Chapter 29 : Determinants of Poliovirus Pathogenesis

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This chapter provides a brief synopsis of the natural history of paralytic poliomyelitis, and gives an overview of the status of research concerning the molecular determinants of the pathogenesis of paralytic poliomyelitis. Determinants of the pathogenesis of poliomyelitis are either of viral origin, e.g., non-coding viral sequences, structural or nonstructural viral gene products, or of host origin, e.g., distribution of the cellular receptor and host cell factors required for viral replication. To provide a rational account of the relative contributions of a multitude of factors toward a complex phenomenon, the chapter is subdivided into sections dealing with the main parameters of poliovirus neurological disease. Tropism, neurovirulence, and conditions of the host are discussed separately. The chapter discusses experimental evidence for the genetic basis of neurovirulence in the 5’ non-translated region (5’ NTR) and the coding regions for the structural and nonstructural proteins of poliovirus. Extraneural determinants of neuropathogenicity, such as invasion of or spread within the CNS, combine with intraneural factors, such as IRES-mediated cell type specificity or the efficiency of genome replication. Excellent studies in nonhuman primates in the prevaccine era and recent progress through the advent of genetic engineering and transgenic animal models for human disease have afforded us detailed insight into the pathogenic mechanism of paralytic poliomyelitis.

Citation: Gromeier M, Nomoto A. 2002. Determinants of Poliovirus Pathogenesis, p 367-379. In Semler B, Wimmer E (ed), Molecular Biology of Picornavirus. ASM Press, Washington, DC. doi: 10.1128/9781555817916.ch29
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Image of FIGURE 1

Attenuating mutations within the serotype 1 (PV1/LS-c, 2ab) and 3 (PV3/Leon 12ab) poliovirus strains of Sabin ( ). The general organization of the poliovirus genome is shown below. The positions of the IRES and individual stem-loop domains are indicated by roman numerals atop. Sequence divergence in noncoding regions is indicated by asterisks, mutations in coding regions are shown as vertical bars. PV2 (Sabin) is a naturally occurring attenuated strain whose neurovirulent ancestor is not known. PV1(S) is characterized by a large number of mutations within the coding region P1 for the capsid proteins. Both PV1(S) and PV3(S) feature attenuating mutations within stem-loop V of the IRES.

Citation: Gromeier M, Nomoto A. 2002. Determinants of Poliovirus Pathogenesis, p 367-379. In Semler B, Wimmer E (ed), Molecular Biology of Picornavirus. ASM Press, Washington, DC. doi: 10.1128/9781555817916.ch29
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Image of FIGURE 2

The pathogenic mechanism of provocation poliomyelitis. (A) Anatomical representation of the sciatic nerve dissection procedure. Proximal sciatic nerve dissection severs the connection between the gastrocnemius muscle and the spinal cord by interrupting the supplying peripheral nerve. This blocks the retrograde axonal transport route along the peroneal and sciatic nerves into the CNS. (B) The “localization effect” describes the salient clinical feature of provocation poliomyelitis: localization of initial symptoms of paralysis to the injected limb. CD155 tg mice that are infected with poliovirus by the intravenous route develop paraparesis (simultaneous weakness in both lower extremities) at the onset of clinically overt disease (group I). Trivial skeletal muscle trauma in the form of multiple intramuscular (1M) injections diverts initial neurological symptoms to the lower left extremity, where multiple injections had been administered (group II). Dissection of the sciatic nerve abolishes the localization effect, with >70% of infected animals developing initial paraparesis.

Citation: Gromeier M, Nomoto A. 2002. Determinants of Poliovirus Pathogenesis, p 367-379. In Semler B, Wimmer E (ed), Molecular Biology of Picornavirus. ASM Press, Washington, DC. doi: 10.1128/9781555817916.ch29
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1. Agol, V. I.,, S. G. Drozdov,, T. A. Ivannikova,, M. S. Kolesnikova,, M. B. Korolev,, and E. A. Tolskaya. 1989. Restricted growth of attenuated poliovirus strains in cultured cells of a human neuroblastoma. J. Virol. 63: 4034 4038.
2. Anderson, G.,, and A. Skaar. 1951. Poliomyelitis occurring after antigen injections. Pediatrics 7: 741 759.
3. Armstrong, C. 1939. The experimental transmission of poliomyelitis to the eastern cotton rat, Sigmodon hispidus hispidus. Public Health Rep. 54: 1719 1721.
4. Bergelson, J. M.,, J. A. Cunningham,, G. Droguett,, E. A. Kurt-Jones,, A. Krithivas,, J. S. Hong,, M. S. Horwitz,, R. L. Crowell,, and R. W. Finberg. 1997. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275: 1320 1323.
5. Bernhardt, G.,, J. A. Bibb,, J. Bradley,, and E. Wimmer. 1994. Molecular characterization of the cellular receptor for poliovirus. Virology 199: 105 113.
6. Bibb, J. A.,, G. Witherell,, G. Bernhardt,, and E. Wimmer. 1994. Interaction of poliovirus with its cell surface binding site. Virology 201: 107 115.
7. Blinzinger, K.,, J. Simon,, D. Magrath,, and L. Boulger. 1969. Poliovirus crystals within the endoplasmic reticulum of endothelial and mononuclear cells in the monkey spinal cord. Science 163: 1336 1337.
8. Bodian, D. 1953. Experimental studies on passive immunization against poliomyelitis. III. Passive-active immunization and pathogenesis after virus feeding in chimpanzees. Am. J. Hyg. 58: 81 92.
9. Bodian, D. 1954. Viraemia in experimental poliomyelitis. II. Viraemia and the mechanism of the "provoking" effect of injections or trauma. Am. J. Hyg. 60: 358 370.
10. Bodian, D. 1955. Emerging concept of poliomyelitis infection. Science 122: 105 108.
11. Bodian, D. 1955. Viremia, invasiveness and the influence of injections. Ann. N.Y. Acad. Sci. 61: 877 882.
12. Bodian, D.,, and H. A. Howe. 1941. Experimental studies of intraneural spread of poliomyelitis virus. Bull. Johns Hopkins Hosp. 68: 248 267.
13. Borman, A. M.,, F. G. Deliat,, and K. M. Kean. 1994. Sequences within the poliovirus internal ribosome entry segment control viral RNA synthesis. EMBO J. 13: 3149 3157.
14. Bouchard, M. J.,, D.-H. Lam,, and V. R. Racaniello. 1995. Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine. J. Virol. 69: 4972 4978.
15. Bradford Hill, A.,, and J. Knowelden. 1950. Inoculation and poliomyelitis. Br. Med. J. 11: 1 6.
16. Chapman, N. M.,, A. I. Ramsingh,, and S. Tracy. 1997. Genetics of coxsackievirus virulence. Curr. Top. Microbiol. Immunol. 223: 227 258.
17. Christodoulou, C.,, F. Colbere-Garapin,, A. Macadam,, L. F. Taffs,, S. Marsden,, P. Minor,, and F. Horaud. 1990. Mapping of mutations associated with neurovirulence in monkeys infected with Sabin 1 poliovirus revertants selected at high temperature. J. Virol. 64: 4922 4929.
18. Chumakov, M.,, M. Voroshilova,, L. Shindarov,, I. Lavrova,, L. Gracheva,, G. Koroleva,, S. Vasilenko,, I. Brodvarova,, M. Nikolova,, S. Gyurova,, M. Gacheva,, G. Mitov,, N. Ninov,, E. Tsylka,, I. Robinson,, M. Frolova,, V. Bashkirtsev,, L. Martiyanova,, and V. Rodin. 1979. Enterovirus 71 isolated from cases of epidemic poliomyelitislike disease in Bulgaria. Arch. Virol. 60: 329 340.
19. DesGroseillers, L.,, M. Barette,, and R. Jolicoeur. 1984. Physical mapping of the paralysis-inducing determinant of a wild mouse ectropic neurotropic virus. J. Virol. 52: 356 363.
20. Eberle, E.,, P. Dubreuil,, M. G. Mattel,, E. Devilard,, and M. Lopez. 1995. The human PRR21 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene. Gene 4: 267 272.
21. Eilbott, D. J.,, N. Peress,, H. Burger,, D. LaNeve,, J. Orenstein,, H. E. Gendelman,, R. Seidman,, and B. Weiser. 1989. Human immunodeficiency virus expression and replication in macrophages in the spinal cords of AIDS patients with myelopathy. Proc. Natl. Acad. Sci. USA 86: 3337 3341.
22. Evans, D. M. A.,, G. Dunn,, P. D. Minor,, G. C. Schild,, A. J. Cann,, and J. Almond. 1985. Increased neurovirulence associated with a single nucleotide change in a non-coding region of the Sabin type 3 poliovaccine genome. Nature 314: 548 550.
23. Fazakerley, J. K.,, S. E. Parker,, F. Bloom,, and M. J. Buchmeier. 1992. The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type 4 is neuroattenuated by its reduced rate of spread in the central nervous system. Virology 187: 178 188.
24. Filman, D. J.,, R. Syed,, M. Chow,, A. J. Macadam,, P. D. Minor,, and J. M. Hogle. 1989. Structural factors that control conformational transitions and serotype specificity in type 3 poliovirus. EMBO J. 8: 1567 1679.
25. Freistadt, M. S.,, H. B. Fleit,, and E. Wimmer. 1993. Poliovirus receptor on human blood cells: a possible extra-neural site of poliovirus replication. Virology 195: 798 803.
26. Geraghty, R. J.,, C. Krummenacher,, G. H. Cohen,, R. J. Eisenberg,, and P. G. Spear. 1998. Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor. Science 280: 1618 1620.
27. Grist, N. R.,, and E. J. Bell. 1970. Enteroviral etiology of the paralytic poliomyelitis syndrome. Arch. Environ. Health 21: 382 387.
28. Gromeier, M.,, L. Alexander,, and E. Wimmer. 1996. Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants. Proc. Natl. Acad. Sci. USA 93: 2370 2375.
29. Gromeier, M.,, B. Bossert,, M. Arita,, A. Nomoto,, and E. Wimmer. 1999. Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence. J. Virol. 73: 958 964.
30. Gromeier, M.,, H. H. Lu,, G. Bernhardt,, J. J. Harber,, J. A. Bibb,, and E. Wimmer. 1995. The human poliovirus receptor. Receptor-virus interaction and parameters of disease specificity. Ann. N. Y. Acad. Sci. 753: 19 36.
31. Gromeier, M.,, H. H. Lu,, and E. Wimmer. 1995. Mouse-neurovirulent poliovirus strains cause damage in the central nervous system distinct from poliomyelitis. Microb. Pathog. 18: 253 267.
32. Gromeier, M.,, D. Solecki,, D. Patel,, and E. Wimmer. Expression of the human poliovirus receptor/CD 155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis. Virology 273: 248 257.
33. Gromeier, M.,, and E. Wimmer. 1998. Mechanism of injury-provoked poliomyelitis. J. Virol. 72: 5056 5060.
34. Gromeier, M.,, and E. Wimmer. 1999. The relation of prophylactic inoculations to the onset of poliomyelitis. Rev. Med. Virol. 9: 219 226.
35. Gromeier, M.,, E. Wimmer,, and A. E. Gorbalenya,. 1999. Genetics, pathogenesis and evolution of picornaviruses, p. 287 345. In E. Domingo,, R. Webster,, and J. Holland (ed.), Origin and Evolution of Viruses. Academic Press, London, United Kingdom.
36. Guyer, B.,, A. Bison,, J. Gold,, M. Brigaud,, and M. Aymard. 1980. Infections and paralytic poliomyelitis in tropical Africa. Bull. WHO 58: 285 291.
37. Haller, A. A.,, and B. L. Semler. 1995. Stem-loop structure synergy in binding cellular proteins to the 5' non-coding region of poliovirus RNA. Virology 206: 923 934.
38. Haller, A. A.,, S. R. Stewart,, and B. L. Semler. 1996. Attenuation stem-loop lesions in the 5' noncoding region of poliovirus RNA: neuronal cell-specific translation defects. J. Virol. 70: 1467 1474.
39. Higgins, P. G.,, and T. E. Chapman. 1977. Coxsackievirus A24 and acute haemorrhagic conjunctivitis in Sri Lanka. Lancet 1: 361.
40. Honda, T.,, H. Saitoh,, M. Masuko,, T. Katagiri-Abe,, K. Tominaga,, I. Kozakai,, K. Kobayashi,, T. Kumanishi,, Y. G. Watanabe,, S. Odani,, and R. Kuwano. 2000. The coxsackievirus-adenovirus receptor protein as a cell adhesion molecule in the developing mouse brain. Mol. Brain Res. 77: 19 28.
41. Horstmann, D. M. 1950. Acute poliomyelitis: relation of physical activity at the time of onset to the course of disease. JAMA 142: 236 241.
42. Horstmann, D. M.,, and J. R. Paul. 1947. The incubation period in human poliomyelitis and its implications. JAMA 135: 11 14.
43. Jacobi, M. P., 1886. Infantile spinal paralysis, p. 1113 1164. In W. Pepper (ed.), A System of Medicine by American Authors, vol. 5.
44. Jang, S. K.,, H. G. Kraeusslich,, M. J. H. Nicklin,, G. M. Duke,, A. C. Palmenberg,, and E. Wimmer. 1988. A segment of the 5' non-translated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J. Virol. 62: 2636 2643.
45. Karnauchow, T. M.,, D. L. Tolson,, B. A. Harrison,, E. Altman,, D. M. Lublin,, and K. Dimock. 1996. The HeLa cell receptor for enterovirus 70 is decay-accelerating factor (CD55). J. Virol. 70: 5143 5152.
46. Kawamura, N.,, M. Kohara,, S. Abe,, T. Komatsu,, K. Tago,, M. Arita,, and A. Nomoto. 1989. Determinants in the 5' noncoding region of poliovirus Sabin 1 RNA that influence the attenuation phenotype. J. Virol. 63: 1302 1309.
47. Kawano, H.,, V. Rostapshov,, L. Rosen,, and C. J. Lai. 1993. Genetic determinants of dengue type 4 virus neurovirulence for mice. J. Virol. 67: 6567 6575.
48. Koike, S.,, I. Ise,, Y. Sato,, H. Yonekawa,, O. Gotoh,, and A. Nomoto. 1992. A second gene for the African green monkey poliovirus receptor that has no putative NM-glycosylation site in the functional N-terminal immunoglobulin-like domain. J. Virol. 66: 7059 7066.
49. Koike, S.,, S. Taya,, T. Kurata,, S. Abe,, I. Ise,, H. Yonekawa,, and A. Nomoto. 1991. Transgenic mice susceptible to poliovirus. Proc. Natl. Acad. Sci. USA 88: 951 955.
50. La Monica, N.,, and V. R. Racaniello. 1989. Differences in replication of attenuated and neurovirulent poliovirus in human neuroblastoma cell lines SH-SY5Y. J. Virol. 63: 2357 2360.
51. Lopez, M.,, F. Eberle,, M. G. Mattei,, J. Gaert,, G. Birg,, F. Bardin,, C. Maroc,, and P. Dubreuil. 1995. Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene. Gene 3: 261 265.
52. Lustig, S.,, A. Jackson,, C. S. Hahn,, D. E. Griffin,, E. G. Strauss,, and J. H. Strauss. 1988. Molecular basis of Sindbis virus neurovirulence in mice. J. Virol. 62: 2329 2336.
53. Macadam, A. J.,, G. Ferguson,, C. Arnold,, and P. D. Minor. 1991. An assembly defect as a result of an attenuating mutation in the capsid proteins of the poliovirus type 3 vaccine strain. J. Virol. 65: 5225 5231.
54. Macadam, A. J.,, G. Ferguson,, J. Burlison,, D. Stone,, R. Skuce,, J. W. Almond,, and P. D. Minor. 1992. Correlation of RNA secondary structure and attenuation of Sabin vaccine strains of poliovirus in tissue culture. Virology 189: 415 422.
55. Macadam, A. J.,, S. R. Pollard,, G. Ferguson,, G. Dunn,, R. Skuce,, J. W. Almond,, and P. D. Minor. 1991. The 5' non-coding region of the type 2 poliovirus vaccine strain contains determinants of attenuation and temperature sensitivity. Virology 181: 451 458.
56. McCloskey, B. P. 1950. The relation of prophylactic inoculations to the onset of poliomyelitis. Lancet 1: 659 663.
57. McGoldrick, A.,, A. J. Macadam,, G. Dunn,, W. Rowe,, J. Burlison,, P. D. Minor,, J. Meredith,, D. J. Evans,, and J. W. Almond. 1995. Role of mutations G-480 and C-6203 in the attenuation phenotype of Sabin type 1 poliovirus. J. Virol. 69: 7601 7605.
58. Melnick, J. L., 1990. Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses, p. 549 605. In B. N. Fields, and D. M. Knipe (ed.), Fields Virology. Raven Press, New York, N.Y.
59. Mendelsohn, C. L.,, E. Wimmer,, and V. R. Racaniello. 1989. Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. Cell 56: 855 865.
60. Minor, P. D. 1992. The molecular biology of poliovaccines. J. Gen. Virol. 73: 3065 3077.
61. Minor, P. D.,, G. Dunn,, D. M. Evans,, D. I. Magrath,, A. John,, J. Howlett,, A. Phillips,, G. Westrop,, K. Wareham,, J. W. Almond, et al. 1989. The temperature sensitivity of the Sabin type 3 vaccine strain of poliovirus: molecular and structural effects of a mutation in the capsid protein VP3. J. Gen. Virol. 70: 1117 1123.
62. Morrison, M. E.,, and V. R. Racaniello. 1992. Molecular cloning and expression of a murine homolog of the human poliovirus receptor gene. J. Virol. 66: 2807 2813.
63. Moss, E. G.,, and V. R. Racaniello. 1991. Host range determinants located on the interior of the poliovirus capsid. EMBO J. 5: 1067 1074.
64. Murray, M. G.,, J. Bradley,, X. F. Yang,, E. Wimmer,, E. G. Moss,, and V. R. Racaniello. 1988. Poliovirus host range is determined by a short amino acid sequence in neutralization antigenic site I. Science 241: 213 215.
65. Nathanson, N.,, and A. D. Langmuir. 1963. The Cutter incident. Poliomyelitis following formaldehyde-inactivated poliovirus vaccination in the United States during the spring of 1955. I. Background. Am. J. Hyg. 78: 16 28.
66. Nathanson, N.,, and A. D. Langmuir. 1963. The Cutter incident. Poliomyelitis following formaldehyde-inactivated poliovirus vaccination in the United States during the spring of 1955. II. Relationship of poliomyelitis to Cutter vaccine. Am. J. Hyg. 78: 29 60.
67. Nathanson, N.,, and A. D. Langmuir. 1963. The Cutter incident. Poliomyelitis following formaldehyde-inactivated poliovirus vaccination in the United States during the spring of 1955. III. Comparison of the clinical character of vaccinated and contact cases occurring after use of high rate lots of Cutter vaccine. Am. J. Hyg. 78: 61 81.
68. Nieke, J.,, and M. Schachner. 1985. Expression of the neural cell adhesion molecules L1 and N-CAM and their common carbohydrate epitope 1.2/HNK-1 during development and after transection of the mouse sciatic nerve. Differentiation 30: 141 151.
69. Nomoto, A.,, T. Omata,, H. Toyoda,, S. Kuge,, H. Horie,, Y. Kataoka,, Y. Genba,, Y. Nakano,, and N. Imura. 1982. Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome. Proc. Natl. Acad. Sci. USA 79: 5793 5797.
70. Ohka, S.,, W. X. Yang,, E. Terada,, K. Iwasaki,, and A. Nomoto. 1998. Retrograde transport of intact poliovirus through the axon via the fast transport system. Virology 250: 67 75.
71. Omata, T.,, M. Kohara,, S. Kuge,, T. Komatsu,, W. Abe,, B. L. Sender,, A. Kameda,, H. Itoh,, M. Arita,, E. Wimmer,, and A. Nomoto. 1986. Genetic analysis of the attenuation phenotype of poliovirus type 1. J. Virol. 58: 348 358.
72. Paul, A.,, J. A. Mugavero,, J. Yin,, S. Hobson,, S. Schulz,, J. H. Van Boom,, and E. Wimmer. 2000. Studies on the attenuation phenotype of polio vaccines: poliovirus RNA polymerase derived from Sabin type 1 sequence is temperature sensitive in the uridylylation of VPg. Virology 272: 72 84.
73. Paul, A. V.,, J. H. Van Boom,, D. Filipov,, and E. Wimmer. 1998. Protein-primed RNA synthesis by purified poliovirus RNA polymerase. Nature 393: 280 284.
74. Pelletier, J.,, and N. Sonenberg. 1988. Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334: 320 325.
75. Peluso, R.,, A. Hasase,, L. Stowring,, M. Edwards,, and P. Ventura. 1985. A Trojan horse mechanism for the spread of visna in monocytes. Virology 147: 231 236.
76. Pilipenko, E. V.,, E. G. Viktorova,, E. V. Khitrina,, S. V. Maslova,, N. Jarousse,, M. Brahic,, and V. I. Agol. 1999. Distinct attenuation phenotypes caused by mutations in the translational starting window of Theiler's murine encephalomyelitis virus. J. Virol. 73: 3190 3196.
77. Ren, R.,, F. Costantini,, E. J. Gorgacz,, J. J. Lee,, and V. R. Racaniello. 1990. Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis. Cell 63: 353 362.
78. Ren, R.,, E. G. Moss,, and V. R. Racaniello. 1991. Identification of two determinants that attenuated vaccine-related type 2 polioviruses. J. Virol. 65: 1377 1382.
79. Ren, R.,, and V. R. Racaniello. 1992. Poliovirus spreads from muscle to the central nervous system by neural pathways. J. Infect. Dis. 166: 747 752.
80. Roivainen, M.,, L. Piirainen,, T. Hovi,, I. Virtanen,, T. Riikonen,, J. Heino,, and T. Hyypia. 1994. Entry of coxsackievirus A9 into host cells: specific interactions with alpha v beta 3 integrin, the vitronectin receptor. Virology 203: 357 365.
81. Russell, W. R. 1947. Poliomyelitis: the preparalytic stage and the effect of physical activity on the severity of paralysis. Br. Med. J. 2: 1023.
82. Sabin, A. B. 1956. Pathogenesis of poliomyelitis. Reappraisal in the light of new data. Science 123: 1151 1157.
83. Sabin, A. B.,, and L. Boulger. 1973. History of Sabin attenuated poliovirus oral live vaccine strains. J. Biol. Stand. 1: 115 118.
84. Schultz, D. E.,, M. Honda,, L. E. Whetter,, K. L. McKnight,, and S. M. Lemon. 1996. Mutations within the 5' nontranslated RNA of cell culture-adapted hepatitis A virus which enhance cap-independent translation in cultured African green monkey kidney cells. J. Virol. 70: 1041 1049.
85. Seif, I.,, P. Coulon,, P. E. Rollin,, and A. Flamand. 1985. Rabies virulence: effect on pathogenicity and sequence characterization of rabies virus mutations affecting antigenic site III of the glycoprotein. J. Virol. 53: 926 934.
86. Skinner, M. A.,, V. R. Racaniello,, G. Dunn,, J. Cooper,, P. D. Minor,, and J. W. Almond. 1989. New model for the secondary structure of the 5' non-coding RNA of poliovirus is supported by biochemical and genetic data that also shows that RNA secondary structure is important in neurovirulence. J. Mol. Biol. 207: 379 392.
87. Solecki, D.,, G. Bernhardt,, M. Lipp,, and E. Wimmer. 2000. Identification of a nuclear respiratory factor-1 binding site within the core promoter of the human poliovirus receptor/CD155 gene. J. Biol. Chem. 275: 12453 12462.
88. Solecki, D.,, S. Schwarz,, E. Wimmer,, M. Lipp,, and G. Bernhardt. 1997. The promoters from human and monkey poliovirus receptors. J. Biol. Chem. 272: 5579 5586.
89. Solecki, D.,, E. Wimmer,, M. Lipp,, and G. Bernhardt. 1999. Identification and characterization of the cis-acting elements of the human CD155 gene core promoter. J. Biol. Chem. 274: 1791 1800.
90. Spriggs, D. R.,, R. T. Bronson,, and B. N. Fields. 1983. Hemagglutinin variants of Reovirus type 3 have altered central nervous system tropism. Science 220: 505 507.
91. Squitti, R.,, M. E. De Stefano,, D. Edgar,, and G. Toschi. 1999. Effects of axotomy on the expression and ultra-structural localization of N-cadherin and neural cell adhesion molecule in the quail ciliary ganglion: an in vivo model of neuroplasticity. Neuroscience 91: 707 722.
92. Strebel, P. M.,, N. Ion-Nedelcu,, A. L. Baughman,, R. M. Sutter,, and S. L. Cochi. 1995. Intramuscular injections within 30 days of immunization with oral poliovirus vaccine—a risk factor for vaccine-associated paralytic poliomyelitis. N. Engl. J. Med. 332: 500 506.
93. Sutter, R. W.,, P. A. Patriarca,, A. J. Suleiman,, S. Brogan,, P. G. Malankar,, S. L. Cochi,, A. A. Al-Ghassani,, and M. S. el-Bualy. 1992. Attributable risk of DTP (diphtheria and tetanus toxoids and pertussis vaccine) injection in provoking paralytic poliomyelitis during a large outbreak in Oman. J. Infect. Dis. 165: 444 449.
94. Tardy-Panit, M.,, B. Blondel,, A. Martin,, F. Tekaia,, F. Horaud,, and F. Delpeyroux. 1993. A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice. J. Virol. 67: 4630 4638.
95. Tomko, R. P.,, R. Xu,, and L. Philipson. 1997. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and B coxsackieviruses. Proc. Natl. Acad. Sci. USA 94: 3352 3356.
96. Toyoda, H.,, C. F. Yang,, N. Takeda,, A. Nomoto,, and E. Wimmer. 1987. Analysis of RNA synthesis of type 1 poliovirus by using an in vitro molecular genetic approach. J. Virol. 61: 2816 2822.
97. Triantafilou, M.,, K. Triantafilou,, K. M. Wilson,, Y. Takada,, N. Fernandez,, and G. Stanway. 1999. Involvement of beta2-microglobulin and integrin alphavbeta3 molecules the coxsackievirus A9 infectious cycle. J. Gen. Virol. 80: 2591 2600.
98. Voroshilova, M.,, and M. Chumakov. 1959. Poliomyelitis-like properties of AB-IV coxsackie A7 group of viruses. Prog. Med. Virol. 2: 106 107.
99. Wadia, N. H.,, S. M. Katrak,, V. P. Misra,, P. N. Wadia,, K. Miyamura,, K. Hashimoto,, T. Ogino,, T. Hikiji,, and R. Kono. 1983. Polio-like motor paralysis associated with acute hemorrhagic conjunctivitis in an outbreak in 1981 in Bombay, India: clinical and serologic studies. J. Infect. Dis. 147: 660 668.
100. Wang, S. M.,, C. C. Liu,, H. W. Tseng,, J. R. Wang,, C. C. Huang,, Y. J. Chen,, Y. J. Yang,, S. J. Lin,, and T. F. Yeh. 1999. Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications. Clin. Infect. Dis. 29: 184 190.
101. Westrop, G. D.,, K. A. Wareham,, D. M. A. Evans,, G. Dunn,, P. D. Minor,, D. I. Magrath,, F. Taffs,, S. Marsden,, M. A. Skinner,, G. Schild,, and J. W. Almond. 1989. Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine. J. Virol. 63: 1338 1344.
102. Wimmer, E.,, J. J. Harber,, J. A. Bibb,, M. Gromeier,, H. H. Lu,, and G. Bernhardt,. 1994. Poliovirus receptors, p. 101 127. In E. Wimmer (ed.), Cellular Receptors for Animal Viruses. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
103. Wimmer, E.,, C. U. T. Hellen,, and X. M. Cao. 1993. Genetics of poliovirus. Annu. Rev. Genet. 27: 353 436.
104. Yang, W.-X.,, T. Tersaki,, K. Shiroki,, S. Ohka,, J. Aoki,, S. Tanabe,, T. Nomura,, E. Terada,, Y. Sugiyama,, and A. Nomoto. 1997. Efficient delivery of circulating poliovirus to the central nervous system independently of poliovirus receptor. Virology 229: 421 428.
105. Yin-Murphy, M. 1984. Acute hemorrhagic conjunctivitis. Prog. Med. Virol. 29: 23 44.
106. Zhang, S.,, and V. R. Racaniello. 1997. Expression of the poliovirus receptor in intestinal epithelial cells is not sufficient to permit poliovirus replication in the mouse gut. J. Virol. 71: 4915 4920.


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Picornaviruses, their clinical manifestations, and receptor specificities

ND, not determined; HCAR, human coxsackievirus B and adenovirus receptor; DAF, decay-accelerating factor; ICAM-1, intercellular adhesion molecule 1; LDL, low-density lipoprotein; HAVcr-1, receptor for hepatitis A virus; VCAM-1, vascular cell adhesion molecule 1.

Citation: Gromeier M, Nomoto A. 2002. Determinants of Poliovirus Pathogenesis, p 367-379. In Semler B, Wimmer E (ed), Molecular Biology of Picornavirus. ASM Press, Washington, DC. doi: 10.1128/9781555817916.ch29
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Members of the CD155-related family of genes

CD155, and mPRR2 are secreted splice variants.

Citation: Gromeier M, Nomoto A. 2002. Determinants of Poliovirus Pathogenesis, p 367-379. In Semler B, Wimmer E (ed), Molecular Biology of Picornavirus. ASM Press, Washington, DC. doi: 10.1128/9781555817916.ch29

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