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Chapter 2 : Epidemiology of Infection

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Abstract:

This chapter provides the reader with the most recent data in regard to the epidemiology of and reviews current areas of controversy. infection is ubiquitous and infects both males and females. Natural acquisition of infection occurs, for the most part, in childhood. Once established within the gastric mucosa, the bacterium persists for life. The possibility that may be a zoonosis first arose following the publication of two seroepidemiological studies that showed that the prevalence of infection in abattoir and meat workers was significantly increased as compared with that in subjects not involved in handling animals or animal products. Confirming the importance of adult-child transmission, seroconversion only occurred among children living with -positive mothers over the period of the study. The presence of in the gastric juice of up to 58% of patients infected with raises the possibility that refluxed gastric juice may represent a vehicle of transmission for the organism. The ability to detect -specific DNA from the oral cavity has varied significantly. Attempts to detect DNA in feces by PCR have resulted in variable outcomes. Given the association between and peptic ulcer disease, gastric cancer, and B-cell mucosa-associated lymphoid tissue (MALT) lymphoma, there is an urgent need for the development of intervention strategies to prevent the spread of the bacterium.

Citation: Mitchell H. 2001. Epidemiology of Infection, p 7-18. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch2

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1. Albenque, M.,, F. Tall,, F. Dabis,, and F. Megraud. 1990. Epidemiological study of Helicobacter pylori transmission from mother to child in Africa. Enferm. Digest. 78: 48.
2. Al-Moagel, M. A.,, D. G. Evans,, M. E. Abdulghani,, E. Adam,, D.J.J. Evans,, H. M. Malaty,, and D. Y. Graham. 1990. Prevalence of Helicobacter (formerly Campylobacter) pylori infection in Saudi Arabia, and comparison of those with and without upper gastrointestinal symptoms. Am. J. Gastroenterol. 85: 944 948.
3. Ansorg, R.,, E. H. Vonheinegg,, and G. Vonrecklinghausen. 1995. Cat owner's risk of acquiring a Helicobacter pylori infection. Zentralbl. Bakteriol. Int. J. Med. Microbiol. Vir. Parasitol. Infect. Dis. 283: 122 126.
4. Asaka, M.,, T. Kimura,, and M. Kudo. 1992. Relationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology 102: 760 766.
5. Axon, A. T. R. 1995. Is Helicobacter pylori transmitted by the gastro-oral route? Aliment. Pharmacol. Ther. 9: 585 588.
6. Bamford, K. B.,, J. Bickley,, J. S. A. Collins,, B. T. Johnston,, S. Potts,, V. Boston,, R. J. Owen,, and J. M. Sloan. 1993. Helicobacter pylori—comparison of DNA fingerprints provides evidence for intrafamilial infection. Gut 34: 1348 1350.
7. Banatvala, N.,, C. R. Lopez,, R. J. Owen,, A. Hurtado,, Y. Abdi,, G. R. Davies,, J. M. Hardie,, and R. A. Feldman. 1994. Use of the polymerase chain reaction to detect Helicobacter pylori in the dental plaque of healthy and symptomatic individuals. Microb. Ecol. Health Dis. 7: 1 8.
8. Banatvala, N.,, K. Mayo,, F. Megraud,, R. Jennings,, J.J. Deeks,, and R. A. Feldman. 1993. The cohort effect and Helicobacter pylori. J. Infect. Dis. 168: 219 221.
9. Bardhan, P. K. 1997. Epidemiological features of Helicobacter pylori infection in developing countries. Clin. Infect. Dis. 25: 973 978.
10. Basso, L.,, S. Beattie,, S. Lawlor,, J. Clune,, and C. O'Morain. 1994. A descriptive follow-up study on Helicobacter pylori infection before and after exposition to a war area. Eur. J. Epidemiol. 10: 109 111.
11. Berkowicz, J.,, and A. Lee. 1987. Person-to-person transmission of Campylobacter pylori. Lancet ii: 680 681.
12. Bickley, J.,, R. J. Owen,, A. G. Fraser,, and R. E. Pounder. 1993. Evaluation of the polymerase chain reaction for detecting the urease c gene of Helicobacter pylori in gastric biopsy samples and dental plaque. J. Med. Microbiol. 39: 338 344.
13. Bode, G.,, F. Mauch,, and P. Malfertheiner. 1993. The coccoid forms of Helicobacter pylori—criteria for their viability. Epidemiol. Infect. 111: 483 490.
14. Bode, G.,, D. Rothenbacher,, H. Brenner,, and G. Adler. 1998. Pets are not a risk factor for Helicobacter pylori infection in young children—results of a population-based study in southern Germany. Pediatr. Infect. Dis. J. 17: 909 912.
15. Brenner, H.,, D. Rothenbacher,, G. Bode,, P. Dieudonne,, and G. Adler. 1999. Active infection with Helicobacter pylori in healthy couples. Epidemiol. Infect. 122: 91 95.
16. Breuer, T.,, T. Sudhop,, J. Hoch,, T. Sauerbruch,, and P. Malfertheiner. 1996. Prevalence of and risk factors for Helicobacter pylori infection in the western part of Germany. Eur. J. Gastroenterol. Hepatol. 8: 47 52.
17. Cammarota, G.,, A. Tursi,, M. Montalto,, A. Papa,, G. Veneto,, S. Bernardi,, A. Boari,, V. Colizzi,, G. Fedeli,, and G. Gasbarrini. 1996. Role of dental plaque in the transmission of Helicobacter pylori infection. J. Clin. Gastroenterol. 22: 174 177.
18. Casswall, T. H.,, S. A. Sarker,, M. J. Albert,, G. J. Fuchs,, M. Bergstrom,, L. Bjorck,, and L. Hammarstrom. 1998. Treatment of Helicobacter pylori infection in infants in rural Bangladesh with oral immunoglobulins from hyperimmune bovine colostrum. Aliment. Pharmacol. Ther. 12: 563 568.
19. Cellini, L.,, N. Alloocati,, A. Piattelli,, I. Petrelli,, P. Fanci,, and B. Dainelli. 1995. Microbiological evidence of Helicobacter pylori from dental plaque in dyspeptic patients. Microbiologica 18: 187 192.
20. Cho, M. J.,, W. K. Lee,, Y. S. Jeon,, K. H. Kim,, S. H. Kim,, S. C. Baik,, K. H. Rhee,, Y. O. Kim,, H. S. Yoon,, and N. S. Kim. 1995. Intrafamilial transmission of Helicobacter pylori detected by random amplified polymorphic DNA fingerprinting. Molecules Cells 5: 508 513.
21. Chow, T.,, J. R. Lambert,, M. L. Wahlqvist,, and B. Hsuhage. 1995. Helicobacter pylori in Melbourne Chinese immigrants—evidence for oral-oral transmission via chopsticks. J. Gastroenterol. Hepatol. 10: 562 569.
22. Clemens, J.,, M. J. Albert,, M. Rao,, S. Huda,, F. Qadri,, F. P. L. Vanloon,, B. Pradhan,, A. Naficy,, and A. Banik. 1996. Sociodemographic, hygienic and nutritional correlates of Helicobacter pylori infection of young Bangladeshi children. Pediatr. Infect. Dis.J. 15: 1113 1118.
23. Gullen, D. J. E.,, B. J. Collins,, K. J. Christiansen,, J. Epis,, J. R. Warren,, I. Surveyor,, and K. J. Cullen. 1993. When is Helicobacter pylori infection acquired? Gut 34: 1681 1682.
24. de Oliveira, A. M. R.,, G. A. Rocha,, D. Queiroz,, S. B. de Moura,, and A. L. T. Rabello. 1999. Seroconversion for Helicobacter pylori in adults from Brazil. Trans. R. Soc. Trop. Med. Hyg. 93: 261 263.
25. Desai, H. G.,, H. H. Gill,, K. Shankaran,, P. R. Mehta,, and S. R. Prabhu. 1991. Dental plaque: a permanent reservoir of Helicobacter pylori? Scand. J. Gastroenterol. 26: 1205 1208.
26. Dore, M. P.,, M. Bilotta,, D. Vaira,, A. Manca,, G. Massarelli,, G. Leandro,, A. Atzei,, G. Pisanu,, D. Y. Graham,, and G. Realdi. 1999. High prevalence of Helicobacter pylori infection in shepherds. Dig. Dis. Sci. 44: 1161 1164.
27. Dore, M. P.,, A. R. Sepulveda,, M. S. Osato,, G. Realdi,, and D. Y. Graham. 1999. Helicobacter pylori in sheep milk. Lancet 354: 132.
28. Dowsett, S. A.,, L. Archila,, V. A. Segreto,, C. R. Gonzalez,, A. Silva,, K. A. Vastola,, R. D. Bartizek,, and M. J. Kowolik. 1999. Helicobacter pylori infection in indigenous families of Central America: serostatus and oral and fingernail carriage. J. Clin. Microbiol. 37: 2456 2460.
29. Drumm, B.,, P. G. I. Perez,, M. J. Blaser,, and P. M. Sherman. 1990. Intrafamilial clustering of Helicobacter pylori infection. N. Engl. J. Med. 322: 359 363.
30. Dubois, A.,, N. Fiala,, L. M. Hemanackah,, E. S. Drazek,, A. Tarnawski,, W. N. Fishbein,, G. I. Perez Perez,, and M. J. Blaser. 1994. Natural gastric infection with Helicobacter pylori in monkeys: a model for spiral bacteria infection in humans. Gastroenterology 106: 1405 1417.
31. Dye, K. R.,, B. J. Marshall,, H. F. Frierson, Jr.,, D. J. Pambianco,, and R. W. McCallum. 1990. Campylobacter pylori colonizing heterotopic gastric tissue in the rectum. Am. J. Clin. Pathol. 93: 144 147.
32. Eaton, K. A.,, C. E. Catrenich,, K. M. Makin,, and S. Krakowka. 1995. Virulence of coccoid and bacillary forms of Helicobacter pylori in gnotobiotic piglets. J. Infect. Dis. 171: 459 462.
33. Eaton, K. A.,, D. R. Morgan,, and S. Krakowka. 1990. Persistence of Helicobacter pylori in conventionalized piglets. J. Infect. Dis. 161: 1299 1301.
34. Engstrand, L.,, S. Gustavsson,, A. Jorgensen,, A. Schwan,, and A. Scheynius. 1990. Inoculation of barrier-born pigs with Helicobacter pylori: a useful animal model for gastritis type B. Infect. Immun. 58: 1763 1768.
35. Enroth, H.,, K. Wreiber,, R. Rigo,, D. Risberg,, A. Uribe,, and L. Engstrand. 1999. In vitro aging of Helicobacter pylori: changes in morphology, intracellular composition and surface properties. Helicobacter 4: 7 16.
36. Fan, X. G.,, A. Chua,, T. G. Li,, and Q. S. Zeng. 1998. Survival of Helicobacter pylori in milk and tap water. J. Gastroenterol. Hepatol. 13: 1096 1098.
37. Ferguson, D. A.,, L. Chuanfu,, N. R. Patel,, W. R. Mayberry,, D. S. Chi,, and E. Thomas. 1993. Isolation of Helicobacter pylori from saliva. J. Clin. Microbiol. 31: 2802 2804.
38. Forman, D.,, G. Debacker,, J. Elder,, H. Moller,, L. C. Damotta,, P. Roy,, L. Abid,, G. Debacker,, A. Tjonneland,, H. Boeing,, T. Haubrich,, J. Wahrendorf,, O. Manousos,, A. Kafatos,, H. Tulinius,, H. Ogmundsdottir,, D. Palli,, F. Cipriani,, A. Fukao,, S. Tsugane,, Y. Miyajima,, W. Zatonski,, J. Tycznski,, J. Calheiros,, M. P. Zakelj,, M. Potocnik,, P. Webb,, T. Knight,, A. Wilson,, S. Kaye,, J. Potter,, D. G. Newell,, K. J. Hengeis,, S. Kyrtopoulos,, C. Wild,, H. Moller,, P. Webb,, D. Newell,, D. Forman,, D. Palli,, K. Hengeis,, J. Elder,, G. Debacker,, and M. Coleman. 1993. Epidemiology of, and risk factors for, Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. Gut 34: 1672 1676.
39. Fox, J. G. 1995. Non-human reservoirs of Helicobacter pylori. Aliment. Pharmacol. Ther. 9: 93 103.
40. Furuta, T.,, T. Kamata,, M. Takashima,, H. Futami,, H. Arai,, H. Hanai,, and E. Kaneko. 1997. Study of transmission routes of Helicobacter pylori in relation to seroprevalence of hepatitis A virus. J. Clin. Microbiol. 35: 1891 1893.
41. Georgopoulos, S. D.,, A. F. Mentis,, C. A. Spiliadis,, L. S. Tzouvelekis,, E. Tzelepi,, A. Moshopoulos,, and N. Skandalis. 1996. Helicobacter pylori infection in spouses of patients with duodenal ulcers and comparison of ribosomal RNA gene patterns. Gut 39: 634 638.
42. Goh, K. L. 1997. Prevalence of and risk factors for Helicobacter pylori infection in a multi-racial dyspeptic Malaysian population undergoing endoscopy. J. Gastroenterol. Hepatol. 12: S29 S35.
43. Goodman, K. J.,, and P. Correa. 2000. Transmission of Helicobacter pylori among siblings. Lancet 355: 358 362.
44. Goodman, K. J.,, P. Correa,, H. J. T. Aux,, H. Ramirez,, J. P. Delany,, O. G. Pepinosa,, M. L. Quinones,, and T. C. Parra. 1996. Helicobacter pylori infection in the Colombian Andes—a population-based study of transmission pathways. Am. J. Epidemiol. 144: 290 299.
45. Graham, D. Y.,, E. Adam,, G. T. Reddy,, J. P. Agarwal,, R. Agarwal,, D. J. Evans,, H. M. Malaty,, and D. G. Evans. 1991. Seroepidemiology of Helicobacter pylori infection in India. Comparison of developing and developed countries. Dig. Dis. Sci. 36: 1084 1088.
46. Graham, D. Y.,, L. C. Alpert,, J. L. Smith,, and H. H. Yoshimura. 1988. Iatrogenic Campylobacter pylori infection is a cause of epidemic achlorhydria. Am. J. Gastroenterol. 83: 974 980.
47. Graham, D. Y.,, G. M. Lew,, P. D. Klein,, D. G. Evans,, D. J. Evans,, Z. A. Saeed,, and H. M. Malaty. 1992. Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer, a randomized, controlled study. Ann. Intern. Med. 116: 705 708.
48. Graham, D. Y.,, H. M. Malaty,, D. G. Evans,, D. J. J. Evans,, P. D. Klein,, and E. Adam. 1991. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology 100: 1495 1501.
49. Granström, M.,, Y. Tindberg,, and M. Blennow. 1997. Seroepidemiology of Helicobacter pylori infection in a cohort of children monitored from 6 months to 11 years of age. J. Clin. Microbiol. 35: 468 470.
50. Grasso, G. M.,, G. Ripabelli,, M. L. Sammarco,, A. Ruberto,, and G. Iannitto. 1996. Prevalence of Helicobacter-like organisms in porcine gastric mucosa—a study of swine slaughtered in Italy. Comp. Immunol. Microbiol. Infect. Dis. 19: 213 217.
51. Grubel, P.,, J. S. Hoffman,, F. K. Chong,, N. A. Burstein,, C. Mepani,, and D. R. Cave. 1997. Vector potential of houseflies (Musca domestica) for Helicobacter pylori. J. Clin. Microbiol. 35: 1300 1303.
52. Grubel, P.,, L. L. Huang,, N. Masubuchi,, F. J. Stutzenberger,, and D. R. Cave. 1998. Detection of Helicobacter pylori DNA in houseflies (Musca domestica) on three continents. Lancet 352: 788 789.
53. Handt, L. K.,, J. G. Fox,, F. E. Dewhirst,, G. J. Fraser,, B. J. Paster,, L. L. Yan,, H. Rozmiarek,, R. Rufo,, and I. H. Stalis. 1994. Helicobacter pylori isolated from the domestic cat: public health implications. Infect. Immun. 62: 2367 2374.
54. Handt, L. K.,, J. G. Fox,, L. L. Yan,, Z. Shen,, W. J. Pouch,, D. Ngai,, S. L. Motzel,, T. E. Nolan,, and H. J. Klein. 1997. Diagnosis of Helicobacter pylori infection in a colony of rhesus monkeys (Macaca mulatta). J. Clin. Microbiol. 35: 165 168.
55. Hazell, S. L.,, H. M. Mitchell,, M. Hedges,, X. Shi,, P. J. Hu,, Y. Y. Li,, A. Lee,, and E. Reisslevy. 1994. Hepatitis A and evidence against the community dissemination of Helicobacter pylori via feces. J. Infect. Dis. 170: 686 689.
56. Hopkins, R. J.,, P. A. Vial,, C. Ferreccio,, J. Ovalle,, P. Prado,, V. Sotomayor,, R. G. Russell,, S. S. Wasserman,, and J. G. Morris. 1993. Seroprevalence of Helicobacter pylori in Chile—vegetables may serve as one route of transmission. J. Infect. Dis. 168: 222 226.
57. Hulten, K.,, H. Enroth,, T. Nyström,, and L. Engstrand. 1998. Presence of Helicobacter species DNA in Swedish water. J. Appl. Microbiol. 85: 282 286.
58. Hulten, K.,, S. W. Han,, H. Enroth,, P. D. Klein,, A. R. Opekun,, R. H. Gilman,, D. G. Evans,, L. Engstrand,, D. Y. Graham,, and F. Elzaatari. 1996. Helicobacter pylori in the drinking water in Peru. Gastroenterology 110: 1031 1035.
59.International Agency for Research on Cancer. 1994. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 61, p. 177240. World Health Organization, Lyon, France.
60. Jones, D. M.,, J. Eldridge,, A. J. Fox,, P. Sethi,, and P. J. Whorwell. 1986. Antibody to the gastric campylobacter-like organism ("Campylobacter pyloridis")—clinical correlations and distribution in the normal population. J. Med. Microbiol. 22: 57 62.
61. Katelaris, P.,, G. Tippett,, G. Zoli,, D. Lowe,, P. Norbu,, and M. Farthing. 1993. An evaluation of factors affecting Helicobacter pylori prevalence in Tibetans exiled in India. Trans. R. Soc. Trop. Med. Hyg. 87: 400 403.
62. Kelly, S. M.,, M. C. L. Pitcher,, S. M. Farmery,, and G. R. Gibson. 1994. Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom. Gastroenterology 107: 1671 1674.
63. Kimura, A.,, T. Matsubasa,, H. Kinoshita,, N. Kuriya,, Y. Yamashita,, T. Fujisawa,, H. Terakura,, and M. Shinohara. 1999. Helicobacter pylori seropositivity in patients with severe neurologic impairment. Brain Dev. 21: 113 117.
64. Klein, P. D.,, R. H. Gilman,, R. Leonbarua,, F. Diaz,, E. O. Smith,, and D. Y. Graham. 1994. The epidemiology of Helicobacter pylori in Peruvian children between 6 and 30 months of age. Am. J. Gastroenterol. 89: 2196 2200.
65. Klein, P. D.,, D. Y. Graham,, A. Gaillour,, A. R. Opekun,, and E. O. Smith. 1991. Water source as risk factor for Helicobacter pylori infection in Peruvian children. Gastrointestinal Physiology Working Group. Lancet 337: 1503 1506.
66. Krajden, S.,, M. Fuksa,, J. Anderson,, J. Kempston,, A. Boccia,, C. Petrea,, C. Babida,, M. Karmali,, and J. L. Penner. 1989. Examination of human stomach biopsies, saliva, and dental plaque for Campylobacter pylori. J. Clin. Microbiol. 27: 1397 1398.
67. Kusters, J. G.,, M. M. Gerrits,, J. Vanstrijp,, and C. Vandenbrouckegrauls. 1997. Coccoid forms of Helicobacter pylori are the morphologic manifestation of cell death. Infect. Immun. 65: 3672 3679.
68. Lambert, J. R.,, S. K. Lin,, W. Sievert,, L. Nicholson,, M. Schembri,, and C. Guest. 1995. High prevalence of Helicobacter pylori antibodies in an institutionalized population—evidence for person-to-person transmission. Am. J. Gastroenterol. 90: 2167 2171.
69. Lee, A. 1994. The microbiology and epidemiology of Helicobacter pylori infection. Scand. J. Gastroenterol. 29: 2 6.
70. Leung, W. K.,, K. L. K. Siu,, C. K. L. Kwok,, S. Y. Chan,, R. Sung,, and J. J. Y. Sung. 1999. Isolation of Helicobacter pylori from vomitus in children and its implication in gastro-oral transmission. Am. J. Gastroenterol. 94: 2881 2884.
71. Leung, W. K.,, J. J. Y. Sung,, T. K. W. Ling,, K. L. K. Siu,, and A. F. B. Cheng. 1999. Use of chopsticks for eating and Helicobacter pylori infection. Dig. Dis. Sci. 44: 1173 1176.
72. Li, C. F.,, T. Z. Ha,, D. A. Ferguson,, D. S. Chi,, R. G. Zhao,, N. R. Patel,, G. Krishnaswamy,, and E. Thomas. 1996. A newly developed PCR assay of H. pylori in gastric biopsy, saliva, and feces—evidence of high prevalence of H. pylori in saliva supports oral transmission. Dig. Dis. Sci. 41: 2142 2149.
73. Lin, S. K.,, J. R. Lambert,, M. A. Schembri,, L. Nicholson,, and I. H. Johnson. 1998. The prevalence of Helicobacter pylori in practising dental staff and dental students. Aust. Dent. J. 43: 35 39.
74. Lin, S. K.,, J. R. Lambert,, M. A. Schembri,, L. Nicholson,, and M. G. Korman. 1994. Helicobacter pylori prevalence in endoscopy and medical staff, ]. Gastroenterol. Hepatol. 9: 319 324.
75. Luzza, F.,, M. Imeneo,, M. Maletta,, G. Paluccio,, A. Giancotti,, F. Perticone,, A. Foca,, and F. Pallone. 1997. Seroepidemiology of Helicobacter pylori infection and hepatitis A in a rural area—evidence against a common mode of transmission. Gut 41: 164 168.
76. Luzza, F.,, M. Mancuso,, M. Imeneo,, A. Contaldo,, L. Giancotti,, L. Pensabene,, P. Doldo,, M. C. Liberto,, P. Strisciuglio,, A. Foca,, S. Guandalini,, and F. Pallone. 2000. Evidence favouring the gastro-oral route in the transmission of Helicobacter pylori infection in children. Eur. J. Gastroenterol. Hepatol. 12: 623 627.
77. Malaty, H. M.,, L. Engstrand,, N. L. Pedersen,, and D. Y. Graham. 1994. Helicobacter pylori infection: genetic and environmental influences. Ann. Intern. Med. 120: 982 986.
78. Malaty, H. M.,, D. G. Evans,, D. J. Evans,, and D. Y. Graham. 1992. Helicobacter pylori in Hispanics—comparison with blacks and whites of similar age and socioeconomic class. Gastroenterology 103: 813 816.
79. Malaty, H. M.,, D. J. Evans,, K. Abramovitch,, D. G. Evans,, and D. Y. Graham. 1992. Helicobacter pylori infection in dental workers: a seroepidemiology syudy. Am. J. Gastroenterol. 87: 1728 1731.
80. Malaty, H. M.,, and D. Y. Graham. 1994. Importance of childhood socioeconomic status on the current prevalence of Helicobacter pylori infection. Gut 35: 742 745.
81. Malaty, H. M.,, D. Y. Graham,, I. Isaksson,, L. Engstrand,, and N. L. Pedersen. 1998. Co-twin study of the effect of environment and dietary elements on acquisition of Helicobacter pylori infection. Am. J. Epidemiol. 148: 793 797.
82. Malaty, H. M.,, D. Y. Graham,, W. A. Wattigney,, S. R. Srinivasan,, M. Osato,, and G. S. Berenson. 1999. Natural history of Helicobacter pylori infection in childhood: 12-year follow-up cohort study in a biracial community. Clin. Infect. Dis. 28: 279 282.
83. Malaty, H. M.,, J. G. Kim,, S. D. Kim,, and D. Y. Graham. 1996. Prevalence of Helicobacter pylori infection in Korean children—inverse relation to socioeconomic status despite a uniformly high prevalence in adults. Am. J. Epidemiol. 143: 257 262.
84. Malaty, H. M.,, T. Kumagai,, E. Tanaka,, H. Ota,, K. Kiyosawa,, D. Y. Graham,, and T. Katsuyama. 2000. Evidence from a nine-year birth cohort study in Japan of transmission pathways of Helicobacter pylori infection. J. Clin. Microbiol. 38: 1971 1973.
85. Mapstone, N. P.,, F. A. Lewis,, D. S. Tompkins,, D. A. F. Lynch,, A. T. R. Axon,, M. F. Dixon,, and P. Quirke. 1993. PCR identification of Helicobacter pylori in faeces from gastritis patients. Lancet 341: 447.
86. Mapstone, N. P.,, D. A. F. Lynch,, F. A. Lewis,, A. T. R. Axon,, D. S. Tompkins,, M. F. Dixon,, and P. Quirke. 1993. Identification of Helicobacter pylori DNA in the mouths and stomachs of patients with gastritis using PCR. J. Clin. Pathol. 46: 540 543.
87. Marshall, B. J.,, D. B. McGechie,, P. A. Rogers,, and R. J. Glancy. 1985. Pyloric Campylobacter infection and gastroduodenal disease. Med. J. Aust. 142: 439 444.
88. McCallion, W. A.,, L. J. Murray,, A. G. Bailie,, A. M. Dalzell,, D. Oreilly,, and K. B. Bamford. 1996. Helicobacter pylori infection in children—relation with current household living conditions. Gut 39: 18 21.
89. Megraud, F. 1995. Transmission of Helicobacter pylori—faecal-oral versus oral-oral route. Aliment. Pharmacol. Ther. 9: 85 91.
90. Megraud, F.,, M. P. Brassens Rabbe,, F. Denis,, A. Belbouri,, and D. Q. Hoa. 1989. Seroepidemiology of Campylobacter pylori infection in various populations. J. Clin. Microbiol. 27: 1870 1873.
91. Mendall, M. A.,, P. M. Goggin,, N. Molineaux,, J. Levy,, T. Toosy,, D. Strachan,, and T. C. Northfield. 1992. Childhood living conditions and Helicobacter pylori seropositivity in adult life. Lancet 339: 896 897.
92. Mitchell, H. M. 1999. The epidemiology of Helicobacter pylori. Gastroduodenal Disease and Helicobacter pylori: Pathophysiology, Diagnosis and Treatment 241: 11 30.
93. Mitchell, H. M., 1993. The epidemiology of Helicobacter pylori infection and its relation to gastric cancer, p. 95 114. In C. S. Goodwin, and B. W. Wormsley (ed.), Helicobacter pylori: Biology and Clinical Practice. CRC Press, Boca Raton, Fla..
94. Mitchell, H. M.,, T. Bohane,, R. A. Hawkes,, and A. Lee. 1993. Helicobacter pylori infection within families. Zentralbl. Bakteriol. Int. J. Med. Microbiol. 280: 128 136.
95. Mitchell, H. M.,, S. L. Hazell,, T. Kolesnikow,, J. Mitchell,, and D. Frommer. 1996. Antigen recognition during progression from acute to chronic infection with a cagA-positive strain of Helicobacter pylori. Infect. Itnmun. 64: 1166 1172.
96. Mitchell, H. M.,, A. Lee,, and T. D. Bohane,. 1989. Evidence for person-to-person spread of Campylobacter pylori, p. 197 202. In B. J. Rathbone, and R. V. Heatley (ed.), Campylobacter pylori and Gastroduodenal Disease. Blackwell Scientific Publications, Oxford, United Kingdom.
97. Mitchell, H. M.,, A. Lee,, and J. Carrick. 1989. Increased incidence of Campylobacter pylori infection in gastroenterologists: further evidence to support person-to-person transmission of C. pylori. Scand. J. Gastroenterol. 24: 396 400.
98. Mitchell, H. M.,, Y. Li,, P. Hu,, S. L. Hazell,, G. Du,, D. J. Byrne,, and A. Lee. 1992. The susceptibility of Helicobacter pylori to bile may be an obstacle to faecal transmission. Eur. J. Gastroenterol. Hepatol. 4: S79 S83.
99. Mitchell, H. M.,, Y. Y. Li,, P. J. Hu,, Q. Liu,, M. Chen,, G. G. Du,, Z.J. Wang,, A. Lee,, and S. L. Hazell. 1992. Epidemiology of Helicobacter pylori in Southern China—identification of early childhood as the critical period for acquisition. J. Infect. Dis. 166: 149 153.
100. Mitchell, J. D.,, H. M. Mitchell,, and V. Tobias. 1992. Acute Helicobacter pylori infection in an infant, associated with gastric ulceration and serological evidence of intra-familial transmission. Am. J. Gastroenterol. 87: 382 386.
101. Miyaji, H.,, T. Azuma,, S. Ito,, Y. Abe,, F. Gejyo,, N. Hashimoto,, H. Sugimoto,, H. Suto,, Y. Ito,, Y. Yamazaki,, Y. Kohli,, and M. Kuriyama. 2000. Helicobacter pylori infection occurs via close contact with infected individuals in early childhood. J. Gastroenterol. Hepatol. 15: 257 262.
102. Morris, A.,, G. Nicholson,, G. Lloyd,, D. Haines,, A. Rogers,, and D. Taylor. 1986. Seroepidemiology of Campylobacter pyloridis. N. Z. Med. J. 99: 657 659.
103. Murray, L. J.,, E. E. McCrum,, A. E. Evans,, and K. B. Bamford. 1997. Epidemiology of Helicobacter pylori infection among 4742 randomly selected subjects from northern Ireland. Int. J. Epidemiol. 26: 880 887.
104. Namavar, F.,, R. Roosendaal,, E. J. Kuipers,, P. Degroot,, M. W. Vanderbijl,, A. S. Pena,, and J. Degraaff. 1995. Presence of Helicobacter pylori in the oral cavity, oesophagus, stomach and faeces of patients with gastritis. Eur. J. Clin. Microbiol. Infect. Dis. 14: 234 237.
105. Newell, D.,, M. J. Hudson,, and A. Baskerville. 1987. Naturally occurring gastritis associated with Campylobacter pylori infection in the rhesus monkey. Lancet ii: 1338.
106. Nguyen, A.,, F. Elzaatari,, and D. Y. Graham. 1995. Helicobacter pylori in the oral cavity. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontics 79: 705 709.
107. Nguyen, A. M. H.,, L. Engstrand,, R. M. Genta,, D. Y. Graham,, and F. A. K. Elzaatari. 1993. Detection of Helicobacter pylori in dental plaque by reverse transcription polymerase chain reaction. J. Clin. Microbiol. 31: 783 787.
108. Notarnicola, M.,, F. Russo,, A. Cavallini,, M. Bianco,, E. Jirillo,, S. Pece,, C. Leoci,, G. Dimatteo,, and A. Dileo. 1996. PCR identification of Helicobacter pylori DNA in faeces from patients with gastroduodenal pathology. Med. Sci. Res. 24: 785 787.
109. Olmos, J. A.,, H. Rios,, and R. Higa. 2000. Prevalence of Helicobacter pylori infection in Argentina—results of a nationwide epidemiologic study. J. Clin. Microbiol. 31: 33 37.
110. Osato, M. S.,, K. Ayub,, H. H. Le,, R. Reddy,, and D. Y. Graham. 1998. Houseflies are an unlikely reservoir or vector for Helicobacter pylori. J. Clin. Microbiol. 36: 2786 2788.
111. Parsonnet, J.,, S. Hansen,, L. Rodriguez,, A. B. Gelb,, R. A. Warnke,, E. Jellum,, N. Orentreich,, J. H. Vogelman,, and G. D. Friedman. 1994. Helicobacter pylori infection and gastric lymphoma. N. Engl. J. Med. 330: 1267 1271.
112. Parsonnet, J.,, H. Shmuely,, and T. Haggerty. 1999. Fecal and oral shedding of Helicobacter pylori from healthy infected adults. JAMA 282: 2240 2245.
113. Peach, H. G.,, D. C. Pearce,, and S. J. Farish. 1997. Helicobacter pylori infection in an Australian regional city—prevalence and risk factors. Med. J. Aust. 167: 310 313.
114. Perez-Perez, G. I.,, D. N. Taylor,, L. Bodhidatta,, J. Wongsrichanalai,, W. B. Baze,, B. E. Dunn,, P. D. Echeverria,, and M. J. Blaser. 1990. Seroprevalence of Helicobacter pylori infections in Thailand. J. Infect. Dis. 161: 1237 1241.
115. Perez-Perez, G. I.,, S. S. Witkin,, M. D. Decker,, and M. J. Blaser. 1991. Seroprevalence of Helicobacter pylori infection in couples. J. Clin. Microbiol. 29: 642 644.
116. Perri, F.,, M. Pastore,, R. Clemente,, V. Festa,, M. Quitadamo,, G. Niro,, P. Conoscitore,, P. Rutgeerts,, and A. Andriulli. 1998. Helicobacter pylori infection may undergo spontaneous eradication in children—a 2-year follow-up study. J. Pediatr. Gastroenterol. Nutr. 27: 181 183.
117. Polish, L. B.,, J. M. J. Douglas,, A. J. Davidson,, G. I. Perez Perez,, and M.J. Blaser. 1991. Characterisation of risk factors for Helicobacter pylori infection among men attending a sexually transmitted disease clinic: lack of evidence for sexual transmission. J. Clin. Microbiol. 29: 2139 2143.
118. Raedsch, R.,, S. Pohl,, J. Plachky,, A. Stiehl,, and B. Kommerell,. 1989. The growth of Campylobacter pylori is inhibited by intragastric bile acids, p. 409 412. In F. Megraud, and H. Lamouliatte (ed.), Gastroduodenal Pathology and Campylobacter pylori. Elsevier, Amsterdam, The Netherlands.
119. Ramsey, E. J.,, K. V. Carey,, W. L. Peterson,, J. J. Jackson,, F. K. Murphy,, and N. W. T. Read. 1979. Epidemic gastritis with hypochlorhydria. Gastroenterology 76: 1449 1457.
120. Redlinger, T.,, K. O'Rourke,, and K. J. Goodman. 1999. Age distribution of Helicobactor pylori seroprevalence among young children in a United States/Mexico border community: evidence for transitory infection. Am. J. Epidemiol. 150: 225 230.
121. Replogle, M. L.,, W. Kasumi,, K. B. Ishikawa,, S. F. Yang,, T. Juji,, K. Mild,, G. C. Rabat,, and J. Parsonnet. 1996. Increased risk of Helicobacter pylori associated with birth in wartime and post-war Japan. Int. J. Epidemiol. 25: 210 214.
122. Riggio, M. P.,, and A. Lennon. 1999. Identification by PCR of Helicobacter pylori in subgingival plaque of adult periodontitis patients. J. Med. Microbiol. 48: 317 322.
123. Rocha, G. A.,, D. M. M. Queiroz,, E. N. Mendes,, A. M. R. Oliveira,, S. B. Moura,, and R. J. A. Silva. 1992. Source of Helicobacter pylori infection: studies in abattoir workers and pigs. Am. J. Gastroenterol. 87: 15 25.
124. Rosenstock, S. J.,, L. P. Andersen,, C. V. Rosenstock,, O. Bonnevie,, and T. Jorgensen. 1996. Socioeconomic factors in Helicobacter pylori infection among Danish adults. Am. J. Public Health 86: 1539 1544.
125. Rothenbacher, D.,, G. Bode,, G. Berg,, U. Knayer,, T. Gonser,, G. Adler,, and H. Brenner. 1999. Helicobacter pylori among preschool children and their parents: evidence of parent-child transmission. J. Infect. Dis. 179: 398 402.
126. Rothenbacher, D.,, G. Bode,, and H. Brenner. 2000. Helicobacter pylori among siblings. Lancet 355: 1998.
127. Rothenbacher, D.,, G. Bode,, T. Winz,, G. Berg,, G. Adler,, and H. Brenner. 1997. Helicobacter pylori in out-patients of a general practitioner—prevalence and determinants of current infection. Epidemiol. Infect. 119: 151 157.
128. Sarker, S. A.,, M. M. Rahman,, D. Mahalanabis,, P. K. Bardham,, P. Hildebrand,, C. Beglinger,, and K. Gyr. 1995. Prevalence of Helicobacter pylori infection in infants and family contacts in a poor Bangladesh community. Dig. Dis. Sci. 40: 2669 2672.
129. Sasaki, K.,, Y. Tajiri,, M. Sata,, Y. Fujii,, F. Matsubara,, M. G. Zhao,, S. Shimizu,, A. Toyonaga,, and K. Tanikawa. 1999. Helicobacter pylori in the natural environment. Scand. J. Infect. Dis. 31: 275 280.
130. Sathar, M. A.,, E. Gouws,, A. E. Simjee,, and A. M. Mayat. 1997. Seroepidemiological study of Helicobacter pylori infection in South African children. Trans. R. Soc. Trop. Med. Hyg. 91: 393 395.
131. Schutze, K.,, E. Hentschel,, B. Dragosics,, and A. M. Hirschl. 1995. Helicobacter pylori reinfection with identical organisms—transmission by the patients' spouses. Gut 36: 831 833.
132. Shames, B.,, S. Krajden,, M. Fuksa,, C. Babida,, and J. L. Penner. 1989. Evidence for the occurrence of the same strain of Campylobacter pylori in the stomach and dental plaque. J. Clin. Microbiol. 27: 2849 2850.
133. Sipponen, P. 1995. Helicobacter pylori: a cohort phenomenon. Am. J. Surg. Pathol. 19: S30 S36.
134. Song, O.,, T. Lange,, A. Spahr,, G. Adler,, and G. Bode. 2000. Characteristic distribution pattern of Helicobacter pylori in dental plaque and saliva detected with nested PCR. J. Med. Microbiol. 49: 349 353.
135. Suzuki, J.,, H. Muraoka,, I. Kobayasi,, T. Fujita,, and T. Mine. 1999. Rare incidence of interspousal transmission of Helicobacter pylori in asymptomatic individuals in Japan. J. Clin. Microbiol. 37: 4174 4176.
136. Teh, B. H.,, J. T. Lin,, W. H. Pan,, S. H. Lin,, L. Y. Wang,, T. K. Lee,, and C. J. Chen. 1994. Seroprevalence and associated risk factors of Helicobacter pylori infection in Taiwan. Anticancer Res. 14: 1389 1392.
137. Thomas, J. E.,, A. Dale,, M. Harding,, W. A. Coward,, T. J. Cole,, and L. T. Weaver. 1999. Helicobacter pylori colonization in early life. Pediatr. Res. 45: 218 223.
138. Thomas, J. E.,, G. R. Gibson,, M. K. Darboe,, A. Dale,, and L. T. Weaver. 1992. Isolation of Helicobacter pylori from human faeces. Lancet 340: 1194 1195.
139. Tomb, J. F.,, O. White,, A. R. Kerlavage,, R. A. Clayton,, G. G. Sutton,, R. D. Fleischmann,, K. A. Ketchum,, H. P. Klenk,, S. Gill,, B. A. Dougherty,, K. Nelson,, J. Quackenbush,, L. X. Zhou,, E. F. Kirkness,, S. Peterson,, B. Loftus,, D. Richardson,, R. Dodson,, H. G. Khalak,, A. Glodek,, K. Mckenney,, L. M. Fitzegerald,, N. Lee,, M. D. Adams,, and E. K. Hickey. 1997. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388: 539 547.
140. Torres, J.,, Y. Lealherrera,, G. Perez Perez,, A. Gomez,, M. Camorlingaponce,, R. Cedillorivera,, R. Tapiaconyer,, and O. Munoz. 1998. A community-based seroepidemiologic study of Helicobacter pylori infection in Mexico. J. Infect. Dis. 178: 1089 1094.
141. Vaira, D.,, C. D'Anastasio,, J. Holton,, J. F. Dowsett,, M. Londei,, F. Bertoni,, E. Beltrandi,, P. Grauenfels,, P. R. Salmon,, and L. Gandolfi. 1988. Campylobacter pylori in abattoir workers: is it a zoonosis? Lancet ii: 725 726.
142. Van Zanten, S. 1995. Do socio-economic status, marital status and occupation influence the prevalence of Helicobacter pylori infection? Aliment. Pharmacol. Ther. 9: 41 44.
143. Vanzanten, S. J. O. V.,, P. T. Pollak,, L. M. Best,, G. S. Bezanson,, and T. Marrie. 1994. Increasing prevalence of Helicobacter pylori infection with age—continuous risk of infection in adults rather than cohort effect. J. Infect. Dis. 169: 434 437.
144. Vanzwet, A. A.,, J. C. Thijs,, A. M. D. Koolstrasmid,, J. Schirm,, and J. A. M. Snijder. 1994. Use of PCR with feces for detection of Helicobacter pylori infections in patients. J. Clin. Microbiol. 32: 1346 1348.
145. Varoli, O.,, M. P. Landini,, M. LaPlaca,, A. Tucci,, R. Corinaldesi,, G. F. Paparo,, V. Stanghellini,, and L. Barbara. 1991. Presence of Helicobacter pylori in gastric juice. Am. J. Gastroenterol. 86: 249.
146. Velazquez, M.,, and J. M. Feirtag. 1999. Helicobacter pylori: characteristics, pathogenicity, detection methods and mode of transmission implicating foods and water. Int. J. Pood Microbiol. 53: 95 104.
147. Vincent, P.,, F. Gottrand,, P. Pernes,, M. O. Husson,, M. Lecomtehoucke,, D. Turck,, and H. Leclerc. 1994. High prevalence of Helicobacter pylori infection in cohabiting children—epidemiology of a cluster, with special emphasis on molecular typing. Gut 35: 313 316.
148. Webb, P. M.,, T. Knight,, S. Greaves,, A. Wilson,, D. G. Newell,, J. Elder,, and D. Forman. 1994. Relation between infection with Helicobacter pylori and living conditions in childhood—evidence for person to person transmission in early life. Br. Med. J. 308: 750 753.
149. Webb, P. M.,, T. Knight,, D. G. Newell,, J. B. Elder,, and D. Forman. 1996. Helicobacter pylori transmission—evidence from a comparison with hepatitis A virus. Eur. J. Gastroenterol. Hepatol. 8: 439 441.
150. Woodward, M.,, C. Morrison,, and K. McColl. 2000. An investigation into factors associated with Helicobacter pylori infection. J. Clin. Epidemiol. 53: 175 181.

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