Chapter 19 : Virus-Induced Immunosuppression

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Many laboratories are studying the immunosuppression induced by measles virus (MV) infection. One theory about the mechanism is that the viral infections shift a type 1 immune response to a type 2 immune response. This mechanism was explored further to demonstrate that the interaction of MV with its cellular receptor, CD46, results in the suppression of IL-12 which is required for type 1 immune responses. Another theory about the mechanism is that an as-yet-unidentified soluble factor is able to inhibit lymphoproliferation. Research groups are addressing the role that the MV proteins play in immunosuppression, while examining the role of the alternate MV receptor, signaling lymphocytic activation molecule (SLAM), in immunosuppression. A research group is examining the Fas-mediated apoptosis of MV-infected dendritic cells (DCs) as a means of explaining the presence of both a specific immune response and immunosuppression. Regardless of the extensive work that has been done on MV-induced immunosuppression, the exact molecular mechanism remains unresolved and may be multifactorial.

Citation: Libbey J, Fujinami R. 2002. Virus-Induced Immunosuppression, p 377-387. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch19
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MV genome. The structure of the MV RNA and resultant viral proteins is shown.

Citation: Libbey J, Fujinami R. 2002. Virus-Induced Immunosuppression, p 377-387. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch19
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Potential mechanisms of MV-induced immunosuppression

Citation: Libbey J, Fujinami R. 2002. Virus-Induced Immunosuppression, p 377-387. In Brogden K, Guthmiller J (ed), Polymicrobial Diseases. ASM Press, Washington, DC. doi: 10.1128/9781555817947.ch19

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