,, and R. Andino. 1998. Poliovirus vaccine vectors elicit antigen-specific cytotoxic T cells and protect mice against lethal challenge with malignant melanoma cells expressing a model antigen. Proc. Natl. Acad. Sci. USA 95: 8216 8221.
150. Martin, L. R.,, Z. C. Neal,, M. S. McBride,, and A. C. Palmenberg. 2000. Mengovirus and encephalomyocarditis virus poly(C) tract lengths can affect virus growth in murine cell culture. J. Virol. 74: 3074 3081.
151. Martinez, M. A.,, C. Carrillo,, F. Gonzalez-Candelas,, A. Moya,, E. Domingo,, and F. Sobrino. 1991. Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies. J. Virol. 65: 3954 3957.
152. Martinez, M. A.,, J. Dopazo,, J. Hernandez,, M. G. Mateu,, F. Sobrino,, E. Domingo,, and N. J. Knowles. 1992. Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades. J. Virol. 66: 3557 3565.
153. Martinez, M. A.,, N. Verdaguer,, M. G. Mateu,, and E. Domingo. 1997. Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus. Proc. Natl. Acad. Sci. USA 94: 6798 6802.
154. Marvil, P.,, N. J. Knowles,, A. P. Mockett,, P. Britton,, T. D. Brown,, and D. Cavanagh. 1999. Avian encephalomyelitis virus is a Picornavirus and is most closely related to hepatitis A virus. J. Gen. Virol. 80: 653 662.
155. Mason, P. W.,, M. E. Piccone,, T. S. Mckenna,, J. Chinsangaram,, and M. J. Grubman. 1997. Evaluation of a live-attenuated foot-and-mouth disease virus as a vaccine candidate. Virology 227: 96 102.
156. Melchers, W. J.,, J. M. Bakkers,, H. J. Bruins Slot,, J. M. Galama,, V. I. Agol,, and E. V. Pilipenko. 2000. Crosstalk between orientation-dependent recognition determinants of a complex control RNA element, the enterovirus oriR. RNA 6: 976 987.
157. Melchers, W. J. G.,, H. Heenderop,, H. J. Bruins Slot,, C. Pleij,, E. V. Pilipenko,, V. I. Agol,, and J. Galama. 1997. Kissing of the two predominant hairpin loops in the Coxsackie B virus 3'UTR in the origin of replication required for (—) strand RNA synthesis. J. Virol. 71: 686 696.
158. Melnick, J. L. 1953. Poliomyelitis. Adv. Virus Res. 1: 229 275.
159. Melnick, J. L., 1996. Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses, p. 655 712. In B. N. Fields,, D. M. Knipe,, and P. M. Howley (ed.), Fields Virology, 3rd ed. Lippincott-Raven, Philadelphia, Pa.
160. Melnick, J. L.,, D. Crowther,, and J. Barrera-Oro. 1961. Rapid development of drug resistant mutants of poliovirus. Science 134: 557.
161. Meredith, J. M.,, J. B. Rohll,, J. W. Almond,, and D. J. Evans. 1999. Similar interactions of the poliovirus and rhinovirus 3D polymerases with the 3' untranslated region of rhinovirus 14. J. Virol. 73: 9952 9958.
162. Minor, P. D.,, A. M. John,, M. Ferguson,, and J. P. Icenogle. 1986. Antigenic and molecular evolution of the vaccine strain of type 3 poliovirus during the period of excretion by a primary vaccinee. J. Gen. Virol. 67: 693 706.
163. Minor, P. D.,, G. C. Schild,, J. Bootman,, D. M. Evans,, M. Ferguson,, P. Reeve,, M. Spitz,, G. Stanway,, A. J. Cann,, R. Hauptmann,, L. D. Clarke,, R. C. Mountford,, and J. W. Almond. 1983. Location and primary structure of a major antigenic site for poliovirus neutralization. Nature 301: 674 679.
164. Mirmomeni, M. H.,, P. J. Hughes,, and G. Stanway. 1997. An RNA structure in the 3' untranslated region of enteroviruses is necessary for efficient replication. J. Virol. 71: 2363 2370.
165. Molla, A.,, A. V. Paul,, and E. Wimmer. 1991. Cell-free, de novo synthesis of poliovirus. Science 254: 1647 1651.
166. Mosser, A. G.,, and R. R. Rueckert. 1993. WIN 51711-dependent mutants of poliovirus type 3: evidence that virions decay after release from cells unless drug is present. J. Virol. 67: 1246 1254.
167. Mueller, S.,, and E. Wimmer. 1998. Expression of foreign proteins by poliovirus polyprotein fusion: analysis of genetic stability reveals deletions and formation of cardioviruslike open reading frames. J. Virol. 72: 20 31.
168. Mulders, M. N.,, G. Y. Lipskaya,, H. G. A. M. van der Avoort,, M. P. G. Koopmans,, O. M. Kew,, and A. M. van Loon. 1995. Molecular epidemiology of wild poliovirus type 1 in Europe, the Middle East and the Indian subcontinent. J. Infect. Dis. 171: 1399 1405.
169. Mulders, M. N.,, J. H. Reimerink,, M. Stenvik,, I. Alaeddinoglu,, H. G. van der Avoort,, T. Hovi,, and M. P. Koopmans. 1999. ? Sabin vaccine-derived field isolate of poliovirus type 1 displaying aberrant phenotypic and genetic features, including a deletion in antigenic site 1. J. Gen. Virol. 80: 907 916.
170. Murakami, M.,, H. Watanabe,, Y. Niikura,, T. Kameda,, K. Saitoh,, M. Yamamoto,, Y. Yokouchi,, A. Kuroiwa,, K. Mizumoto,, and H. Iba. 1997. High-level expression of exogenous genes by replication-component retrovirus vectors with an internal ribosomal entry site. Gene 202: 23 29.
171. Neff, S.,, D. Sa-Carvalho,, E. Rieder,, P. W. Mason,, S. D. Blystone,, E. J. Brown,, and B. Baxt. 1998. Foot-and-mouth disease virus virulent for cattle utilizes the integrin alpha(v)beta3 as its receptor. J. Virol. 72: 3587 3594.
172. Novak, J. E.,, and K. Kirkegaard. 1994. Coupling between genome translation and replication in an RNA virus. Genes Dev. 8: 1726 1737.
173. Novak, M. J.,, L. E. Smythies,, S. A. McPherson,, P. D. Smith,, and C. D. Morrow. 1999. Poliovirus replicons encoding the B subunit of Helicobacter pylori urease elicit a Thl associated immune response. Vaccine 17: 2384 2391.
174. Nugent, C. I.,, K. L. Johnson,, P. Saraow,, and K. Kirkegaard. 1999. Functional coupling between replication and packaging of poliovirus replicon RNA. J. Virol. 73: 427 435.
175. Pata, J. D.,, S. C. Schultz,, and K. Kirkegaard. 1995. Functional oligomerization of poliovirus RNA-dependent RNA polymerase. RNA 1: 466 477.
176. Paul, A. V.,, J. H. van Boom,, D. Filippov,, and E. Wimmer. 1998. Protein-primed RNA synthesis by purified poliovirus RNA polymerase. Nature 393: 280 284.
177. Pilipenko, E. V.,, V. M. Blinov,, and V. I. Agol. 1990. Gross rearrangements within the 5'-untranslated region of the picornaviral genomes. Nucleic Acids Res. 18: 3371 3375.
178. Pilipenko, E. V.,, A. P. Gmyl,, and V. I. Agol. 1995. A model for rearrangements in RNA genomes. Nucleic Acids Res. 23: 1870 1875.
179. Pilipenko, E. V.,, A. P. Gmyl,, S. V. Maslova,, E. V. Khitrina,, and V. I. Agol. 1995. Attenuation of Theiler's murine encephalomyelitis virus by modifications of the oligopyrimidine/AUG tandem, a host-dependent translational cis-element. J. Virol. 69: 864 870.
180. Pilipenko, E. V.,, A. P. Gmyl,, S. V. Maslova,, Y. V. Svitkin,, A. N. Sinyakov,, and V. I. Agol. 1992. A prokaryotic-like cis-element in the cap-independent internal initiation of translation on Picornavirus RNA. Cell 68: 119 131.
181. Pilipenko, E. V.,, T. V. Pestova,, V. G. Kolupaeva,, E. V. Khitrina,, A. N. Poperechnaya,, V. I. Agol,, and C. U. Hellen. 2000. A cell cycle-dependent protein serves as a template-specific translation initiation factor. Genes Dev. 14: 2028 2045.
182. Pilipenko, E. V.,, K. V. Poperechny,, S. V. Maslova,, W. J. G. Melchers,, H. J. Bruins Slot,, and V. I. Agol. 1996. Cis-element, oriR, involved in the initiation of (—) strand poliovirus RNA: a quasi-globular multi-domain RNA structure maintained by tertiary (“kissing”) interaction. EMBO J. 19: 5428 5436.
183. Pilipenko, E. V.,, E. G. Viktorova,, E. V. Khitrina,, S. V. Maslova,, N. Jarousse,, M. Brahic,, and V. I. Agol. 1999. Distinct attenuation phenotypes caused by mutations in the translational starting window of Theiler's murine encephalomyelitis virus. J. Virol. 73: 3190 3196.
184. Pincus, S. E.,, H. Rohl,, and E. Wimmer. 1987. Guanidine-dependent mutants of poliovirus: identification of three classes with different growth requirements. Virology 157: 83 88.
185. Porter, D. C.,, D. C. Ansardi,, and C. D. Morrow. 1995. Encapsidation of poliovirus replicons encoding the complete human immunodeficiency virus type 1 gag gene by using a complementation system which provides the P1 capsid protein in trans. J. Virol. 69: 1548 1555.
186. Porter, D. C.,, D. C. Ansardi,, J. Wang,, S. McPherson,, Z. Moldoveanu,, and C. D. Morrow. 1998. Demonstration of the specificity of poliovirus encapsidation using a novel replicon which encodes enzymatically active firefly luciferase. Virology 243: 1 11.
187. Poyry, T.,, L. Kinnunen,, J. Kapsenberg,, O. Kew,, and T. Hovi. 1990. Type 3 poliovirus/Finland/1984 is genetically related to common Mediterranean strains. J. Gen. Virol. 71: 2535 2541.
188. Provost, P. J.,, P. A. Conti,, P. A. Giesa,, F. S. Banker,, E. B. Buynak,, W. J. McAleer,, and M. R. Hilleman. 1983. Studies in chimpanzees of live, attenuated hepatitis A vaccine candidates. Proc. Soc. Exp. Biol. Med. 172: 357 363.
189. Racaniello, V. R.,, and D. Baltimore. 1981. Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome. Proc. Natl. Acad. Sci. USA 78: 4887 4891.
190. Racaniello, V. R.,, and D. Baltimore. 1981. Cloned poliovirus complementary DNA is infectious in mammalian cells. Science 214: 916 919.
191. Ramesh, N.,, S. T. Kim,, M. Q. Wei,, M. Khalighi,, and W. R. Osborne. 1996. High-titer bicistronic retroviral vectors employing foot-and-mouth disease virus internal ribosome entry site. Nucleic Acids Res. 24: 2697 2700.
192. Reid, C. E.,, and D. W. Lazinski. 2000. A host-specific function is required for ligation of a wide variety of ribozyme-processed RNAs. Proc. Natl. Acad. Sci. USA 97: 424 429.
193. Rico-Hesse, R.,, M. A. Pallansch,, B. K. Nottay,, and O. M. Kew. 1987. Geographic distribution of wild poliovirus type 1 genotypes. Virology 160: 311 322.
194. Rieder, E.,, T. Bunch,, F. Brown,, and P. W. Mason. 1993. Genetically engineered foot-and-mouth disease viruses with poly(C) tracts of two nucleotides are virulent in mice. J. Virol. 67: 5139 5345.
195. Rightsel, W. A.,, J. R. Dice,, R. J. McAlpine,, E. A. Timm,, I. W. McLean,, G. J. Dixon,, and F. M. Schabel. 1961. Antiviral effect of guanidine. Science 134: 558 559.
196. Roberts, L. O.,, and G. J. Belsham. 1997. Complementation of defective Picornavirus internal ribosome entry site (IRES) elements by the coexpression of fragments of the IRES. Virology 227: 53 62.
197. Roca-Garcia, M.,, A. W. Moyer,, and H. R. Cox. 1953. Poliomyelitis. 2. Propagation of MEF-1 strain of poliomyelitis virus in developing chick embryo by yolk sac inoculation. Proc. Soc. Exp. Biol. Med. 81: 519 525.
198. Rohll, J. B.,, D. H. Moon,, D. J. Evans,, and J. W. Almond. 1995. The 3? untranslated region of Picornavirus RNA: features required for efficient genome replication. J. Virol. 69: 7835 7844.
199. Romanova, L. I.,, V. M. Blinov,, E. A. Tolskaya,, E. G. Viktorova,, M. S. Kolesnikova,, E. A. Guseva,, and V. I. Agol. 1986. The primary structure of crossover regions of intertypic poliovirus recombinants: a model of recombination between RNA genomes. Virology 155: 202 213.
200. Romanova, L. I.,, E. A. Tolskaya,, M. S. Kolesnikova,, and V. I. Agol. 1980. Biochemical evidence for intertypic genetic recombination of polioviruses. FEBS Lett. 1: 109 112.
201. Rose, C.,, W. Andrews,, M. Ferguson,, J. McKeating,, J. Almond,, and D. Evans. 1994. The construction and characterization of poliovirus antigen chimeras presenting defined regions of the human T lymphocyte marker CD4. J. Gen. Virol. 75: 969 977.
202. Rowe, A.,, G. L. Ferguson,, P. D. Minor,, and A. J. Macadam. 2000. Coding changes in the poliovirus protease 2A compensate for 5'NCR domain V disruptions in a cell-specific manner. Virology 269: 284 293.
203. Ryan, M. D.,, and M. Flint. 1997. Virus-encoded proteinases of the Picornavirus supergroup. J. Gen. Virol. 78: 699 723.
204. Sabin, A. B. 1955. Behavior of chimpanzee-avirulent poliomyelitis viruses in experimentally infected human volunteers. Am. J. Med. Sci. 230: 1 8.
205. Sabin, A. B. 1985. Oral poliovirus vaccine: history of its development and use, and current challenge to eliminate poliomyelitis from the world. J. infect. Dis. 151: 420 436.
206. Sala, M.,, and S. Wain-Hobson,. 1999. Drift and conservatism in RNA virus evolution: are they adapting or merely changing? p. 115 140. In E. Domingo,, R. G. Webster,, and J. J. Holland (ed.), Origin and Evolution of Viruses. Academic Press, San Diego, Calif.
207. Santti, J.,, H. Harvala,, L. Kinnunen,, and T. Hyypia. 2000. Molecular epidemiology and evolution of coxsackievirus A9. J. Gen. Virol. 81: 1361 1372.
208. Santti, J.,, T. Hyypia,, L. Kinnunen,, and M. Salminen. 1999. Evidence of recombination among enteroviruses. J. Virol. 7: 8741 8749.
209. Sarnow, P.,, H. D. Bernstein,, and D. Baltimore. 1986. A poliovirus temperature-sensitive RNA synthesis mutant located in a noncoding region of the genome. Proc. Natl. Acad. Sci. USA 83: 571 575.
210. Saunders, K.,, A. M. King,, D. McCahon,, J. W. Newman,, W. R. Slade,, and S. Forss. 1985. Recombination and oligonucleotide analysis of guanidine-resistant foot-and-mouth disease virus mutants. J. Virol. 56: 921 929.
211. Schwerdt, C. E.,, and F. L. Schaffen 1955. Some physical and chemical properties of purified poliomyelitis virus preparations. Ann. N. Y. Acad. Sci. 61: 740 750.
212. Semler, B. L.,, V. H. Johnson,, and S. Tracy. 1986. A chimeric plasmid from cDNA clones of poliovirus and coxsackievirus produces a recombinant virus that is temperature-sensitive. Proc. Natl. Acad. Sci. USA 83: 1777 1781.
213. Sergiescu, D.,, F. Horodniceanu,, and A. Aubert-Combiescu. 1972. The use of inhibitors in the study of Picornavirus genetics. Prog. Med. Virol. 14: 123 199.
214. Sevilla, N.,, C. M. Ruiz-Jarabo,, G. Gomez-Mariano,, E. Baranowski,, and E. Domingo. 1998. An RNA virus can adapt to the multiplicity of infection. J. Gen. Virol. 79: 2971 2980.
215. Sevilla, N.,, N. Verdaguer,, and E. Domingo. 1996. Antigenically profound amino acid substitutions occur during large population passages of foot-and-mouth disease virus. Virology 225: 400 405.
216. Shepard, D. A.,, B. A. Heinz,, and R. R. Rueckert. 1993. WIN 52035-2 inhibits both attachment and eclipse of human rhinovirus 14. J. Virol. 67: 2245 2254.
217. Sherry, B.,, and R. Rueckert. 1985. Evidence for at least two dominant neutralization antigens on human rhino-virus 14. J. Virol. 53: 137 143.
218. Shulman, L. M.,, R. Handsher,, C. F. Yang,, S. J. Yang,, J. Manor,, A. Vonsover,, Z. Grossman,, M. Pallansch,, E. Mendelson,, and O. M. Kew. 2000. Resolution of the pathways of poliovirus type 1 transmission during an outbreak. J. Clin. Microbiol. 38: 945 952.
219. Sierra, S.,, M. Dävila,, P. R. Lowenstein,, and E. Domingo. 2000. Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity. J. Virol. 74: 8316 8323.
220. Slobodskaya, O. R.,, A. P. Gmyl,, S. V. Maslova,, E. A. Tolskaya,, E. G. Viktorova,, and V. 1. Agol. 1996. Poliovirus neurovirulence correlates with the presence of a cryptic AUG upstream of the initiator codon. Virology 221: 141 150.
221. Sobrino, F.,, M. Davila,, J. Ortin,, and E. Domingo. 1983. Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture. Virology 128: 310 318.
222. Stanway, G.,, and T. Hyypia. 1999. Parechoviruses. J. Virol. 73: 5249 5254.
223. Stapleton, J. T.,, and S. M. Lemon. 1987. Neutralization escape mutants define a dominant immunogenic neutralization site on hepatitis A virus. J. Virol. 61: 491 498.
224. Stave, J. W.,, J. L. Card,, D. O. Morgan,, and V. N. Vakharia. 1988. Neutralization sites of type O1 foot-and-mouth disease virus defined by monoclonal antibodies and neutralization-escape virus variants. Virology 62: 21 29.
225. Stone, D. M.,, J. W. Almond,, J. K. Brangwyn,, and G. J. Belsham. 1993. trans complementation of cap-independent translation directed by poliovirus 5' non-coding region deletion mutants: evidence for RNA-RNA interactions. J. Virol. 67: 6215 6223.
226. Takeda, N.,, M. Tanimura,, and K. Miyamura. 1994. Molecular evolution of the major capsid protein VP1 of enterovirus 70. J. Virol. 68: 854 862.
227. Teterina, N. L.,, W. D. Zhou,, M. W. Cho,, and E. Ehrenfeld. 1995. Inefficient complementation activity of poliovirus 2C and 3D proteins for rescue of lethal mutations. J. Virol. 69: 4245 4254.
228. Todd, S.,, and B. L. Semler. 1996. Structure-infectivity analysis of the human rhinovirus genomic RNA 3' non-coding region. Nucleic Acids Res. 24: 2133 2142.
229. Todd, S.,, J. S. Towner,, D. M. Brown,, and B. L. Semler. 1997. Replication-competent picornaviruses with complete genomic RNA 3? noncoding region deletions. J. Virol. 71: 8868 8874.
230. Tolskaya, E. A.,, L. I. Romanova,, V. M. Blinov,, E. G. Viktorova,, A. N. Sinyakov,, M. S. Kolesnikova,, and V. I. Agol. 1987. Studies on the recombination between RNA genomes of poliovirus: the primary struture and nonrandom distribution of crossover regions in the genomes of intertypic poliovirus recombinants. Virology 161: 54 62.
231. Tolskaya, E. A.,, L. I. Romanova,, M. S. Kolesnikova,, and V. I. Agol. 1983. Intertypic recombination in poliovirus: genetic and biochemical studies. Virology 124: 121 132.
232. Tolskaya, E. A.,, L. I. Romanova,, M. S. Kolesnikova,, A. P. Gmyl,, A. E. Gorbalenya,, and V. I. Agol. 1994. Genetic studies on the NTP-binding pattern containing 2C protein of poliovirus: possible mechanism of guanidine effect on 2C function and evidence for importance of 2C oligomerization. J. Mol. Biol. 236: 1310 1323.
233. Towner, J. S.,, M. M.. Mazanet,, and B. L. Semler. 1998. Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins. J. Virol. 72: 7191 7200.
234. Toyoda, H.,, M. Kohara,, Y. Kataoka,, T. Suganuma,, T. Omata,, N. Imura,, and A. Nomoto. 1984 - Complete nucleotide sequences of all three poliovirus serotype genomes. Implication for genetic relationship, gene function and antigenic determinants. J. Mol. Biol. 174: 561 585.
235. van Kuppeveld, F. J.,, P. J. van den Hurk,, W. van der Vliet,, J. M. Galama,, and W. J. Melchers. 1997. Chimeric Coxsackie B3 virus genomes that express hybrid coxsackievirus-poliovirus 2B proteins: functional dissection of structural domains involved in RNA replication. J. Gen. Virol. 78: 1833 1840.
236. Wang, J.,, J. M. Bakkers,, J. M. Galama,, H. J. Bruins Slot,, E. V. Pilipenko,, V. I. Agol,, and W. J. Melchers. 1999. Structural requirements of the higher order RNA kissing element in the enteroviral 3'UTR. Nucleic Acids Res. 27: 485 449.
237. Ward, C. D.,, and J. B. Flanegan. 1992. Determination of the poliovirus RNA polymerase error frequency at eight sites in the viral genome. J. Virol. 66: 3784 3793.
238. Ward, C. D.,, M. A. Stokes,, and J. B. Flanegan. 1988. Direct measurement of the poliovirus RNA polymerase error frequency in vitro. J. Virol. 62: 558 562.
239. Wecker, E.,, and G. Lederhilger. 1964. Curtailment of the latent period by double infection with polioviruses. Proc. Natl. Acad. Sci. USA 52: 246 251.
240. Wecker, E.,, and G. Lederhilger. 1964. Genomic masking produced by double infection of HeLa cells with heterotypic polioviruses. Proc. Natl. Acad. Sci. USA 52: 705 709.
241. Wien, M. W.,, S. Curry,, D. J. Filman,, and J. M. Hogle. 1997. Structural studies of poliovirus mutants that overcome receptor defects. Nat. Struct. Biol. 4: 666 674.
242. Wimmer, E.,, C. U. Hellen,, and X. Cao. 1993. Genetics of poliovirus. Annu. Rev. Genet. 27: 353 436.
243. Xiang, W.,, A. Cuconati,, D. Hope,, K. Kirkegaard,, and E. Wimmer. 1998. Complete protein linkage map of poliovirus P3 proteins: interaction of polymerase 3Dpol with VPg and with genetic variants of 3AB. J. Virol. 72: 6732 6741.
244. Zell, R.,, K. Klingel,, M. Sauter,, U. Fortmuller,, and R. Kandolf. 1995. Coxsackieviral proteins functionally recognize the polioviral cloverleaf structure of the 5'-NTR of a chimeric enterovirus RNA: influence of species-specific host cell factors on virus growth. Virus Res. 39: 87 103.
245. Zhang, G.,, D. T. Haydon,, N. J. Knowles,, and J. W. McCauley. 1999. Molecular evolution of swine vesicular disease virus. J. Gen. Virol. 80: 639 651.

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